Participant was a 70-yearold female patient, single; she presented progressive memory loss of an immediate verbal nature. [repository.ucc.edu.co]

Abstract Atypical Parkinson syndromes are a heterogeneous group of neurodegenerative diseases which present with parkinsonism and other non-motor symptoms. [ncbi.nlm.nih.gov]

Alzheimer’s disease and corticobasal degeneration presenting as corticobasal syndrome. Mov Disord. 2009; 24 (9) 1375-1379 26 Josephs K A, Whitwell J L, Boeve B F et al. [thieme-connect.com]

«Increased tau burden in the cortices of progressive supranuclear palsy presenting with corticobasal syndrome». Mov Disord (núm. 20, págs. 982-288). Williams, D. R.; Lees, A. J. (2009). [cv.uoc.edu]

Kompoliti K, Goetz CG, Boeve BF et al. (1998) Clinical presentation and pharmacological therapy in corticobasal degeneration. Arch Neurol 55: 957–961 PubMed CrossRef 34. [springermedizin.de]

• Disability

  Occupational, physical, and speech therapy can help in managing disability. Read More Read Less Prognosis Prognosis Corticobasal degeneration usually progresses slowly over the course of 6 to 8 years. [ninds.nih.gov]

  «A longitudinal follow-up study of depression, disability and body concept in torticollis». Behavioral Neurology (núm. 3, págs. 233-246). Jahanshahi, M.; Czernecki, V.; Zurowski, A. M. (2011). [cv.uoc.edu]

  Tison F, Yekhlef F, Chrysostome V et al. (2002) Parkinsonism in multiple system atrophy: natural history, severity (UPDRS-III), and disability assessment compared with Parkinson’s disease. Mov Disord 17: 701–709 PubMed CrossRef 72. [springermedizin.de]

• Myoclonus

  Clonazepam may help the myoclonus. Occupational, physical, and speech therapy can help in managing disability. Read More Read Less Prognosis Prognosis Corticobasal degeneration usually progresses slowly over the course of 6 to 8 years. [ninds.nih.gov]

  «Cognition and psychopathology in myoclonus-dystonia». Journal of Neurology, Neurosurgery and Psychiatry (núm. 83, págs. 814-820). Wenzel, T.; Schnider, P.; Wimmer, A.; Steinhoff, N.; Moraru, E.; Auff, E. (1998). [cv.uoc.edu]

  Salazar G, Valls-Sole J, Marti MJ et al. (2000) Postural and action myoclonus in patients with parkinsonian type multiple system atrophy. Mov Disord 15: 77–83 PubMed CrossRef 60. [springermedizin.de]

• Aphasia

  «Atypical progressive supranuclear palsy underlying progressive apraxia of speech and nonfluent aphasia». Neurocase (núm. 11, págs. 283-296). Lee, W.; Williams, D. R.; Storey, E. (2012). [cv.uoc.edu]

• Stroke

  Progressive cognitive deficits in a mouse model of recurrent photothrombotic stroke. Stroke. 2015 Apr;46(4):1127-31. Lueg G, Gross CC, Lohmann H, Johnen A, Kemmling A, Deppe M, Groger J, Minnerup J, Wiendl H, Meuth SG, Duning T. [medizin.uni-muenster.de]

Read More Read Less Treatment Treatment There is no treatment available to slow the course of corticobasal degeneration, and the symptoms of the disease are generally resistant to therapy. [ninds.nih.gov]

Treatments which inhibit pathological protein aggregation and its spreading were developed and showed promising results in animal models. [ncbi.nlm.nih.gov]

Althaus A, Becker OA, Spottke A et al. (2008) Frequency and treatment of depressive symptoms in a Parkinson’s disease registry. Parkinsonism Relat Disord (in press) 4. [springermedizin.de]

Treatment Avenues for the Juvenile and Adult Onset Mitochondriopathies Alpers Syndrome, Ataxia Neuropathy Spectrum, MEMSA and PEO Caused by Polymerase-Gamma Mutations Ala467Thr and Trp748Ser. SM J Neurol Neurosci. 2017; 3(2): 1013. Review. [humangenetik.uk-koeln.de]

«Cognitive processes in idiopathic dystonia treated with high-dose anticholinergic therapy: implications for treatment strategies». Clinical Neuropharmacology (núm. 14, págs. 62-77). [cv.uoc.edu]

Read More Read Less Prognosis Prognosis Corticobasal degeneration usually progresses slowly over the course of 6 to 8 years. Death is generally caused by pneumonia or other complications of severe debility such as sepsis or pulmonary embolism. [ninds.nih.gov]

Watanabe H, Saito Y, Terao S et al. (2002) Progression and prognosis in multiple system atrophy: an analysis of 230 Japanese patients. Brain 125: 1070–1083 PubMed CrossRef 80. [springermedizin.de]

«Progression and prognosis in multiple system atrophy: an analysis of 230 Japanese patients». Brain (núm. 125, págs. 1070-1083). Wenning, G. K.; Ben-Shlomo, Y.; Magalhaes, M.; Daniel, S. E.; Quinn, N. P. (1994). [cv.uoc.edu]

Hoglinger GU, Michel PP, Champy P et al. (2005) Experimental evidence for a toxic etiology of tropical parkinsonism. Mov Disord 20: 118–119 PubMed CrossRef 27. [springermedizin.de]

Epidemiologic aspects. Adv Neurol. 2000; 82 53-59 2 Wadia P M, Lang A E. The many faces of corticobasal degeneration. Parkinsonism Relat Disord. 2007; 13 (Suppl 3) S336-S340 3 Bartel C. Demenz bei degenerativen Systemerkrankungen. [thieme-connect.com]

Epidemiological Study of Dystonia in Europe (ESDE) (2000). «A prevalence study of primary dystonia in eight European countries». Journal of Neurology (vol. 10, núm. 247, págs. 787-792). [cv.uoc.edu]

«The pathophysiology of primary dystonia». Brain (núm. 121, págs. 1195-1212). Bihari, K.; Hill, J. L.; Murphy, D. L. (1992). «Obsessive-compulsive characteristics in patients with idiopathic spasmodic torticollis». [cv.uoc.edu]

The goals of these studies are to increase scientific understanding of these disorders and to find ways to prevent, treat, and cure them. [ninds.nih.gov]