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Cyclobenzaprine

N N Dimethyl 5H Dibenzo(a D)cycloheptene DELTA(5 Gamma) Propylamine


Presentation

  • We report on a patient presenting with torticollis and myoclonic movements after treatment with cyclobenzaprine, who was successfully treated with intravenous biperiden.[ncbi.nlm.nih.gov]
  • The present open trial presents a new promising pharmacotherapy for tinnitus that should be validated in placebo-controlled double-blind trials. Copyright 2012 S. Karger AG, Basel.[ncbi.nlm.nih.gov]
  • A review of the pharmacology of cyclobenzaprine, as well as the management of patients who overdose on this drug, is presented.[ncbi.nlm.nih.gov]
  • Abstract The purpose of present investigation was to formulate and characterize the cyclobenzaprine HCl (CBZ)-loaded thiolated chitosan nanoparticles and assessment of in-vitro cell viability, trans-mucosal permeability on RPMI2650 cell monolayer, in-vivo[ncbi.nlm.nih.gov]
  • The patient remained agitated for 48 hours after presentation and required frequent sedation.[occup-med.com]
Painter
  • Painter and Leslie J. Crofford, Chronic Opioid Use in Fibromyalgia Syndrome, Journal of Clinical Rheumatology, 10.1097/RHU.0b013e3182863447, 19, 2, (72-77), (2013). Howard S.[doi.org]
Hyperthermia
  • ., diaphoresis, tachycardia, labile blood pressure, hyperthermia), neuromuscular abnormalities (e.g., tremor, ataxia, hyperreflexia, clonus, muscle rigidity) and/or gastrointestinal symptoms (e.g., nausea, vomiting, diarrhea).[drugs.com]
Respiratory Distress
  • Abstract A full-term male infant presented shortly after birth with respiratory distress.[ncbi.nlm.nih.gov]
Clay-Colored Stool
  • […] especially on one side of the body; * Sudden headache, confusion, problems with vision, speech, or balance; * Feeling light-headed, fainting; * Confusion, weakness, lack of coordination; * Nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored[weedguru.com]
  • […] weakness, especially on one side of the body; sudden headache, confusion, problems with vision, speech, or balance; feeling light-headed, fainting; confusion, weakness, lack of coordination; nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored[cardiosmart.org]
Tachycardia
  • The major symptoms displayed by the patient were tachycardia and metabolic acidosis, symptoms consistent with cyclobenzaprine and ibuprofen intoxication, respectively.[ncbi.nlm.nih.gov]
  • Her initial electrocardiogram (ECG) demonstrated sinus tachycardia at 139 beats per minute, QRS duration 112 ms, and terminal R-wave in lead aVR 3 mm.[ncbi.nlm.nih.gov]
  • Dysrhythmias beyond sinus tachycardia were infrequent, and none were life-threatening. No seizures occurred. Common effects were lethargy, sinus tachycardia, and agitation, and both hypertension and hypotension were seen.[ncbi.nlm.nih.gov]
  • Tachyarrhythmia's include sinus tachycardia which is very common however even ventricular tachycardia unresponsive to ACLS has been reported.[occup-med.com]
Orthostatic Hypotension
  • CV: Tachycardia, syncope, palpitation, vasodilation, chest pain, orthostatic hypotension, dyspnea; with high doses, possibility of severe arrhythmias.[robholland.com]
Formication
  • Isocratic elution was applied using acetonitrile-water (40:60, v/v) containing 10 m M ammonium acetate and 0.1% formic acid.[ncbi.nlm.nih.gov]
Dermatitis
  • During the CER 15-mg treatment sequence, 5 subjects experienced 5 AEs (headache, dizziness, musculoskeletal pain, dermatitis, and glossodynia); during the CER 30-mg treatment sequence, 2 subjects experienced 2 AEs (somnolence and dysmenorrhea).[ncbi.nlm.nih.gov]
Muscle Twitch
  • Call your healthcare provider right away or go to the nearest hospital emergency room if you become severely ill and have some or all of these symptoms: agitation, hallucinations, coma, or other changes in mental status coordination problems or muscle[amrix.com]
  • twitching [ Ref ] Ocular Postmarketing reports : Blurred vision, diplopia, tinnitus [ Ref ] Respiratory Common (1% to 10%): Upper respiratory infection, pharyngitis [ Ref ] References 1.[drugs.com]
  • Nervous System and Psychiatric : Seizures, ataxia ; vertigo ; dysarthria ; tremors; hypertonia ; convulsions; muscle twitching; disorientation; insomnia ; depressed mood; abnormal sensations; anxiety ; agitation; psychosis, abnormal thinking and dreaming[web.archive.org]
  • . • Central Nervous System : Seizures, incoordination, speech disorder, tremors, increased muscle tone, convulsions, muscle twitching, disorientation, depressed mood, abnormal sensations, anxiety, agitation, abnormal thinking and dreaming, hallucinations[medindia.net]
Morning Stiffness
  • An exception was morning stiffness, which became significantly more reduced in the patients taking C plus I. No patient discontinued the trial owing to adverse side-effects.[ncbi.nlm.nih.gov]
  • There was a trend toward improvement in the symptoms of fatigue, but morning stiffness was not alleviated. These improvements in symptoms were associated with a significant reduction in the total number of tender points and in muscle tightness.[ncbi.nlm.nih.gov]
Confusion
  • Less frequent side effects include: tremor, agitation, coma, ataxia, hypertension, slurred speech, dizziness, confusion, nausea, vomiting and hallucinations.[rxight.com]
  • Check with your doctor immediately if any of the following side effects occur while taking cyclobenzaprine: Rare Clumsiness or unsteadiness confusion fainting mental depression problems in urinating ringing or buzzing in the ears skin rash , hives , or[drugs.com]
  • Adverse Reactions: Drowsiness, dry mouth, dizziness, fatigue, headache, GI upset, asthenia, irritability, nervousness, blurred vision, confusion, arrhythmias, tachycardia, hypotension. Note: Formerly known under the brand names Flexeril, Fexmid.[thecardiologyadvisor.com]
Slurred Speech
  • Less frequent side effects include: tremor, agitation, coma, ataxia, hypertension, slurred speech, dizziness, confusion, nausea, vomiting and hallucinations.[rxight.com]
  • Stop using this medicine and call your doctor at once if you have: fast or irregular heartbeats; chest pain or pressure, pain spreading to your jaw or shoulder; or sudden numbness or weakness (especially on one side of the body), slurred speech, balance[drugs.com]
  • Less common effects include body twitches (tremor), the loss of control of bodily movements (ataxia), hypertension, agitation, slurred speech, nausea, confusion, dizziness, hallucination, vomiting and coma.[livescience.com]
Ataxia
  • Nervous System and Psychiatric : Seizures, ataxia ; vertigo ; dysarthria ; tremors; hypertonia ; convulsions; muscle twitching; disorientation; insomnia ; depressed mood; abnormal sensations; anxiety ; agitation; psychosis, abnormal thinking and dreaming[web.archive.org]
  • Less frequent side effects include: tremor, agitation, coma, ataxia, hypertension, slurred speech, dizziness, confusion, nausea, vomiting and hallucinations.[rxight.com]
  • There have been reports of people suffering ataxia when taking the drug in extremely high doses. Ataxia is a neurological condition in which someone no longer has control of their muscle movements.[therecoveryvillage.com]
  • At even higher doses, cyclobenzaprine may cause severe ataxia, a neurologic condition in which you lose control of your muscle movements.[everydayhealth.com]
Lethargy
  • Lethargy and anticholinergic effects are prominent, though serious toxicity is infrequent.[ncbi.nlm.nih.gov]
  • Abstract A 19-year-old black man presented to the emergency room with superficial cuts on the anterior wrists, lethargy, tachycardia, and metabolic acidosis. Multiple containers of medication were found at the scene.[ncbi.nlm.nih.gov]
  • Benzodiazepines enter breast milk and can cause lethargy and weight loss in the newborn . Therefore, they should not be used in nursing mothers. Cyclobenzaprine There are no adequate studies of cyclobenzaprine in pregnant women.[medicinenet.com]

