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Coxiella Burnetii


Presentation

  • Disease never reported OIE Handistatus, 2005 Belgium No information available OIE Handistatus, 2005 Bosnia-Hercegovina Reported present or known to be present OIE Handistatus, 2005 Bulgaria Reported present or known to be present OIE Handistatus, 2005[cabi.org]
  • Abstract Q fever caused by Coxiella burnetii usually presents asymptomatically or as an undifferentiated febrile disease and rarely as rash or other cutaneous manifestations of the disease.[ncbi.nlm.nih.gov]
  • We showed that GP present in the pathogen's outer membrane underwent considerable modifications during the phase variation that might be related to impact of various environmental factors.[ncbi.nlm.nih.gov]
  • Herein, we report the first case of a patient who presented to the emergency department of our hospital with a prosthetic hemodialysis AV graft infection due to Coxiella burnetii.[ncbi.nlm.nih.gov]
  • Here we present the case of a sternoclavicular joint infection caused by Coxiella burnetii and localized by positron emission tomography scanning.[ncbi.nlm.nih.gov]
Wound Infection
  • We report a case of chronic sternal wound infection, polyclonal gammopathy, and mixed cryoglobulinemia in which Q fever endocarditis was subsequently diagnosed.[ncbi.nlm.nih.gov]
Pseudotumor
  • A needle CT-guided lung biopsy documented an inflammatory pseudotumor, lymphoplasmacytic type. Serology showed high titer antibodies to phase II Coxiella burnetii infection.[ncbi.nlm.nih.gov]
Splenectomy
  • Resection of the aneurysm, splenectomy, and distal pancreatectomy were performed. In all patients with culture-negative endocarditis and mycotic aneurysm, C. burnetii infection should be ruled out. Copyright (c) 2010 Annals of Vascular Surgery Inc.[ncbi.nlm.nih.gov]
Jaw Claudication
  • A 72-year-old man, who is a hunter, presented with weight loss, fever, jaw claudication, and hardened temporal arteries associated with a persistent inflammatory syndrome and arteritis of the whole aorta, including the brachiocephalic arteries, as seen[ncbi.nlm.nih.gov]
Fracture
  • A dry fracture of a Vero cell exposing the contents of a vacuole where Coxiella burnetii (the Bacteria that cause Q Fever) are busy growing - NIAID.jpg 2 424 2 032; 476 KB Coxiella burnetii 01.JPG 2 103 1 503; 1,3 MB Coxiella burnetii, the bacteria that[commons.wikimedia.org]
Knee Pain
  • Here we present a 41-year-old male complaining of body ache, fever, nausea, malaise, bilateral knee pain and vomiting. Clinical examination revealed a notable erythematous blanching rash all over his body.[ncbi.nlm.nih.gov]
Cutaneous Manifestation
  • Abstract Q fever caused by Coxiella burnetii usually presents asymptomatically or as an undifferentiated febrile disease and rarely as rash or other cutaneous manifestations of the disease.[ncbi.nlm.nih.gov]
Agitation
  • Antibodies were incubated with 100 µl PAS-Net2 at a 1 50 dilution for 16 h at 4 C with gentle agitation. PAS-antibody conjugates were then washed five times with 400 µl cold Net2 buffer as above.[doi.org]

Workup

  • Workup revealed positive serologic testing for C. burnetii and skin biopsy of the rash revealed leukocytoclastic vasculitis. 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.[ncbi.nlm.nih.gov]
  • These increased possibilities provide new challenges concerning analytical workup and reporting of anaerobes. In February 2015, an extensive web-based survey on pre-analytical, analytical and post-analytical procedures ... Read more Diagn.[pdf.manuscriptpro.com]
Listeria Monocytogenes
  • ., Yersinia pseudotuberculosis and Listeria monocytogenes [13] – [16]. The sRNAs of intracellular bacterial pathogens are poorly characterized, and there are no reports on sRNAs of C. burnetii.[doi.org]
  • Stephanie Schüller, Silke Kügler and Werner Goebel , Suppression of major histocompatibility complex class I and class II gene expression in Listeria monocytogenes‐infected murine macrophages , FEMS Immunology & Medical Microbiology , 20 , 4 , (289-299[doi.org]
Liver Biopsy
  • We also selected patients who revealed granuloma in liver biopsy and with no Q fever diagnosis within the last 3 years as control.[ncbi.nlm.nih.gov]

