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Crimean-Congo Hemorrhagic Fever Virus


Presentation

  • It also masks the conserved caspase-3 cleavage site present at the tip of the stalk region from host cell caspase-3 interaction and cleavage.[ncbi.nlm.nih.gov]
  • Seroprevalence of infection was 10% in a sample from an outbreak region and increased with patient age, indicating that the virus had been previously present in Turkey. We also estimated that 88% of infections were subclinical.[ncbi.nlm.nih.gov]
  • It was seen for the first time in the south of present day Ukraine and thus named, Crimean fever. 1 In 1956, the virus was isolated in a patient with similar symptoms residing in Congo, Kenya and the virus was named Congo virus.[ncbi.nlm.nih.gov]
  • In the present study, we provide serological evidence of CCHFV infection in Lepus europeus using newly developed antibody detection assays.[ncbi.nlm.nih.gov]
  • Presented are the materials and methods currently available to study CCHFV transcription, replication, and translation in the context of a minigenome or VLP. KEYWORDS: CCHFV; Minigenome; Polymerase; Replication; Reverse-genetics; Transcription; VLP[ncbi.nlm.nih.gov]
Suggestibility
  • Furthermore, we found in CCHFV-infected cells the over-expression of PUMA, Noxa and CHOP suggesting the crosstalk between the ER-stress and mitochondrial apoptosis.[ncbi.nlm.nih.gov]
  • Published evidence suggests that the increase in human cases reported in the Balkans, Turkey, and Russia is perhaps less due to the effect of changes in climate, but rather result from the impact of yet unexplored mechanisms of amplification that might[ncbi.nlm.nih.gov]
  • Previous experiments suggested that CCHFV enters the cells via a clathrin dependent pathway. Therefore, we have evaluated the potential anti-CCHFV activity of several molecules targeting this entry possibility.[ncbi.nlm.nih.gov]
  • Shutdown of this translation mechanism might selectively impact viral protein synthesis, suggesting that an NP-mediated translation strategy is a target for therapeutic intervention against this viral disease.[ncbi.nlm.nih.gov]
  • These results suggest that chaperones of the HSP70 family are required for nairovirus replication and thus represent a genetically stable cellular therapeutic target for preventing nairovirus-mediated disease.[ncbi.nlm.nih.gov]

Workup

  • […] headache also warrant imaging, as they may have a mass or a bleed that is gradually growing, pressing on surrounding structures and causing worsening pain. [26] People with neurological findings on exam, such as weakness, also need further workup. [26[en.wikipedia.org]
Human Herpesvirus 8
  • Salata, C. et al. vOX2 glycoprotein of human herpesvirus 8 modulates human primary macrophages activity. J. Cell. Physiol . 219 , 698–706 (2009). 12. Wang, Y. et al.[nature.com]

Treatment

  • Previous studies demonstrate that pre-treatment with type I IFNs have an antiviral effect against CCHFV, while established CCHFV infection is almost insensitive to subsequent IFN-α treatment.[ncbi.nlm.nih.gov]
  • […] particular, the development of the noninfectious minigenome and virus-like particle (VLP) systems is a tremendous technological advance, as these systems allow for precisely targeting proteins or nucleic acids and measuring the effects these mutations or treatments[ncbi.nlm.nih.gov]
  • Abstract Crimean Congo hemorrhagic fever virus (CCHFV) is a human pathogen that causes a severe disease with high fatality rate for which there is currently no specific treatment. Knowledge regarding its replication cycle is also highly limited.[ncbi.nlm.nih.gov]
  • There is no approved vaccine or specific treatment against CCHF virus (CCHFV) infections. In this context, an accurate diagnosis as well as a reliable surveillance of CCHFV infections is essential.[ncbi.nlm.nih.gov]
  • Currently, there are no specific treatments or licensed vaccines available for CCHFV. Recently, two research groups have found adult mice with defective interferon responses allowed to lethal CCHFV infection.[ncbi.nlm.nih.gov]

Prognosis

  • Prognosis The case-fatality rate is 15-30%. Shock, bleeding, neurological manifestations, high viremia, aspartate aminotransferase (AST) 150 IU/L, and pregnancy confer a poor prognosis.[orpha.net]

Etiology

  • This article provides a definitive review of experimental studies of the role of wild animals and livestock in the maintenance and transmission of Crimean-Congo hemorrhagic fever virus (CCHFV), the etiologic agent of Crimean-Congo hemorrhagic fever (CCHF[ncbi.nlm.nih.gov]
  • Etiology Over 25 different viruses cause viral hemorrhagic fever. CCHF virus is a member of the virus family Bunyaviridae , genus Nairovirus .[orpha.net]
  • "Headaches in a pediatric emergency department: etiology, imaging, and treatment". Headache . 40 (1): 25–9. doi : 10.1046/j.1526-4610.2000.00004.x . PMID 10759899 . Burton LJ, Quinn B, Pratt-Cheney JL, et al. (1997).[en.wikipedia.org]

Epidemiology

  • Gov't MeSH terms Adult Aged Aged, 80 and over Animals Antibodies, Viral/blood* Enzyme-Linked Immunosorbent Assay/methods Greece/epidemiology Hemorrhagic Fever Virus, Crimean-Congo/classification Hemorrhagic Fever Virus, Crimean-Congo/immunology Hemorrhagic[ncbi.nlm.nih.gov]
  • Gov't MeSH terms Africa/epidemiology Animals Antibodies, Monoclonal/immunology* Antibodies, Monoclonal/isolation & purification Antibodies, Viral/blood* Antigens, Viral/genetics Antigens, Viral/immunology Asia/epidemiology Cattle Enzyme-Linked Immunosorbent[ncbi.nlm.nih.gov]
  • […] playing a role for the high seroprevalence of Crimean-Congo hemorrhagic fever virus in the human population of Thesprotia prefecture, Greece, serum samples were collected from residents of the area together with a questionnaire about demographic and epidemiological[ncbi.nlm.nih.gov]
  • Author information 1 State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, PR China. shpchen@hotmail.com Abstract Crimean-Congo hemorrhagic fever virus (CCHFV), which is widely distributed[ncbi.nlm.nih.gov]
  • Abstract This review aims to summarize the current knowledge of the eco-epidemiology of Crimean-Congo hemorrhagic fever (CCHF) virus transmission reviewing the most recent scientific advances in the last few decades of epidemic and non-epidemic ("silent[ncbi.nlm.nih.gov]
Sex distribution
Age distribution

Pathophysiology

  • Sleisenger & Fordtran's gastrointestinal and liver disease pathophysiology, diagnosis, management (PDF) (9th ed.). St. Louis, Mo.: MD Consult. ISBN 978-1-4160-6189-2 .[en.wikipedia.org]
  • Pathophysiology, clinical manifestations and diagnosis of migraine in adults. In: UpToDate, Post TW (Ed), UpToDate, San Francisco, CA. (Accessed on April 23, 2014.) Goadsby, P.J. (January 2009).[en.wikipedia.org]

Prevention

  • Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA. kyj7@cdc.gov. 3 Viral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, GA[ncbi.nlm.nih.gov]
  • No preventative or therapeutic strategies against nairovirus-mediated disease are currently available.[ncbi.nlm.nih.gov]
  • There are no widely accepted therapeutics available to prevent or treat the disease.[ncbi.nlm.nih.gov]
  • Author information 1 Viral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA. 2 Department[ncbi.nlm.nih.gov]
  • Based on this knowledge, guidelines for the risk classification of a region and for outbreak prevention are given.[ncbi.nlm.nih.gov]

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