Collections of epithelioid macrophages were present in both cases and were reminiscent of epithelioid granulomas. [ncbi.nlm.nih.gov]

A 62-year-old male presented with multiple asymptomatic swellings over the posterior aspect of the left ear of 1-year duration. [cdriadvlkn.org]

• Pathologist

  Beyond its usefulness to general pathologists, dermatopathologists, and hematopathologists, this information is intended to be helpful for dermatologists, hematologists/oncologists, fellows, and residents. [books.google.com]

  Main Pathologists typically encounter many disparate exogenous materials in clinical specimens during their routine histopathological examinations. [nature.com]

  Having this reference on hand is essential for all dermatologists, dermatopathologists, oncologists, and general pathologists who need a synthesis of the current thinking in the field. [books.google.de]

  The experienced clinician may perhaps be able to suggest a diagnosis of CLH but it is the pathologist who will put forward a diagnosis that can, ultimately, be confirmed for certain by comparing the clinical presentation with the skin biopsy results. [therapeutique-dermatologique.org]

  [Pseudolymphoma of the skin: ambiguous terminology: a survey among dermatologists and pathologists]. Levy E, Godet J, Cribier B, Lipsker D. Levy E, et al. Ann Dermatol Venereol. 2013 Feb;140(2):105-11. doi: 10.1016/j.annder.2012.10.600. [pubmed.ncbi.nlm.nih.gov]

• Prolapse

  Peutz-Jeghers症候群：Peutz-Jeghers syndrome ◎リンパ管腫 ◎カルチノイド腫瘍：carcinoid tumor 乳頭部癌：carcinoma of major papilla 悪性リンパ腫：malignant lymphoma 4）大腸，肛門 ヒルシュスプルング病：Hirschsprung disease ◎憩室炎：diverticulitis ◎虚血性大腸炎：ischemic colitis 閉塞性大腸炎：obstructive colitis ◎粘膜脱症候群：mucosal prolapse [medical-e.net]

• Skin Lesion

  Furthermore, the presence of vaccine products was investigated in skin lesions by using histochemical, microanalytic, and electronic microscopy techniques. [ncbi.nlm.nih.gov]

  Lyme disease Skin lesion Tick bite [en.wikipedia.org]

• Insect Bite

  However, histology showed a lot of eosinophilic infiltrate suggestive of insect bite, but patient denied such insect bite history. [cdriadvlkn.org]

  We report a case in which a 63-year-old female presented with a 5-month history of a progressive skin eruption and an enlarging subcutaneous mass following a presumed insect bite. [ncbi.nlm.nih.gov]

  There was no history of insect bite, trauma, and infection at that site in the past. There was no history of drug ingestion. A wide excision was done; the histopathology was reported as cutaneous pseudolymphoma. [idoj.in]

  These include foreign agents such as: Tattoo dye,Insect bites,Scabies, Stings and spider bites Vaccinations Desensitisation injections Trauma Acupuncture Gold earring piercing Infections with :-Borrelia burgdorferi (Lyme disease), Varicella zoster (chickenpox [slideshare.net]

• Angiokeratoma

  Acral pseudolymphomatous angiokeratoma of children: a pseudolymphoma rather than an angiokeratoma. Br J Dermatol. Sep 2001;145(3):512-514. [uscapknowledgehub.org]

  Acral pseudolymphomatous angiokeratoma of children (APACHE) is a recently recognized, rare clinical entity. We report a case of APACHE in a 9-year-old Japanese girl with a dark red, linear plaque on the posterior area of the right lower leg. [ncbi.nlm.nih.gov]

  Linear acral pseudolymphomatous angiokeratoma of children (APACHE): Further evidence that APACHE is a cutaneous pseudolymphoma. J am acad dermatol. Feb 2003;48:15-7. 5. Shtilionova S, Drumeva P, Balabanova M, Krasnaliev. [de.slideshare.net]

