Didona Unusual clinical presentations of vasculitis : What some clinical aspects can .... [docpile.net]

Among them, CV was present in 44/61 (72,1%; 14 also with pSS), and pSS in 17/61 (27,9%; and 14/17 had CV). [rheuma-schweiz.ch]

Rose’s original investigations on the autoimmune basis of thyroid disease in 1956 opened the present era of research on autoimmunity. He has since investigated many areas of autoimmunity and related issues in clinical and basic immunology. Dr. [books.google.de]

"— Presentation transcript: 1 2 Bronchiolitis Obliterans with Organizing Pneu- monia (BOOP). [slideplayer.com]

• Anemia

  Polyarteritis nodosa; Inflammation of the arteries;Iron deficiency anemia; infectious mono; Hyperthyroidism; Thrombotic thrombocytopenic purpura Low platelets, blood clots, and bruising; Diabetes;etc; etc. [au.answers.yahoo.com]

  Of Chronic Disease C0002873 APLASTIC ANEMIA C0002874 MYELOPHTHISIC ANEMIA C0002890 PERNICIOUS ANEMIA C0002892 SICKLE CELL ANEMIA C0002895 ANGINA PECTORIS C0002962 ANGINA VARIANT C0002963 CRESCENDO ANGINA C0002965 CERAMIDE TRIHEXOSIDE LIPOIDOSIS C0002986 [medical-language-international.com]

  M., 1975, Nephropathy associated with sickle cell anemia: An autologous immune complex nephritis. II. Clinicopathologic study of seven patients, Am. J. Med. 59 :650. PubMed CrossRef Google Scholar Wilson, C. B., and Dixon, F. [link.springer.com]

  *Goodpasture’s syndrome is characterized by the presence of pulmonary hemorrhage concurrent with glomerulonephritis and associated with haemoptysis ,unexplained anemia. 18. [slideshare.net]

• Relapsing Polychondritis

  Monitoring for relapse with clinical follow-up, renal function tests, and ANCA is recommended. Recommendation 5. [powershow.com]

  polychondritis * Behcet’s disease * Idiopathic * Type I: Antiglomerular basement membrane antibody disease * Type II: immune complex-mediated disease * Type III: pauci-immune (ANCA- associated) disease * Type IV: mixed and anti-GBM and ANCA associated [slideshare.net]

  POLYCHONDRITIS C0032453 POLYCYTHEMIA VERA C0032463 POLYMYALGIA RHEUMATICA C0032533 TOXEMIA OF PREGNANCY C0032914 Pregnancy Last Trimester C0032981 ECTOPIC PREGNANCY C0032987 CARDIOMYOPATHY PRIMARY C0033141 PROLACTINOMA C0033375 PROTEIN-LOSING ENTEROPATHY [medical-language-international.com]

  We describe the case of a patient with relapsing polychondritis associated to Budd–Chiari syndrome due to antiphospholipid syndrome. [personale.unimore.it]

• Rapidly Progressive Glomerulonephritis

  Published on Apr 19, 2017 RAPIDLY PROGRESSIVE GLOMERULONEPHRITIS(RPGN) RAPIDLY PROGRESSIVE GLOMERULONEPHRITIS(RPGN) 1. (RPGN) * Dr Manjunath Anvekar KVG Medical college. [slideshare.net]

  Keywords Systemic Lupus Erythematosus Glomerular Basement Membrane Rapidly Progressive Glomerulonephritis Immunoglobulin Deposit Immune Complex Glomerulonephritis These keywords were added by machine and not by the authors. [link.springer.com]

• Congestive Heart Failure

  Clinical diagnoses included the purpura-weakness-arthralgias syndrome, posthepatitis cirrhosis, congestive heart failure and mitral stenosis. [karger.com]

  Complications commonly requiring this intervention include: hyperviscosity disease with severe symptoms of neurological (e.g., stroke, mental impairment, and myelitis ) and/or cardiovascular (e.g., congestive heart failure, myocardial infarction ) disturbances [en.wikipedia.org]

• Pallor

  […] staining indicates the presence of anti-dsDNA antibodies Diagnostic Criteria for SLE ANA, butterfly rash, migratory arthralgia, proteinuria, hematuria, casts, Raynaud's phenomenon, thrombocytopenia, circulating immune complexes, pleuritis, pericarditis Pallor [quizlet.com]

