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Cutaneous Lupus Erythematosus


Presentation

  • Haroon et al. reported in 1972 an unusual presentation of CCLE with hypertrophic follicular scars seen in acne vulgaris.[ncbi.nlm.nih.gov]
Fatigue
  • Patients with CLE reported having poor quality of life and experienced symptoms ranging from pain, pruritus and fatigue to photosensitivity. There is a limited number of studies examining PRO in patients with CLE.[ncbi.nlm.nih.gov]
  • We ask about general symptoms (anxious mood, depressed mood, fatigue, pain, and stress) regardless of condition. Last updated: January 31, 2019[patientslikeme.com]
  • The general signs and symptoms of cutaneous lupus erythematosus include the following: Sudden onset of fever without any cause Body weakness and fatigue Malaise or a general feeling of discomfort Development of skin rashes Increased sensitivity to sunlight[healthh.com]
Pseudotumor
  • […] to 86.9 percent. 76 – 80 The recommended dose for acitretin and isotretinoin in CLE is 0.2 to 1.0mg/kg bodyweight/day. 52 Common side effects include xerosis and xerophthalmia while gastrointestinal problems, skeletal toxicity, hair loss, depression, pseudotumor[ncbi.nlm.nih.gov]
Recurrent Urinary Tract Infection
  • Three months earlier, she had been prescribed six months prophylactic nitrofurantoin for recurrent urinary tract infections, treated with nitrofurantoin and trimethoprim.[ncbi.nlm.nih.gov]
Yawning
  • Rocca WA, Yawn BP, St Sauver JL, Grossardt BR, Melton LJ. History of the Rochester Epidemiology Project: half a century of medical records linkage in a US population.[ncbi.nlm.nih.gov]
Musculoskeletal Pain
  • In patients with systemic lupus erythematosus, fatigue and musculoskeletal pain were assessed. Safety was assessed up to week 55.[ncbi.nlm.nih.gov]
Cutaneous Larva Migrans
  • Although flares are typically photo-induced, we present an annular eruption typical of subacute cutaneous lupus erythematosus with concurrent pinworm infestation, with recurrence of disease with cutaneous larva migrans.[ncbi.nlm.nih.gov]
Larva Migrans
  • Although flares are typically photo-induced, we present an annular eruption typical of subacute cutaneous lupus erythematosus with concurrent pinworm infestation, with recurrence of disease with cutaneous larva migrans.[ncbi.nlm.nih.gov]
Acneiform Eruption
  • Numerous case reports have described various cutaneous reactions in response to bevacizumab therapy including acneiform eruptions and exfoliative dermatitis.[ncbi.nlm.nih.gov]
Perseveration
  • […] is also being developed for use in both clinical trials and clinical care. 9 Improvement in clinical outcomes by integrating all this new knowledge while extremely challenging is also exhilarating and relies on the continued dedication, passion and perseverance[dx.doi.org]
Secondary Amenorrhea
  • Paresthesia was reported in 18 percent of patients and seven women reported secondary amenorrhea.[ncbi.nlm.nih.gov]
Genital Lesions
  • Although rare, genital involvement of lupus erythematosus must be considered in the differential diagnosis of genital lesions.[ncbi.nlm.nih.gov]

Workup

  • […] distinguished For patients who fail topical steroids, especially for management of systemic immunosuppression or antimalarial medication dosing and monitoring Clinical Cases Case 1 31-year-old woman with recurrent lesions on cheeks and scalp Negative workup[derm101.com]
  • Systemic Lupus Erythematosus (SLE) Workup. (19 September 2016 updated.) Available online at . Accessed March 27, 2017. Fonti utilizzate nelle precedenti revisioni (2003 August). Handout on Health: Systemic Lupus Erythematosus.[labtestsonline.it]
  • (See Workup and Treatment .) SCLE lesions heal without scarring or atrophy, but they may result in dyspigmentation, which can be prominent. Severe systemic disease is unusual, but when it occurs, the patient may develop life-altering sequelae.[emedicine.medscape.com]

Treatment

  • The concept of combination therapy is also on the horizon for the treatment of CLE.[ncbi.nlm.nih.gov]

Prognosis

  • […] diagnosis of cutaneous lupus erythematosus / FlorianWeber, Peter Fritsch ; Photosensitivity in lupus erythematosus / Percy Lehmann, Annegret Kuhn ; Relationship between cutaneous and systemic lupus erythematosus / Christof Specker, Matthias Schneider ; Prognosis[worldcat.org]
  • The prognosis for this condition is generally good, although a small proportion of patients will go on to develop systemic lupus erythematosus. The occupational implications of this condition require thoughtful management in the military population.[ncbi.nlm.nih.gov]

Etiology

  • Humans Infant, Newborn Lupus Erythematosus, Cutaneous/complications* Lupus Erythematosus, Cutaneous/therapy Lupus Erythematosus, Systemic/complications* Lupus Erythematosus, Systemic/congenital Lupus Erythematosus, Systemic/etiology Lupus Erythematosus[ncbi.nlm.nih.gov]
  • Etiology Etiology is still elusive but it is thought to be multifactorial, involving a genetic predisposition.[orpha.net]

Epidemiology

  • Epidemiology and socioeconomic impact of skin disease in lupus erythematosus. Lupus. 1997; 6 (2):96–104. [ PubMed ] [ Google Scholar ] 3. Petri M. Epidemiology of systemic lupus erythematosus.[ncbi.nlm.nih.gov]
  • Search of the Rochester Epidemiology Project database identified 683 medical records for review.[dx.doi.org]
  • Epidemiological studies have reported that up to 23% of patients with cutaneous lupus erythematosus (CLE) develop systemic lupus erythematosus (SLE), with some progressing over several years. 1 As these data have been important in estimating one’s risk[archderm.jamanetwork.com]
Sex distribution
Age distribution

Pathophysiology

  • Though the pathophysiology of CLE has yet to be fully characterized, current research provides direction for future research and therapies.[ncbi.nlm.nih.gov]
  • However, a complete understanding of the diverse pathophysiological mechanisms and interactions does not exist.[academic.oup.com]
  • Prevalence and Clinical Severity of Cutaneous Lupus Erythematosus The database has yielded valuable information and clinical insights into the pathophysiology, disease processes, treatments and quality of life associated with CLE.[centerwatch.com]

Prevention

  • INTRODUCTION: Treatment and prevention are of critical importance in patients with cutaneous lupus erythematosus (CLE), as the disease can have a devastating effect on patient well-being and quality of life.[ncbi.nlm.nih.gov]
  • Summary Continued research to understand the mechanisms driving CLE will provide new methods for prevention and treatment of cutaneous lesions.[dx.doi.org]
  • Treatment of specific manifestations of SLE is aimed at prevention of complications.[medical-dictionary.thefreedictionary.com]

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