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Corneal Disease


Presentation

  • RESULTS: Among the 175 pre-intervention and 97 post-intervention patients, delay in presentation improved only slightly.[ncbi.nlm.nih.gov]
  • A 45-year-old man presented with the complaints of frequent change in glass prescriptions over the past 5 years. Erythema, dryness, and scaling were noted over both eyelids and the face.[ncbi.nlm.nih.gov]
  • Images were recorded on super VHS videotape, digitized and processed on a computer workstation, and photographed for presentation.[ncbi.nlm.nih.gov]
  • Its production is biochemically distinct from that of normally present proteoglycans.[ncbi.nlm.nih.gov]
  • By comparing the zymographic activity profiles of the gelatinases present in the samples obtained, it was deduced that the main source of these MMPs was granulocytes.[ncbi.nlm.nih.gov]
Falling
  • There was a 5 year probability of 0.7 of maintaining a clear graft but if both a clear graft and normal intraocular pressure are considered then the probability falls to 0.5 at 5 years.[ncbi.nlm.nih.gov]
  • Wolfe Eye Clinic offers complete corneal disease expertise throughout Iowa, including Ames, Cedar Falls, Cedar Rapids, Des Moines, Fort Dodge, Iowa City, Marshalltown, Ottumwa, Spencer, Waterloo, and Pleasant Hill.[wolfeeyeclinic.com]
  • The demand for human corneal tissue is growing, but the supply is falling due to the popularity of LASIK surgeries, which weaken the corneal stroma and make it unsuitable for donation.[nei.nih.gov]
Hyperkeratosis
  • Histopathology of the host corneal button showed complete loss of Bowman's layer, hyperkeratosis of the epithelium, stromal neovascularization, and leukocyte infiltration. Descemet's membrane and endothelium were irregular in both specimens.[ncbi.nlm.nih.gov]
Long Arm
  • The abnormal metaphases had a terminal deletion of the long arm of chromosome 18 as clonal abnormality. The cytogenetics findings were 46,XY, del (18)(q21.2)[12]/46,XY[20].[ncbi.nlm.nih.gov]
  • Meesmann corneal dystrophy has been linked to mutations to two separate genes, one (KTR3) on the long arm of chromosome 17 (17q12) and one (KTR12) on the long arm of chromosome 12 (12q13).[rarediseases.org]
Excessive Tearing
  • Although they vary by the specific disease or injury and the severity, the following symptoms of corneal conditions are very common: Pain Blurry vision Redness Excessive tearing Sensitivity to light Scarring Corneal Injury Most corneal injuries consist[correctiveeye.com]
  • A sensitivity to light (photophobia) and excessive tear formation (lacrimation) can occur in this form of corneal dystrophy. Clouding (opacity) of the cornea rarely occurs, but may develop in some elderly individuals.[rarediseases.org]
  • As the cornea is altered, vision may be blurry and accompanied by: Moderate to severe pain Increase sensitivity to light Excessive tearing A feeling that something is in your eye Treatment may include an eye patch, eye drops, and ointments.[eyesurgeonspc.com]
  • Excessive tearing. A feeling that something is in your eye Most patients with this condition require no treatment.[my.clevelandclinic.org]
Suggestibility
  • These findings suggested that an inflammatory spectrum of Terrien's disease may exist.[ncbi.nlm.nih.gov]
  • Furthermore, recent studies suggest that CD8( ) T cells are directly involved in maintaining virus latency in infected trigeminal ganglia.[ncbi.nlm.nih.gov]
  • We conclude that plasmin is released into the tear fluid in the presence of corneal or conjunctival lesions or infections, suggesting a pathogenic role of plasmin in these disorders.[ncbi.nlm.nih.gov]
  • We propose revisions to the visual function assessment and suggest its inclusion in a priority scheme for penetrating keratoplasty that also includes pain and other clinical indices.[ncbi.nlm.nih.gov]
  • TFF1 and TFF3 production by goblet cells in pterygia is comparable to the healthy conjunctiva suggesting that TFF peptides do not play a significant role in the pathogenesis of pterygia.[ncbi.nlm.nih.gov]

Workup

Pseudomonas
  • IL-1 beta was detected in tear fluid from five eyes (three eyes with chemical burns, one with a Pseudomonas aeruginosa corneal ulcer, and one with a peripheral corneal ulcer) at concentrations between 29 and 218 pg/mL.[ncbi.nlm.nih.gov]
  • PURPOSE: Pseudomonas aeruginosa enters corneal epithelial cells in vitro via membrane microdomains or lipid rafts. Bacterial entry, mediated by the cystic fibrosis transmembrane conductance regulator (CFTR), promotes infection and disease.[ncbi.nlm.nih.gov]
  • Abstract We have previously shown that ExoU, a type III secreted cytotoxin of Pseudomonas aeruginosa, causes acute cytotoxicity towards corneal epithelial cells in vitro, and contributes to corneal disease pathology and ocular colonization in vivo.[ncbi.nlm.nih.gov]

