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Cutaneous Metastasis in Breast Cancer

Metastasis of Malignant Neoplasm to Skin of Breast


Presentation

  • Skin lesions were assessed by Response Evaluation Criteria In Solid Tumors and cutaneous symptoms by present/absent criteria. RESULTS: A total of 23 metastatic breast cancer patients with skin metastasis who were treated with eribulin were analyzed.[ncbi.nlm.nih.gov]
  • However, they can be the presenting lesions. [3] Histologically, these metastases usually show features reminiscent of the primary breast malignancy, but with variable degrees of differentiation. [4] Case report Case report 1 A 45-year-old woman presented[ccij-online.org]
  • In this paper, we present the rare case of a patient who presented to our clinic with a scalp mass, and was operated with a preliminary diagnosis of a pyogenic granuloma&59; however, the patient’s histologic assessment revealed a diagnosis of late-term[ingentaconnect.com]
  • Her case was presented at our institution’s tumor board and neoadjuvant chemotherapy was recommended.[karger.com]
  • They are usually seen in patients with advanced disease, but they can be the presenting lesion. Case presentation A 48-year-old woman presented with a 3-month history of progressive appearance of multiple asymptomatic nodular lesions on the chest.[casesjournal.biomedcentral.com]
Splenomegaly
  • There was no evidence of distant/metastatic disease except for underlying cirrhosis of liver, portal hypertension, and splenomegaly.[karger.com]
Wound Infection
  • Our patient developed multiple wound infections, requiring surgical debridement and removal of infected breast implant.[karger.com]
Intestinal Disease
  • Topics covered include the cutaneous manifestations of connective tiss ue diseases; nonimmunologic arthritides; immune and complement deficie ncies; malignancies; hematologic disorders; endocrine diseases; gastro intestinal diseases; metabolic diseases[books.google.com]
Cutaneous Manifestation
  • Topics covered include the cutaneous manifestations of connective tiss ue diseases; nonimmunologic arthritides; immune and complement deficie ncies; malignancies; hematologic disorders; endocrine diseases; gastro intestinal diseases; metabolic diseases[books.google.com]
  • Cutaneous manifestations of breast carcinoma. Dermatol Ther 2010;23:581-9. 6. Bassioukas K, Nakuci M, Dimou S, Kanellopoulou M, Alexis I. Zosteriform cutaneous metastases from breast adenocarcinoma. J Eur Acad Dermatol Venereol 2005;19:593-6. 7.[ccij-online.org]
  • Chemotherapy has allowed the improvement of cutaneous manifestations ( Figures 4, 5 ).[omicsonline.org]
  • References: DermNet Nz on cutaneous manifestations of internal malignancy: Medscape on cutaneous signs and symptoms associated with internal malignancies: Guys and St Thomas NHS on genetic skin diseases: NHS Choices on ichthyosis: Medline Plus on ectodermal[news-medical.net]
Impulsivity
  • A short time after the chemotherapy drug is given, electrical impulses are given directly to the area using an electrode with the help of a specially designed needle probe.[breastcancercare.org.uk]
  • Other therapies that may be helpful include imiquimod cream, photodynamic therapy, carbon dioxide laser therapy, pulsed dye laser therapy, intralesional chemotherapy, and cytokines. [8] Electrochemotherapy, a new treatment that uses electrical impulses[ccij-online.org]
  • […] metastasis in some cases of melanoma Liquid nitrogen cryotherapy Photodynamic therapy Excision Carbon dioxide laser therapy Pulsed dye laser therapy Topical and intralesional chemotherapy and cytokines Electrochemotherapy , a treatment that uses electrical impulses[dermnetnz.org]
Scalp Mass
  • Due to these rates, the preliminary diagnosis of the skin metastasis of breast cancer can be overlooked in case of a scalp mass, and this can result in inadequate or extra surgery.[ingentaconnect.com]

Workup

  • Other distant metastatic workup is negative. ER/PR &her2neu was negative for breast specimen. Post op adjuvant chemotherapy given with AC Regimen. DISCUSSION: Cutaneous metastasis may herald the diagnosis of internal malignancy.[jemds.com]

