Lipids Lipids are present and located in the envelope. Genome Organization and Replication By itself, genomic nucleic acid is infectious. Transcription: Sub-genomic RNA is present in infected cells. [datamed.org]

SpaceNext50 Britannica presents SpaceNext50, From the race to the Moon to space stewardship, we explore a wide range of subjects that feed our curiosity about space! [britannica.com]

Fred Murphy, Sylvia Whitfield, USCDCP capsid, rubella virus, positive, single cell, SSRNA genome intracellular, group, tumor, virus, particles, present, central, nervous, system ultrastructural, morphology, intact, rotavirus, double, shelled, particles [pixnio.com]

A spreadsheet predicting the inactivation of coronaviruses and the associated uncertainty is presented and can be used to predict virus inactivation for untested temperatures, time points, or any coronavirus strains belonging to Alphacoronavirus and Betacoronavirus [research.pasteur.fr]

REPLICATION CYTOPLASMIC Attachment of the viral S protein (maybe also HE if present) to host receptors mediates endocytosis of the virus into the host cell. [viralzone.expasy.org]

• Fever

  Most people confirmed to have MERS-CoV infection have had severe acute respiratory illness with symptoms of: fever cough shortness of breath Some people also had gastrointestinal symptoms including diarrhea and nausea/vomiting. [cdc.gov]

  Chapter 10 African Swine Fever Virus Linda K. Dixon, Charles C. Abrams, Dave G. [web.archive.org]

  Virus purification　ウイルスの精製 Group I (ds)DNAウイルス Adenoviridae アデノウイルス科 Adenovirus (Application Sheet V07) アデノウイルス Helper-dependent virus, separation from (Application Sheet V07 ) ヘルパー依存型ウイルス Asfaviridae アスファウイルス科 African swine fever virus (Application Sheet [cosmobio.co.jp]

• Nightmare

  Locations: Nightmare Realm Swallowed Price: N/A (Dropped by Germs ) Sellback: 625 Gold Rarity: Unknown Rarity Description: You suddenly crave glycoproteins! this squishy morph is one of the germs that cause the common cold. [aqwwiki.wikidot.com]

  SARS-CoV spread within months to more than 30 countries causing the first epidemic of the new millennium and becoming a public health nightmare in the countries affected. [web.archive.org]

• Asymptomatic

  These infections are usually asymptomatic in bats but the mechanism of this tolerance is not yet understood. For those viruses, bats are efficient reservoirs and disseminators. [ncbi.nlm.nih.gov]

  As testing paradigms changed and contacts were increasingly tested, more asymptomatic and mild infections were recognized [ 163 ]. [doi.org]

  Symptoms The clinical spectrum of MERS-CoV infection ranges from no symptoms (asymptomatic) or mild respiratory symptoms to severe acute respiratory disease and death. [who.int]

• Pneumonia

  6011000124106~MAPPRIORITY~1 6011000124106~MAPRULE~OTHERWISE TRUE 6011000124106~MAPPRIORITY~5 6011000124106~MAPADVICE~IF PNEUMONIA CAUSED BY SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS CHOOSE J12.81 | CONSIDER ADDITIONAL CODE TO IDENTIFY SPECIFIC CONDITION [bioportal.bioontology.org]

  We have isolated a SARS-associated CoV (SARS-CoV) strain by injecting Vero cells with a sputum specimen from an Italian patient affected by a severe pneumonia; the patient traveled from Vietnam to Italy in March 2003. [moh-it.pure.elsevier.com]

  Early transmission dynamics in wuhan, china, of novel coronavirus–infected pneumonia. N Engl J Med. 2020. doi: 10.1056/NEJMoa2001316. Zhu N, Zhang D, Wang W, Li X, Yang B, Song J. A novel coronavirus from patients with pneumonia in China, 2019. [medigraphic.com]

  For many people with MERS, more severe complications followed, such as pneumonia and kidney failure. About 3 to 4 out of every 10 people reported with MERS have died. Most of the people who died had an underlying medical condition. [cdc.gov]

• Respiratory Distress

  الصفحة 171 - Acute Respiratory Distress Syndrome Network: Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. ‏ [books.google.com]

