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Crohn's Disease

Crohn Disease

Crohn's disease is a chronic inflammatory disorder of the intestines that can affect many other organs. Varied genetic factors and environmental conditions are suspected to play a role in its development, but its cause remains unknown. Its management depends on the severity of the condition.


Presentation

General appearance

The disease most often appears before the age of 40 with nonspecific symptoms of inflammation. Thus, the patient presents with fever, fatigue, abdominal pain and tenderness (often in the right lower quadrant), and diarrhea. In children, retarded growth and development often occur before any other manifestation. As the disease progresses, sequelae such as strictures and fistulae start arising [1] [2], which may result in bowel obstruction.

Intestinal manifestations

The most commonly affected sites in Crohn's disease are the distal small intestine and the proximal colon, although the disease can occur throughout the whole gastrointestinal (GI) tract. Vomiting becomes a frequent symptom in gastroduodenal involvement [3]. Excessive pain, oozing fistulae, and scars characterize a perianal disease. If the colon is affected, there may be the blood in the stool [4].

Extraintestinal manifestations

Numerous extraintestinal manifestations can exist in Crohn's disease [5]. Arthritic and musculoskeletal pain is the most common [6]. Aphthous ulceration of the mouth is also frequent, as is erythema nodosum of the skin. Episcleritis and uveitis are the principal eye presentations. Hepatobiliary problems such as primary sclerosing cholangitis, which also happens in ulcerative colitis, are also common. Gallstones and kidney stones arise presumably because of malabsorption of fats and bile salts. Apart from kidney stones, the urologic complications include enterovesical fistulae and hydronephrosis. Crohn's disease is also characterized by a hypercoagulable state, osteopenia and osteoporosis, and deficiencies in iron, vitamin B12, and folate, which lead to anemia. Other anemic states are also possible, for example owing to gastrointestinal bleeding.

