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Congenital Trigeminal Anesthesia


Presentation

  • Due to corneal anesthesia, it usually presents with recurrent, painless eye infections, painless corneal opacities and/or poorly healing, ulcerated wounds on the facial skin and mucosa (typically the buccal mucosa and/or nasal septum).[orpha.net]
  • A 2-month-old infant presented with bilateral corneal erosions and complete corneal anesthesia. Her sister presented at age 3 years with a corneal ulcer and corneal hypoesthesia (sensation markedly decreased).[ncbi.nlm.nih.gov]
  • Fleisher and Roizen present a completely revised new edition that includes coverage of many new conditions, procedures, and drugs.[books.google.com]
Anosmia
  • 254 Chapter 28 RuvalcabaMyhre Syndrome 261 DISEASES WITH XLINKED INHERITANCE 263 Chapter 29 FabryAnderson Disease 265 Chapter 30 Adrenoleukodystrophy 273 Chapter 31 Kinky Hair Disease 284 Chapter 32 Incontinentia Pigmenti 293 Chapter 33 A Syndrome of Anosmia[books.google.com]
Failure to Thrive
  • Fred Ferri’s popular "5 books in 1" format provides quick guidance on menorrhagia, Failure to Thrive (FTT), Cogan’s syndrome, and much more.[books.google.com]
Hydrops Fetalis
  • Stay at the forefront of your field thanks to new and completely revised chapters covering topics such as: Principles and Practice l Immune and Non-immune Hydrops Fetalis l Amniotic Fluid Volume l Enhancing Safe Prescribing in the Neonatal Intensive Care[books.google.com]
Corneal Opacity
  • Due to corneal anesthesia, it usually presents with recurrent, painless eye infections, painless corneal opacities and/or poorly healing, ulcerated wounds on the facial skin and mucosa (typically the buccal mucosa and/or nasal septum).[orpha.net]
  • Karger AG, Basel Case Report A 16-month-old boy was referred to the Yamaguchi University Hospital on 10 December 2009 because of untreatable corneal opacity.[karger.com]
Ulcer
  • Her older sister initially required antibiotic ointment for her corneal ulcer but now requires only ocular lubrication for congenital trigeminal anesthesia.[ncbi.nlm.nih.gov]
  • Due to corneal anesthesia, it usually presents with recurrent, painless eye infections, painless corneal opacities and/or poorly healing, ulcerated wounds on the facial skin and mucosa (typically the buccal mucosa and/or nasal septum).[orpha.net]
  • Initially this was investigated as an infected ulcer and treated for several weeks as herpetic ulceration with no beneficial effect.[insights.ovid.com]
Kinky Hair
  • Syndrome 241 Chapter 26 Progeria 247 Chapter 27 Neuroectodermal Melanolysosomal Disease 254 Chapter 28 RuvalcabaMyhre Syndrome 261 DISEASES WITH XLINKED INHERITANCE 263 Chapter 29 FabryAnderson Disease 265 Chapter 30 Adrenoleukodystrophy 273 Chapter 31 Kinky[books.google.com]

Workup

  • Given that malignancy is a prominent feature of recently diagnosed preganglionic Horner syndrome, patients may avoid an unnecessary extensive workup for carcinoma if the lesion can be shown to be old or long-standing.[emedicine.medscape.com]

Treatment

  • Make informed clinical choices for each patient, from diagnosis and treatment selection through post-treatment strategies and management of complications, with new evidence-based criteria throughout.[books.google.com]
  • The material is in no way intended to replace professional medical care by a qualified specialist and should not be used as a basis for diagnosis or treatment.[orpha.net]

Prognosis

  • […] aqueductal stenosis sutural synostosis other supratentorial abnormalities 8 hypoplasia of the commissural system ( corpus callosum, anterior commissure ) hypoplasia of the anterior visual pathway agenesis of the posterior lobe of the pituitary Treatment and prognosis[radiopaedia.org]
  • An accurate and up-to-date classification is important for therapy, prognosis, and genetic counseling of the affected children and their families.[austinpublishinggroup.com]
  • Prognosis Several undesirable side effects may follow the procedure. The first is that the numbness may have an unpleasant or painful sensation. Often the numbness has an undesirable quality; similar to the way it feels after a Novocain injection.[ufhealth.org]
  • […] posterior communicating artery aneurysm ) Pupillary sparing often due to ischemic microangiopathy Treatment Compressive lesions: surgery Ischemic microangiopathy or demyelinating lesions: medical management with adequate control of the underlying disease Prognosis[amboss.com]
  • The estimated frequency of the numb chin syndrome in breast cancer is approximately 4% and is usually associated with a poor prognosis [ 46 ].[neupsykey.com]

Etiology

  • Etiology Clinical features Extorsion of the eye : inability to depress and adduct the eyeball simultaneously (the pupil shoots upward during attempted adduction of the eyeball) Diplopia ( double vision ) Mild esotropia Trigeminal nerve lesion (V) Etiology[amboss.com]
  • TN is classified as symptomatic when the etiology is known and as idiopathic when the etiology is unknown.[ncbi.nlm.nih.gov]
  • Another common etiology of neurotrophic keratopathy is diabetes mellitus. Diabetes either may be the primary cause of neurotrophic keratopathy or secondarily may predispose patients to this condition.[aao.org]

Epidemiology

  • Epidemiologic features of chronic atrial fibrillation: the Framingham study. N Engl J Med 1982; 306 : 1018–1022. 15. Roark S F, McCarthy E A, Lee K L, Pritchett E L C.[nature.com]
Sex distribution
Age distribution

Pathophysiology

  • A spectrum of pathophysiological processes may affect the trigeminal nerves, including traumatic, vascular, inflammatory, demyelinating, infectious, and neoplastic disorders.[oasisdiscussions.ca]
  • Pathophysiology The cornea has a high density of nerve endings from the long posterior ciliary nerves and is 100 times more sensitive than the conjunctiva.[aao.org]
  • With multiple etiologies causing corneal anesthesia, the cellular pathophysiological mechanisms are complex and not yet fully investigated [ 4 ].[journals.plos.org]

Prevention

  • Rapidly find the answers you need with separate sections on diseases and disorders, differential diagnosis, clinical algorithms, laboratory results, and clinical preventive services, plus an at-a-glance format that uses cross-references, outlines, bullets[books.google.com]
  • Anesthesia: Goals are to provide brain relaxation for good surgical exposure and to maintain adequate CPP (at least 70 mmHg) to prevent cerebral ischemia from brain retraction.[anesthesia.ucsf.edu]
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  • […] don’t know how to prevent trigeminal neuralgia.[healthlibrary.brighamandwomens.org]

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