It is part of a group of diseases that cause Cushing’s syndrome, characterized by signs and symptoms that may include weight gain around the trunk and in the face, stretch marks, easy bruising, a hump on the upper back, muscle weakness, tiredness, thin [rarediseases.info.nih.gov]

Cushing’s Disease Symptoms The most common symptoms of Cushing’s disease are: unexplained weight gain, particularly around the neck and midsection, thinning of the arms and legs and muscle weakness, diabetes, high blood pressure, easy bruising, moodiness [mskcc.org]

Symptoms and signs of Cushings syndrome and disease may include: Change in body habitus: weight gain in face (moon face), above the collar bone (supraclavicular) and on back of neck (buffalo hump) Skin changes with easy bruising, purplish stretch marks [pituitary.org]

[…] of Cushing’s syndrome: patients with Cushing’s disease usually present with one or more signs and symptoms secondary to the presence of excess cortisol Symptoms include: moon face (resulting in a large chin and large forehead) extra fat around neck easy [pietromortini.com]

The symptoms resulting from excess ACTH and cortisol are quite different and include mainly weight gain (central distribution), high blood pressure, fatigue, excess hair growth and menstrual irregularities in woman, skin thinning, easy bruising/ecchymosis [csrf.net]

It is part of a group of diseases that cause Cushing’s syndrome, characterized by signs and symptoms that may include weight gain around the trunk and in the face, stretch marks, easy bruising, a hump on the upper back, muscle weakness, tiredness, thin [rarediseases.info.nih.gov]

Cushing’s Disease Symptoms The most common symptoms of Cushing’s disease are: unexplained weight gain, particularly around the neck and midsection, thinning of the arms and legs and muscle weakness, diabetes, high blood pressure, easy bruising, moodiness [mskcc.org]

Patients are often diagnosed with Cushing’s disease after several years of symptoms which might include progressive weight gain, new onset hypertension or diabetes and mood changes. [pacificneuroscienceinstitute.org]

Typically, patients have the following clinical features 6 : rounded face, sometimes described as 'moon-shaped' progressive centripetal obesity and weight gain prominent supraclavicular fat pad, sometimes known as a 'buffalo hump' purple skin striae easy [radiopaedia.org]

Symptoms and signs of Cushings syndrome and disease may include: Change in body habitus: weight gain in face (moon face), above the collar bone (supraclavicular) and on back of neck (buffalo hump) Skin changes with easy bruising, purplish stretch marks [pituitary.org]

Associated conditions include those that result in increased intracranial pressure, such as pseudotumor cerebri. [glowm.com]

infections Female patients with Cushing syndrome may also have signs of androgen excess (e.g. hirsutism, acne, changes in libido, virilisation) and menstrual changes 6. [radiopaedia.org]

Promising preventive measures may include preoperative routine sputum smear and India-ink stain for screening, preoperative treatment of cryptococcal pneumonia, postoperative antibiotic management, and a more secure skull base reconstruction. [ncbi.nlm.nih.gov]

Stati, Identification of seven hormone producing cell types in the human pharyngeal hypophysis. J. Clin. Endocrinol. Metab. 60, 212–216 (1985) PubMed CrossRef Google Scholar 31. R. Melchionna, R. Moore, The pharyngeal pituitary gland. Am. J. [link.springer.com]

Over the ensuing years, the patient developed Nelson's syndrome with hyperpigmentation and markedly elevated ACTH levels. [ncbi.nlm.nih.gov]

Avascular necrosis Death of bone due to decreased blood supply 0010885 Bipolar affective disorder Bipolar disorder 0007302 Cardiomyopathy Disease of the heart muscle 0001638 Cataract Clouding of the lens of the eye Cloudy lens [ more ] 0000518 Generalized hyperpigmentation [rarediseases.info.nih.gov]

Furthermore, certain patient groups may demonstrate additional or atypical clinical features depending on the etiology of Cushing syndrome 6 : patients with Cushing disease: hyperpigmentation, because melanocyte-stimulating hormone (MSH) and adrenocorticotropic [radiopaedia.org]

Hyperpigmentation is often seen and when the adenoma grows large enough there may be visual field defects or cranial nerve symptoms. [path.upmc.edu]

Neverthless, hyperpigmentation is a possible but rarely observed finding. Sometimes a psychiatric condition can be associated and, in a more advanced phase, osteoporosis and muscle wasting can become evident. [primarycare.imedpub.com]

