Symptoma

Cutaneous Leishmaniasis

MATERIALS AND METHODS: A retrospective study was performed among patients who presented at The Sheba Medical Center between 2005 and 2014 with atypical clinical presentations of CL due to L. major. [ncbi.nlm.nih.gov]

  • Weight Gain

    weight gain, defervescence, significant decrease in spleen size, and doubling of the CD4 T-cell count from 176 to 374 cells/μl. The lesions subsequently resolved with continuation of maintenance therapy for VL and topical paromomycin for 1 month. [doi.org]

  • Vascular Disease

    Pentoxifylline is a methylxanthine that was originally licensed in the United States for the treatment of peripheral vascular disease [ 20 ], but it has recently been used experimentally for a number of inflammatory conditions [ 21, 22–23 ]. [doi.org]

  • Lip Swelling

    We present a 12-year-old boy with diffuse persistent lip swelling mimicking granulomatous cheilitis. Systemic glucantime was started. However, severe hypotension and bradycardia was developed after injection. [ncbi.nlm.nih.gov]

  • Follicular Plugging

    All the biopsies had strikingly similar light microscopic features with characteristic findings: a dense lymphohistiocytic infiltrate beneath an atrophic epidermis, pronounced follicular plugging, vascular hyalinization and collagen changes and negative [doi.org]

  • Joint Stiffness

    Secondary outcomes: Adverse effects Mild to moderate muscle and joint stiffness were experienced by 62% (13/21) participants in the low‐dose group and 58% (11/19) participants in the high‐dose group. [doi.org]

  • Musculoskeletal Pain

    Side effects of this treatment regimen included T-wave inversion on electrocardiogram (4 patients), abnormal liver function tests (10 patients), and musculoskeletal pain (24 patients). No side effects occurred during week 1 of therapy. [doi.org]

BACKGROUND: Several case reports describe diseases presenting with skin ulcerations, which resemble pyoderma gangrenosum especially in immune-compromised patients, often proven on further workup, to have an infective or malignant etiology. [ncbi.nlm.nih.gov]

[…] considered include the following: CBC count, coagulation studies, liver function tests, peripheral blood smear Measurements of lipase, amylase, gamma globulin, and albumin Leishmanin (Montenegro) skin testing (LST) (not FDA approved in the United States) See Workup [emedicine.medscape.com]

  • Albuminuria

    myalgias, anorexia, nausea, vomiting, lack of appetite, malaise, tremors, diarrhoea, fever, urticaria, headache, rash, phlebitis, mild to moderate muscle and joint stiffness, itch, cough, herpes zoster, mild leucopenia, thrombocytopenia, jaundice, albuminuria [doi.org]

  • Liver Enzymes Abnormal

    Other serious side effects associated with the administration of pentavalent antimonial drugs include pancreatitis, liver‐enzyme abnormalities, cardiac and electrocardiographic malfunctions and severe renal toxic effects ( Sampaio 1997 ; Berman 1996 ; [doi.org]

  • Pseudomonas

    FINDINGS Biopsies of ten lesions showed secondary infection by one or two microorganisms (Staphylococcus aureus, Pseudomonas aeruginosa, Enterococcus faecalis, Streptococcus pyogenes and Candida parapsilosis). [ncbi.nlm.nih.gov]

  • Visceromegaly

    An eighty-one-year-old woman presented three pleomorphic skin lesions that were not associated with systemic symptoms or visceromegalies. Multilocus enzyme electrophoresis identified L. [ncbi.nlm.nih.gov]

B, Day 10 of treatment, with signs of reepithelialization. C, Day 20 of treatment, with complete reepithelialization. Figure 1 Photograph of skin lesions on a 17-year-old patient with cutaneous leishmaniasis. A, Before treatment. [doi.org]

BACKGROUND: Pentavalent antimonials remain as the standard drugs in the treatment of cutaneous leishmaniosis. [ncbi.nlm.nih.gov]

Abstract The clinical manifestations and prognosis of cutaneous leishmaniasis (CL) can be influenced by the immune response of the patient and the species of the parasite. [ncbi.nlm.nih.gov]

However, a spontaneous resolution of the skin ulcers is also observed in some cases The prognosis depends upon the promptness in providing treatment. [dovemed.com]

The presentation and prognosis will vary depending on the species involved. [dermnetnz.org]

CONCLUSIONS: Leishmania major is confirmed to be the etiological agent of cutaneous leishmaniasis in northwestern Saudi Arabia. [ncbi.nlm.nih.gov]

However, the epidemiology of the disease in this area is not well understood. Thus, an epidemiological survey was conducted in 2015-2016 to identify the circulating parasite and the sand fly fauna in the region of Hail. [ncbi.nlm.nih.gov]

American cutaneous leishmaniasis is a dynamic disease with unclear pathophysiology because of continually changing environments, demographics, and human behaviors. [ncbi.nlm.nih.gov]

University Tropical Parasitology: Protozoans, Worms, Vectors and Human Diseases This course provides students an understanding of important human parasitic diseases, including their life cycles, vectors of transmission, distribution and epidemiology, pathophysiology [coursera.org]

References 1 Recent advances in the pathophysiology and treatment of human cutaneous leishmaniasis, Curr Opin Dermatol, 1997, vol. 4 (pg. 51 - 8 ) 2 Polar and sub-polar diffuse cutaneous leishmaniasis in Brazil: clinical and immunopathological aspects [academic.oup.com]

[…] venezuelensis CL/MCL OWNW L aethiopicaL braziliensis complexL (Viannia) braziliensisL (Viannia) colombiensisL (Viannia) guyanensisL (Viannia) panamensisL (Viannia) peruviana VL/CL OWNW L donovani complexL donovaniL infantumL donovani complexL chagasi Pathophysiology [clinicaladvisor.com]

Pathophysiology Modes of transmission In leishmaniasis, the obligatory intracellular protozoa are transmitted to mammals via the bite of the tiny 2- to 3-mm female sandfly of the genus Phlebotomus in the Old World (Eastern Hemisphere) and Lutzomyia in [emedicine.medscape.com]

Centers for Disease Control and Prevention. Parasites- Leishmaniasis (Internet). Centers for Disease Control and Prevention. 2015. 67. World Health Assembly. Control of Leishmaniasis. World Health Organization; 2007 Mar. Report No.: 12.3. 68. [doi.org]

The clinical manifestations and course can vary substantially, with appropriate management ranging from observation for self-healing lesions to urgent treatment to prevent damaging anatomical and cosmetic sequelae. [ncbi.nlm.nih.gov]

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