[…] mutations in MAMLD1 ( CXorf6 ) gene ( Horm Res 2009;71:245 ) Urethral opening is usually near glans Hypospadias and epispadias are associated with abnormal descent of testes, urinary tract malformations, obstruction, urinary tract infections and possibly infertility [pathologyoutlines.com]

Without surgical correction, severe hypospadias may cause urination problems and infertility. [ummchealth.com]

Without treatment, affected individuals experience delayed puberty or do not go through puberty, and may be unable to conceive children (infertile). Congenital leptin deficiency is a rare disorder. [ghr.nlm.nih.gov]

Symptoms can include abnormal pain before a period, abnormal bleeding and infertility issues. [northwell.edu]

[…] confounders (Maternal age, maternal race, ethnic group, maternal education, year of LMP, study center, smoking and alcohol 1st trimester, history of a birth defect in first degree relative, BMI, parity, presence/absence of seizures, DM, hypertension, infertility [richtlijnendatabase.nl]

However, if a small head circumference is detected in the neonatal period it is prudent to perform an x ray of the skull to look for evidence of early closure of all the cranial sutures (total craniosynostosis). [jnnp.bmj.com]

ORThe occipitofrontal circumference is more than two standard deviations below normal for gestational age, the disproportionally small head. Causes Intrauterine infectione.g.Rubella. Alcohol syndrome. Some trisomic disorders,That is chromosomal defecte.g.Down [slideshare.net]