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Corneal Transplantation

Cornea Transplantation


Presentation

  • The local risk factors (corneal vascularity and elevated intraocular pressure) were present to a greater extent in the nonrejected eye.[ncbi.nlm.nih.gov]
Progressive Dementia
  • In early July 2002 the patient developed rapidly progressive dementia. Attempts were made to procure information regarding the corneal donors. No information was available. The patient expired slightly less than 1 month after her onset of symptoms.[ncbi.nlm.nih.gov]
Sputum
  • PURPOSE: To determine the prevalence of postkeratoplasty fungal infection when corneal tissue from donors with a recent medical history of oral thrush or respiratory, urine, wound, sputum, bronchial, tracheal, or throat culture positive for fungus is[ncbi.nlm.nih.gov]
Self-Mutilation
  • We describe penetrating keratoplasty for corneal scarring in a patient with congenital sensory neuropathy and repeated self-mutilation.[ncbi.nlm.nih.gov]
Self Mutilation
  • We describe penetrating keratoplasty for corneal scarring in a patient with congenital sensory neuropathy and repeated self-mutilation.[ncbi.nlm.nih.gov]
Claustrophobia
  • […] was 4.4 0.62 (n 354), and the average score to the question "How would you rate your experience within the operation unit, taking into consideration feelings of claustrophobia and how comfortable you felt?" was 4.1 0.82 (n 348).[ncbi.nlm.nih.gov]
Low Self-Esteem
  • RESULTS: Before the transplantation, patients suffered from disability and low self-esteem but remained hopeful. After the transplantation, they felt satisfied with whatever visual gain they got and described the process as 'a miracle'.[ncbi.nlm.nih.gov]
Psychiatric Symptoms
  • CONCLUSION: Assessment for psychiatric symptoms should be considered in individuals facing corneal surgery. Copyright 2016 The Academy of Psychosomatic Medicine. Published by Elsevier Inc. All rights reserved.[ncbi.nlm.nih.gov]
Phenylketonuria
  • To report a patient with a rare complication of bilateral keratomalacia induced by uncontrolled phenylketonuria (PKU) that was successfully treated with amniotic membrane transplantation in 1 eye and penetrating keratoplasty in the second eye.[ncbi.nlm.nih.gov]
Dysautonomia
  • A 15-year-old girl with familial dysautonomia had acute corneal ulcerations while on a respiratory during a dysautonomic crisis. Within 18 days she developed irritating corneal ring calcifications.[ncbi.nlm.nih.gov]

Workup

  • Workup includes 12-lead ECG, cardiac enzymes, echocardiogram, and possibly cardiology consultation. Once the patient is stabilized, surgery can proceed.[clinicaladvisor.com]
  • Pre-Op: Nine days before the surgery, I had the required complete physical exam, blood workup, and EKG. Despite just getting over a cold, I came through with flying colors. Seven days before surgery, I met with my eye doctor and surgeon Dr.[fuchs-dystrophy.org]

Treatment

  • New potential treatments include collagen cross-linking (CXL), cultured endothelial cell injection, and topical treatment with Rho-associated kinase (ROCK) inhibitor.[ncbi.nlm.nih.gov]

Prognosis

  • This study reports a good prognosis in cases having high risk factors for failure.[ncbi.nlm.nih.gov]
  • The prognosis for visual restoration and maintenance of ocular health with corneal transplants is generally very good. Risks for failure or guarded prognoses are multifactorial.[en.wikipedia.org]
  • Regraft is possible, but the long-term prognosis is worse than for the original graft. Keratoprosthesis (artificial cornea) can be placed if grafts fail repeatedly.[msdmanuals.com]
  • In conclusion, the data so far have been encouraging with regard to the feasibility of using the KeraKlear artificial cornea as an alternative to corneal transplantation when tissue is not available or when the prognosis for transplantation is poor.[healio.com]

Etiology

  • These data were compared with the prevalence and etiology of corneal blindness in each respective region worldwide.[ncbi.nlm.nih.gov]
  • Some of the more important global etiologies for corneal blindness include trachoma, corneal ulceration and ocular trauma. In the pediatric age group, xerophthalmia and ophthalmia neonatorum both contribute to corneal blindness.[healio.com]

Epidemiology

  • Reported by: KG Banull, MD, JW Janelle, MD, Div of Infectious Diseases; WT Driebe, MD, Dept of Ophthalmology; LL Fauerbach, MS, Shands Hospital; L Archibald, MD, Div of Epidemiology, Univ of Florida, Gainesville.[cdc.gov]
  • Ritter et al discuss the need for further study of the genetic modification of corneal grafts prior to surgery to prevent rejection. [4] Epidemiology Frequency United States In 2016, 82,994 corneal transplantations were performed in the United States.[emedicine.medscape.com]
Sex distribution
Age distribution

Pathophysiology

  • The potential involvement of immune cells as an underlying pathophysiology for late endothelial failure deserves further examination.[ncbi.nlm.nih.gov]
  • Pathophysiology Corneal transplantation has a high success rate in part because of the relative immune privilege of the cornea.[emedicine.medscape.com]

Prevention

  • Corticosteroids remain the first-line therapy for the prevention and treatment of immune rejection.[ncbi.nlm.nih.gov]

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