Weight Loss
  • Symptoms include fever, diarrhea, stomach cramps, vomiting, and weight loss. Regional enteritis increases the risk of colorectal cancer and small intestine cancer. It is a type of inflammatory bowel disease (ibd).[icd9data.com]
  • Symptoms include abdominal pain and diarrhea, sometimes bloody, and weight loss.[webmd.com]
  • It causes inflammation of your digestive tract, which can lead to abdominal pain, severe diarrhea, fatigue, weight loss and malnutrition. Inflammation caused by Crohn's disease can involve different areas of the digestive tract in different people.[mayoclinic.com]
  • We report a case of a previously healthy young woman with symptoms of dysphagia, odynophagia, chest pain and weight loss, who presented oesophageal ulcers at upper endoscopy and whose histology revealed granulomatous oesophagitis.[ncbi.nlm.nih.gov]
Fever
  • Symptoms include fever, diarrhea, stomach cramps, vomiting, and weight loss. Regional enteritis increases the risk of colorectal cancer and small intestine cancer. It is a type of inflammatory bowel disease (ibd).[icd9data.com]
  • CASE REPORT: We report a case of a woman admitted to our Department with acute abdominal pain and fever. The surgical and histological investigation, revealed a rare coexistence that has never been mentioned in the published medical literature.[ncbi.nlm.nih.gov]
  • Fever and neutrophilic leukocytosis are also common features.[ncbi.nlm.nih.gov]
  • Fever. Fatigue. Loss of appetite and weight loss. Feeling that you need to pass stools, even though your bowels are already empty. It may involve straining, pain, and cramping. Watery diarrhea, which may be bloody.[nlm.nih.gov]
Fatigue
  • Abstract A 53-year-old man with Crohn's disease treated with adalimumab was hospitalised with abdominal pain, fatigue, fever and chills. CT scan of the abdomen showed chronic thickening of the terminal ileum and cecum and new-onset ascites.[ncbi.nlm.nih.gov]
  • The symptoms of the non-IBS prodrome in subjects with Crohn's disease were bloating, diarrhea, stomach pain, heartburn, fever, weight loss, and fatigue.[ncbi.nlm.nih.gov]
  • It causes inflammation of your digestive tract, which can lead to abdominal pain, severe diarrhea, fatigue, weight loss and malnutrition. Inflammation caused by Crohn's disease can involve different areas of the digestive tract in different people.[mayoclinic.com]
  • Symptoms of Crohn’s Disease Common symptoms of Crohn's disease include: Diarrhea Abdominal cramps and pain Rectal bleeding Anemia Weight loss Fatigue, weakness Nausea Fever Mouth sores Sores, abscesses in the anal area[upmc.com]
Anemia
  • Abstract Anemia often complicates the course of Inflammatory Bowel Disease (IBD). Hepcidin, a liver-produced peptide hormone, is a key mediator of anemia of chronic disease (ACD).[doi.org]
  • They may be particularly vulnerable to adverse effects of anemia. 19 The most common etiologies for anemia in CD are iron deficiency and the anemia of chronic disease. 20 Iron deficiency can result from inadequate dietary intake, malabsorption of iron[doi.org]
  • Anemia of chronic disease results in a normocytic anemia.[en.wikipedia.org]
  • Among these problems are anemia, skin disorders, osteoporosis, arthritis, and gallbladder or liver disease. Medication risks.[mayoclinic.com]
Chills
  • Abstract A 53-year-old man with Crohn's disease treated with adalimumab was hospitalised with abdominal pain, fatigue, fever and chills. CT scan of the abdomen showed chronic thickening of the terminal ileum and cecum and new-onset ascites.[ncbi.nlm.nih.gov]
  • If you have chills, fever, pain, dizziness , or bloody diarrhea while away, call a doctor immediately.[webmd.com]
  • Other signs that require a doctor's attention include fever, shaking chills, and repetitious vomiting.[disabled-world.com]
  • Call your doctor immediately if you feel faint or your pulse is abnormal, you have severe abdominal pain, fever or shaking chills, or persistent vomiting. "Crohn's disease can differ for every single person," Balzora said.[livescience.com]
  • You have a fever or shaking chills. You are vomiting again and again. How is Crohn's disease diagnosed? Your doctor will ask you about your symptoms and do a physical examination.[healthlinkbc.ca]
Abdominal Pain
  • We describe the case of a 51-year-old man presenting with 7 months of right lower quadrant abdominal pain on the background of known Crohn's disease.[ncbi.nlm.nih.gov]
  • It causes inflammation of your digestive tract, which can lead to abdominal pain, severe diarrhea, fatigue, weight loss and malnutrition. Inflammation caused by Crohn's disease can involve different areas of the digestive tract in different people.[mayoclinic.com]
  • Symptoms include abdominal pain and diarrhea, sometimes bloody, and weight loss.[webmd.com]
  • CASE REPORT: We report a case of a woman admitted to our Department with acute abdominal pain and fever. The surgical and histological investigation, revealed a rare coexistence that has never been mentioned in the published medical literature.[ncbi.nlm.nih.gov]
Diarrhea
  • If you have chills, fever, pain, dizziness , or bloody diarrhea while away, call a doctor immediately.[webmd.com]
  • It causes inflammation of your digestive tract, which can lead to abdominal pain, severe diarrhea, fatigue, weight loss and malnutrition. Inflammation caused by Crohn's disease can involve different areas of the digestive tract in different people.[mayoclinic.com]
  • Watery diarrhea, which may be bloody.[nlm.nih.gov]
Vomiting
  • Symptoms include fever, diarrhea, stomach cramps, vomiting, and weight loss. Regional enteritis increases the risk of colorectal cancer and small intestine cancer. It is a type of inflammatory bowel disease (ibd).[icd9data.com]