• Gagging

  Group of 10+ autosomal recessive disorders characterized by defective lysosomal degradation of glycosaminoglycans (GAGs), also known as mucopolysaccharides (MPS). GAG accumulation = damages organs that it accumulates in. [quizlet.com]

  Hallucinations Tactile C0233767 Confabulation C0233800 Judgment Impaired C0233818 Tremor Action C0234376 Tremor Intention C0234376 Tremor Resting C0234379 Agnosia Auditory C0234501 Agnosia Visual C0234502 Agnosia Tactile C0234505 Astereognosis C0234505 Reflex Gag [medical-language-international.com]

• Hypertension

  This group of chapters includes Acid-Base Physiology and Pathophysiology (Arruda and Kurtzman); Mineral Metabolism in Health and Disease (Agus, Goldfarb, and Was serstein); Hypertension and the Renin-Angiotensin-Aldosterone Axis (Williams and Hollenberg [books.google.com]

  Solitary kidney Active kidney infections Renal artery vasculitis with aneurysms Hydronephrosis Uncontrolled severe hypertension Uncooperative patient May Be Useful or Indicated In Acute renal allograft dysfunction • Primary nonfunction for >10 to 14 days [scribd.com]

  HEART DISEASE C0152105 SYDENHAMS CHOREA C0152113 PULMONARY HYPERTENSION PRIMARY C0152171 TUBERCULOSIS DISSEMINATED C0152915 THYROIDITIS CHRONIC C0154162 GLAUCOMA ACUTE ANGLE CLOSURE C0154946 MITRAL REGURGITATION RHEUMATIC C0155563 MYOCARDIAL INFARCTION [medical-language-international.com]

  A Atchley and others studied the effects of hypertension, endocarditis, and circulatory diseases on the kidney and few years ago we never heard of kidney disease and now you are speaking of patients in the hundreds of thou spawned successive generations [books.google.de]

  Disease Systemic vasculitis Pulmonary- Renal vasculitic syndrome Wegeners Granulomatosis C-ANCA Disease Anti-GBM Disease 8 Clinical features Clinical features common to the three forms of RPGN include Hematuria Proteinuria Decreased urine output Edema Hypertension [powershow.com]

• Heart Disease

  […] in heart disease or early renal failure. [scribd.com]

  C0518992 ENDOCARDITIS INFECTIVE RIGHT HEART C0518993 ENDOCARDITIS SUBACUTE INFECTIVE LEFT HEART C0518994 EPILEPSY IDIOPATHIC GRAND MAL C0518995 EPILEPSY IDIOPATHIC PSYCHOMOTOR C0518997 ESTROGEN INDUCED JAUNDICE C0518998 EXUDATIVE ASCITES C0518999 FATTY [medical-language-international.com]

  […] of ILD or PAH at baseline, nor other lung or heart diseases able to affect DLCO, were recruited at our Rheumatology Centre. [personale.unimore.it]

• Acrocyanosis

  Interruption of blood flow to other tissues in type I disease can cause cutaneous manifestations of purpura, blue discoloration of the arms or legs (acrocyanosis), necrosis, ulcers, and livedo reticularis ; spontaneous nose bleeds, joint pain, membranoproliferative [en.wikipedia.org]

• Hepatosplenomegaly

  Hepatosplenomegaly was found in one patient, a young child, 4 months after the illness. In the other cases nothing suggestive of liver disease has been observed after the results of liver function tests became normal within some weeks or months. [annals.org]

  GI: autoimmune hepatitis (jaundice), mesenteric vasculitis  bowel infarction, hepatosplenomegaly SLE – ... low-grade fever, anorexia • Vasculitis : palmar erythema, digital hemorrhagic infarction ... uveitis, seronegative polyarthritis, retinal vasculitis [docpile.net]

• Arthralgia

  Cryoglobulinemic vasculitis is characterized by the classical triad of purpura, weakness and arthralgia, frequent multiple organ involvement, and with infrequent late lymphatic and hepatic malignancies. [davidsyounger.com]

