A 54-year-old female with a prosthetic mitral valve presented with a 3-day history of dizziness, subjective fever, and chills. Blood cultures were positive for a pleomorphic Gram-positive rod. [ncbi.nlm.nih.gov]

Its symptoms include sore throat, fever, and malaise. A thick, gray-green fibrin membrane, the 'pseudomembrane', can be found at the site where infection occurs. [creative-diagnostics.com]

Diphtheria is most commonly an infection of the upper respiratory tract and causes fever, sore throat, and malaise. [ncbi.nlm.nih.gov]

The symptoms of the disease are sore throat, malaise, low-grade fever and swollen neck glands. [thenativeantigencompany.com]

The illness is characterized by fever, malaise, and sore throat with a distinguishing thick pseudomembrane present over the involved mucosa. A swab from beneath the pseudomembrane is the preferred specimen for culture. [mayocliniclabs.com]

A 54-year-old female with a prosthetic mitral valve presented with a 3-day history of dizziness, subjective fever, and chills. Blood cultures were positive for a pleomorphic Gram-positive rod. [ncbi.nlm.nih.gov]

Other clinical manifestations may include a sore throat, dysphagia, hoarseness, enlarged lymph nodes, difficulty breathing, nasal discharge, fever, and chills. [dentalcare.com]

Symptoms : Should your child get diphtheria, he would come down with a sore throat, a mild fever (101 degrees or less), chills, and swollen neck glands. [thevaccinemom.com]

It usually affects the nose and throat and causes a bad sore throat, swollen glands, fever, and chills. [fpnotebook.com]

He presented with fever, epistaxis and congestive heart failure. He received high-dose penicillin therapy and diphtheria antitoxin with clinical improvement. [ncbi.nlm.nih.gov]

Systemic complications that are life-threatening may occur as a result of the action of diphtheria toxin on peripheral motor the myocardium and neurons, such as loss of motor function and congestive heart failure. [creative-diagnostics.com]

Congestive heart failure. These are the clinical signs of nasopharyngeal diphtheria infection: A sore throat. Dysphagia. Bloody nasal discharge. Pseudomembrane formation. [labpedia.net]

Infants become susceptible to the disease at age 6-12 months after their transplacentally derived immunity wanes. [17] Since the advent of diphtheria vaccination, cases of pediatric disease have declined dramatically. [emedicine.medscape.com]

She also has marked cervical lymphadenopathy and edema of the neck. She is immediately admitted for monitoring, antibiotics, and antitoxin. [medbullets.com]

On examination cervical lymphadenopathy was noted along with grayish white membrane in the throat. What is your diagnosis? Clinically, this appears to be a case of pharyngeal or faucial diphtheria. [microrao.com]

A few other smaller cervical lymphadenopathies were present. Laboratory analyses revealed a normal C-reactive protein (CRP) (5 mg/l) and normal complete blood count. Renal and hepatic functions were also normal. [frontiersin.org]

There are four combination vaccines available to prevent diphtheria, tetanus and pertussis: DTaP, Tdap, DT, and Td. [dentalcare.com]

Diseases / Streptococcal / Tetanus 1 4 Completed Prevention Diphtheria / Pertussis / Tetanus 1 4 Completed Prevention Diphtheria / Tetanus 1 4 Completed Treatment End Stage Renal Disease (ESRD) 1 4 Recruiting Basic Science Human Immunodeficiency Virus [drugbank.ca]

Today, the diphtheria toxoid vaccine, which is in most formulations combined with tetanus and pertussis antigens, is one of the oldest and safest vaccines known. [onlinelibrary.wiley.com]

Anticoagulant Drugs 47 terms Antihypertensive Drugs 39 terms Antihyperlipidemics 16 terms Antianginal Drugs THIS SET IS OFTEN IN FOLDERS WITH... 15 terms Stages of Disease and Reservoirs of Infection 15 terms Linezolid/Synercid 7 terms Case Study: Bordetella pertussis [quizlet.com]

Review Topic QID: 106293 1 Pertussis toxin inhibits the G-protein Gi alpha subunit via ADP ribosylation 2 Overactivates guanylate cyclase 3 Inactivates the 60S ribosomal subunit 4 Inactivates elongation factor 2 M1 Select Answer to see Preferred Response [medbullets.com]

Clinical Presentation Incubation period – 2-4 days Respiratory tract involvement Anterior nasal disease Faucial disease – classic membranes on pharynx and tonsils, cervical adenopathy, and fever Laryngeal and tracheobronchial disease – hoarseness, dyspnea, stridor [arupconsult.com]

Case reports Case 1 A 10-year-old female child presented to the Pediatric emergency with history of fever, respiratory distress and stridor. [ijmm.org]

She did not have stridor, respiratory distress, cardiac murmur, or organomegaly. The remainder of the examination was normal. [pediatrics.aappublications.org]

[…] soft-tissue edema Clinical Presentation Incubation period – 2-4 days Respiratory tract involvement Anterior nasal disease Faucial disease – classic membranes on pharynx and tonsils, cervical adenopathy, and fever Laryngeal and tracheobronchial disease – hoarseness [arupconsult.com]

Other clinical manifestations may include a sore throat, dysphagia, hoarseness, enlarged lymph nodes, difficulty breathing, nasal discharge, fever, and chills. [dentalcare.com]