  • It may occur with acute or chronic symptomatology, such as vomiting or postprandial abdominal pain, and it is usually caused by a lack of mesenteric fat pad under conditions of severe weight loss. Crohn's disease can be one of them.[ncbi.nlm.nih.gov]
  • A 20-year-old male patient with a past medical history of appendectomy and ileocecal Crohn's disease, presented with abdominal pain and vomiting. Ileocolonoscopy showed an ulcerated and congested appearance of the upper rectum and sigmoid.[ncbi.nlm.nih.gov]
  • However, diarrhea, vomiting, and fever occurred for approximately 3 months.[ncbi.nlm.nih.gov]
  • Common adverse events reported in the EN group included heartburn, flatulence, diarrhea and vomiting, and for steroid therapy acne, moon facies, hyperglycemia, muscle weakness and hypoglycemia.[ncbi.nlm.nih.gov]
Rectal Bleeding
  • Diarrhea Rectal bleeding Weight loss Arthritis Skin problems Fever Rectal bleeding may be serious and continuous enough to cause anemia (low red blood count). Children who have Crohn's disease may have delayed development and stunted growth.[genome.gov]
  • Rectal bleeding, fever , weight loss, arthritis , and anemia are indications of moderate to severe disease. Some patients develop fistulas , or abnormal passages connecting the bowel to other organs, such as the bladder or the vagina .[britannica.com]
  • Other symptoms may include: Constipation Sores or swelling in the eyes Draining of pus, mucus, or stools from around the rectum or anus (caused by something called a fistula ) Joint pain and swelling Mouth ulcers Rectal bleeding and bloody stools Swollen[nlm.nih.gov]
Loss of Appetite
  • People suffering from Crohn’s often experience loss of appetite and may lose weight as a result. A feeling of low energy and fatigue is also common. Among younger children, Crohn's may delay growth and development.[ccfa.org]
  • Typical symptoms include chronic diarrhea (which sometimes is bloody), crampy abdominal pain, fever, loss of appetite, and weight loss.[msdmanuals.com]
  • Signs and Symptoms Diagnosis Treatment Common symptoms of Crohn's disease include the following: Loose, watery or frequent bowel movements Abdominal cramps and pain Fever Rectal bleeding Loss of appetite and subsequent weight loss During periods of active[ucsfhealth.org]
Aphthous Stomatitis
  • stomatitis, geographic tongue, and migratory stomatitis in higher prevalence than the general population.[en.wikipedia.org]
Night Sweats
  • sweats Loss of normal menstrual cycle Even if you think you are showing signs of Crohn’s disease symptoms, only proper testing performed by your doctor can render a diagnosis.[ccfa.org]
  • Other symptoms of Crohn’s disease can include: night sweats high temperature unintended weight-loss blood in mucus and/or faeces.[nutritionist-resource.org.uk]
  • Less common symptoms include poor appetite, fever , night sweats , rectal pain , and occasionally rectal bleeding . The symptoms of Crohn's disease are dependent on the location, the extent, and the severity of the inflammation.[medicinenet.com]
Arthritis
  • […] fever (38.5 C), dyspnea, left pleuritic pain, and weight loss (more than 6 kg) about six weeks after beginning treatment with ustekinumab, a human monoclonal antibody approved in the United States for two indications (plaque psoriasis and psoriatic arthritis[ncbi.nlm.nih.gov]
  • Ustekinumab is approved for psoriasis and psoriatic arthritis treatment and has been successfully evaluated in phase II and III trials for patients with Crohn's disease (CD).[ncbi.nlm.nih.gov]
  • Researchers have ... read more Bacteria in Milk and Beef Linked to Rheumatoid Arthritis Jan. 30, 2018 — A strain of bacteria commonly found in milk and beef may be a trigger for developing rheumatoid arthritis in people who are genetically at risk, according[sciencedaily.com]
  • Sanjeevi CB, Miller EN, Dabadghao P, et al. (2000) Polymorphism at NRAMP1 and D2S1471 loci associated with juvenile rheumatoid arthritis. Arth Rheum 43(6):1397–1404 CrossRef Google Scholar 8.[doi.org]
  • Crohn's disease has several extra-intestinal manifestations, including iritis, arthritis, erythema nodosum and pyoderma gangrenosum [ 2 ] .[patient.info]
Arthralgia
  • Common adverse events included infections, mild leukopenia, abdominal symptoms, arthralgias, headache and elevated liver enzymes.[ncbi.nlm.nih.gov]
  • Symptoms or findings presumed related to Crohn's disease Select each set corresponding to patient's symptoms: arthritis or arthralgia iritis or uveitis erythema nodosum, pyoderma gangrenosum, apththous stomatitis anal fissure, fistula or perirectal abscess[ibdjohn.com]
  • […] may also reveal pallor in patients with anemia or jaundice in those with concomitant liver disease The most common ocular findings are episcleritis and anterior uveitis The most common extraintestinal manifestations of Crohn disease are arthritis and arthralgia[emedicine.com]
  • Side effects that occurred during the trials included: headache, worsening of Crohn's disease, abdominal pain, arthralgia, colitis, influenza syndrome, infection, nausea, vomiting, fatigue, hypersensitivity‐like reactions, and the development of antibodies[dx.doi.org]
Low Back Pain
  • Low back pain, sacroiliitis, and the relationship with HLA-B27 in Crohn’s disease. J Rheumatol 2003 ; 30 : 518 –22. Ferraz M B , Tugwell P, Goldsmith C H, et al. Meta-analysis of sulfasalazine in ankylosing spondylitis.[doi.org]
Myalgia
  • KEYWORDS: Crohn's disease; extraintestinal manifestation; gastrocnemius myalgia syndrome[ncbi.nlm.nih.gov]