Treatment

  • After treatment, 43% of patients exhibited a partial response, 35% stable disease and 22% progressive disease.[ncbi.nlm.nih.gov]
  • The prognosis of cancer breast with CM depends primarily on the pathology and biological behavior of the primary tumor and its response to treatment. CM from breast cancer usually occurs in advanced stages and the treatment outcome is poor.[ccij-online.org]
  • Treatment with capecitabine, along with trastuzumab, was therefore initiated.[karger.com]
  • Getting treatment Electrochemotherapy is a relatively new treatment, but is now available in an increasing number of hospitals in England, Scotland and Wales. You can ask your treatment team if this is a suitable treatment option for you.[breastcancercare.org.uk]
  • Photodynamic therapy (PDT), which combines a porphyrin-based photosensitizer and activation by light, can be employed for breast cancer (especially cutaneous metastases) but tumor control after PDT has not surpassed traditional treatments methods such[ncbi.nlm.nih.gov]

Prognosis

  • Abstract Cutaneous metastasis is the main cause of morbidity and mortality of cancer patients, denoting a guarded prognosis. The clinical spectrum of the disease is broad and can mimic benign conditions.[ncbi.nlm.nih.gov]
  • The prognosis of cancer breast with CM depends primarily on the pathology and biological behavior of the primary tumor and its response to treatment. CM from breast cancer usually occurs in advanced stages and the treatment outcome is poor.[ccij-online.org]
  • The stage of your breast cancer when you’re diagnosed plays an important role in your prognosis.[healthline.com]
  • They are frequently a sign of poor prognosis.[omicsonline.org]

Etiology

  • Hypothesis The main goal of this study is to understand the etiology of IBC cutaneous metastasis.[theibcnetwork.org]
  • Etiology Metastases arise as disconnected extensions of a primary tumor. This occurs when cancerous cells break away from a primary tumor and spread elsewhere. By definition, this makes the primary tumor malignant.[emedicine.medscape.com]

Epidemiology

  • Kim WR, et al: Epidemiology and natural history of primary biliary cirrhosis in a U.S. community . Gastroenterology 2000;119: 1631–1636. Kouroumalis E, Notas G: Primary biliary cirrhosis: from bench to bedside .[karger.com]
  • Trends in inflammatory breast carcinoma incidence and survival: the surveillance, epidemiology, and end results program at the National Cancer Institute. J Natl Cancer Inst. 2005;97: 966–975. 2. Dawood S, Merajver SD, Viens P, et al.[jcadonline.com]
  • Epidemiology The incidence of cutaneous malignancy varies. In some autopsy studies of patients with metastatic carcinoma, as many as 9% of individuals were noted to have cutaneous metastases. Other studies suggest a range of 3-4%.[emedicine.medscape.com]
  • Epidemiology Skin metastases from solid tumor are not rare.[intechopen.com]
Sex distribution
Age distribution

Pathophysiology

  • Efthimiou P (2006) Tumor necrosis factor-alpha in inflammatory myopathies: pathophysiology and therapeutic implications. Semin Arthritis Rheum 36:168–172. doi: 10.1016/j.semarthrit.2006.07.003 CrossRef PubMed Google Scholar 11.[link.springer.com]

Prevention

  • In addition, we will use commercially available inhibitors of TGFβ that are currently in clinical trials to determine their effect on preventing invasion and growth. Aim 2. Examine the TGFβ signaling pathways IBC cells .[theibcnetwork.org]
  • Conservative measures such as keeping the lesions clean and dry are important to prevent infection.[aocd.org]
  • Skin Cancer Classification Skin Cancer Causes Skin Cancer Diagnosis Skin Cancer Prevention[news-medical.net]
  • Hydrocolloid dressings may be used to help prevent secondary infection. Consent Written informed consent was obtained from the patient for publication of this case report and accompanying images.[casesjournal.biomedcentral.com]

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