Presentation
It also masks the conserved caspase-3 cleavage site present at the tip of the stalk region from host cell caspase-3 interaction and cleavage. [ncbi.nlm.nih.gov]
It was seen for the first time in the south of present day Ukraine and thus named, Crimean fever. 1 In 1956, the virus was isolated in a patient with similar symptoms residing in Congo, Kenya and the virus was named Congo virus. [eurekaselect.com]
Psychiatrical
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Suggestibility
Previous experiments suggested that CCHFV enters the cells via a clathrin dependent pathway. Therefore, we have evaluated the potential anti-CCHFV activity of several molecules targeting this entry possibility. [ncbi.nlm.nih.gov]
Workup
[…] headache also warrant imaging, as they may have a mass or a bleed that is gradually growing, pressing on surrounding structures and causing worsening pain. [26] People with neurological findings on exam, such as weakness, also need further workup. [26 [en.wikipedia.org]
Microbiology
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Human Herpesvirus 8
Salata, C. et al. vOX2 glycoprotein of human herpesvirus 8 modulates human primary macrophages activity. J. Cell. Physiol. 219, 698–706 (2009). 12. Wang, Y. et al. [nature.com]
Treatment
Previous studies demonstrate that pre-treatment with type I IFNs have an antiviral effect against CCHFV, while established CCHFV infection is almost insensitive to subsequent IFN-α treatment. [ncbi.nlm.nih.gov]
Prognosis
Prognosis The case-fatality rate is 15-30%. Shock, bleeding, neurological manifestations, high viremia, aspartate aminotransferase (AST) 150 IU/L, and pregnancy confer a poor prognosis. [orpha.net]
Etiology
This article provides a definitive review of experimental studies of the role of wild animals and livestock in the maintenance and transmission of Crimean-Congo hemorrhagic fever virus (CCHFV), the etiologic agent of Crimean-Congo hemorrhagic fever (CCHF [ncbi.nlm.nih.gov]
Etiology Over 25 different viruses cause viral hemorrhagic fever. CCHF virus is a member of the virus family Bunyaviridae, genus Nairovirus. [orpha.net]
"Headaches in a pediatric emergency department: etiology, imaging, and treatment". Headache. 40 (1): 25–9. doi : 10.1046/j.1526-4610.2000.00004.x. PMID 10759899. Burton LJ, Quinn B, Pratt-Cheney JL, et al. (1997). [en.wikipedia.org]
Epidemiology
Gov't MeSH terms Adult Aged Aged, 80 and over Animals Antibodies, Viral/blood* Enzyme-Linked Immunosorbent Assay/methods Greece/epidemiology Hemorrhagic Fever Virus, Crimean-Congo/classification Hemorrhagic Fever Virus, Crimean-Congo/immunology Hemorrhagic [ncbi.nlm.nih.gov]
Pathophysiology
Sleisenger & Fordtran's gastrointestinal and liver disease pathophysiology, diagnosis, management (PDF) (9th ed.). St. Louis, Mo.: MD Consult. ISBN 978-1-4160-6189-2. [en.wikipedia.org]
Prevention
Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA. [email protected] 3 Viral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, GA [ncbi.nlm.nih.gov]