In this review, we report a case of COIF who presented with bilateral micronychia with a Y-shaped bifurcation of the distal phalanx. [koreauniv.pure.elsevier.com]

[…] normal number of fingers or toes, is presented. megalodactyly. // Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p1429 A definition of the term "megalodactyly," which refers to having very large fingers or toes is, presented. megalosyndactyly [connection.ebscohost.com]

Narrowing of the distal phalanx is a characteristic radiographic finding, but it is not always present. [actasdermo.org]

Ectodermal dysplasia’s is usually associated with hair, palmoplantar involvement and dental abnormalities which are not present in our case. [2] The present case has been reported for the rarity of the condition, newborn presentation, associated features [ijpd.in]

We report a case of a COIF presenting as a congenital bifid nail deformity with underlying bone deformity. [ncbi.nlm.nih.gov]

• Nail Abnormality

  Various nail abnormalities are observed, including (1) anonychia (lack of a fingernail), (2) micronychia (a small fingernail deviated to 1 side of the nail bed), (3) polyonychia (multiple, small, individual nails on one nail bed), (4) hemionychogryphosis [dermaamin.com]

  Abnormalities of collagen VII make the nail attachment vulnerable to mild trauma. Recurrent nail loss then leads to scarring and nail dystrophy, mainly of the big toes. [handresearch.com]

  Matrix or nail bed abnormalities are most common. An abnormal nail is defined as one which looks different than a normal nail should look, regardless of the discrepancy, (shape and size) because there may be associated a phalangeal abnormality. [sites.google.com]

  Nail changes in: Children, elderly, pregnancy. Aims To study the abnormal nail changes in patients coming to the Department of Dermatology. [odermatol.com]

• Sepsis

  […] arthritis (RA) 関節リウマチ rib肋骨 ricketsくる病 root［神経］根 rotation１．回旋、軸旋、２．捻転 rotator cuff［肩］［回旋筋］腱板 s sacral 仙骨の、仙椎の sacrum 仙骨 salvage operationサルベージ手術、救済手術 sarcoidosisサルコイドーシス sarcoma肉腫 sciatic nerve坐骨神経 sciatica 坐骨神経痛 scintigramシンチグラム scoliosis［脊柱］側弯［症］ sepsis [tokyo-med.ac.jp]

• Systolic Murmur

  Echocardiogra-phy performed because of a systolic murmur demon-strated a tiny patent foramen ovale and a moderate ven-triculoseptal defect. [docslide.com.br]

• Skin Disease

  DISEASE NAIL(ANATOMY) CONGENITAL DISEASE HUMAN DERMATOLOGY Keyword (es) DERMATOLOGIA Classification Pascal 002 Biological and medical sciences / 002B Medical sciences / 002B08 Dermatology Discipline Dermatology Origin Inist-CNRS Database PASCAL INIST [pascal-francis.inist.fr]

  Molecular advances in genetic skin diseases. Curr Opin Pediatr 2002; 14: 419-25 Smith F. The molecular genetics of keratin disorders. Am J Clin Dermatol 2003; 4: 347-64 Virtanen M, Smith SK, Gedde-Dahl T Jr, et al. [books.google.com]

  People with NOMID … Epidermolysis Bullosa April 15, 2018 by Peter Ciszewski Epidermolysis bullosa (EB) is a group of genetic skin diseases that cause the skin to become fragile and to blister very easily. [checkrare.com]

  While only a small number of skin diseases account for most visits to the physician, thousands of skin conditions have been described. [howlingpixel.com]

  Neerja Puri e-mail: neerjaash[email protected] Abstract Nails act as a window to diagnosis of skin diseases. Various dermatosis affect the nails and the severity of the skin disorder is reflected in the nails. [odermatol.com]

• Erythema

  […] caused by chemicals, nail damage due to drug, nail deformity, nail diseases, nail disorder, nail disorders, nail dystrophy, nail dystrophy due diseases classified elsewhere, nail dystrophy due to trauma, nail infections, nailbed assessment, nailbed erythema [live.babelnet.org]

  Splinter haemorrhages were seen in 12% and Beau’s lines were observed in 14% cases salmon patches in 10 % cases, longitudinal ridging in 12% cases, longitudinal melanonychia in 4% cases, perilunular erythema/red lunules in 5% cases and twenty nail dystrophy [odermatol.com]

  The distal pulp in most of cases shows mild erythema and scaling. It is often misdiagnosed as onychomycosis. [handresearch.com]

  These areas may become impetiginized, with severe erythema and exudation. Verrucosities appear in some cases and result in grotesque skin changes (Figs 5-21 and 5-22). [sites.google.com]