Workup

The standard laboratory tests do not show results specific for Crohn's disease. Anemia and hypoalbuminemia are common. C-reactive protein (CRP) levels and erythrocyte sedimentation rate (ESR) may be of use since there is an association with the presence of complications of Chron's disease [7]. Fecal calprotectin may serve as a marker for intestinal inflammation.

There are two serological tests of significant importance, one indicating the presence of anti-Saccharomyces cerevisiae antibodies (ASCA) which are mainly seen in Crohn's disease, the other showing positive results in patients with ulcerative colitis for perinuclear antineutrophil cytoplasmic antibodies (p-ANCA). These tests may help to distinguish these two diseases.

A number of imaging techniques are available for diagnosis. Whereas barium contrast imaging has been used for a long time, it is being replaced by ultrasound, computed tomography (CT), magnetic resonance imaging (MRI), and capsule endoscopy methods. These modalities have been extensively evaluated for accuracy in detecting various pathological aspects of Chron's disease [8], such as the extent of the disease at different locations within the GI tract, the severity of the lesions, the detection of intraabdominal fistulae and abscesses, and other features. Ultrasonography is a widely used and affordable technique that does not involve ionizing radiation, but its accuracy for diagnosing Crohn's disease depends on the location of the lesions, whereas the precision of MRI diagnosis is less depended on the position of the pathologic changes. All three methods (ultrasound, CT, and MRI) are highly accurate in identifying stenosis, fistulae, and abscesses. Barium studies can also detect fistulae. CT scans efficiently reveal extramural and hepatobiliary complications [9], as well as bowel wall thickening and edema. The advantage of MRI is the absence of radiation. Other imaging modalities include esophagogastroduodenoscopy (EGD), endoscopic retrograde cholangiopancreatography (ERCP), ileocolonoscopy, and balloon enteroscopy.

In Chron's disease lesions of the intestine often alternate with unaffected areas, which is the reason why they are called skip lesions. The histology may show the presence of non-caseating granulomas.

