Metz, MD, FACP Patients with ITP continue to present difficulties in diagnosis and management. Two experts discuss the current approach to ITP. [books.google.com]

Constitutional Symptoms Constitutional symptoms are a cluster of signs and symptoms that a patient may present with that will indicate disease processes that are systemic in nature. [screeningthesacroiliacjoint.weebly.com]

Case presentation Here we present a case using Ruxolitinib for disabling constitutional symptoms despite complete bone marrow response in a patient with aggressive systemic mastocytosis. [biomarkerres.biomedcentral.com]

Example sentences with "constitutional symptom", translation memory A 39 year old female presented with rapidly enlarging goitre, minimal obstructive symptoms and no constitutional symptoms. [glosbe.com]

He presented a comparison of his MMS results with conventional analytical approaches. [redshiftbio.com]

• Constitutional Symptom

  Example sentences with "constitutional symptom", translation memory A 39 year old female presented with rapidly enlarging goitre, minimal obstructive symptoms and no constitutional symptoms. [glosbe.com]

  In fact, various types of cancer, in the early stages, exhibit symptoms that are constitutional in nature. Constitutional Symptoms List Constitutional symptoms can be one of these (given below), meaning they can occur in isolation or in groups. [buzzle.com]

  Constitutional symptoms Fatigue Fever Lymphadenopathy Systemic lupus erythematosus Medicine(all) Immunology and Microbiology(all) Cite this Apa Standard Harvard Vancouver BIBTEX RIS @inbook{202eae203aa74c62a0ef7b6123381f2c, title = "Constitutional Symptoms [ukm.pure.elsevier.com]

  RESULTS: Constitutional symptoms except weight loss were all strongly related to all measures of quality of life. [ncbi.nlm.nih.gov]

  […] by the impact of an illness on the entire body or constitution are frequently referred to as constitutional symptoms. [btb.termiumplus.gc.ca]

• Fever

  […] includes only fever. [ukm.pure.elsevier.com]

  […] were fever (76.1%), cough (54.8%) and constitutional symptoms (56.8%). [glosbe.com]

  Influenza is often accompanied by fever and body aches, which usually is not the case with common cold. [buzzle.com]

  Examples include weight loss, fevers, headache, fevers of unknown origin, hyperhidrosis, generalized hyperhidrosis, chronic pain, fatigue, dyspnea, and malaise.Other examples include chills, night sweats, and decreased appetite.Generally, they are very [en.wikipedia.org]

  PATIENTS AND METHODS: Two hundred five HIV-infected patients (93% male, 26% African American, 28% Latino, 39% white, 7% other ethnicity) with diarrhea, fever, or weight loss were studied at a county hospital and a Veterans Administration hospital in southern [ncbi.nlm.nih.gov]

• Weight Loss

  Symptom indicating a systemic effect of a disease; e.g., weight loss. [medical-dictionary.thefreedictionary.com]

  RESULTS: Constitutional symptoms except weight loss were all strongly related to all measures of quality of life. [ncbi.nlm.nih.gov]

  The most frequent manifestations are fatigue, followed by fever and weight loss. Other less common features are lymphadenopathy and splenomegaly. [ukm.pure.elsevier.com]

  loss, night sweats, and bone pain). [bloodjournal.org]

  B symptoms refer to systemic symptoms of fever, night sweats, and weight loss which can be associated with both Hodgkin's lymphoma and non-Hodgkin's lymphoma. [en.wikipedia.org]

• Weakness

  For example, fatigue and weakness are common enough concerns, especially if their onset is protracted, that they can be very easy to ignore. [diversalertnetwork.org]

  Signs and symptoms of a TIA include: Headache Dizziness Weakness or numbness on one side of the body, Blurred or double vision Slurred speech Unexpected or exaggerated bleeding. [lls.org]

  Weakness of the legs and arms may develop. [iwmf.com]

  Symptoms of peripheral neuropathy are: Pins and needles of the hands and feet Burning pains in feet, legs, hands and arms Muscle weakness Loss of coordination Sharp stabbing pains that are often worse at night Numbness and a reduced ability to feel pain [dred.com]

  Calcarea Carb Children weak and emaciated, with well developed head but puny sickly bodies. [homoeopathyclinic.com]

• Chills

  Any weight loss or weight gain, fatigue, fever, chills, sweats, appetite or sleep problems?" My cases include the complete list of questions for all 14 standard review of systems (and much much more information). [usmleforum.com]