  The presence of plasma cells and eosinophils favours a benign diagnosis. acral pseudolymphomatous angiokeratoma of children shows papules of acral sites. [e-immunohistochemistry.info]

  Papular pseudolymphoma of adults as a variant of acral pseudolymphomatous angiokeratoma of children (APACHE). Wagner G, Rose C, Sachse MM. Wagner G, et al. J Dtsch Dermatol Ges. 2014 May;12(5):423-4. doi: 10.1111/ddg.12291. Epub 2014 Mar 14. [pubmed.ncbi.nlm.nih.gov]

• Subcutaneous Mass

  We report a case in which a 63-year-old female presented with a 5-month history of a progressive skin eruption and an enlarging subcutaneous mass following a presumed insect bite. [ncbi.nlm.nih.gov]

• Acne Vulgaris

  Acne vulgaris. C. Secondary syphilis. D. Urticaria pigmentosa. E. Lymphocytoma cutis. Discussion The answer is D: urticaria pigmentosa. [aafp.org]

• Suggestibility

  Histological and immunohistochemical findings were suggestive of cutaneous pseudolymphoma (CPL), and extensive screening for malignant lymphoma (ML) remained negative. [ncbi.nlm.nih.gov]

  Hence, this case is reported as its histopathology was suggestive of pseudolymphoma secondary to insect bite reaction. [cdriadvlkn.org]

  Finally, the use of hydroxychloroquine sulfate is suggested for the therapy of pseudolymphoma cutis, especially when the causal factor is unknown. [moh-it.pure.elsevier.com]

• Confusion

  While these advances have increased understanding of skin lymphomas, they have also produced an extensive and sometimes confusing litany of articles, studies, and classification schemes. [books.google.com]

  Cutaneous lymphoid hyperplasia is the preferred term because it accurately describes the underlying pathophysiology of the lesion and is unlikely to be confused with terms used to describe various forms of cutaneous lymphoma. 1 – 6 In most cases, CLH [accessmedicine.mhmedical.com]

  Clinically and histologically it could be confused as lymphoma, thus, the study by immunohistochemistry will be the gold standard for diagnosis. [new.medigraphic.com]

  The confusion is furthered because the prototypic drug stimulus in both is phenytoin. [emedicine.medscape.com]

  Confusion between pseudolymphoma and lymphoma can arise if a biopsy is submitted to the pathologist without an adequate history. Pseudolymphomas are classified according to the histological components into B-cell and T-cell variants. [cdriadvlkn.org]

In the event that there is still uncertainty as to whether the lymphoid infiltrate represents a pseudolymphoma or a lymphoma, additional workup can be helpful. [plasticsurgerykey.com]

Staging workup should include bone marrow biopsy and CT of the abdomen to exclude extrathoracic disease. Lymphangiograms and bone scans could be part of the preoperative staging [65]. [cardiothoracicsurgery.biomedcentral.com]

The aim of this systematic review is to summarize all reported treatments for CPL. [ncbi.nlm.nih.gov]

Imiquimod 5%: a successful treatment for pseudolymphoma. Acta Derm Venereol. 2014 Jul. 94(4):469. [QxMD MEDLINE Link]. Singletary HL, Selim MA, Olsen E. Subcutaneous interferon alfa for the treatment of cutaneous pseudolymphoma. [emedicine.medscape.com]

We review here the treatment of pseudolymphoma of the skin according to its aetiology. We also suggest a treatment algorithm that may help physicians in choosing treatment. There is no previous systematic review of the treatment of CPL. [medicaljournals.se]

The prognosis of CPL is good, but the underlying disease process should be taken into account. If an antigenic stimulus is identified, it should be removed. In patients with idiopathic CPL, a close follow-up control strategy should be adopted. [ncbi.nlm.nih.gov]

Familial occurrence has been reported. [4] Prognosis Prognosis is good because lymphocytic infiltration of the skin may resolve spontaneously. Lymphocytic infiltration of the skin (LIS) is not associated with increased mortality. [emedicine.medscape.com]

