This arginine is highly conserved not only among several vertebrate species, ranging from fish to primates, but also among human EFNB members 1–3. [ncbi.nlm.nih.gov]

[…] adhesion, migration, and patterning 15 – 18 to regulate many developmental roles, including bone formation, 19, 20 skeletogenesis, 21 neuronal wiring, 22, 23 angiogenesis, 24 and retinocollicular mapping, 25 in addition to disease monitoring such as inflammation [ncbi.nlm.nih.gov]

[…] body height Small stature [ more ] 0004322 Split nail Longitudinal splitting of nail 0001809 Telecanthus Corners of eye widely separated 0000506 Toe syndactyly Fused toes Webbed toes [ more ] 0001770 Umbilical hernia 0001537 Unilateral breast hypoplasia [rarediseases.info.nih.gov]

Patients also had cleft lip-cleft palate (10 percent), ear deformities (19 percent), strabismus or esotropia (81 percent), dry frizzy hair (100 percent), syndactyly (14 percent), and nail (100 percent) or other anomalies. [ncbi.nlm.nih.gov]

This group needs regular eye examinations to assess for visual impairment and provide timely intervention for modifiable causes of visual loss. [ncbi.nlm.nih.gov]

neck Short stature Split nail Telecanthus Toe syndactyly Umbilical hernia Unilateral breast hypoplasia Wide nasal bridge Widow's peak X-linked dominant inheritance Last updated: 1/1/2017 Source: GARD (NIH) 1 • • • Back to: « Craniofrontonasal dysplasia [familydiagnosis.com]

neck Decreased length of neck 0000470 Short stature Decreased body height Small stature [ more ] 0004322 Split nail Longitudinal splitting of nail 0001809 Telecanthus Corners of eye widely separated 0000506 Toe syndactyly Fused toes Webbed toes [ more [rarediseases.info.nih.gov]

Skeletal deformities may include a short neck, rounded and sloping shoulders, abnormalities involving scapula (Sprengel anomaly) and the clavicle (pseudoarthrosis), broad first toes, short first fingers, brachydactyly, clinodactyly, gaps between the first [mjdrdypu.org]

In conclusion, individuals diagnosed with frontonasal dysplasia usually are of average intelligence and can expect a normal life span. The affected individual may die shortly after birth if corrective surgery is not performed as soon as possible. [ruralneuropractice.com]