  Clinical diagnoses included the purpura-weakness-arthralgias syndrome, posthepatitis cirrhosis, congestive heart failure and mitral stenosis. [karger.com]

  […] staining ... actinic dermatitis  Vitiligo  Alopecia areata  Necrotizing vasculitis  Recurrent apthous ulcer CD4+ cell ... disorder HIV-related vasculitis Clinical features:  palpable purpura  digital necrotic ulcers  swelling ... of hands & feet  arthralgia [docpile.net]

  While arthralgias are one of the most frequent symptoms, clear signs of sinovitis are quite rare. [ojrd.biomedcentral.com]

  *The onset of disease may be associated with arthralgias, fever, myalgias, and abdominal pain. [slideshare.net]

• Purpura

  B or C infection with vasculitis and/or cryoimmunoglobulinemia Multisystemi diseases ... ’s disease  Henoch-Schonlein purpura  Necrotizing vasculitis (including Wegener’s gransulomatosis)  Cryoimmunoglobinemia ... [docpile.net]

  The diagnosis is suggested by clinical evidence of purpura, circulating mixed cryoglobulinemia and low C4 levels, and pathologically evident leukocytoclastic vasculitis in skin biopsy lesions. [davidsyounger.com]

  Pelzig A. : Essential cryoglobulinemia with purpura — Arch. Dermatol. Syph. (Chic.) 67, 429, 1953. Google Scholar 18. Steinhardt M. J., Fisher G. S. : Cold urticaria and purpura as allergic aspects of cryoglobulinemia — J. Allergy 24, 335, 1953. [link.springer.com]

  Circulating mixed cryoglobulins, low C4 levels and orthostatic skin purpura are the hallmarks of the disease. [orpha.net]

  SLE, Henoch-scholein purpura, rheumatoid arthritis. Crescents complicating pre-existing nephritis, e.g. [powershow.com]

• Skin Lesion

  Barr and Dan- ielsson showed that despite negative culture and gram stain of the skin lesion in disseminated gonorrhea, posi- tive immunofluorescent findings for the organism were detected in the same lesion (2). [documents.tips]

  Leukocytoclastic vasculitis involving medium- and, more often, small-sized blood vessels is the typical pathological finding, easily detectable by means of skin biopsy of recent vasculitic lesions. [orpha.net]

  One or more skin lesions including palpable purpura, ulcers, digital gangrene, and areas of necrosis occur in 69-89% of these mixed disease cases (see attached photograph); less common findings include painful peripheral neuropathy (often manifesting [en.wikipedia.org]

  Skin lesions represent the most frequent manifestations of the MC [ 6 – 10, 14, 24, 25 ]. [ojrd.biomedcentral.com]

• Skin Ulcer

  […] refractory scleroderma skin ulcers. 2002 - HCV and cryoglobulinemic vasculitis. [personale.unimore.it]

  ulcers, erythema nodosum Takayasu ... young females Polyarteritis Nodosa Inflammatory necrotizing vasculitis of medium and small-sized ... [docpile.net]

  […] on the legs after repeated episodes of purpura; both orthostatic purpura and these permanent ochraceous lesions represent the typical skin manifestations of MC; (d) severe vasculitic manifestation; (e) wide skin ulcer, often resistant to treatment. [ojrd.biomedcentral.com]

  Candidiasis C0006846 BRONCHIOLAR-ALVEOLAR CELL CARCINOMA C0007120 RENAL CELL CARCINOMA C0007134 CARDIAC TAMPONADE C0007177 CARPAL TUNNEL SYNDROME C0007286 Libido Decreased C0011124 Skin Decubitus Ulcer(s) C0011127 Dehydration C0011175 Delirium C0011206 [medical-language-international.com]

  Whereas, MC is characterized by a typical triad purpura, weakness, arthralgias as well as by multisystem organ involvement including chronic hepatitis, membranoproliferative glomerulonephritis, peripheral neuropathy, skin ulcers, widespread vasculitis [wjgnet.com]

• Petechiae

  She admitted to our hospital because of myalgia in bilateral gastrocnemius and petechiae in both lower extremities in addition to the complaints described above. [ci.nii.ac.jp]

