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Cutaneous Pseudolymphoma

Lymphocytoma Cutis


Presentation

  • We report herein a series of 9 patients presenting with cutaneous and subcutaneous pseudolymphoma.[ncbi.nlm.nih.gov]
  • Collections of epithelioid macrophages were present in both cases and were reminiscent of epithelioid granulomas.[ncbi.nlm.nih.gov]
  • Abstract Cutaneous pseudolymphomas (CPLs) include a wide range of clinicopathological presentations sharing in common the presence of clinical and histopathological features mimicking those of primary cutaneous lymphomas.[ncbi.nlm.nih.gov]
  • The first reported case of phenytoin-induced generalized nodular cutaneous pseudolymphoma without symptoms of the phenytoin hypersensitivity syndrome is presented.[ncbi.nlm.nih.gov]
  • In addition to previous descriptions, the patient presented with a distinct linear lesion. Vacuolar alteration of the basal cell layer and scattered eosinophilic bodies in the epidermis were observed, which suggested a lichenoid tissue reaction.[ncbi.nlm.nih.gov]
Myxedema
  • Pityriasis rubra pilaris 585 188 Polycystic ovary syndrome 587 189 Polymorphic light eruption 589 190 Pompholyx 592 191 Porokeratoses 595 192 Porphyria cutanea tarda 598 193 Port wine stain nevus flammeus 601 194 Pregnancy dermatoses 606 195 Pretibial myxedema[books.google.de]
Subcutaneous Mass
  • We report a case in which a 63-year-old female presented with a 5-month history of a progressive skin eruption and an enlarging subcutaneous mass following a presumed insect bite.[ncbi.nlm.nih.gov]
Subcutaneous Mass
  • We report a case in which a 63-year-old female presented with a 5-month history of a progressive skin eruption and an enlarging subcutaneous mass following a presumed insect bite.[ncbi.nlm.nih.gov]
Necrolytic Migratory Erythema
  • migratory erythema 497 160 Nephrogenic systemic fibrosis 499 161 Neurofibromatosis type 1 501 162 Nevoid basal cell carcinoma syndrome 504 163 Nevus sebaceus 509 164 Notalgia paresthetica 511 165 Onchocerciasis 513 166 Oral lichen planus 516 167 Orf[books.google.de]
Trichotillomania
  • […] capitis 752 234 Tinea pedis and skin dermatophytosis 756 235 Tinea unguium 759 236 Tinea versicolor pityriasis versicolor 763 237 Toxic epidermal necrolysis and StevensJohnson syndrome 766 238 Transient acantholytic dermatosis Grover disease 770 239 Trichotillomania[books.google.de]

Workup

  • In the event that there is still uncertainty as to whether the lymphoid infiltrate represents a pseudolymphoma or a lymphoma, additional workup can be helpful.[plasticsurgerykey.com]

Treatment

  • The aim of this systematic review is to summarize all reported treatments for CPL.[ncbi.nlm.nih.gov]
  • Controlled trials and long-term monitoring are warranted to further explore this treatment modality for CPL.[ncbi.nlm.nih.gov]
  • We describe a 74-year-old woman who rapidly developed bilateral voluminous nodules on the upper eyelids, following 4 months' treatment for chalazion.[ncbi.nlm.nih.gov]
  • From the review of the literature, the T cell predominance suggests a reclassification of tattoo-induced CPL and there is not a gold standard treatment yet.[ncbi.nlm.nih.gov]
  • A brief period of discontinuation of the drug will demonstrate the regression associated with benign lymphoproliferation and will forestall needless treatment.[ncbi.nlm.nih.gov]

Prognosis

  • The prognosis of CPL is good, but the underlying disease process should be taken into account. If an antigenic stimulus is identified, it should be removed. In patients with idiopathic CPL, a close follow-up control strategy should be adopted.[ncbi.nlm.nih.gov]
  • Familial occurrence has been reported. [4] Prognosis Prognosis is good because lymphocytic infiltration of the skin may resolve spontaneously. Lymphocytic infiltration of the skin (LIS) is not associated with increased mortality.[emedicine.medscape.com]
  • […] and predictive factors The prognosis of cutaneous pseudolymphomas by definition is excellent, showing spontaneous regression of the lesions after cessation of the causative factor or due to treatment with nonaggressive treatment modalities.[drdigambiro.blogspot.com]
  • References Prognosis Spontaneous regression of lymphocytoma cutis often occurs. If the inciting agent is removed, the lymphocytoma cutis typically resolves. Idiopathic cases of lymphocytoma cutis tend to be chronic and indolent.[img.medscape.com]
  • DHS is associated with a mortality rate of 10%, whereas drug-induced cutaneous pseudolymphomas always have an excellent prognosis, although it may take a long time for the eruption to clear even after the cessation of causative agents (8).[medicaljournals.se]