  Examples include weight loss, fevers, headache, fevers of unknown origin, hyperhidrosis, generalized hyperhidrosis, chronic pain, fatigue, dyspnea, and malaise.Other examples include chills, night sweats, and decreased appetite.Generally, they are very [en.wikipedia.org]

  Examples include weight loss, shaking, chills, fever, and vomiting. con·sti·tu·tion·al symp·tom ( kon'sti-tū'shŭn-ăl simp'tŏm ) A symptom indicating a systemic effect of a disease; e.g., weight loss. con·sti·tu·tion·al symp·tom ( kon'sti-tū'shŭn-ăl simp'tŏm [medical-dictionary.thefreedictionary.com]

  Hot: Fever/chills, sweats Tired: Fatigue, change in sleep habits Not hungry: Appetite, weight loss There are several good mnemonics for taking a pain history, many are variations of “OPQRST”: O: Onset P: Provocation and palliation Q: Quality (Is it sharp [theweeklymnemonic.wordpress.com]

  Fever Headache Unexplained fatigue Malaise Lethargy Weight loss or gain Weakness Arthralgia (joint pain) Myalgia (muscle pain) Shaking Chills Nausea Vomiting Loss of appetite Abdominal pain Change in bowel function Backaches Difficulty in sleeping Breathing [buzzle.com]

• Dyspnea

  Examples include weight loss, fevers, headache, fevers of unknown origin, hyperhidrosis, generalized hyperhidrosis, chronic pain, fatigue, dyspnea, and malaise.Other examples include chills, night sweats, and decreased appetite.Generally, they are very [en.wikipedia.org]

  Cardiopulmonary symptoms, known commonly as "the chokes," include a dry cough; chest pain behind the sternum, or breastbone; and breathing difficulty, also known as "dyspnea." [diversalertnetwork.org]

  Significant reductions were seen in fatigue, weight loss, dyspnea, insomnia, and pain [ 7, 8 ]. [biomarkerres.biomedcentral.com]

  Nonproductive cough, dyspnea, or orthopnea with no obvious cause that persists for more than two to three weeks and does not respond to treatment, or that is associated with other disturbing findings (lymphadenopathy, weight loss, fever, pallor, facial [aafp.org]

• Respiratory Distress

  […] failure, acute respiratory distress syndrome, septic shock, and multi-organ failure. [cdc.gov]

• Vomiting

  Examples include weight loss, shaking, chills, fever, and vomiting. con·sti·tu·tion·al symp·tom ( kon'sti-tū'shŭn-ăl simp'tŏm ) A symptom indicating a systemic effect of a disease; e.g., weight loss. con·sti·tu·tion·al symp·tom ( kon'sti-tū'shŭn-ăl simp'tŏm [medical-dictionary.thefreedictionary.com]

  This cluster of symptoms include: Fever Diaphoresis Night sweats Nausea Vomiting Diarrhea Pallor Dizziness/Syncope Fatigue Weight Loss References: 1. Goodman, C. & Snyder, T. (2007). [screeningthesacroiliacjoint.weebly.com]

  Consenting subjects were administered a battery that included 11 scales measuring various aspects of health-related quality of life and detailed questions about six constitutional symptoms or symptom complexes (myalgias, exhaustion, anorexia/nausea/vomiting [ncbi.nlm.nih.gov]

  Abdominal masses, as well as any degree of hepatosplenomegaly, call for further investigation with ultrasonography, especially if they are associated with anorexia, vomiting, fever, pain, or a child who appears ill. 5, 12 Persistent vomiting also requires [aafp.org]

  In a 2009 study in the "New England Journal of Medicine" nearly 40 percent of people with H1N1 flu or "swine" flu reported vomiting (25 percent), diarrhea (25 percent) or both (13 percent). [livestrong.com]

• Diarrhea

  This cluster of symptoms include: Fever Diaphoresis Night sweats Nausea Vomiting Diarrhea Pallor Dizziness/Syncope Fatigue Weight Loss References: 1. Goodman, C. & Snyder, T. (2007). [screeningthesacroiliacjoint.weebly.com]

  PATIENTS AND METHODS: Two hundred five HIV-infected patients (93% male, 26% African American, 28% Latino, 39% white, 7% other ethnicity) with diarrhea, fever, or weight loss were studied at a county hospital and a Veterans Administration hospital in southern [ncbi.nlm.nih.gov]

  In a 2009 study in the "New England Journal of Medicine" nearly 40 percent of people with H1N1 flu or "swine" flu reported vomiting (25 percent), diarrhea (25 percent) or both (13 percent). [livestrong.com]

  Among young children with influenza, nausea, vomiting or diarrhea may also occur with respiratory symptoms. [cdc.gov]

