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Cryoimmunoglobulinemic Syndrome


  • Rose’s original investigations on the autoimmune basis of thyroid disease in 1956 opened the present era of research on autoimmunity. He has since investigated many areas of autoimmunity and related issues in clinical and basic immunology. Dr.[books.google.de]
  • The present issue is a com pilation of essays reflecting some of the facets of this particular diamond and I am especially grateful to authors and publishers alike in the unusual and tragic circumstances which attended its preparation.[books.google.de]
  • This reference guide will be the must-have of any internist or medical professional, as it takes a vast quantity of data across a sweeping grid of disorders, diseases, and presentations, and boils them down to individual parts, facilely indexed, and located[books.google.de]
  • Among them, CV was present in 44/61 (72,1%; 14 also with pSS), and pSS in 17/61 (27,9%; and 14/17 had CV).[rheuma-schweiz.ch]
  • Didona Unusual clinical presentations of vasculitis : What some clinical aspects can ... .[docpile.net]
Rapidly Progressive Glomerulonephritis
  • Published on Apr 19, 2017 RAPIDLY PROGRESSIVE GLOMERULONEPHRITIS(RPGN) RAPIDLY PROGRESSIVE GLOMERULONEPHRITIS(RPGN) 1. (RPGN) * Dr Manjunath Anvekar KVG Medical college.[slideshare.net]
  • Keywords Systemic Lupus Erythematosus Glomerular Basement Membrane Rapidly Progressive Glomerulonephritis Immunoglobulin Deposit Immune Complex Glomerulonephritis These keywords were added by machine and not by the authors.[link.springer.com]
  • […] staining indicates the presence of anti-dsDNA antibodies Diagnostic Criteria for SLE ANA, butterfly rash, migratory arthralgia, proteinuria, hematuria, casts, Raynaud's phenomenon, thrombocytopenia, circulating immune complexes, pleuritis, pericarditis Pallor[quizlet.com]
  • STAPHYLOCOCCUS AUREUS MENINGITIS C0393435 LUPUS CEREBRITIS C0393968 Hepatitis C Acute C0400914 Hepatitis E Acute C0400916 Diarrhea Chronic C0401151 Seizure(s) Somatosensory C0422850 Headache Throbbing C0423618 Suicidal Thought(s) C0424000 Hyperkinesia C0424295 Rigor[medical-language-international.com]
Limb Pain
  • ; Clodoveo Ferri abstract Background Phantom limb pain [PLP] may complicate limb amputation.[personale.unimore.it]
  • Hepatosplenomegaly was found in one patient, a young child, 4 months after the illness. In the other cases nothing suggestive of liver disease has been observed after the results of liver function tests became normal within some weeks or months.[annals.org]
  • GI: autoimmune hepatitis (jaundice), mesenteric vasculitis  bowel infarction, hepatosplenomegaly SLE – ... low-grade fever, anorexia • Vasculitis : palmar erythema, digital hemorrhagic infarction ... uveitis, seronegative polyarthritis, retinal vasculitis[docpile.net]
  • Interruption of blood flow to other tissues in type I disease can cause cutaneous manifestations of purpura , blue discoloration of the arms or legs (acrocyanosis) , necrosis, ulcers, and livedo reticularis ; spontaneous nose bleeds , joint pain , membranoproliferative[en.wikipedia.org]
  • Cryoglobulinemic vasculitis is characterized by the classical triad of purpura, weakness and arthralgia, frequent multiple organ involvement, and with infrequent late lymphatic and hepatic malignancies.[davidsyounger.com]
  • Clinical diagnoses included the purpura-weakness-arthralgias syndrome, posthepatitis cirrhosis, congestive heart failure and mitral stenosis.[karger.com]
  • Carpenter Case Presentation.pptx presentation ... meds. – More numerous lesions, more necrotic lesions, Large lesions. – Prior infection ... infection • Presentations – Urticaria, arthralgias, GN, vasculitis several days to weeks before ... cirrhosis.[docpile.net]
  • While arthralgias are one of the most frequent symptoms, clear signs of sinovitis are quite rare.[ojrd.biomedcentral.com]
  • *The onset of disease may be associated with arthralgias, fever, myalgias, and abdominal pain.[slideshare.net]
  • […] infections 221 Vesicoureteral reflux and reflux nephropathy 234 Management of genitourinary tuberculosis 255 Vasculitic diseases of the kidney 273 Noninflammatory vascular diseases of the kidney 283 Hemolytic uremic syndrome and thrombotic thrombocytopenic purpura[books.google.de]
