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Crimean Hemorrhagic Fever

CCHF


Presentation

  • 2011 Iran Present 2000 Bente et al., 2013 Iraq Present 1979 Bente et al., 2013 Kazakhstan Present 1948 Bente et al., 2013 Kyrgyzstan Present Bente et al., 2013 Oman Present 1995 CAB ABSTRACTS Data Mining 2001; Bente et al., 2013 Pakistan Present 1976[cabi.org]
  • Overall identity of the sequences ranged from 98.8–100% and we detected three amino acid changes; S272N (present in samples KS153 and KS149), K316R (present in samples KS208, KS213 and KS223) and V327I (present in samples KS172 and KS88)(amino acid positions[doi.org]
  • Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website.[cdc.gov]
  • Collection includes both citations and many full-text, downloadable documents from mid-1900s to present. AULIMP - Air University Library Index to Military Periodicals.[dtic.mil]
Fever
  • The fever had infected 120 people in 2008 from which 19 deaths were reported. Several cases of Crimean-Congo hemorrhagic fever (CCHF), an arboviral disease, have been reported since the summer of 1999 across different areas of Iran.[web.archive.org]
  • Clinical presentation was characterized by fever, myalgia and haemorrhage.[ncbi.nlm.nih.gov]
  • Convert to ICD-10-CM : 065.0 converts directly to: 2015/16 ICD-10-CM A98.0 Crimean-Congo hemorrhagic fever Approximate Synonyms Congo-Crimean hemorrhagic fever Crimean-congo hemorrhagic fever Applies To Central Asian hemorrhagic fever ICD-9-CM Volume[icd9data.com]
  • Abstract This paper describes the clinical, epidemiological, and laboratory investigations undertaken to isolate and identify the etiological agent of a nosocomial cluster of hemorrhagic fever cases due to Crimean hemorrhagic fever (CHR)-Congo virus.[ncbi.nlm.nih.gov]
  • Crimean-Congo hemorrhagic fever orthonairovirus 1) Taxonomy ID: 1980519 (for references in articles please use NCBI:txid1980519) current name Crimean-Congo hemorrhagic fever orthonairovirus, ICTV accepted 1) acronym: CCHFV NCBI BLAST name: viruses Rank[ncbi.nlm.nih.gov]
High Fever
  • Onset is sudden, with initial symptoms including high fever, joint pain, stomach pain, and vomiting. Red eyes, a flushed face and red spots in the throat are also common.[web.archive.org]
  • Symptoms come on suddenly and include headache, high fever, vomiting, and back, joint and stomach pain. As the illness continues, there can be severe bruising and nosebleeds, as well as bleeding in the face, mouth and throat.[mnn.com]
Ascitic Fluid
  • Gross examination revealed generalized visceral edema, with substantial amounts of serohematic ascitic fluid and disseminated cutaneous and visceral hemorrhages.[doi.org]
Respiratory Distress
  • Disseminated intravascular coagulation may occur, as well as acute kidney failure, shock, and sometimes acute respiratory distress syndrome. People usually begin to recover after 9–10 days first symptoms appeared.[en.wikipedia.org]
  • Acute respiratory distress syndrome after convalescent plasma use: treatment of a patient with Ebola virus disease contracted in Madrid, Spain. Lancet Respir Med 2015 ;3: 554 - 562 15. Leblebicioglu H, Sunbul M, Barut S, et al.[doi.org]
Tachycardia
  • Other clinical signs include tachycardia (fast heart rate), lymphadenopathy (enlarged lymph nodes), and a petechial rash (a rash caused by bleeding into the skin) on internal mucosal surfaces, such as in the mouth and throat, and on the skin.[web.archive.org]
  • ·Other clinical signs which emerge include tachycardia (fast heart rate), lymphadenopathy (enlarged lymph nodes), and a petechial rash (a rash caused by bleeding into the skin), both on internal mucosal surfaces, such as in the mouth and throat, and on[web.archive.org]
Flushing
  • Red eyes, a flushed face and red spots in the throat are also common. As the illness progresses, patients can develop large areas of severe bruising, severe nosebleeds, and uncontrolled bleeding.[bbc.co.uk]
  • Red eyes, a flushed face, a red throat, and petechiae (red spots) on the palate are common. Symptoms may also include jaundice, and in severe cases, changes in mood and sensory perception.[globalbiodefense.com]
Petechiae
  • Red eyes, a flushed face, a red throat, and petechiae (red spots) on the palate are common. Symptoms may also include jaundice, and in severe cases, changes in mood and sensory perception.[globalbiodefense.com]
  • The petechiae may give way to larger rashes called ecchymoses, and other haemorrhagic phenomena.[web.archive.org]
  • Physical examination revealed subconjunctival hemorrhage in the right eye, cutaneous petechiae on pressure areas, and vaginal bleeding.[doi.org]
  • In up to 75% of cases, signs of bleeding can appear within 3–5 days of the onset of illness in case of bad containment of the first symptoms: mood instability, agitation, mental confusion and throat petechiae; and soon after nosebleeds, vomiting, and[en.wikipedia.org]
Skin Lesion
  • He had macroscopic hematuria, worsening of purpuric skin lesions and hematomas, fulminant hepatic failure, severe respiratory insufficiency, encephalopathy, hypoglycemia, and severe metabolic acidosis.[doi.org]
Epistaxis
  • The petechiae may give way to ecchymoses (like a petechial rash, but covering larger areas) and other haemorrhagic phenomena such as melaena (bleeding from the upper bowel, passed as altered blood in the faeces), haematuria (blood in the urine), epistaxis[web.archive.org]
Vaginal Bleeding
  • Physical examination revealed subconjunctival hemorrhage in the right eye, cutaneous petechiae on pressure areas, and vaginal bleeding.[doi.org]

