Clinical description Cooks syndrome is congenital and presents with hypo/anonychia, small or absent distal phalanges and digitalization of the thumbs. [orpha.net]

We present a case and discussion of a patient with congenital anonychia, absent distal phalanges, and rudimentary hypoplastic middle phalanges and brachydactyly, consistent with Cooks syndrome. [ncbi.nlm.nih.gov]

Hence this could be considered to be an incomplete presentation or “ forme fruste” of Cooks syndrome. [oatext.com]

• Short Finger

  5th finger Short fifth finger Short fifth fingers Short little finger Short pinkie finger Short pinky finger [ more ] 0009237 Short philtrum 0000322 Shortening of all distal phalanges of the fingers Shortening of all outermost bones of the fingers 0006118 [rarediseases.info.nih.gov]

• Hypoplastic Nails

  Chapter First Online: 06 December 2014 Abstract Cooks syndrome is a brachydactyly with absent or hypoplastic nails affecting all digits. Absent flexion creases can be noted in the digits. [link.springer.com]

  […] of both hands’ ring fingers and little fingers and both feet's 5th toenails and hypoplastic nails of the 2nd, 3rd and 4th toes, since birth (Figure 1). [actasdermo.org]

  In autosomal dominant brachydactyly with absence of middle phalanges and hypoplastic nails, the changes in the middle phalanges are distinctive. [ijpd.in]

• Absent Nails

  A family is reported with nail dysplasia and/or absent nails, long and broad finger-like thumbs, camptodactyly and absent fingers. Radiological studies revealed hypoplasia of metacarpals, metatarsals and distal phalanges. [scinapse.io]

  High palate Elevated palate Increased palatal height [ more ] 0000218 Nail dysplasia Atypical nail growth 0002164 Nail dystrophy Poor nail formation 0008404 Prominent nasal bridge Elevated nasal bridge High nasal bridge Prominent bridge of nose Prominent [rarediseases.info.nih.gov]

  Lynch SA, Gardner-Medwin D, Burn J, Bushby KM (1997) Absent nails, Kinesogenic choreoathetosis, epilepsy and developmental delay - a new autosomal dominant disorder? Clinical Dysmorphology 6: 133. [oatext.com]

• Normal Hair

  Sexual development was normal. No facial anomaly was detected. Hair and mucous membrane did not reveal any abnormality. The anterior fontanalle was normal for age. [ijpd.in]

• Brachydactyly

  A novel patient with Cooks syndrome supports splitting from “classic” brachydactyly type B. Am J Med Genet Part A 143A:195–199. [doi.org]

  Metacarpals and bones of forearm appear normal Click here to view Brachydactyly A, brachydactyly B and mammary-digital-nail syndrome were considered for the differential diagnosis. [ijpd.in]

  brachydactyly type B and Cooks syndrome. [en.wikipedia.org]

  […] affected by an isolated form of brachydactyly type B (BDB)-like malformation of the limbs consistent with Cooks syndrome (CS). [scinapse.io]

• Short Fifth Finger

  5th finger Short fifth finger Short fifth fingers Short little finger Short pinkie finger Short pinky finger [ more ] 0009237 Short philtrum 0000322 Shortening of all distal phalanges of the fingers Shortening of all outermost bones of the fingers 0006118 [rarediseases.info.nih.gov]

The material is in no way intended to replace professional medical care by a qualified specialist and should not be used as a basis for diagnosis or treatment. [orpha.net]

The information presented is not intended to replace medical advice or treatment from your own doctor or healthcare provider. [wellnessadvocate.com]

Photograph: Navesh Chitrakar/Reuters Manjura poses for a photograph before undergoing laser hair removal treatment Photograph: Navesh Chitrakar/Reuters Manjura rests on a hospital bed as a nurse prepares her for laser hair removal treatment at Dhulikhel [theguardian.com]

The treatment of severe adhesions remains a challenge. [laparoscopy.blogs.com]

Management and treatment of Asherman syndrome The treatment strategy of AS could be summarized in four main steps: 1. Treatment (Dilatation and curettage, hysteroscopy, hysterotomy) 2. [rbej.biomedcentral.com]

Prostate Cancer Prostate cancer is predominantly an indolent cancer with a variable and unpredictable prognosis. Therefore, the main goals of Dr. [dceg.cancer.gov]

Prognosis - Brachydactyly absence of distal phalanges Not supplied. Treatment - Brachydactyly absence of distal phalanges Not supplied. Resources - Brachydactyly absence of distal phalanges Not supplied. [checkorphan.org]

Mortality/Morbidity Prognosis is generally good, but it depends on the severity of the cardiac malformations. Morbidity/mortality Structural lesions are present at birth. Prognosis depends on the severity of the cardiac lesions. [emedicine.medscape.com]

To date, only 20 cases have been described in world literature. [5] Hence, it is very important for the dermatologist to know about anonychia and counsel the parents regarding the prognosis of this rare entity. References 1. Irvine AD, Mellerio JE. [ijpd.in]

Etiology The exact etiology of Cooks syndrome is still unknown but microduplications on chromosome 17q24.3 and involvement of a non-coding element of the SOX9 gene (17q24.3) have recently been associated in some patients with Cooks syndrome. [orpha.net]

Cook’s prostate cancer research program are to study clinically-relevant disease—defined as aggressive, progressive, and fatal forms—to elucidate etiology and discover prognostic biomarkers. The specific aims of Dr. [dceg.cancer.gov]

Summary Epidemiology To date, less than 20 individuals have been described in the world literature. [orpha.net]

Biography Research Interests Scientific Publications Metabolic Epidemiology Branch Biography Dr. Michael B. [dceg.cancer.gov]

Epidemiology To date, less than 20 individuals have been described in the world literature. Clinical description Cooks syndrome is congenital and presents with hypo/anonychia, small or absent distal phalanges and digitalization of the thumbs. [rarediseases.info.nih.gov]

Epidemiology Frequency United States Holt-Oram syndrome is the most common form of heart-hand syndrome, with prevalence estimated at 0.95 cases per 100,000 total births. Approximately 85% of cases are attributed to new mutations. [emedicine.medscape.com]

The pathophysiologic sequelae are a direct result of malformations of the heart and upper limbs. [emedicine.medscape.com]

[…] retained products of conception. 4-5 The incidence of uterine synechiae has apparently risen in the past two decades, likely as a result of improved diagnosis or to more uterine surgery (including pregnancy-related curettage), or both. 4 ETIOLOGY AND PATHOPHYSIOLOGY [laparoscopy.blogs.com]

Epidemiology and aetiology Data regarding pathophysiology of AS and IUA are still limited in literature. [rbej.biomedcentral.com]

And are not intended to diagnose, treat, cure or prevent disease. The information presented is not intended to replace medical advice or treatment from your own doctor or healthcare provider. [wellnessadvocate.com]

The use of IUD in order to prevent adhesion recurrence was one of the first attempts to be documented in literature [ 8 ]. [rbej.biomedcentral.com]

Both of these are sub-optimal in preventing intrauterine adhesions. [laparoscopy.blogs.com]

The neo-TAD that was not associated with a phenotype was insulated from the neighboring genes, preventing the duplicated regions from interacting with SOX9, KCNJ2, and KCNJ16. [cancerdiscovery.aacrjournals.org]

When these infections are preventable, we want EVERYONE to know. [cookmedical.com]