  • purpura (leukocytoclastic vasculitis ) • Dx: biopsy • Bx: basement membrane ...[docpile.net]
  • The diagnosis is suggested by clinical evidence of purpura, circulating mixed cryoglobulinemia and low C4 levels, and pathologically evident leukocytoclastic vasculitis in skin biopsy lesions.[davidsyounger.com]
  • Pelzig A. : Essential cryoglobulinemia with purpura — Arch. Dermatol. Syph. (Chic.) 67 , 429, 1953. Google Scholar 18. Steinhardt M. J., Fisher G. S. : Cold urticaria and purpura as allergic aspects of cryoglobulinemia — J. Allergy 24 , 335, 1953.[link.springer.com]
  • Circulating mixed cryoglobulins, low C4 levels and orthostatic skin purpura are the hallmarks of the disease.[orpha.net]
Skin Lesion
  • This study needs to be expanded in reference to skin lesions in varying stages and to the relationship of gonococcal antigen to C3 deposits.[documents.tips]
  • MC is characterized by variable organ involvement including skin lesions (orthostatic purpura, ulcers), chronic hepatitis, membranoproliferative glomerulonephritis, peripheral neuropathy, diffuse vasculitis, and, less frequently, interstitial lung involvement[orpha.net]
  • One or more skin lesions including palpable purpura, ulcers, digital gangrene , and areas of necrosis occur in 69-89% of these mixed disease cases (see attached photograph); less common findings include painful peripheral neuropathy (often manifesting[en.wikipedia.org]
  • Skin lesions represent the most frequent manifestations of the MC [ 6 – 10 , 14 , 24 , 25 ].[ojrd.biomedcentral.com]
  • Moreover, infectious complications may severely compromise the outcome of skin lesions in a significant percentage of patients.[personale.unimore.it]
  • .         A granulomatouse inflammatory process with necrotizing vasculitis Primarily affects the upper and ... ) in 15%-50%, dermatologic findings ( necrotic ulceration, vesicles or petechiae) Laboratory ... inflammation with multinucleated giant[docpile.net]
  • Sign Positive C0240823 Pulse Pressure Narrow C0240840 Scalp Hyperesthesia C0240936 Ceruloplasmin Serum Decreased C0240997 Muscle(s) Weakness Shoulder Girdle C0241035 Shoulder Pain Left C0241039 Shoulder Pain Right C0241040 Skin Bullae C0241054 Skin Petechiae[medical-language-international.com]
  • Orthostatic purpura is generally intermittent, the dimension and diffusion of purpuric lesions largely varied, from sporadic isolated petechias to severe vasculitic lesions, often complicated by torpid ulcers of the legs and malleolar areas (Fig. 2 ).[ojrd.biomedcentral.com]
Palpable Purpura
  • purpura (leukocytoclastic vasculitis ) • Dx: biopsy • Bx: basement membrane ...[docpile.net]
  • One or more skin lesions including palpable purpura, ulcers, digital gangrene , and areas of necrosis occur in 69-89% of these mixed disease cases (see attached photograph); less common findings include painful peripheral neuropathy (often manifesting[en.wikipedia.org]
  • purpura, are particularly sensitive to the smallest variations of daily steroid dosage (1–2 mg).[ojrd.biomedcentral.com]
  • Cryoglobulins cause tissue damage by three mechanisms; they can: a) increase blood viscosity thereby reducing blood flow to tissues to cause the hyperviscosity syndrome (i.e. headache, confusion, blurry or loss of vision, hearing loss, and epistaxis ;[en.wikipedia.org]
  • The last five chapters, which are more clinically oriented, include Uremia (Friedman and Lundin); Nutrition in Renal Disease (Mitch); Dialysis (Maher); Renal Transplantation (Strom); and, finally, Drugs and the Kidney (Bennett).[books.google.com]
  • […] management of renal insufficiency 495 Management of renal osteodystrophy 505 Peritoneal dialysis 516 Jonas Bergstrom M D 521 Dialysis access surgery 533 Dialyzers and water treatment 545 Dialysis ultrafiltration and hemofiltration 555 Use of drugs in uremia[books.google.de]
  • The common symptoms are paresthesias with painful and/or burning sensations in the lower limbs, often with nocturnal exacerbation.[ojrd.biomedcentral.com]
  • […] absence of associated HCV infection; namely, complete/partial remission of pre-treatment active manifestations was observed in 74% of skin purpuric lesions, up to 87% of non-healing vasculitic leg ulcers, and 44% of the peripheral neuropathy, mainly paresthesias[personale.unimore.it]


