Common signs and symptoms of hypothyroidism include fatigue; weakness; weight gain; coarse, dry hair; dry, rough, pale skin; hair loss; intolerance to the cold; muscle cramps; constipation; depression; irritability; memory loss; abnormal menstrual cycles [fortherecordmag.com]

With early onset of the disease signs may be indistinct and go undetected such as general fatigue, slight weight gain from fluid retention and decreased metabolism, dry skin, or cold sensitivity. [physio-pedia.com]

Both chronically high blood glucose and hyperthyroidism can cause weight loss despite good appetite, weakness, and fatigue. [diabetesselfmanagement.com]

At first, you may notice general symptoms including: fatigue lethargy sensitivity to cold depression muscle weakness Because the thyroid hormones control the metabolism of all your cells, you might also gain weight. [healthline.com]

A child with an underactive thyroid may experience fatigue, weight gain, constipation, decreased growth, and a host of other issues. [chop.edu]

Fatigue Syndrome [4] [2] [3] [5] Case Reports 1.) [physio-pedia.com]

(These two articles discuss the linkage of the long arm of Chromosome 15 with kindreds having RTSH without known mutations in the TSHR. [endocrinologyadvisor.com]

The open reading frames of the THOX1 and THOX2 genes are divided among 33 exons, spanning 36 and 22 kb, respectively, on the long arm of chromosome 15. All 33 coding exons for both genes were PCR-amplified from genomic DNA of the patients. [nejm.org]

Another form of TSH resistance is dominantly inherited and has been linked to the long arm of chromosome 15 [ 42 ]. Resistance occurs in the absence of a TSH receptor mutation and can again cause thyroid hypoplasia [ 43 ]. [ojrd.biomedcentral.com]