  J Paediatr Child Health 44:176–181 CrossRef PubMed Van Boheemen S et al. 2012.Genomic characterization of a newly discovered coronavirus associated with acute respiratory distress syndrome in humans. MBio. 2012; 3: e00473–12. [springermedizin.de]

• Cough

  Cover your nose and mouth with a tissue when you cough or sneeze, then throw the tissue in the trash. Avoid touching your eyes, nose and mouth with unwashed hands. [cdc.gov]

  They can be transmitted through close-contact respiratory droplets, such as those released from sneezing and coughing. [study.com]

  Coronaviruses - the cause of SARS SARS is a type of viral pneumonia, with symptoms including fever, a dry cough, dyspnea (shortness of breath), headache, and hypoxaemia (low blood oxygen concentration). [web.archive.org]

• Common Cold

  Coronavirus and the common cold Follow this link for comprehensive information on Management, Therapy, and Prevention of the common cold. [web.stanford.edu]

  […] this squishy morph is one of the germs that cause the common cold. Notes: Male and Female look the same. Also see: Fusobacterium. Helicobacter. Paramecium. Staphylococcus. Thanks to Redsion, Shal and Tendou no Mazo. [aqwwiki.wikidot.com]

  However, its initial signs are tricky because they mimic the signs of the common cold and flu. This may therefore lead to an improper diagnosis of an individual, thereby delaying their treatment. [study.com]

  In fact, human coronaviruses are responsible for 15-30% of common colds each year Public discussion and documents reveal that the FDA knows that rushed-to-market COVID-19 vaccines may cause a wide range of life-threatening side effects, including death [greenmedinfo.com]

  Oral-fecal transmission Humans: Poliomyelitis, myocarditis, Hepatitis, meningitis, common cold Cattle: Foot and mouth disease Poliovirus (Picornaviridae) A model picornavirus for vaccine development and studies of replication One of the most successful [quizlet.com]

• Dyspnea

  Pleuritis causing dyspnea is observed in some cats, and there are reports of neurologic and ocular disease, occurring in others. Affected cats die within 1 to 8 weeks. [web.archive.org]

• Diarrhea

  3Cl-pro, putative coronavirus nsp2) ‎ (24 D) ► Coronavirus NSP10-like ‎ (1 K) ► Coronavirus NSP7-like ‎ (1 K) ► Coronavirus nucleocapsid protein ‎ (6 D) ► Coronavirus RNA-binding domain ‎ (1 K) ► Coronavirus S2 glycoprotein ‎ (1 K) P ► Porcine epidemic diarrhea [commons.wikimedia.org]

  Most people confirmed to have MERS-CoV infection have had severe acute respiratory illness with symptoms of: fever cough shortness of breath Some people also had gastrointestinal symptoms including diarrhea and nausea/vomiting. [cdc.gov]

  位置 Release( 釋出 ) secretory pathway( 分泌方式 ) 離開細胞，病毒顆粒被包裹在高爾基氏體分泌囊泡中，並藉由囊泡和 細胞膜 融合來釋放到細胞外 incubation period 感染源 vector 感染方式 病理現象 primary site target site 病毒 (229E & OC43) 感染上呼吸道的上皮細胞 造成病害方式 疾病 SARS ： SARS-CoV 造成的疾病 (SARS 是一種 atypical pneumonia) 20% 以上會 diarrhea [smallcollation.blogspot.com]

  Respiratory Syndrome Coronavirus Avian infectious bronchitis virus Bovine coronavirus N/A Canine coronavirus N/A Feline infectious peritonitis virus N/A Human coronavirus 299E N/A Human coronavirus OC43 N/A Murine hepatitis virus N/A Porcine epidemic diarrhea [virology.net]

  Porcine hemagglutinating encephalomyelitis virus (strain 67N) (HEV-67N) reference strain 7 entries Bat coronavirus 512/2005 (BtCoV) (BtCoV/512/2005) reference strain 7 entries Human coronavirus NL63 (HCoV-NL63) reference strain 7 entries Porcine epidemic diarrhea [expasy.org]

• Myalgia

  Lancet volume 361, 03 May 2003, the authors report that: The most common reported symptom is fever (94%), with 51–72% of patients reporting general influenza-like symptoms, chills, malaise, loss of appetite, and myalgia. [web.archive.org]