Nephrolithiasis
  • […] from normal to those of an acute abdomen; assess for rectal sphincter tone, gross rectal mucosal abnormalities, presence of hematochezia Genitourinary: May include presence of skin tags, fistulae, ulcers, abscesses, and scarring in the perianal region; nephrolithiasis[emedicine.medscape.com]
Colonic Stricture
  • ., Aydin, F. and Buyukbayram, H. (2005) A rare cause of colonic stricture, amebiasis.[scirp.org]
  • In Crohn’s disease, colonic strictures may be followed with annual surveillance and biopsy if the lesion can be traversed with a standard pediatric colonoscope.[doi.org]
  • ., Aydin, F. and Buyukbayram, H. (2005) A rare cause of colonic stricture, amebiasis. Turkish Journal of Gastroenterology, 16, 236-239.[dx.doi.org]
Microcytic Anemia
  • Diagnosis Laboratory data for Crohn disease are nonspecific, as follows: The CBC may show hypochromic microcytic anemia, from iron deficiency due to GI blood loss, or normocytic anemia of chronic disease levels of acute-phase reactants (ESR and CRP) are[emedicine.com]
  • Our patients with ST and IBD had mild microcytic anemia and elevated levels of SF, consistent with anemia of chronic disease (ACD) [ 4 , 21 ]. sTfR is superior than ferritin to discriminate IDA from ACD [ 22–24 ].[doi.org]
Macrocytic Anemia
  • Subjects were excluded if there was a known history of iron deficiency anemia (IDA), 14 UC, or macrocytic anemia. Furthermore, patients who used iron supplementation, B12 or folate within 3 months of study enrollment were also excluded.[doi.org]
Colitis
  • Of the 66 subjects analyzed, 45 had Crohn's disease and 21 had ulcerative colitis. The prodromal period was 7.7 /- 10.7 yr for Crohn's disease and 1.2 /- 1.8 yr for ulcerative colitis (p 0.05).[ncbi.nlm.nih.gov]
  • Crypt-associated giant cells and granulomas can occur in ulcerative colitis and in themselves are unreliable features for the discrimination between Crohn's disease and ulcerative colitis.[ncbi.nlm.nih.gov]
  • […] between ulcerative colitis and Crohn's disease.[dx.doi.org]
  • Thus heredity as an aetiological factor is stronger in Crohn's disease than in ulcerative colitis. Monozygotic twins with Crohn's disease were more likely to be smokers than monozygotic twins with ulcerative colitis.[doi.org]
HLA-B27
  • However, they have only a transient benefit in HLA-B27 transgenic rats[ 24 ].[doi.org]
  • HLA-B27 and HLA-DR0103 human leukocyte antigen haplotypes, etc.) and with responses to pharmacologic treatment (i.e. pharmacogenomics).[doi.org]
  • Dieleman , Adoptive transfer of nontransgenic mesenteric lymph node cells induces colitis in athymic HLAB27 transgenic nude rats , Clinical & Experimental Immunology , 143 , 3 , (474-483) , (2006) . Geertruida M.[doi.org]
  • Dieleman LA et al . (2003) Lactobacillus GG prevents recurrence of colitis in HLA-B27 transgenic rats after antibiotic treatment . Gut 52 : 370–376 85.[dx.doi.org]

Treatment

Mild Crohn's disease patients are usually initially prescribed 5-aminosalicylic acid preparations. If no improvement is noted, corticosteroids, 6-mercaptopurine/azathioprine or methotrexate are indicated, while biological agents are considered last resort before surgery. Moderate and severe cases benefit from the top-down approach, that uses a combination of biologic agents and steroids from the beginning. 6-mercaptopurine combined with a biologic agent efficiently induces remission [10].

5-aminosalicylic acid preparations include sulfasalazine and mesalazine. Mesalazine better prevents relapse than its peer. Corticosteroids effectively relieve severe systemic symptoms but are reserved for situations where obvious infection signs are absent. They should be administered for short periods of time and if withdrawal proves difficult, immunosuppressants should be considered. This therapy category is not without side effects, so patients need careful monitoring.

Biologic therapy includes agents such as infliximab, a chimeric mouse-human monoclonal antibody against tumor necrosis factor alpha (TNF-α), adalimumab and certolizumab pegol. The latter agents are less immunogenic, but seemingly equally effective. Natalizumab and vedolizumab are integrin antagonists, while ustekinumab inhibits interleukins 12 and 23. Other therapeutic agents that may prove beneficial include tacrolimus and mycophenolate mofetil. Surgical treatment is required for fistulae, abscesses, toxic megacolon, perforation, intractable hemorrhage, and strictures.

