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Coxsackievirus Infection

Coxsackie Virus Infection


Presentation

  • In the present study, eight candidate miRNAs, the functions of which are associated with myocarditis, were selected and their expression levels were evaluated by reverse transcription-quantitative polymerase chain reaction. miR-146b and miR-214 were found[ncbi.nlm.nih.gov]
  • Infection with coxsackievirus B4 (CB4) enhances type 1 diabetes onset in NOD mice by accelerating the presentation of beta-cell antigen to autoreactive T-cells.[ncbi.nlm.nih.gov]
  • CASE REPORT: We briefly describe a 36-year-old man who presented with acute pancreatitis and a maculopapular rash.[ncbi.nlm.nih.gov]
  • In this review we will discuss the evidence associating coxsackievirus infection to T1D and present the current state of knowledge on the potential mechanism of coxsackievirus-mediated T1D.[ncbi.nlm.nih.gov]
  • Serologic evidence of coxsackievirus infection was present in all children, with no significant difference in geometric mean antibody titers between case patients and control subjects.[ncbi.nlm.nih.gov]
Fatigue
  • The common symptoms of Coxsackie virus are fever, sore throat, fatigue and loss of appetite. It would be only for two or three days. Then it appears as sores and blisters on the mouth, throat and hands.[diseasespictures.com]
  • Symptoms include shortness of breath, chest pain, fatigue , and leg swelling. The injury to the heart may be transient or permanent. Severe Infection of the Newborn Newborns may acquire the virus from infected adults or children.[emedicinehealth.com]
  • There are also possible associations of Coxsackieviruses with post-viral fatigue syndromes, Reye's syndrome and pancreatitis.[patient.info]
Sore Throat
  • Coxsackie viruses are a common cause of sore throats, especially for children, often in spring and summer. Typical symptoms are a fever, and sore throat and tongue in some cases.[familydoctor.co.nz]
  • HFMD usually causes a sore throat, fever , and the characteristic blister rash described above. It is mild and resolves on its own.[emedicinehealth.com]
  • Children should be encouraged to drink plenty of fluids since they may refuse to eat anything because of sore throat and ulcerous growth on oral cavity.[diseasespictures.com]
  • Others suddenly get a high fever, headache, and muscle aches, and some also develop a sore throat, abdominal discomfort, or nausea. A child with a coxsackievirus infection may simply feel hot but have no other symptoms.[kidshealth.org]
Chest Pain
  • When to Call Your Pediatrician Call your pediatrician if your child complains of neck pain, chest pain, difficulty breathing, listlessness, or lethargy.[healthychildren.org]
  • It causes a sudden onset of sharp chest pain which gets worse when taking a deep breath. Pain may also be present in the abdomen. The pain comes and goes in waves or spasms.[emedicinehealth.com]
  • Some suffer chest pain when breathing. Other variations of the coxsackie virus include myositis, a muscle infection; meningitis, an infection of the membranes that cover the brain; and encephalitis, a brain infection.[familydoctor.co.nz]
  • Fever, headache or nonspecific abdominal pain - either as prodromal symptoms or with the onset of chest pain. May be myalgia elsewhere. Duration is normally a few days, but may be 3 weeks; it can recur/relapse.[patient.info]
Maculopapular Rash
  • CASE REPORT: We briefly describe a 36-year-old man who presented with acute pancreatitis and a maculopapular rash.[ncbi.nlm.nih.gov]
  • Case report: We briefly describe a 36-yearold man who presented with acute pancreatitis and a maculopapular rash.[pancreas.imedpub.com]
Suggestibility
  • Abstract Coxsackievirus B3 (CVB3) infections produce an inflammatory and immune response that suggests the involvement of cytokines.[ncbi.nlm.nih.gov]
  • Together, our results suggest that cleavage of AUF1 may be a strategy employed by CVB3 to enhance the stability of its viral genome.[ncbi.nlm.nih.gov]
  • Taken together, our findings in this study suggest a novel host defense machinery through which CV-B3 infection is limited by the cleavage of a pro-viral protein.[ncbi.nlm.nih.gov]
  • Abstract Recently, it has been suggested that coxsackievirus plays an etiologic role in juvenile dermatomyositis (DM).[ncbi.nlm.nih.gov]
  • These data suggest that peroxynitrite is an endogenous effector of the immune response to viruses.[ncbi.nlm.nih.gov]
Seizure
  • Febrile seizures may occur in children. Seizures are less common in adults, although adults may complain of fatigue that lasts for weeks after the meningitis resolves.[emedicinehealth.com]
  • If you experience a rash, fever, seizure, severe headache, stiff neck, shortness of breath, or chest pain, you should seek medical attention to gain a proper diagnosis for your symptoms.[belmarrahealth.com]
  • Possible complications that may result from HFMD include: Loss of body fluids (dehydration) Seizures due to high fever ( febrile seizures ) Call your provider if there are signs of complications, such as pain in the neck or arms and legs.[medlineplus.gov]
  • Complications of hand, foot and mouth disease Complications of HFMD include (5): High fever in children leading to dehydration High fever may lead to febrile seizures or convulsions in very young children Infections of the lesions by bacteria or superimposed[news-medical.net]