          A granulomatouse inflammatory process with necrotizing vasculitis Primarily affects the upper and ... ) in 15%-50%, dermatologic findings ( necrotic ulceration, vesicles or petechiae) Laboratory ... inflammation with multinucleated giant [docpile.net]

  Sign Positive C0240823 Pulse Pressure Narrow C0240840 Scalp Hyperesthesia C0240936 Ceruloplasmin Serum Decreased C0240997 Muscle(s) Weakness Shoulder Girdle C0241035 Shoulder Pain Left C0241039 Shoulder Pain Right C0241040 Skin Bullae C0241054 Skin Petechiae [medical-language-international.com]

  Orthostatic purpura is generally intermittent, the dimension and diffusion of purpuric lesions largely varied, from sporadic isolated petechias to severe vasculitic lesions, often complicated by torpid ulcers of the legs and malleolar areas (Fig. 2 ). [ojrd.biomedcentral.com]

• Palpable Purpura

  […] presentation ... • RF high • + palpable purpura (leukocytoclastic vasculitis ) • Dx: biopsy • Bx: basement membrane ... + Wegners: - Respiratory track and kidneys - Necrotizing vasculitis - Sinusitis, 70% - Renal, 80%, RPGN ... or MPO Churg Strauss Cryoglobulinemic [docpile.net]

  One or more skin lesions including palpable purpura, ulcers, digital gangrene, and areas of necrosis occur in 69-89% of these mixed disease cases (see attached photograph); less common findings include painful peripheral neuropathy (often manifesting [en.wikipedia.org]

  Usually, LAC-diet and/or low dosage of steroids (6-methyl-prednisolone 2–4 mg/day) may be sufficient to improve mild manifestations (arthralgias, sporadic purpura, etc .) of the MC (Fig. 8, 9, 10 ); patients with mild-moderate symptoms, such as palpable [ojrd.biomedcentral.com]

• Epistaxis

  Cryoglobulins cause tissue damage by three mechanisms; they can: a) increase blood viscosity thereby reducing blood flow to tissues to cause the hyperviscosity syndrome (i.e., headache, confusion, blurry or loss of vision, hearing loss, and epistaxis [en.wikipedia.org]

• Paresthesia

  The common symptoms are paresthesias with painful and/or burning sensations in the lower limbs, often with nocturnal exacerbation. [ojrd.biomedcentral.com]

  […] absence of associated HCV infection; namely, complete/partial remission of pre-treatment active manifestations was observed in 74% of skin purpuric lesions, up to 87% of non-healing vasculitic leg ulcers, and 44% of the peripheral neuropathy, mainly paresthesias [personale.unimore.it]

545 Dialysis ultrafiltration and hemofiltration 555 Use of drugs in uremia and dialysis 567 Donor and recipient selection in renal transplantation 587 Immunosuppression and treatment of rejection in renal transplantation 595 XIII 606 Renal tubular and [books.google.de]

Management and treatment The first-line treatment of MC should focus on eradication of HCV by antiviral treatment (peg-interferon plus ribavirin). [orpha.net]

Treatment of relapses should be similar to original treatment. 26 Treatment for pauci-immune crescentic GN should be Pulse methylprednisolone Followed by oral corticosteroids and cyclophosphamide for 6 to 12 months 27 Evidence-Based Treatment Recommendations [powershow.com]

The first-line treatment of MC should focus on eradication of HCV by combined interferon-ribavirin treatment. [ojrd.biomedcentral.com]

Treatment is directed toward eradicating hepatitis C viral infection employing combination PEGylated- interferon-alpha and ribavirin treatment, immunomodulatory and immunosuppressant medications as warranted by the level of clinical severity. [davidsyounger.com]

Prognosis The overall prognosis is poorer in patients with renal disease, liver failure, lymphoproliferative disease and malignancies. The documents contained in this web site are presented for information purposes only. [orpha.net]

Important Points: The prognosis of RPGN depends upon Number of crescents. Important Points: i. Crescents are produced by Proliferation of the parietal epithelial cells of Bowman 's capsule, Infiltration of monocytes and macrophages. ii. [gradestack.com]

The prognosis is poor in patients with renal disease, liver failure, and malignancy. [davidsyounger.com]