  • 545 Dialysis ultrafiltration and hemofiltration 555 Use of drugs in uremia and dialysis 567 Donor and recipient selection in renal transplantation 587 Immunosuppression and treatment of rejection in renal transplantation 595 XIII 606 Renal tubular and[books.google.de]
  • Management and treatment The first-line treatment of MC should focus on eradication of HCV by antiviral treatment (peg-interferon plus ribavirin).[orpha.net]
  • Treatment of relapses should be similar to original treatment. 26 Treatment for pauci-immune crescentic GN should be Pulse methylprednisolone Followed by oral corticosteroids and cyclophosphamide for 6 to 12 months 27 Evidence-Based Treatment Recommendations[powershow.com]
  • The first-line treatment of MC should focus on eradication of HCV by combined interferon-ribavirin treatment.[ojrd.biomedcentral.com]
  • Treatment is directed toward eradicating hepatitis C viral infection employing combination PEGylated- interferon-alpha and ribavirin treatment, immunomodulatory and immunosuppressant medications as warranted by the level of clinical severity.[davidsyounger.com]


  • Prognosis The overall prognosis is poorer in patients with renal disease, liver failure, lymphoproliferative disease and malignancies. The documents contained in this web site are presented for information purposes only.[orpha.net]
  • Important Points: The prognosis of RPGN depends upon Number of crescents. Important Points: i. Crescents are produced by Proliferation of the parietal epithelial cells of Bowman 's capsule, Infiltration of monocytes and macrophages. ii.[gradestack.com]
  • The prognosis is poor in patients with renal disease, liver failure, and malignancy.[davidsyounger.com]
  • Azathioprine, methotrexate, MMF, cyclosporin Future therapies Leflunomide Inhibitor of de novo pyrimidine synthesis Deoxyspergualin Tumor necrosis factor (TNF) blockade Antibodies against T cells 32 Predictive value of the effect of plasmapheresis on long-term prognosis[powershow.com]
  • The overall prognosis is poorer in patients with renal disease, liver failure, lymphoproliferative disease and malignancies.[ojrd.biomedcentral.com]


  • Shoenfeld received the EULAR prize in 2005, in Vienna, Austria: "The infectious etiology of anti-phospholipid syndrome".[books.google.de]
  • It does not denote a specific etiologic form of glomerulonephritis. Causes of RPGN 1. Primary (idiopathic) diffuse crescentic glomerulonephritis a. Type I: anti-GBM antibody disease without pulmonary hemorrhage b.[gradestack.com]
  • Etiology The etiopathogenesis of MC is not completely understood. Hepatitis C virus (HCV) infection has been suggested to play a causative role, with the contribution of genetic and/or environmental factors.[orpha.net]
  • Hemorrhage Recurrent hemoptysis, dyspnea, and hypoxemia  diffuse alveolar opacities  suspect alveolar hemorrhage Etiology: SLE; wegener’s granulomatosi ; behcet’s disease; allergic Chur-Strauss granulomatosis; Henoch-Schonlein purpura syndrome; Essential[slideplayer.com]
  • […] process with necrotizing vasculitis Primarily affects the upper and ... ) in 15%-50%, dermatologic findings ( necrotic ulceration, vesicles or petechiae) Laboratory ... inflammation with multinucleated giant cells, vasculitis and microabscess formation Etiology[docpile.net]


  • Summary Epidemiology It is considered to be a rare disorder, but its true prevalence remains unknown. The disease is more common in Southern Europe than in Northern Europe or Northern America.[orpha.net]
  • EPIDEMIOLOGY 1.Primary glomerulonephritis. *IgA nephropathy *Post-infectious glomerulonephritis *MPGN 2.Secondary glomerulonephritis(systemic). *SLE, *Cryoglobulinemia *IgA vasculitis(HSP).[slideshare.net]
  • It is considered to be a rare disorder, however, yet there are no adequate epidemiological studies regarding its overall prevalence.[ojrd.biomedcentral.com]
  • HCV AND TYPE 2 DIABETES The epidemiological link between HCV and type 2 diabetes mellitus (T2DM) is common and widely reported[ 235 - 238 ], and the infection with HCV increase the risk of T2DM development[ 239 ].[wjgnet.com]
  • A causative role of hepatitis C virus (HCV) in over 4/5 patients has been definitely established on the basis of epidemiological, pathological, and laboratory studies.[personale.unimore.it]
Sex distribution
Age distribution


  • Chapters 5-10 are more pathophysiologically oriented, and each contains an "appropriate mix" of basic and clinical information.[books.google.com]
  • DISCUSSION The data presented do not support the role of immune complexes in the pathophysiology of dissemi- nated gonococcal disease.[documents.tips]
  • PubMed Central PubMed Google Scholar Mondelli MU, Zorzoli I, Cerino A, Cividini A, Bissolati M, Segagni L, Perfetti V, Anesi E, Garini P, Merlini G: Clonality and specificity of cryoglobulins associated with HCV: pathophysiological implications.[ojrd.biomedcentral.com]
  • Research has shown an emerging role for chemokines and type 1 cytokines in the pathophysiology of this vasculitis.[personale.unimore.it]


  • Discuss with your health care provider the options to prevent skin breakdown (for chronic edema) such as a pressure-reducing mattress, a lamb's wool pad, or a flotation ring. Maintain everyday activities.[au.answers.yahoo.com]
  • Use of GS would prevent the loss of valuable heparin-binding proteins from blood while removing EDA-FN. However, use of GS in EDA-FN removal therapy is not without limitations.[omicsonline.org]
  • It is possible that the gono- coccal organism is rapidly bound to the skin or syno- vium and may be altered, preventing any detection in the body fluids by current techniques.[documents.tips]
  • The early detection of SSc patients who are at high risk to develop digital ulcers could allowa preventive treatment of these complications with reduction of morbidity and social costs.[personale.unimore.it]

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