Etiology

  • […] studies and molecular analysis of clonality have been shown to be reliable tools, providing significant help in the differential diagnosis between primary cutaneous lymphoid malignancy and pseudolymphoma involving the skin, the identification of an etiological[ncbi.nlm.nih.gov]
  • In summary, IgG4-related sclerosing disease can manifest with skin lesions, and is also one of the potential etiologies of cutaneous pseudolymphomas.[ncbi.nlm.nih.gov]
  • Commonly occurring etiological causes have been tabulated along with salient histological features [Table 1].[idoj.in]
  • Only cases with a B. burgdorferi etiology (typical locations, positivity of serologic and/or polymerase chain reaction (PCR) tests, clinical history) were included in the study.[ingentaconnect.com]
  • Cases with known etiologies involve a reaction to tattoo dye, jewelry (especially gold), arthropod bites, medications, folliculitis, trauma, infections (ie, with Borrelia burgdorferi,molluscum contagiosum), vaccinations, and acupuncture.[thehealthscience.com]

Epidemiology

  • This form of the disease is a response to an infection due to Borrelia burgdorferi subsp afzelius that is transmitted by a tick bite. [1] Epidemiology Frequency United StatesNo data on US prevalence or incidence of lymphocytoma cutis are available.[thehealthscience.com]
  • This form of the disease is a response to an infection due to Borrelia burgdorferi subsp afzelius that is transmitted by a tick bite. [1] References Epidemiology Frequency United States No data on US prevalence or incidence of lymphocytoma cutis are available[img.medscape.com]
  • Epidemiology Frequency The incidence and prevalence is unknown. It is considered uncommon. Race Lymphocytic infiltration of the skin has no known racial predilection. Sex The reported sex ratio varies depending upon the source consulted.[emedicine.medscape.com]
  • No significant epidemiologic data are available CTPL Age Individuals of any age may be affected, but localized, nodular CPL is MC in early life. Mean age of onset is 34 years. 2/3 of patients are younger than 40 years at time of biopsy.[slideshare.net]
  • In reported cases of localized pseudolymphoma, the female-to-male ratio is approximately 2:1. 4 No significant epidemiologic data are available regarding entities in the T-cell pattern pseudolymphoma spectrum.[drdigambiro.blogspot.com]
Sex distribution
Age distribution

Pathophysiology

  • Case Overview lymphocytoma cutis Member Rated 0 Patient case no. 2292 Date added 14 June 2003 Patient details Age --Undetermined-- Localisation Trunk / back Description Primary Lesions Plaque / erythematous Nodule Pathophysiology tumors and proliferative[dermquest.com]
  • Pathophysiology In lymphocytoma cutis, lymphocytes and other inflammatory cells are recruited to a localized area of the skin in response to known or unknown stimuli. Most cases of lymphocytoma cutis are idiopathic.[thehealthscience.com]
  • Cutaneous lymphoid hyperplasia is the preferred term because it accurately describes the underlying pathophysiology of the lesion and is unlikely to be confused with terms used to describe various forms of cutaneous lymphoma. 1 – 6 In most cases, CLH[accessmedicine.mhmedical.com]
  • ., “Cutaneous pseudolymphoma: background, pathophysiology, etiolgy”, Medscape Reference, 2014, disponible en: . medscape.com/article/1099188-overview.[new.medigraphic.com]
  • References Pathophysiology In lymphocytoma cutis, lymphocytes and other inflammatory cells are recruited to a localized area of the skin in response to known or unknown stimuli. Most cases of lymphocytoma cutis are idiopathic.[img.medscape.com]

Prevention

  • Your skin Holds body fluids in, preventing dehydration Keeps harmful microbes out, preventing infections Helps you feel things like heat, cold, and pain Keeps your body temperature even Makes vitamin D when the sun shines on it Anything that irritates[icdlist.com]
  • Antibacterial treatment is necessary in all patients to eliminate the spirochete, cure current disease, and prevent late sequelae.[sites.google.com]
  • ., pulsed dye laser) Hydroxychloroquine (200 mg PO twice daily) Systemic corticosteroids (60/40/20 mg PO taper, 5 days each) Local radiation therapy The principal preventive strategy is to avoid contact with, or ingestion of, agents known to induce CLH[plasticsurgerykey.com]

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