Nonnephrotic proteinuria with progressive disease Evaluation or monitoring of collagen diseases, especially SLE Others Not Indicated In 2 No nn ep hr ot ic p ro te in ur ia ( 3. 5 g/ d ) be ca u se of go od prognosis and indications for therapy are rare [scribd.com]

Azathioprine, methotrexate, MMF, cyclosporin Future therapies Leflunomide Inhibitor of de novo pyrimidine synthesis Deoxyspergualin Tumor necrosis factor (TNF) blockade Antibodies against T cells 32 Predictive value of the effect of plasmapheresis on long-term prognosis [powershow.com]

It does not denote a specific etiologic form of glomerulonephritis. Causes of RPGN 1. Primary (idiopathic) diffuse crescentic glomerulonephritis a. Type I: anti-GBM antibody disease without pulmonary hemorrhage b. [gradestack.com]

Shoenfeld received the EULAR prize in 2005, in Vienna, Austria: "The infectious etiology of anti-phospholipid syndrome". [books.google.de]

Etiology The etiopathogenesis of MC is not completely understood. Hepatitis C virus (HCV) infection has been suggested to play a causative role, with the contribution of genetic and/or environmental factors. [orpha.net]

Hemorrhage Recurrent hemoptysis, dyspnea, and hypoxemia  diffuse alveolar opacities  suspect alveolar hemorrhage Etiology: SLE; wegener’s granulomatosi ; behcet’s disease; allergic Chur-Strauss granulomatosis; Henoch-Schonlein purpura syndrome; Essential [slideplayer.com]

[…] process with necrotizing vasculitis Primarily affects the upper and ... ) in 15%-50%, dermatologic findings ( necrotic ulceration, vesicles or petechiae) Laboratory ... inflammation with multinucleated giant cells, vasculitis and microabscess formation Etiology [docpile.net]

Summary Epidemiology It is considered to be a rare disorder, but its true prevalence remains unknown. The disease is more common in Southern Europe than in Northern Europe or Northern America. [orpha.net]

EPIDEMIOLOGY 1.Primary glomerulonephritis. *IgA nephropathy *Post-infectious glomerulonephritis *MPGN 2.Secondary glomerulonephritis(systemic). *SLE, *Cryoglobulinemia *IgA vasculitis(HSP). [slideshare.net]

It is considered to be a rare disorder, however, yet there are no adequate epidemiological studies regarding its overall prevalence. [ojrd.biomedcentral.com]

HCV AND TYPE 2 DIABETES The epidemiological link between HCV and type 2 diabetes mellitus (T2DM) is common and widely reported[ 235 - 238 ], and the infection with HCV increase the risk of T2DM development[ 239 ]. [wjgnet.com]

A causative role of hepatitis C virus (HCV) in over 4/5 patients has been definitely established on the basis of epidemiological, pathological, and laboratory studies. [personale.unimore.it]

Chapters 5-10 are more pathophysiologically oriented, and each contains an "appropriate mix" of basic and clinical information. [books.google.com]

DISCUSSION The data presented do not support the role of immune complexes in the pathophysiology of dissemi- nated gonococcal disease. [documents.tips]

PubMed Central PubMed Google Scholar Mondelli MU, Zorzoli I, Cerino A, Cividini A, Bissolati M, Segagni L, Perfetti V, Anesi E, Garini P, Merlini G: Clonality and specificity of cryoglobulins associated with HCV: pathophysiological implications. [ojrd.biomedcentral.com]

Research has shown an emerging role for chemokines and type 1 cytokines in the pathophysiology of this vasculitis. [personale.unimore.it]

Discuss with your health care provider the options to prevent skin breakdown (for chronic edema) such as a pressure-reducing mattress, a lamb's wool pad, or a flotation ring. Maintain everyday activities. [au.answers.yahoo.com]

Use of GS would prevent the loss of valuable heparin-binding proteins from blood while removing EDA-FN. However, use of GS in EDA-FN removal therapy is not without limitations. [omicsonline.org]

It is possible that the gono- coccal organism is rapidly bound to the skin or syno- vium and may be altered, preventing any detection in the body fluids by current techniques. [documents.tips]

The early detection of SSc patients who are at high risk to develop digital ulcers could allowa preventive treatment of these complications with reduction of morbidity and social costs. [personale.unimore.it]