Presentation
It is easily diagnosed when presented in its typical manifestation. Atypical or rare clinical presentations can pose diagnostic difficulties. [ncbi.nlm.nih.gov]
Gastrointestinal
- Constipation
Some of the more common findings during a review of systems include the following: weight loss, weakness/fatigue, dyspnea, edema, paresthesias, light-headedness, syncope, constipation/diarrhea, and hoarseness/change of voice. [dermatologyadvisor.com]
Skin
- Erythema
Further detailed physical examination revealed folliculitis-like small pustules with surrounding erythema on the upper back. Also, she stated past histories of genital ulcers 10 years ago and erythema nodosum on the lower legs 4 years ago. [ncbi.nlm.nih.gov]
Periungual erythema and capillary loops in proximal nail-folds were also revealed. Figure 2. Microscopic findings from the skin biopsy. [jrheum.org]
Erythema and pigmentation was also seen on his abdomen and back, but without skin sclerosis. [medicaljournals.se]
There were neither changes like atrophy, telangectesia, sclerotic changes nor malar erythema noted. But since past 3-4 years, patient was getting recurrent attacks of blisters with crusting and itching particularly over exposed areas. [e-ijd.org]
There was no telangiectasia, erythema, or atrophy. The nails, hair, teeth, mucous membranes, soles and palms had a normal appearance. The systematic examination was unremarkable except for one patient with colon cancer. [ojrd.biomedcentral.com]
Neurologic
- Paresthesia
Some of the more common findings during a review of systems include the following: weight loss, weakness/fatigue, dyspnea, edema, paresthesias, light-headedness, syncope, constipation/diarrhea, and hoarseness/change of voice. [dermatologyadvisor.com]
Treatment
[…] dressings, surgical modalities, laser treatment, and phototherapy. [ncbi.nlm.nih.gov]
A comprehensive review of the literature on the treatment options for PCA showed no controlled trials available. However, case series indicated phototherapy (UVB, narrow band UVB, photochemotherapy) as the most successful treatment. [clinicaldermatology.eu]
Prognosis
Primary systemic amyloidosis, which carries a poorer prognosis than does nodular amyloidosis, also may give rise to ecchymoses and many other cutaneous and extracutaneous findings. [ncbi.nlm.nih.gov]
Nodular amyloidosis is extremely rare, and there are notable differences in clinical presentation, prognosis, histology, and pathogenesis between this entity and the macular and lichenoid variants. [actasdermo.org]
Dialysis-related amyloidosis Pathophysiology Systemic Amyloidosis Organ-specific Amyloidosis Microscopic Pathology Causes Differentiating Amyloidosis from other Diseases Epidemiology and Demographics Risk Factors Screening Natural History, Complications and Prognosis [wikidoc.org]
Etiology
Amyloidosis cutis dyschromica is mostly a congenital disorder with hypersensitivity to UVB and DNA repair defects due to repeated UVB damage as possible etiological factors. [e-ijd.org]
Herrera, Ahmet Dogan Humana Press, ١٧/٠٨/٢٠١٥ - 542 من الصفحات The second edition of this text presents an overview of the most recent developments in this area including clinical presentation, etiology, pathogenesis, and differential diagnosis. [books.google.com]
However, the etiology of amyloidosis remains unclear and population-based studies would prove to be of great benefit in evaluating the exact etiology of amyloidosis. [idoj.in]
Whether there exists an association with regard to female sex hormones in the etiology of PCA still requires elaboration. [pigmentinternational.com]
A patient with nephrotic syndrome, without a clear etiology, should be further evaluated for primary systemic amyloidosis. [dermatologyadvisor.com]
Epidemiology
However, no large-scale epidemiological study of PCA and its associations with other diseases has been conducted so far. [ncbi.nlm.nih.gov]
The present study was an attempt to study the epidemiology of PLCA and the effectiveness of DMSO on the lesions. [idoj.in]
“The epidemiology of AL and AA amyloidosis”. Baillieres Clin Rheumatol. vol. 8. 1994. pp. 627-34. [dermatologyadvisor.com]
Clinico-epidemiological study of macular amyloidosis from North India. Indian J Dermatol, 57(4), 269-74. Beccia, M., Biver, T., & Pardini, A. (2012). [recimundo.com]
Epidemiology of primary cutaneous amyloidoses in southeast Asia. Clin Dermatol 1990;8:20-4. 13. Ollague W, Ollague J, Ferretti H. Epidemiology of primary cutaneous amyloidoses in South America. Clin Dermatol 1990;8:25-9. 14. [pigmentinternational.com]
Pathophysiology
We present the case of a patient with an autoimmune hepatitis-primary biliary cirrhosis overlap syndrome with concomitant cutaneous amyloidosis, a very unusual association, and discuss similar cases and possible pathophysiological implications. [ncbi.nlm.nih.gov]
Amyloidosis Main page Overview Historical Perspective Classification AL amyloidosis AA amyloidosis Heritable amyloidosis Age-related (senile) systemic amyloidosis Dialysis-related amyloidosis Pathophysiology Systemic Amyloidosis Organ-specific Amyloidosis [wikidoc.org]
Pathophysiology As a term, "amyloid" was used historically to define proteins that shared similar microscopic characteristics and affinity for certain stains. Research has revealed that "amyloid" proteins are heterogeneous. [emedicine.medscape.com]
Prevention
While this treatment can achieve therapeutic success, it cannot prevent complications from cirrhosis. This patient remains alive but experienced an emergent gastrointestinal hemorrhage. [ncbi.nlm.nih.gov]
Secondary Prevention Cost-Effectiveness of Therapy Future or Investigational Therapies v t e Urinary system · Pathology · Urologic disease / Uropathy ( N00-N39, 580-599 ) Abdominal Nephropathy / ( nephritis + nephrosis ) Glomerulopathy / glomerulitis [wikidoc.org]
Other treatments to help with symptoms include: Diuretic medicine to remove extra water from your body Thickeners to add to fluids to prevent choking if you have trouble swallowing Compression stockings to relieve swelling in your legs or feet Changes [webmd.com]