• Absent Nails

  […] syndrome renal failure trauma absent nail nail patella syndrome COIF (congenital onychodysplasia of the Index Finger) multiple myeloma scarring Anonychia caused by systemic disease Blue discoloration of lunula wilson's disease Drugs PUVA Argyria short [quizlet.com]

  On examination she was found to have 4 digits bilaterally and absent nail on the right index finger, while the left index finger showed a rudimentary nail. [bioline.org.br]

  The hallmarks of the syndrome, represented in the DOOR acronym, include sensorineural hearing loss, hypoplastic or absent nails on the hands and feet, small or absent distal phalanges of the hands and feet, and mental retardation. [handresearch.com]

• Kidney Failure

  However, in about 5% of those affected, progressive kidney failure may result, causing potentially life-threatening complications. [rarediseases.org]

Treatment - Isolated congenital nail dysplasia There is no known treatment for ICND. Symptomatic treatment helps alleviate the disease burden. Resources - Isolated congenital nail dysplasia [checkorphan.org]

Considerable strides have been made in the treatment of fungal diseases (onychomycoses) with the appearance of new therapeutic agents. [books.google.de]

Babies with birth defects often need special care and treatments. The treatments may include surgery, medicines, assistive devices, and therapies. Centers for Disease Control and Prevention Intersex (Medical Encyclopedia) [ Read More ] [icdlist.com]

Treatment of nail psoriasis is always disappointing. [handresearch.com]

[…] photographs of normal and abnormal skin conditions including images of rare conditions, this easily accessible resource is essential for pediatricians, neonatologists, and dermatologists as well as other healthcare professionals involved in the diagnosis and treatment [books.google.com]

Prognosis - Isolated congenital nail dysplasia The ICND is a lifelong condition. Patient documented by Pavone (1982) lost his nails almost completely in his twenties and did not regain them before he died at 77. [checkorphan.org]

Nail changes are not only seen in extensive alopecia areata but may also be present with minimal hair loss and does not imply a poor prognosis for regrowth. Uniform pitting is the most common abnormality seen in alopecia areata. [odermatol.com]

The etiology of this condition is unknown, but clinical study suggested that ischemia of the finger at a certain period of embryonic life might play an important part in its pathogenesis. [ncbi.nlm.nih.gov]

Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. [icd10coded.com]

Although various hypotheses have been put forward to explain the pathophysiology of the syndrome, its etiology remains unknown. [actasdermo.org]

Classification of these conditions often presents many nosological challenges, since underlying etiologies and pathogenetics are often not known. [howlingpixel.com]

Miscellaneous etiologies A report from 2014 suggests that hepatitis B may have played a role in the development of congenital onychodysplasia of the index fingers. [9] The role of infection is unclear but warrants further consideration. [emedicine.medscape.com]

Haeneke E: Epidemiology and Pathology of onychomycosis. In Onychomycosis Nolting S. Korting Eds. Berlin Springer Verlay 1989; 1-8. 6. Williams HC: The epidemiology of onychomycosis in Britain. Br J Dermatol. 1993; 26: 481-490. 7. [odermatol.com]

A genetic mechanism most likely underlies the pathophysiology of congenital onychodystrophy of the index finger (COIF). [5, 6]. Most cases are sporadic, but autosomal dominant transmission has been described. [emedicine.medscape.com]

Brenner/Rector remains the go-to resource for practicing and training nephrologists and internists who wish to master basic science, pathophysiology, and clinical best practices. [books.google.com]

Although various hypotheses have been put forward to explain the pathophysiology of the syndrome, its etiology remains unknown. [actasdermo.org]

[…] index fingernails Deformities of the nails on other fingers Radiographic abnormalities of the distal bony phalanx on the affected fingers Congenital occurrence, which can be either hereditary or sporadic A genetic mechanism most likely underlies the pathophysiology [dermaamin.com]

Prevention - Isolated congenital nail dysplasia Not available. Genetic counselling may help in families where the disease occurred previously. [checkorphan.org]

Centers for Disease Control and Prevention Intersex (Medical Encyclopedia) [ Read More ] [icdlist.com]

Transplantation Substance Use and Addiction Surgery Surgical Innovation Surgical Pearls Teachable Moment Technology and Finance The Rational Clinical Examination Tobacco and e-Cigarettes Toxicology Trauma and Injury Treatment Adherence United States Preventive [doi.org]

This acellular membrane is tightly adherent and prevents invasive microorganisms reaching the underlying matrix. The lunula (half moon) represents the distal portion of the nail’s proliferative matrix. [clinicalgate.com]