  He developed fever, myalgia and a cough nearly a week later (11 th ). He visited a clinic as an outpatient between the 12 th and 15 th of May and was admitted to Hospital A on the 15 th [ 188 ]. [doi.org]

• Suggestibility

  Thus far, evidence suggests bats may be a reservoir of the virus and that camels may have a role as an intermediate host of MERS-CoV. [niaid.nih.gov]

  Mutational analysis of the extra stem suggests frameshift efficiency can be modulated via manipulation of the secondary structure within the loop 2 of an infectious bronchitis virus-type pseudoknot. [ncbi.nlm.nih.gov]

  It is suggested that the molecular specifiers used to derive LFERs for inhibition of coronavirus proteases can be used to predict which anti-virals will have high inhibitory capability as well as high host cell membrane transport capability against the [hal.archives-ouvertes.fr]

  Structural studies suggest that several nsps, following their release from larger precursor molecules, form dimers or even multimers. [web.archive.org]

  Together, these data suggest that the roles of S3 in −1 frameshifting stimulation may be different from those of S1 to S2. [doi.org]

• Headache

  Coronaviruses - the cause of SARS SARS is a type of viral pneumonia, with symptoms including fever, a dry cough, dyspnea (shortness of breath), headache, and hypoxaemia (low blood oxygen concentration). [web.archive.org]

With this greater understanding of SARS-CoV biology, many researchers have sought to identify agents for the treatment of SARS. [ncbi.nlm.nih.gov]

Treatment There is no specific antiviral treatment recommended for MERS-CoV infection. Individuals with MERS often receive medical care to help relieve symptoms. For severe cases, current treatment includes care to support vital organ functions. [cdc.gov]

This may, therefore, lead to an improper diagnosis of an individual, thereby delaying their treatment. With delayed treatment and the possibility of rapid spread of the disease, the entire kingdom could collapse! [study.com]

Prevention and treatment No vaccine or specific treatment is currently available, however several MERS-CoV specific vaccines and treatments are in development. Treatment is supportive and based on the patient’s clinical condition. [who.int]

Virions are sensitive to treatment with heat, lipid solvents, non-ionic detergents, formaldehyde, and oxidizing agents. Nucleic Acid The genome is not segmented and contains a single molecule of linear positive-sense, single-stranded RNA. [datamed.org]

During the recent severe acute respiratory syndrome (SARS) outbreak, the etiologic agent was identified as a new coronavirus (CoV). [moh-it.pure.elsevier.com]

Abstract During the recent severe acute respiratory (SARS) outbreak, the etiologic agent was identified as a new coronavirus (CoV). [ncbi.nlm.nih.gov]

This picornavirus is the etiological agent of an acute systemic vesicular disease that affects cattle worldwide. [web.archive.org]

[…] of Infectious Bronchitis Virus Molecular Basis of Transmissible Gastroenteritis Virus Epidemiology Pathogenesis of the Porcine Coronaviruses Human Coronavirus Infections The Pathogenesis of Torovirus Infections in Animals and Humans Index Table of Contents [booktopia.com.au]

Over the past several years, I’ve been trying to understand how epidemiological evidence influences thinking in health care. Epidemiological data are critical in deciding public health action, such as when to ease up on social distancing. [msdmanuals.com]

Heparin and SARS-CoV-2: Multiple Pathophysiological Links. Di Micco P, Imbalzano E, Russo V, Attena E, Mandaliti V, Orlando L, Lombardi M, Di Micco G, Camporese G, Annunziata S, Piccinocchi G, Pacelli W, Del Guercio M. Di Micco P, et al. [pubmed.ncbi.nlm.nih.gov]

Prevention Currently, there is no vaccine to prevent MERS-CoV infection. The U.S. National Institutes of Health is exploring the possibility of developing one. [cdc.gov]

Infection prevention and control measures are critical to prevent the possible spread of MERS‐CoV in health‐care facilities. [who.int]

Here we report the utility of the potent antiviral protein griffithsin (GRFT) in the prevention of SARS-CoV infection both in vitro and in vivo. We also show that GRFT specifically binds to the SARS-CoV spike glycoprotein and inhibits viral entry. [ncbi.nlm.nih.gov]

Coronavirus and the common cold Follow this link for comprehensive information on Management, Therapy, and Prevention of the common cold. [web.stanford.edu]