Treatment

  • U18666A treatment led to PVs containing degraded bacteria and a significant loss in bacterial viability.[ncbi.nlm.nih.gov]
  • Surprisingly, it does not respond to antibiotic but to steroids treatment. A hypersensitivity mechanism has been implicated.[ncbi.nlm.nih.gov]
  • Treatment consisted of antibiotic therapy started preoperatively and continued postoperatively and an open repair, including resection of the infected aneurysm, replacement with a rifampin-soaked polyester graft, and an omental wrap covering the grafts[ncbi.nlm.nih.gov]
  • Polymerase chain reaction analysis of the wound tissue was positive for Coxiella burnetii DNA, and treatment of the endocarditis resulted in prompt healing of the wound.[ncbi.nlm.nih.gov]
  • For the next six months the patient's IgG antibody titers remained high, and after treatment with doxycycline, the IgG antibody titers decreased to 50% (anti-phase I 1:128 and anti-phase II 1:512); this profile suggests an infection of C. burnetii.[ncbi.nlm.nih.gov]

Prognosis

  • Acute respiratory failure secondary to Coxiella burnetii infection is an extremely rare but serious complication that usually has a good prognosis after appropriate treatment.[archbronconeumol.org]
  • What is the Prognosis of Chikungunya? (Outcomes/Resolutions) With appropriate diagnosis and treatment, the prognosis for Chikungunya infection is excellent.[dovemed.com]

Etiology

  • We suspect that bone infections due to Coxiella burnetii could be underdiagnosed because this etiology is not frequently seen.[ncbi.nlm.nih.gov]
  • Classical histopathological examination of the valves did not reveal an etiology. However, coxiella-like organisms were demonstrated in valvular material with Köster, Stamp, and Giemsa stains, and the organisms were grown in cell culture.[ncbi.nlm.nih.gov]
  • CONCLUSION: C. burnetii should be considered as etiological agent in patients with a vascular graft and fever, abdominal pain, and laboratory signs of inflammation, with or without exposure history.[ncbi.nlm.nih.gov]
  • We suggest that extending the etiologic search to C. burnetii could decrease the number of undocumented vascular graft infections.[ncbi.nlm.nih.gov]
  • Conversely, extensive etiologic explorations must be performed in case of systemic embolism. New molecular techniques represent a major step forward in infective endocarditis diagnosis.[ncbi.nlm.nih.gov]

Epidemiology

  • CONCLUSION: Our work provides the first epidemiological data on human Q fever in Chile indicating either a very low endemicity or the absence of this pathogen in the studied areas.[ncbi.nlm.nih.gov]
  • Chronic Q fever can occur without epidemiological risk factors for C. burnetii exposure and can produce multisystem inflammatory dysfunction, aberrations of the immune system, and persistent wound infections.[ncbi.nlm.nih.gov]
  • The importance of including the pathogen in the differential diagnosis of ENT patients, in assorted epidemiological settings, and the significance of the proper antibiotic selection are further discussed.[ncbi.nlm.nih.gov]
  • This retrospective case series study was undertaken to understand the epidemiologic trends and clinical features of Q fever endocarditis in Southeast Queensland, Australia.[ncbi.nlm.nih.gov]
  • In addition, epidemiological information, at both the herd and individual level, was collected.[visavet.es]
Sex distribution
Age distribution

Pathophysiology

  • Useful For Suggests clinical disorders or settings where the test may be helpful Aids in diagnosing Coxiella burnetii infection (eg, Q fever) Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a[mayomedicallaboratories.com]
  • Natural history and pathophysiology of Q fever . Lancet Infect Dis. 2005 ;5(4): 219 – 226 . Google Scholar Medline 16. Raoult, D, Vestris, G, Enea, M.[journals.sagepub.com]
  • Natural history and pathophysiology of Q fever. Lancet Infect Dis. 2005;5:219–226 5. Diagnosis and Management of Q Fever - United States. Recommendations from CDC and the Q Fevere Working Group.[journals.lww.com]
  • Natural history and pathophysiology of Q fever. The Lancet Infect Dis. 2005;5(4):219-26. 2. Máttar S, Parra M. Detection of antibodies to Anaplasma, Bartonella and Coxiella in rural inhabitants of the Caribbean area of Colombia.[revistas.unal.edu.co]

Prevention

  • Immunology & Pathology, Korea National Institute of Health, Korea Centers for Disease Control & Prevention, Cheongju, Korea. hwangsd@korea.kr.[ncbi.nlm.nih.gov]
  • Interestingly, ectopic expression of a phospho-mimetic VASP (S239E) mutant protein prevented optimal PV formation, whereas VASP (S157E) mutant expression had no effect.[ncbi.nlm.nih.gov]
  • Axenic cultivation of C. burnetii will facilitate studies of the organism's pathogenesis and genetics and aid development of Q fever preventatives such as an effective subunit vaccine.[ncbi.nlm.nih.gov]
  • Collectively, these results demonstrate the utility of C. elegans for studying the innate immune response against C. burnetii and could lead to discovery of novel methods for prevention and treatment of disease in humans and livestock.[ncbi.nlm.nih.gov]
  • Here we discuss Q-VaxCelerate, a distributed development consortium for the development of a new vaccine to prevent Q fever. KEYWORDS: Coxiella burnetii; Qfever; distribute development; peptide; subunit; vaccine[ncbi.nlm.nih.gov]

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