  Other reported adverse side effects include insomnia, palpitations, and diarrhea, especially in persons who use large doses for prolonged periods. 18 Ginseng should not be used during pregnancy because of possible hormonal effects on the fetus, and it [ahcmedia.com]

• Loss of Appetite

  Fever Headache Unexplained fatigue Malaise Lethargy Weight loss or gain Weakness Arthralgia (joint pain) Myalgia (muscle pain) Shaking Chills Nausea Vomiting Loss of appetite Abdominal pain Change in bowel function Backaches Difficulty in sleeping Breathing [buzzle.com]

  General (non-specific) symptoms Other possible symptoms of HL include: Itching skin Feeling tired (fatigue) Loss of appetite Sometimes the only symptom might be feeling tired all the time. [cancer.org]

  This occurs due to: Loss of appetite due to nausea Low dietary intake caused by ulcers of the mouth or oesophagus which make eating difficult Losing nutrients through diarrhoea, vomiting or poor absorption of nutrients in the intestine Late-stage symptoms [dred.com]

• Hypotension

  Mast cell degranulation leads to various cytokine release, producing pruritus, flushing, dyspepsia, hypotension, and even shock [ 2 ]. The workup of SM includes testing for mutations that play a role in pathogenesis and treatment implications. [biomarkerres.biomedcentral.com]

• Arthritis

  […] chronic fatigue syndrome, inclusion body myositis; Infectious tuberculosis, infectious mononucleosis, hepatitis, following other viral illnesses, hookworm infestation, HIV infection; Inflammatory/Immune systemic lupus erythematosis (SLE), rheumatoid arthritis [mhmedical.com]

  […] found Leukemia, lymphoma, hepatic tumors Vomiting Persistent and recurring; associated with morning headaches; associated with abdominal mass Brain tumors, abdominal tumors (neuroblastoma, Wilms tumor, lymphoma, hepatoblastoma) Bone pain, joint pain/arthritis [aafp.org]

  Arthritis (inflammation of the joints accompanied by swelling) can also be observed in MPA. [web.archive.org]

• Osteoporosis

  Caused by hypersecretion of vasoactive intestinal peptide Neuroblastoma Opsoclonus-myoclonus syndrome (“dancing eyes–dancing feet”) Bursts of rapid, chaotic eye movements with frequent, involuntary, irregular, jerking muscle movements Neuroblastoma Osteoporosis [aafp.org]

  Also, patients who are at risk for or who already have osteoporosis will typically be started on a daily calcium supplement, Vitamin D, and possibly another agent (e.g., a bisphosphonate such as alendronate) designed to strengthen bones. [web.archive.org]

• Sweating

  Individual, previously validated MSAS questions were all highly correlated (all p (fatigue), cough ( same ), pain (both abdominal pain and bone pain ), sweats ( night sweats ), itching ( same ), and weight loss ( same ). [bloodjournal.org]

  Drenching sweats, especially at night. Unintentional weight loss of >10% of normal body weight over a period of 6 months or less. [en.wikipedia.org]

  Symptoms of bacterial pneumonia : Chest pain Shortness of breath A cough producing yellow or green sputum Symptoms of PCP: Fatigue Shortness of breath Rapid breathing Dry cough Fever Chills Night sweats Weight loss Late-stage symptoms of HIV: night sweats [dred.com]

  Night Sweats Drenching Night Sweats Return to top Drenching night sweats is one of the so-called b-symptoms associated with lymphomas. This type usually " involves the entire body and are not confined to a specific hour during the night. [lymphomation.org]

• Anxiety Disorder

  "A phobia is classified as a type of anxiety disorder (a neurosis), since anxiety is its chief symptom." 恐怖症在分类上是焦虑失调(一种精神官能症)的形式，因为焦虑是主要症状。 Now, you must agree that these are indubitable symptoms of insanity." [hujiang.com]

• Headache

  Headache is another example of constitutional symptoms as the causes may vary from as simple as a lack of sleep to some really serious ones such as a brain tumor. In short, it can occur due to various medical conditions. [buzzle.com]

  Examples include weight loss, fevers, headache, fevers of unknown origin, hyperhidrosis, generalized hyperhidrosis, chronic pain, fatigue, dyspnea, and malaise.Other examples include chills, night sweats, and decreased appetite.Generally, they are very [en.wikipedia.org]

  Käännökset Yksikielisiä esimerkkejä It initially produces general symptoms like fatigue, fever, and headache and can rapidly progress to neck stiffness, coma and death in 10% of cases. [fi.bab.la]

  sinusitis, tension headache, and ocular abnormalities are excluded. [aafp.org]

