It usually presents as a single congenital lesion that frequently involves the back and the lower limbs. [escholarship.org]

Diagnosis: congenital smooth muscle hamartoma. ( 19180688 ) UstA1ner P....Ozen O. 2008 10 Myokymia as a presenting sign of congenital smooth muscle hamartoma. ( 18035984 ) Kienast A....Hoeger P.H. 2007 11 Congenital smooth muscle hamartoma presenting [malacards.org]

To our knowledge, this linear clinical presentation has not been described previously. [ncbi.nlm.nih.gov]

• Darier's Sign

  The pseudo-Darier sign was positive. Histopathologic findings were numerous, well-defined bundles of smooth muscle fibers int he dermis (H & E, Masson-trichrome stain). Keywords Congenital smooth muscle hamartoma;Pseudo-Darier's sign [koreascience.or.kr]

  We describe a case of congenital smooth muscle hamartoma with hypertrichosis and pseudo-Darier's sign, and suggest that it is a clinicohistopathological entity distinct from Becker's naevus. [ncbi.nlm.nih.gov]

  Upon stroking, most lesions demonstrate elevation, erythema or papulation, known as the pseudo-Darier’s sign due to transient piloerection (see Figure 2). [healio.com]

  But a pseudo- Darier’s sign was elicited upon rubbing the lesion. His medical history was uneventful and there was no family history of similar lesions. [mymedicine4all.com]

• Papule

  We report a 16-year-old Korean girl with this uncommon form of CSMH who had linearly arranged, hyperpigmented lesions with follicular papules extending from the right flank to the right lower leg from birth. [ncbi.nlm.nih.gov]

  Arrows indicate the presence of small rounded “mother of pearl” papules that tended to coalescence. Figure 2B. [escholarship.org]

  We report a case of CSMH in a 10 year-old girl, who showed a localized skin-colored patch showing prominent follicular papules on the lateral aspect of her right upper arm, which were found at birth. [synapse.koreamed.org]

  Accentuation of macular perifollicular pigment may also distinguish Becker's melanosis from congenital smooth muscle hamartoma, which exhibits follicular papules but not pigmentary papules. [the-medical-dictionary.com]

• Piloerection

  A positive pseudo-Darier's sign (temporary induration or piloerection after rubbing) helped to differentiate CSMH from congenital hairy nevo-cellular nevus. [ncbi.nlm.nih.gov]

  A positive pseudo-Darier's sign (temporary induration or piloerection after rubbing) helped to differentiate CSMH from congenital hairy nevocellular nevus. [deepdyve.com]

  Upon stroking, most lesions demonstrate elevation, erythema or papulation, known as the pseudo-Darier’s sign due to transient piloerection (see Figure 2). [healio.com]

  They are usually sporadic but have been associated with PTEN -mutation neoplastic syndromes and the Michelin tire baby syndrome. 2,3 Transient piloerection or induration with stroking as a result of smooth muscle contraction (positive pseudo-Darier sign [consultant360.com]

  Transient piloerection or elevation of a lesion induced by rubbing, referred to as a pseudo-Darier sign, is often seen. [2], [3], [4], [5] Interestingly, cutaneous smooth muscle hamartomas are said to be the underlying lesions in the 'Michelin tire baby [ijdvl.com]

• Shagreen Patch

  Shagreen patch is commonly associated with tuberous sclerosis. There are flesh coloured ‘orange-peel’ textured lesions of varying sizes, which are usually found on the lower back and nape of the neck. [dermnetnz.org]

  Connective tissue nevi of the collagen type may appear as the shagreen patch of tuberous sclerosis, and patients found to have collagen-type connective tissue nevi should be carefully examined for other signs of tuberous sclerosis. [the-medical-dictionary.com]

• Skin Patch

  The signs and symptoms of Smooth Muscle Hamartoma of Skin may include the following: The presence of a single, well-circumscribed plaque or dark skin patch The size of the skin lesion is variable and may be between 1-10 cm The lesion shows a progressive [dovemed.com]

• Suggestibility

  We describe a case of congenital smooth muscle hamartoma with hypertrichosis and pseudo-Darier's sign, and suggest that it is a clinicohistopathological entity distinct from Becker's naevus. [ncbi.nlm.nih.gov]

  SUMMARY We describe a case of congenital smooth muscle hamartoma with hypertrichosis and pseudo‐Darier's sign, and suggest that it is a clinicohistopathological entity distinct from Becker's naevus. [onlinelibrary.wiley.com]

  The movements suggest coordinated smooth muscle contraction. Differential Diagnosis Clinical diagnosis of congenital smooth muscle hamartoma is difficult because of the lack of specific diagnostic criteria. [the-medical-dictionary.com]