Prognosis

Crohn's disease has an overall favorable prognosis, but the course of the disease is marked by remissions and relapses. The risk of a fatal outcome is very small if the patient follows appropriate treatment. New therapeutic agents have improved survival even in individuals classically considered having increased risk, such as females with long disease duration [11]. The classical course of the disease included complications like chronic obstructive pulmonary disease and gastrointestinal malignancies, but their incidence has diminished in the current era. Relapses are more frequently encountered in the first year after diagnosis and may be as high as 50% of cases. Surgery is required in up to 39% of cases 10 years after diagnosis and sometimes more than on operation is needed [12]. The most common reason for surgery is stricture removal. The younger the patient is at the time of diagnosis, the higher the probability for multiple surgical interventions is. Crohn's disease of the proximal small bowel implies a higher risk of mortality than an ileal or ileocecal disease. The risk for colorectal cancer is also diminished by modern therapy. Life quality is near- normal in cases that are not very severe.

Etiology

The etiology of Crohn's disease is at this time unknown, but several genetic, vascular, immunologic, microbial, environmental and psychosocial factors are thought to be involved. Oral contraceptive use and smoking also seem to play a role in disease etiology, as do nonsteroidal anti-inflammatory agents. These risk factors may cause Crohn's disease in individuals that are susceptible to develop an aberrant immunologic response [13]. Several abnormal genes thought to regulate mucosal immunity have been described. Despite this fact, Crohn's disease is not considered to be a genetic disease and Mendelian inheritance is absent. The first gene ever to be demonstrated to be involved in Crohn's disease susceptibility is CARD15, located on chromosome 16. It can be affected by over 60 mutations, but 3 are most frequent [14]. IL23R, PTPN22, CCR6, JAK2, IL12B, STAT3, CDKAL1 and LRRK2 gene mutations are other possibilities [15]. Most of these translate as immune function abnormalities, whereas the ATG16L1gene impairs the autophagosome pathway, with important implications in disease pathogenesis.

Inflammation caused by Listeria species, Pseudomonas species, and Mycobacterium paratuberculosis is considered dysfunctional in Crohn's disease cases [13]. This condition is believed to be also caused by increased production of TNF-α by macrophages [16]. Smoking increases the risk of Crohn's disease twice [17]. Fat rich diet is also involved in the etiology of this condition [18]. The disease is not caused by the measles vaccine, as once thought [19].

Therefore, there is no single etiology for Crohn's disease. This condition is caused by environmental factors that disrupt gut microbiota balance and abnormally stimulate the intestinal immune response in genetically susceptible individuals.

Epidemiology

Crohn's disease is more frequent in urban areas than rural ones [20]. 43 children in 100.000 and 201 adults in 100.000 are estimated to suffer from this condition in America [21], whereas Europeans have a 5.6 per 100,000 inhabitants incidence [22]. Asian incidence of the disease ranges between 0.5 and 4.2%. Individuals belonging to the upper socioeconomic class are more frequently affected [23], as are individuals living in temperate climates and industrialized areas.

Disease incidence has two peaks, one between 15 and 30 years of age and one between the ages of 60 and 70 years. Most individuals are diagnosed before turning 30 years old. The female sex is slightly more prone to developing this condition, with a 1.1-1.8 times higher incidence than men [24]. However, during childhood, this ratio is reversed, with a male-to-female ratio of 1.6:1.