  Raphael Dolin in "Harrison's Principles of Internal Medicine," include headache, feverishness, chills, muscle pain, malaise and extreme fatigue. [livestrong.com]

• Tingling

  The HIV virus can cause numbness and tingling of the hands and feet, also known as peripheral neuropathy. [dred.com]

  Neurological symptoms may include numbness; paresthesia, or an altered sensation, such as tingling; muscle weakness; an impaired gait, or difficulty walking; The Romberg test evaluates postural control. [diversalertnetwork.org]

  Peripheral neuropathy – characterized by numbness, tingling, burning, or prickling sensations that are commonly first noticed in the feet. [iwmf.com]

  Neurologic symptoms resulting from peripheral nerve damage may also include numbness or tingling in the arm, hand, leg, or foot. [web.archive.org]

  The signs and symptoms in ET are mainly featured by tingling and prickling sensations in footsoles, handpalms, toes and finger [ 9, 10 ], cognitive concentration and visual disturbances [ 7 ]. [omicsonline.org]

• Lethargy

  […] reactions with rapid onset, including life-threatening reactions have occurred after restarting Ziagen in patients who had only one of the key symptoms of hypersensitivity (skin rash, fever, gastrointestinal, respiratory or constitutional symptoms such as lethargy [glosbe.com]

  Fever Headache Unexplained fatigue Malaise Lethargy Weight loss or gain Weakness Arthralgia (joint pain) Myalgia (muscle pain) Shaking Chills Nausea Vomiting Loss of appetite Abdominal pain Change in bowel function Backaches Difficulty in sleeping Breathing [buzzle.com]

  Anorexia and cachexia, asthenia, and lethargy. Hematol Oncol Clin North Am 1996 ; 10 : 189 –206. 2 González Macías J, Riancho JA. Síndrome de afectación general. In: J. García-Conde, J. Merino, J. González Macías, eds. [academic.oup.com]

  Neurologic symptoms occur in many malignancies and are present in 88% of patients with central nervous system tumors at diagnosis. 15, 16 In children younger than two years, common neurologic symptoms are nonspecific and include unexplained irritability or lethargy [aafp.org]

• Asthenia

  This syndrome was defined as a clinical picture characterized by the presence of asthenia, anorexia, and weight loss of at least 5% of body weight in the last six months, not associated with any other symptom or sign suggesting the diagnosis of an organ [proz.com]

  For instance, a young woman presenting with insidious asthenia, predominantly in the morning, mild anorexia and slight weight loss, could probably be assigned a lower value (i.e. 5%). [academic.oup.com]

  So called systemic or constitutional symptoms, such as fever, night sweats, weight loss in excess of 10%, or asthenia, are infrequent at presentation of the disease but can be observed in later stages. [lymphomation.org]

  Asthenia. In Doyle D, Hanks GWC, MacDonald N, eds. Oxford Textbook of Palliative Medicine, 2nd ed. New York: Oxford University Press, 1998. Beal JE, Olson R, Laubenstein L, et al. [thebody.com]

• Difficulty Concentrating

  The inability to finish grocery-shopping because of difficulty concentrating is another example. There are many possibilities. [newyorkdisabilitylawyer.com]

  If you scrape off these spots they will leave small, painless wounds that bleed slightly A burning sensation in the mouth and throat Difficulty swallowing Late-stage HIV symptoms: confusion or difficulty concentrating Cognitive malfunctions could hint [dred.com]

The workup of SM includes testing for mutations that play a role in pathogenesis and treatment implications. [biomarkerres.biomedcentral.com]

In addition to the workup detailed in Anemia, measuring the serum erythropoietin (EPO) level can help distinguish between bone marrow damage (ie, normal EPO level) and inflammatory anemia (ie, low EPO level). [reference.medscape.com]

Risk stratification, treatment goals, and first- and second-line therapies are discussed in detail, and other relevant diagnostic and research issues are also addressed. [books.google.com]

Therefore, a “watch and wait” treatment strategy is reasonable and usually preferred in asymptomatic low- or intermediate-risk patients with MF. [link.springer.com]

Current Treatments Treatments for MF are aimed primarily at managing symptoms and reducing the risks of complications of the condition. [mpninfo.org]

What Are the Available Treatments for MF? There is no single treatment that is effective for all MF sufferers. Each patient has a unique set of symptoms and circumstances that require different treatment options, as prescribed by a doctor. [mpnresearchfoundation.org]

