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Cooks Syndrome

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Presentation

  • Clinical description Cooks syndrome is congenital and presents with hypo/anonychia, small or absent distal phalanges and digitalization of the thumbs.[orpha.net]
  • We present a case and discussion of a patient with congenital anonychia, absent distal phalanges, and rudimentary hypoplastic middle phalanges and brachydactyly, consistent with Cooks syndrome. 2012 Wiley Periodicals, Inc.[ncbi.nlm.nih.gov]
  • The CS clinical spectrum is expanded to include ungueal tumor-like lesions, observed in the present patient.[ncbi.nlm.nih.gov]
  • Hence this could be considered to be an incomplete presentation or “ forme fruste” of Cooks syndrome .[oatext.com]
  • The information presented is not intended to replace medical advice or treatment from your own doctor or healthcare provider.[wellnessadvocate.com]

Treatment

  • The material is in no way intended to replace professional medical care by a qualified specialist and should not be used as a basis for diagnosis or treatment.[orpha.net]
  • The information presented is not intended to replace medical advice or treatment from your own doctor or healthcare provider.[wellnessadvocate.com]
  • […] photographs of normal and abnormal skin conditions including images of rare conditions, this easily accessible resource is essential for pediatricians, neonatologists, and dermatologists as well as other healthcare professionals involved in the diagnosis and treatment[books.google.com]
  • In between, the hospitalist wouldn’t necessarily be getting regular updates on what’s being done, what new medications are being given, and how the treatment strategy may have changed.[suneeldhand.com]
  • Photograph: Navesh Chitrakar/Reuters Manjura poses for a photograph before undergoing laser hair removal treatment Photograph: Navesh Chitrakar/Reuters Manjura rests on a hospital bed as a nurse prepares her for laser hair removal treatment at Dhulikhel[theguardian.com]

Prognosis

  • To date, only 20 cases have been described in world literature. [5] Hence, it is very important for the dermatologist to know about anonychia and counsel the parents regarding the prognosis of this rare entity. References 1. Irvine AD, Mellerio JE.[ijpd.in]
  • Prostate Cancer Prostate cancer is predominantly an indolent cancer with a variable and unpredictable prognosis. Therefore, the main goals of Dr.[dceg.cancer.gov]
  • Prognosis - Brachydactyly absence of distal phalanges Not supplied. Treatment - Brachydactyly absence of distal phalanges Not supplied. Resources - Brachydactyly absence of distal phalanges Not supplied.[checkorphan.org]
  • The moment that doctor discovered Marsh could communicate through blinking was one of profound relief for Marsh and his family – although his prognosis remained critical.[theguardian.com]
  • PMID: 21970208 Prognosis Mumtaz S, Yıldız E, Jabeen S, Khan A, Tolun A, Malik S Am J Med Genet A 2015 Dec;167A(12):3148-52. Epub 2015 Sep 3 doi: 10.1002/ajmg.a.37299.[ncbi.nlm.nih.gov]

Etiology

  • Etiology The exact etiology of Cooks syndrome is still unknown but microduplications on chromosome 17q24.3 and involvement of a non-coding element of the SOX9 gene (17q24.3) have recently been associated in some patients with Cooks syndrome.[orpha.net]
  • The flat rectangular surface of the future nail bed on the dorsal tips is first demarcated by folds visible at 8-10 weeks of IUL. [4] Though the exact etiology of anonychia is not known, molecular genetics reveals microduplications on chromosome 17q24.3[ijpd.in]
  • Cook’s prostate cancer research program are to study clinically-relevant disease—defined as aggressive, progressive, and fatal forms—to elucidate etiology and discover prognostic biomarkers. The specific aims of Dr.[dceg.cancer.gov]
  • They are organised into groups, and further divided into clinical, etiological or histopathological sub-types.[orpha.net]
  • Etiology Burris AM, Ballew BJ, Kentosh JB, Turner CE, Norton SA; NCI DCEG Cancer Genomics Research Laboratory.; NCI DCEG Cancer Sequencing Working Group., Giri N, Alter BP, Nellan A, Gamper C, Hartman KR, Savage SA Pediatr Neurol 2016 Mar;56:62-68.e1.[ncbi.nlm.nih.gov]

Epidemiology

  • Summary Epidemiology To date, less than 20 individuals have been described in the world literature.[orpha.net]
  • Biography Research Interests Scientific Publications Metabolic Epidemiology Branch Biography Dr. Michael B.[dceg.cancer.gov]
  • Several large epidemiologic cohort studies (such as Framingham Offspring Study, Botnia Study, Kuopio Ischemic Heart Disease Study, NHANES II Mortality Study, San Antonio Heart Study and DECODE Study) have documented that metabolic syndrome is associated[dmsjournal.biomedcentral.com]
  • Read about the epidemiology and natural history of NAFLD. The top three leading causes of death in patients with… April 18th, 2016 The Cook Medical clinical specialist team is here to provide training for your vascular access needs.[cookmedical.com]
Sex distribution
Age distribution

Prevention

  • And are not intended to diagnose, treat, cure or prevent disease. The information presented is not intended to replace medical advice or treatment from your own doctor or healthcare provider.[wellnessadvocate.com]
  • The neo-TAD that was not associated with a phenotype was insulated from the neighboring genes, preventing the duplicated regions from interacting with SOX9 , KCNJ2 , and KCNJ16 .[cancerdiscovery.aacrjournals.org]
  • When these infections are preventable, we want EVERYONE to know.[cookmedical.com]
  • Prevention - Brachydactyly absence of distal phalanges Not supplied. Diagnosis - Brachydactyly absence of distal phalanges Not supplied. Prognosis - Brachydactyly absence of distal phalanges Not supplied.[checkorphan.org]
  • Making minor changes can alleviate or prevent the condition. Common symptoms of overuse injuries Occupational overuse syndrome is usually associated with repetitive hand movements such as typing, but any part of the body can be affected.[betterhealth.vic.gov.au]

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