[…] is associated with better prognosis as compared to the Asian type. [ijdpdd.com]

In view of the totally differing treatment modalities and prognosis, IHC with CD3, CD10, CD20 and LCA was done. [jomfp.in]

[…] studies and molecular analysis of clonality have been shown to be reliable tools, providing significant help in the differential diagnosis between primary cutaneous lymphoid malignancy and pseudolymphoma involving the skin, the identification of an etiological [ncbi.nlm.nih.gov]

Commonly occurring etiological causes have been tabulated along with salient histological features [Table 1]. [idoj.in]

Lymphocytoma Cutis: A Case Report Abstract Cutaneous pseudolymphomas are a group of benign reactive T- or B-cell lymphoproliferative processes of diverse etiology that simulate cutaneous lymphomas clinically and histologically. [synergypublishers.com]

Only cases with a B. burgdorferi etiology (typical locations, positivity of serologic and/or polymerase chain reaction (PCR) tests, clinical history) were included in the study. [ingentaconnect.com]

This form of the disease is a response to an infection due to Borrelia burgdorferi subsp afzelius that is transmitted by a tick bite. [1] Epidemiology Frequency United StatesNo data on US prevalence or incidence of lymphocytoma cutis are available. [thehealthscience.com]

No significant epidemiologic data are available regarding entities in the T-cell pattern pseudolymphoma spectrum. [emedicine.medscape.com]

This form of the disease is a response to an infection due to Borrelia burgdorferi subsp afzelius that is transmitted by a tick bite. [1] References Epidemiology Frequency United States No data on US prevalence or incidence of lymphocytoma cutis are available [img.medscape.com]

Case Overview lymphocytoma cutis Member Rated 0 Patient case no. 2292 Date added 14 June 2003 Patient details Age --Undetermined-- Localisation Trunk / back Description Primary Lesions Plaque / erythematous Nodule Pathophysiology tumors and proliferative [dermquest.com]

Pathophysiology In lymphocytoma cutis, lymphocytes and other inflammatory cells are recruited to a localized area of the skin in response to known or unknown stimuli. Most cases of lymphocytoma cutis are idiopathic. [thehealthscience.com]

Cutaneous lymphoid hyperplasia is the preferred term because it accurately describes the underlying pathophysiology of the lesion and is unlikely to be confused with terms used to describe various forms of cutaneous lymphoma. 1 – 6 In most cases, CLH [accessmedicine.mhmedical.com]

Ko, C.J., “Cutaneous pseudolymphoma: background, pathophysiology, etiolgy”, Medscape Reference, 2014, disponible en: http://emedicine. medscape.com/article/1099188-overview. [new.medigraphic.com]

[…] entity with a distinct biologic mechanism; however, the significant clinical overlap (ie, implicated drugs, symptomatology, and presentation) and some histologic overlap make the nosologic distinction of these entities difficult to resolve. [2, 5, 6] Pathophysiology [emedicine.medscape.com]

Your skin Holds body fluids in, preventing dehydration Keeps harmful microbes out, preventing infections Helps you feel things like heat, cold, and pain Keeps your body temperature even Makes vitamin D when the sun shines on it Anything that irritates [icdlist.com]

Antibacterial treatment is necessary in all patients to eliminate the spirochete, cure current disease, and prevent late sequelae. [sites.google.com]

Each of these techniques suffers from important disadvantages that may prevent their use for routine clinical pathology analysis of paraffin-embedded specimens. [nature.com]

Rituximab for prevention and treatment of graft-versus-host disease Int J Hematol. 2011;93:578–85 59. [journals.lww.com]

They suggest performing multiple confirmatory immunophenotyping tests to prevent misinterpretation (19). Cutaneous PSL can progress into a lymphoma. (7) Nihal et al. utilized the IHC and clonality study in 44 PSL patients. [ncbi.nlm.nih.gov]