Sex distribution
Age distribution

Pathophysiology

T lymphocytes play a key role in Crohn's disease pathogenesis. They respond in an unrestrained manner due to their defective regulation and secrete proinflammatory cytokines that recruit other inflammatory cells that, in turn, release more inflammatory substances, leading to unwanted process escalation and intestinal injury. These phenomena are more severe in cases with defective epithelial barrier integrity and abnormal autophagy [25]. The inflammatory infiltrate initially located around a crypt, after forming a crypt abscess progresses to mucosal ulceration and invasion of the deeper layers. The process ends with noncaseating granulomas formation, that extends to the entire intestine and possibly the adjacent structures, such as regional lymph nodes and the mesentery. The granuloma is the pathognomonic lesion of Crohn's disease [13]. The colon becomes atrophic and ulcerated, but lesions are interpolated with normal areas of mucosa.

The pathophysiology of bowel obstruction in Crohn's disease is explained by mucosal edema that narrows the intestinal lumen. Deep ulcers may transform into enterocutaneous, enteroenteral, enterovaginal or enterovesical fistulae. Frank intestinal perforation is rarer in Crohn's disease than other bowel inflammatory diseases because of the presence of multiple adhesions.

Prevention

Crohn's disease cannot be prevented because its etiology remains unclear. Several nonspecific preventive measures have, however, been advanced. These include avoiding or stopping smoking, stress management, good hydration, optimizing vitamin D levels and having a well-balanced diet, rich in fibers, saturated fats, fruits, vegetables and omega-3 fatty acid. Processed food, preservatives, artificial flavors and colors, raw nuts and dairy consumption should be limited.

Summary

Crohn's disease is a chronic condition, part of the intestinal bowel diseases cluster, that extends throughout the entire gastrointestinal system, from the mouth to the anus. It is characterized by periods of relapse and remission. Patients complain about abdominal pain and diarrhea or about more severe symptoms that accompany intestinal obstruction and fistulization. The disease causes malnutrition, anorexia, nausea, vomiting, weight loss and fatigability. Acute periods are accompanied by fever and rectal bleeding. Children experience growth failure, that may precede gastrointestinal symptoms by a ling time. Bone loss and coping difficulties are not uncommon.

Clinical examination may reveal signs of anemia such as tachycardia and paleness. Jaundice is another possibility. The abdomen is more or less painful on palpation and evidence of hematochezia may be present. Skin lesions that may be encountered include ulcerations, pyoderma gangrenosum, and erythema nodosum. Puberty signs may be delayed and visual impairment may be due to episcleritis or uveitis. Arthritis associated with Crohn's disease predominantly affects large joints.

Diagnosis relies on laboratory and imaging tests. The first category includes anti-Saccharomyces cerevisiae antibodies and perinuclear antineutrophil cytoplasmic antibodies, in addition to fecal calprotectin and other standard tests. Computer tomography enterography or magnetic resonance enterography are slowly replacing more simple radiological tests and offer relevant information, such as the existence of strictures and fistulae. Superior digestive endoscopy and ileocolonoscopy must be performed in every case because they not only fully characterize mucosal aspect, but allow biopsy specimens to be obtained and investigated.

Treatment relies on several therapeutic classes: 5-aminosalicylic acid derivates, corticosteroids, immunosuppressive agents and monoclonal antibodies. Discomfort may be alleviated by antidiarrheal agents and anticholinergic and antibiotics are sometimes needed. Surgery is not curative in Crohn's disease, but it is often necessary in order to resolve disease complications like strictures, abscesses, and fistulae.

Patient Information

Crohn's disease causes inflammation throughout the entire digestive system, leading to abdominal pain, malnutrition, weight loss, mouth sores, fatigability, bloody stools, and diarrhea. The inflammatory process can be confined, however, to a single segment of the digestive tract. Symptoms install suddenly, but the patient may also have periods of remission, with no complaints. Affected individuals also complain about eyes and joints inflammation. In children growth and puberty are delayed.

The diagnosis is established using blood tests and imaging methods, but an upper intestinal endoscopy and colonoscopy are usually compulsory. These techniques allow direct visualization of the mucosa and pieces of the diseased tissue can be obtained and analyzed. With treatment, many achieve a good life quality. If complications such as fistulae, abscesses and bowel obstruction arise, surgery is needed.

References

Article

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Last updated: 2018-06-22 10:20