Treatment

  • However, this treatment strategy has to be evaluated in vivo to develop a new treatment strategy for patients suffering with viral myocarditis.[ncbi.nlm.nih.gov]
  • […] may represent a peculiar paraviral eruption, where a predisposing pemphigus-prone genetic background paved the way for the acantholytic autoimmune disorder as a consequence of the combined effect of the coxsackievirus infection and the cephalosporin treatment[ncbi.nlm.nih.gov]
  • CONCLUSIONS: This novel infection model may be useful in investigating the pathogenesis of acute hemorrhagic conjunctivitis and the effectiveness of antiviral treatments.[ncbi.nlm.nih.gov]
  • In conclusion, the results of the present study demonstrated that miR-214 contributed to the adverse inflammatory response to viral infection of the heart during coxsackievirus infection and is therefore a potential therapeutic target for the treatment[ncbi.nlm.nih.gov]
  • Prepare for clinical challenges and save time in addressing them thanks to expert advice on treatment options from international contributors.[books.google.com]

Prognosis

  • Thus, the effects of a relatively common infection during the neonatal period may be long lasting, and the prognosis for newborn infants recovering from acute infection should be reexplored.[ncbi.nlm.nih.gov]
  • The prognosis of HFMD is excellent, with the vast majority resolving spontaneously in 5-10 days.[patient.info]
  • What Is the Prognosis? In most cases, children recover from these infections within 7 to 10 days without problems.[healthychildren.org]
  • Prognosis : There is excellent recovery from Coxsackie infection with prompt medical intervention and treatment. But things get uncontrolled if there is severe outbreak of infection wherein many children are infected and hospitalized.[diseasespictures.com]

Etiology

  • Abstract Recently, it has been suggested that coxsackievirus plays an etiologic role in juvenile dermatomyositis (DM).[ncbi.nlm.nih.gov]
  • Accumulating evidence strongly supports viral infection as an important factor in the etiology of T1D. To this effect, several viruses have been associated with the capacity to induce or exacerbate T1D in both humans and mice.[ncbi.nlm.nih.gov]
  • The incidence of pancreatitis of unknown etiology may even be higher since the diagnosis of acute pancreatitis can be difficult and may go undetected.[pancreas.imedpub.com]
  • These findings indicate that the timing of a coxsackievirus infection, rather than its simple presence or absence, may have important etiological implications for the development of T-cell-mediated autoimmune type 1 diabetes in humans.[diabetes.diabetesjournals.org]
  • However, the concept of the streptococcus as the sole etiologic agent of the rheumatic heart disease (RHD) has been challenged over the past years.[ncbi.nlm.nih.gov]

Epidemiology

  • The epidemiology and pathogenicity of SAFV remain unclear. METHODS: Between July 2009 and October 2010, nasopharyngeal specimens were collected from children with acute respiratory infections.[ncbi.nlm.nih.gov]
  • Abstract Full Text The report is an overview of enterovirus epidemiology in Piemonte during a 5-year period from 2000 to 2004 with an investigative protocol recording epidemiologic, clinical, and laboratory data.[doaj.org]
  • Epidemiology [ 1, 2 ] Infection with this group of enteroviruses is very common. In temperate climates, it is most frequent in summer and autumn and, in the tropics, all year round.[patient.info]
  • To contact the Epidemiology and Emerging Infections Program, please call 860-509-7994.[ct.gov]
  • Epidemiology and Infection. 102: 493-505.[microchemlab.com]
Sex distribution
Age distribution

Pathophysiology

  • Pathophysiology of Coxsackie's virus Coxsackieviruses are transmitted primarily via the fecal -oral route and respiratory aerosols, although transmission via fomites is possible.[slideshare.net]

Prevention

  • Two weeks before the outbreak of the lesions, the patient had suffered from a viral pharyngitis, subsequently diagnosed as herpangina, and had been taking an oral cephalosporin (cefixime) for 1 week to prevent possible bacterial complications.[ncbi.nlm.nih.gov]
  • RESULTS: Here, we report that Tregs induced after CB4 infection in the presence of TGF-beta prevented type 1 diabetes.[ncbi.nlm.nih.gov]
  • There is no vaccine to prevent coxsackievirus infection. Hand washing is the best protection.[kidshealth.org]
  • Tips For Prevention : Children should be instructed to wash their hands properly before eating and after using the toilet. Parents should not send the infected child to school or day care center to prevent spreading of infection to many others.[diseasespictures.com]
  • Simple hand washing is the best form of prevention. Careful hand washing after changing nappies and before preparing food can help stop the spread.[familydoctor.co.nz]

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