The mean MFI-20 score for MPN patients under treatment was 14.8. Interestingly, all relevant fatigue values appeared to peak during treatment, compared to the period before treatment or without treatment. [omicsonline.org]

What is the Prognosis for MF? There is no single prognosis for people who suffer from myelofibrosis– the prognosis of MF is different for every patient. [mpnresearchfoundation.org]

The discovery of the JAK2 V617F mutation in the majority of patients with bcr / abl -negative myeloproliferative neoplasms has stimulated a number of questions regarding the diagnosis, prognosis, and treatment of polycythemia vera, essential thrombocythemia [books.google.com]

The results were correlated to patient groups with favourable and unfavourable prognosis according to pathological stage, histology, spleen involvement and constitutional symptoms. 1. [glosbe.com]

Other factors include prognosis, as well as response to any treatment, and the expected natural history of the disorder with and without treatment. [newyorkdisabilitylawyer.com]

[…] chills and shivering. 6 If fluid and electrolyte loss from fever and sweats is considerable, the clinician must weigh the benefits and burdens of aggressive hydration to restore and maintain fluid balance in light of the patient's goals, values, and prognosis [thebody.com]

Fatigue is the most common disabling symptom reported by SLE patients and the etiology is multifactorial, as even patients with quiescent lupus may continue to experience marked fatigue. [ukm.pure.elsevier.com]

Treatments for fatigue of multiple etiologies include psychostimulants and corticosteroids. [thebody.com]

It is this synthesis of the clinical problem that the homoeopathic diagnosis points to, with the clear conscience that homoeopathy only seeks to cure the chronic disease in its etiological and constitutional aspects and not in its terminal physio-pathological [homoeopathyclinic.com]

Their etiology is unknown. These ulcers can be very painful and can cause dysphagia if left untreated. Hematologic disturbances Upon disease progression, individuals with HIV infection develop a moderate to severe hypoproliferative anemia. [reference.medscape.com]

[…] this justifies that prospective unmet need (PUN) studies are warranted in which the effect of treatment with aspirin, phlebotomy/aspirin, pegylated interferon, anagrelide, hydroxyurea and JAK2 inhibitors in ET, PV and MF patients of various molecular etiology [omicsonline.org]

Epidemiology of myeloproliferative neoplasms in the United States. Leukemia & Lymphoma. 2013;Early online: 1-6. [mpninfo.org]

This represents an epidemiologic challenge in controlling the HIV pandemic. Weeks 10-24 During weeks 10-24, the HIV viral load drops to its lowest point, also known as the set point, which is different in each person. [reference.medscape.com]

Epidemiology In 2013, a total of 6,000 persons (4,500 men and 1,500 women) were newly diagnosed with HIV in the UK. [patient.info]

Epidemiology of childhood cancer. Cancer Treat Rev. 2010;36(4):277–285. 3. Steliarova-Foucher E, Stiller C, Kaatsch P, et al. [aafp.org]

Epidemiology of thrombosis in HIV-infected individuals. The adult/adolescent spectrum of HIV disease project. AIDS 14:321-4, 2000. Padmanabhan S, Rosenberg AS. Cushing's syndrome induced by megestrol acetate in a patient with AIDS. [thebody.com]

We remain committed to the case method of instruction, and believe that there is no better method to learn medicine than to have an individual patient problem as the basis for study of pathophysiology, natural history, diagnosis and management. [books.google.com]

Myeloproliferative neoplasms: Molecular pathophysiology, essential clinical understanding, and treatment strategies. J Clin Oncol. 2011;29(5):573-582. [mpninfo.org]

Pathophysiology Acute HIV infection (also known as seroconversion) is defined as the period between exposure to the virus and completion of the initial immune responses (when an antibody test becomes positive for HIV). [reference.medscape.com]

Secondary chemoprophylaxis is used to prevent the recurrence of an infection that has already occurred. Primary prevention Early disease (WHO stages 1-3). The type of infection will depend on local disease prevalence. [patient.info]

In order to reduce the delay in the diagnosis of PMR and prevent unnecessary and expensive diagnostic methods, education of clinicians about the diagnosis of PMR may be beneficial. [ncbi.nlm.nih.gov]

The flu is a contagious respiratory disease that affects millions of Americans each year, according to the Centers for Disease Control and Prevention (CDC). [livestrong.com]

Perhaps the best way to prevent the flu is to get an annual flu shot before the flu season hits. However, there is much controversy about the safety of flu shots as may be seen in this Google search. [coldcure.com]

The listing for a particular impairment describes a degree of severity that Social Security Administration presumes would prevent a person from performing substantial work. [newyorkdisabilitylawyer.com]