Symptoms Diphtheria signs and symptoms usually begin two to five days after a person becomes infected and may include: A thick, gray membrane covering your throat and tonsils A sore throat and hoarseness Swollen glands (enlarged lymph nodes) in your neck [mayoclinic.org]

If disease is severe, hoarseness and stridor follow. Some patients exhibit a classic “bull neck” due to severe pharyngeal edema and involvement of the tonsils, submandibular lymph nodes, uvula, and anterior neck. [infectiousdiseaseadvisor.com]

Some patients exhibit a classic “bull neck” due to severe pharyngeal edema and involvement of the tonsils, submandibular lymph nodes, uvula, and anterior neck. [infectiousdiseaseadvisor.com]

Other clinical manifestations may include a sore throat, dysphagia, hoarseness, enlarged lymph nodes, difficulty breathing, nasal discharge, fever, and chills. [dentalcare.com]

Although debridement of the epiglottis may lead to postoperative dysphagia, the goals of surgery are eradication and diagnosis of disease. [pediatrics.aappublications.org]

Dysphagia. Bloody nasal discharge. Pseudomembrane formation. Diagnosis Clinical diagnosis depends upon culture-proven toxigenic C.diphtheriae infection of : The skin. Nose, or throat. [labpedia.net]

He had a systolic murmur leading to a clinical suspicion of endocarditis. He had no specific clinical features of diphtheria. Blood cultures were taken and empiric therapy commenced with benzylpenicillin, vancomycin and gentamicin. [casereports.bmj.com]

She had conjunctival erythema, cracked, red lips, and bilateral tonsillar exudates. Cervical nodes were tender and not fluctuant. Plantar desquamation was present. She did not have stridor, respiratory distress, cardiac murmur, or organomegaly. [pediatrics.aappublications.org]

The onset is sudden, with malaise, sore throat, exudative pharyngitis, and a low-grade fever. [bacteriologynotes.com]

Of the child cases, one had congenital cardiac disease, one had recent undergone a major dental treatment and one had an episode of non-exudative pharyngitis two weeks prior to the onset of infection. [omicsonline.org]

ulcers and sore throats. [ncbi.nlm.nih.gov]

Figure 2 Skin ulceration in a wound infected with Corynebacterium diphtheriae. [academic.oup.com]

In the cases presented here, skin ulceration was uncommon (1 case), but dental caries were found in 22% of cases. Dental caries could be a portal of entry. The main limitation of this work is lack of complete data. [wwwnc.cdc.gov]

The lesions then turn into painful skin ulcers with slightly curved and elevated margins ranging from several millimeters to a few centimeters. During the first two weeks the lesions may be covered with a dark pseudomembrane. [wiki.ggc.edu]

Examination was significant for an afebrile, ill-appearing child with prominent neck swelling and left neck redness. She had conjunctival erythema, cracked, red lips, and bilateral tonsillar exudates. Cervical nodes were tender and not fluctuant. [pediatrics.aappublications.org]

Less common consequences include myocarditis (about 20% of cases) and peripheral neuropathy (about 10% of cases) ( Wikipedia ). [bacteria.cz]

Diphtheria vaccines protect against the toxin responsible for pseudomembranes, myocardiopathy, and peripheral neuropathy and are 97% efficacious. 1, 16 Vaccines do not protect against colonization by nontoxigenic C diphtheriae. 22 Although the toxin is [pediatrics.aappublications.org]

Other complications include cardiac dilatation and failure, mycotic aneurysm, endocarditis, rhythm disturbances, secondary bacterial pneumonia, cranial nerve dysfunction and peripheral neuropathy, total paralysis, septicemia, septic arthritis, osteomyelitis [microrao.com]

Laboratory evaluation revealed elevated white blood cell count (17,8 10 3 /μl) with 34% of band neutrophils and 51% of granulocytes, decreased platelet count (29 10 3 /μl), slightly elevated liver enzymes (AST 52 U/L, ALT 41 U/L, LDH 589 U/L, alkaline [ann-clinmicrob.biomedcentral.com]

A prolonged PR interval with changes in the ST-T waves were noted on her electrocardiogram. The immunization history of the child was complete with two booster doses at 1.5 years and 5 years respectively. [ijmm.org]

Blood cultures were positive for a pleomorphic Gram-positive rod. Initial phenotypic testing could only support the identification of a Corynebacterium species. [ncbi.nlm.nih.gov]

Abstract Many surface proteins in Gram-positive bacteria are covalently linked to the cell wall through a transpeptidation reaction catalysed by the enzyme sortase. [ncbi.nlm.nih.gov]

Gram stain also shows gram-positive bacteria. Possible References Used Back to tests [labpedia.net]

[…] facultatively anaerobic, Gram positive organism that is characterized by non-encapsulated, non-sporulated, immobile, straight or curved rods. [1] [2] The genome of C. diphtheriae contains 2,488,635 nucleotides, 2,389 genes, and 69 structural RNA genes. [3] As a gram-positive [wikidoc.org]

The molecular switch that activates the cell wall anchoring step of pilus assembly in Gram-positive bacteria. Proc Natl Acad Sci U S A. 2008;105(37):14147–52. [bmcgenomics.biomedcentral.com]