It is part of a group of diseases that cause Cushing’s syndrome, characterized by signs and symptoms that may include weight gain around the trunk and in the face, stretch marks, easy bruising, a hump on the upper back, muscle weakness, tiredness, thin [rarediseases.info.nih.gov]

Cushing’s Disease Symptoms The most common symptoms of Cushing’s disease are: unexplained weight gain, particularly around the neck and midsection, thinning of the arms and legs and muscle weakness, diabetes, high blood pressure, easy bruising, moodiness [mskcc.org]

Symptoms may include: upper body obesity round face increased fat around neck thinning arms and legs fragile and thin skin stretch marks on abdomen, thighs, buttocks, arms, and breasts bone and muscle weakness severe fatigue high blood pressure high blood [adrenaltumors.org]

Possible signs and symptoms of Cushing's syndrome include: Fat accumulation around your midsection and upper back Exaggerated facial roundness Thinning of the arms and legs with muscle weakness High blood pressure High blood sugar Acne Bone weakening [mayoclinic.org]

Patients with Cushing's may develop diabetes mellitus, high blood pressure, muscle weakness, clotting disorders, infections and obesity. Bone loss with pathologic fractures can occur. [pituitary.mgh.harvard.edu]

fractures Increased fracture rate Increased fractures Multiple fractures Multiple spontaneous fractures Varying degree of multiple fractures [ more ] 0002757 5%-29% of people have these symptoms Abdominal pain Pain in stomach Stomach pain [ more ] 0002027 [rarediseases.info.nih.gov]

[…] tumor in pituitary gland 0002893 Round face Circular face Round facial appearance Round facial shape [ more ] 0000311 Thin skin 0000963 Truncal obesity 0001956 30%-79% of people have these symptoms Acne 0001061 Anxiety Excessive, persistent worry and fear [rarediseases.info.nih.gov]

It is important to remember that the main cause of amenorrhea in females of reproductive potential is pregnancy! [primarycare.imedpub.com]

[…] buffalo hump) Skin changes with easy bruising, purplish stretch marks (stria) and red cheeks (plethora) Excess hair growth (hirsutism) on face, neck, chest, abdomen, and thighs Generalized weakness and fatigue Loss of muscle Menstrual disorders in women (amenorrhea [pituitary.org]

Acromegaly is associated with enlargement of facial features, hands and feet, heart disease, hypertension, arthritis, carpel tunnel syndrome, amenorrhea, and impotence. [emedicine.medscape.com]

Galactorrhea, amenorrhea, decreased libido, and infertility. Age is usually greater than 20-25 What pituitary tumors have a high recurrence rate after resection? TSH secreting tumors. [quizlet.com]

Much more often, it causes absent periods (amenorrhea). In men, it causes impotence and decreased sex drive. [drugs.com]

In contrast, men usually present in the fourth or fifth decades of life and have sexual dysfunction and symptoms related to mass effect attributable to an enlarging sellar mass. [med.virginia.edu]

Signs and symptoms include: Nausea and vomiting Weakness Feeling cold Less frequent or no menstrual periods Sexual dysfunction Increased amount of urine Unintended weight loss or gain Adrenocorticotropic hormone-secreting (ACTH) tumors ACTH tumors produce [mayoclinic.org]

In the early phases, patients complain about one of the symptoms, but after a careful inspection, a constellation of signs and symptoms can be detected.[ 2, 3 ] Sexual dysfunction with decreased libido is one of the main initial complaints (eventually [primarycare.imedpub.com]

[…] intolerance 0001952 Hirsutism Excessive hairiness 0001007 Increased circulating ACTH level High blood corticotropin levels 0003154 Kyphosis Hunched back Round back [ more ] 0002808 Mood changes Moody 0001575 Obesity Having too much body fat 0001513 Oligomenorrhea [rarediseases.info.nih.gov]

The clinical presentation can be subtle and generally patients refer to the GP for oligomenorrhea, irregular menstrual cycles, galactorrhea (spontaneous or expressive through squeezing on the nipples). [primarycare.imedpub.com]

Men may have erectile dysfunction, whereas premenopausal women often experience oligomenorrhea or amenorrhea 6, 11 ( Table 1 5 – 12 ). [aafp.org]

Oligomenorrhea or amenorrhea. Reduced fertility. Loss of libido. Erectile dysfunction. Galactorrhea in the estrogen-primed female breast. [northshore.org]

Lateral skull radiograph in a patient with pituitary adenoma shows an enlarged sella and focal calcification in the adenoma (arrow) Pituitary adenomas are almost always benign with no malignant potential. [emedicine.medscape.com]