Workup

Coxiella Burnetii
  • Serological testing was performed for detection of Leptospira, Salmonella, Rickettsia, Brucella, and Toxoplasma species; agents of Lyme disease, rubella, and herpes; and Coxiella burnetii, cytomegalovirus, and hepatitis A, B, and C viruses.[doi.org]
Liver Biopsy
  • No CCHF virus IgM or IgG antibodies were detected in serum specimens obtained from this patient, but the virus was detected by PCR in a liver biopsy specimen obtained during autopsy.[doi.org]

Treatment

  • Early and extensive supportive treatment is the mainstay of treatment.[journals.lww.com]
  • Despite a number of the mentioned studies that some patients had died, in the present study all patients improved with treatment.[ncbi.nlm.nih.gov]
  • PTI 15 Jul 2013, 18:54:43 IST Rajkot, July 15: As many as seven people died of Crimean-Congo Hemorrhagic Fever in Amerli district of Gujarat over the last one week while six others were undergoing treatment at the civil hospital, officials said here today[web.archive.org]
  • Please consult your own licensed physician regarding diagnosis and treatment of any medical condition! Please see also our disclaimer . This site complies with the HONcode standard for health information: verify here . Database updated 2019-03-22.[diseasesdatabase.com]
  • HMC has no separate treatment facility for such infectious diseases or specialists equipped to deal with patients with the virus.[tribune.com.pk]

Etiology

  • Abstract This paper describes the clinical, epidemiological, and laboratory investigations undertaken to isolate and identify the etiological agent of a nosocomial cluster of hemorrhagic fever cases due to Crimean hemorrhagic fever (CHR)-Congo virus.[ncbi.nlm.nih.gov]
  • It was impossible to decide with certainty the problem of viral etiology of the Crimean hemorrhagic type of illness without observations carried out on people.[dtic.mil]
  • During the Crimean War, the disease was known as "Crimean fever" and contracted by many, including Florence Nightingale.In 1944, Soviet scientists first identified the disease they called Crimean hemorrhagic fever in Crimea They established its viral etiology[en.wikipedia.org]
  • No infectious etiologic agents were detected in 4 patients. We limited our analysis to the 35 patients with CCHF infection. Thirty-two patients (91%) had CCHF virus IgM antibodies.[doi.org]

Epidemiology

  • Abstract This paper describes the clinical, epidemiological, and laboratory investigations undertaken to isolate and identify the etiological agent of a nosocomial cluster of hemorrhagic fever cases due to Crimean hemorrhagic fever (CHR)-Congo virus.[ncbi.nlm.nih.gov]
  • We describe the epidemiological, clinical, and laboratory findings and the role of ribavirin therapy for 35 patients who received a diagnosis of Crimean-Congo hemorrhagic fever (CCHF).[ncbi.nlm.nih.gov]
  • Health officials aim to determine the most important means and patterns of transmission and the epidemiologic characteristics of this disease. NAT/SC/DT[web.archive.org]
  • Eight of the patients had no epidemiological relationship to one another and lived in widely separated areas around Baghdad and Ramadi (110 km to the west of Baghdad).[ncbi.nlm.nih.gov]
  • Although in the epidemiology of CCHF virus Hyalomma ticks are considered to be the most important vectors and reservoirs, the virus has also been reported to occur in other genera of ticks, which conforms to the current data in our study from Sistan and[ncbi.nlm.nih.gov]
Sex distribution
Age distribution

Pathophysiology

  • Prognostic factors, pathophysiology and novel biomarkers in Crimean-Congo hemorrhagic fever. Antiviral Res 2016 ;132: 233 - 243 12. Cevik MA, Erbay A, Bodur H, et al. Viral load as a predictor of outcome in Crimean-Congo hemorrhagic fever.[doi.org]

Prevention

  • The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention.[doi.org]
  • The identification of the CCHFV RBD and its binding partner could provide novel targets for therapy and tools for prevention as well as more complete understanding of the mechanisms of CCHFV entry and pathogenesis.[ncbi.nlm.nih.gov]
  • The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website.[cdc.gov]
  • European Centre for Disease Prevention and Control An agency of the European Union Sorry, we cannot find the page or file you're looking for Page Not Found We have a new website and some links may not work.[ecdc.europa.eu]

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