  Several authors have suggested that Becker's melanosis and CSMH represent opposite ends in the same spectrum of cutaneous organoid hamartomas. 15,30 Others regard these two conditions as separate and distinct clinicopathologic entities. 4,31 Long-term [journals.lww.com]

• Impulsivity

  Local stimulation results in impulses conducted by nerves, with resultant smooth muscle contraction and transient elevation or rippling movements of the lesion. The movements suggest coordinated smooth muscle contraction. [the-medical-dictionary.com]

• Myokymia

  We report a 4-week-old male infant with intermittent asymptomatic bouts of vermicular movements of the skin (myokymia). Myokymia started at the age of 4 days. [ncbi.nlm.nih.gov]

  Diagnosis: congenital smooth muscle hamartoma. ( 19180688 ) UstA1ner P....Ozen O. 2008 10 Myokymia as a presenting sign of congenital smooth muscle hamartoma. ( 18035984 ) Kienast A....Hoeger P.H. 2007 11 Congenital smooth muscle hamartoma presenting [malacards.org]

  […] pinocytotic vesicles and nerve fibers. [2], [3], [4], [5] The clinical differential diagnosis for congenital smooth muscle hamartoma includes a solitary mastocytoma, cafι au lait spot, congenital pigmented hairy nevocellular nevus, Becker's nevus and myokymia [ijdvl.com]

  Myokymia vs transient rippling of the skin. Arch Dermatol 1976;112:554. 15. White LE, Levy RM, Alam M. Neoplasias and Hyperplasias of mascular and Neural Origin. In: Klaus W, Lowell A, Goldsmith S, et al, editors. [e-ijd.org]

Progress logically from the histologic pattern, through the appropriate workup, around the pitfalls, to the best diagnosis. [books.google.com]

Surgical excision is the first-line therapeutic option, but in certain areas such as the face, surgery may be too aggressive, and different treatments should be considered. [ncbi.nlm.nih.gov]

In such cases, when treatment is necessary, surgical excision to remove the lesions may be undertaken The prognosis is usually excellent with suitable treatment, since these lesions are typically benign. [dovemed.com]

Hayasaki A, Nakamura H, Hamasaki T, et al (2009) Successful treatment of intraorbital lymphangioma with tissue fibrin glue. [link.springer.com]

Cutaneous smooth muscle neoplasms: clinical features, histologic findings, and treatment options. J Am Acad Dermatol. 2002;46(4):477-490. [consultant360.com]

(Outcomes/Resolutions) The prognosis of Smooth Muscle Hamartoma of Skin is excellent on its complete excision and removal Since, these are benign conditions, the prognosis is generally excellent even if no treatment is provided and only periodic observation [dovemed.com]

Leiomyosarcoma of the inferior vena cava: prognosis and comparison with leiomyosarcoma of other anatomic sites. Cancer 1999; 85 :1077–1083. 57. Hollenbeck ST, Grobmyer SR, Kent KC et al. [nature.com]

A triple association between juvenile chronic myeloid leukemia, juvenile xanthogranulomas, and NF-1 is recognized ( Fig. 26.11 ). 47 Etiology. The etiology of juvenile xanthogranuloma is unknown. [clinicalgate.com]

(Etiology) The cause of Smooth Muscle Hamartoma of Skin formation is unknown. The tumor may have a congenital origin (seen in most cases) or it may be acquired. [dovemed.com]

A population-based epidemiologic and prognostic study of 48 patients, including cellular DNA content. Cancer 1992; 70 :114–119. 40. Hashimoto H, Daimaru Y, Tsuneyoshi M et al. Leiomyosarcoma of the external soft tissues. [nature.com]

& Vitamin K Antagonists: Anticoagulation Affects on the Clotting Cascade Wilson’s Disease Section 9 - Genodermatoses and Syndromes Addison’s Disease Amyloid Basal Cell Nevus Syndrome Carney Complex Cushing's Syndrome and Disease Cushing's Syndrome: Pathophysiology [euro-libris.ro]

Complement depletion or platelet depletion prevented or reduced proliferation, respectively; these maneuvers also prevented smooth muscle actin and actin gene expression. [jci.org]

Current medical research has not established a method of preventing the occurrence of Smooth Muscle Hamartoma of Skin. [dovemed.com]

Oral subcutaneous midline leiomyomatous hamartoma presenting as congenital incisive papilla overgrowth in a toddler Ashish Loomba 1, Shalini Garg 1, Abhishek Dhindsa 1, Harshaminder Kaur 2, Neetu Jain 1, Promila Dhindsa 3 1 Department of Pediatric and Preventive [contempclindent.org]