Treatment

  • The current paper proposes a novel hypothesis for the treatment and prevention of corneal blindness in disorders such as keratoconus as an alternative to the gold standard treatment of penetrating or partial thickness keratoplasty.[ncbi.nlm.nih.gov]
  • As the feasibility of genetic modification of corneal cells has been successfully demonstrated, there is great potential for gene therapy vectors in the treatment of human corneal disease.[ncbi.nlm.nih.gov]
  • Modes of therapy aimed at one particular chain of events have varying degrees of success, as indeed does more blunderbuss treatment with steroids, anti-inflammatory drugs, or cytotoxic agents.[ncbi.nlm.nih.gov]
  • BACKGROUND: To evaluate the feasibility of partial lamellar keratoplasty (LK) for treatment of peripheral corneal disease (PCD) using a graft from the corneoscleral rim preserved in glycerin.[ncbi.nlm.nih.gov]
  • Refine Results Find a Corneal Disease Treatments Doctor Matching Results Treatments Medical Management Our doctors may prescribe antibiotics, antivirals, or antifungal medications if you have an infection caused by bacteria, virus, or fungus.[dukehealth.org]

Prognosis

  • The prognosis of these 7 cases was particularly grave. For comparison 23 cases are reported of patients with inactive herpetic corneal disease. Causes of failure in both groups are discussed.[ncbi.nlm.nih.gov]
  • The hazard ratio for intraocular pressure control and graft survival between the two groups suggests that combined surgery may offer a better prognosis.[ncbi.nlm.nih.gov]
  • This also applies to prognosis. Corneal ulcer A corneal ulcer is a corrosion that is characteristically indicated by a red, painful eye. Vision worsens and discharge from the eyes may also be present.[morelaokulisti.si]
  • Prognosis The risk of corneal grafting depends primarily on why the surgery is required. Patients with keratoconus and corneal scarring have an excellent prognosis. Grafting is less successful in patients with Herpes eye disease.[drmalcolmmckellar.co.nz]
  • Many corneal diseases are treatable and have a good prognosis. However, vision loss and chronic eye pain are potential complications of corneal disease so it is important to review treatment options carefully with an eye doctor.[rxlist.com]

Etiology

  • RESULTS: Fifty-nine patients with bilateral blindness from corneal disease were included in the study, of which 56 (95%) had bilateral corneal disease resulting from similar etiology and three (5%) of different etiology in both eyes.[ncbi.nlm.nih.gov]
  • METHODS: 1,001 blinding patients of corneal disease were clinically analysed from 1960 to 1989, including etiology, sex, age, occupation, difference between the urban and rural areas etc. RESULTS: The male predominated.[ncbi.nlm.nih.gov]
  • […] slightly less well but still remain healthy for most transplant recipients, according to a study funded by the National Eye Institute (NEI) and led by the UC Davis Health System Eye Center and the University of Cincinnati Eye Institut Pediatric blindness etiology[news-medical.net]
  • "Etiology, Diagnosis, and Management of Keratoconus: New Thoughts and New Understandings". Pacific University College of Optometry. Archived from the original on 7 January 2009. Retrieved 15 December 2008. a b c d e f Arffa R (1997).[en.wikipedia.org]

Epidemiology

  • METHODS: The Corneal Opacity Rural Epidemiological (CORE) study included 12 899 participants from 25 randomly selected clusters of rural Gurgaon, Haryana, India, with the primary objective of determining the prevalence of corneal disease in the general[ncbi.nlm.nih.gov]
  • "A 48-year clinical and epidemiologic study of keratoconus". American Journal of Ophthalmology. 101 (3): 267–73. doi : 10.1016/0002-9394(86)90817-2. PMID 3513592. Weissman BA, Yeung KK.[en.wikipedia.org]
Sex distribution
Age distribution

Pathophysiology

  • The information gained from the knowledge of gene function, aberrant protein production, or altered enzyme activity in the cornea, has resulted in greater knowledge of the pathophysiological mechanisms in these disorders.[ncbi.nlm.nih.gov]
  • Finally, gene therapy is being tested in experimental animals to improve the outcomes of corneal transplantation, and to halt or reverse the pathophysiology of some corneal dystrophies.[ncbi.nlm.nih.gov]
  • These genes include BANP-ZNF469, COL4A4, FOXO1, FNDC3B, IMMP2L and RXRA-COL5A1. [11] Others likely also exist. [11] Pathophysiology [ edit ] A specimen of keratoconic cornea taken out six years after diagnosis: thin stroma, wrinkled posterior surface[en.wikipedia.org]

Prevention

  • PURPOSE OF REVIEW: Preexisting corneal disease can be exacerbated by cataract surgery and may prevent well tolerated cataract extraction.[ncbi.nlm.nih.gov]
  • CONCLUSION: We should try to find more effective strategies to prevent and treat CB caused by HSV-1 keratitis, pay special attention to preschool blindness caused by perforation injuries and avoid infection after corneal injuries of foreign bodies.[ncbi.nlm.nih.gov]
  • There is a solid rationale, therefore, for the development of therapeutic principles aimed at preventing these structural changes from occurring.[ncbi.nlm.nih.gov]
  • Patients with ocular surface disease still require extra lubrication and management of blepharitis to prevent epithelial toxicity at the time of surgery as well as postoperatively.[ncbi.nlm.nih.gov]

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