Workup

  • After a standard workup, he was diagnosed with LAS and treated with oral cyclobenzaprine 5 mg 3 times daily for 7 days.[ncbi.nlm.nih.gov]
Right Axis Deviation
  • DISCUSSION: The patient's lacosamide, cyclobenzaprine and levetiracetam overdose was associated with QRS prolongation and terminal right axis deviation--suggesting sodium channel blockade as a likely etiology for her cardiac arrest.[ncbi.nlm.nih.gov]
Ventricular Hypertrophy
  • An echocardiogram done within the first hour of life showed an elevated pulmonary artery pressure, an associated right ventricular hypertrophy without a patent ductus arteriosus.[ncbi.nlm.nih.gov]
Right Ventricular Hypertrophy
  • An echocardiogram done within the first hour of life showed an elevated pulmonary artery pressure, an associated right ventricular hypertrophy without a patent ductus arteriosus.[ncbi.nlm.nih.gov]

Treatment

  • To perform a systematic review of cyclobenzaprine's effectiveness in the treatment of back pain.[ncbi.nlm.nih.gov]
  • SUBJECTS AND METHODS: 65 patients, who received the drug treatment, were compared to 30 patients on a waiting list, who received no treatment.[ncbi.nlm.nih.gov]
  • Abstract Objective To systematically review the effectiveness of cyclobenzaprine in the treatment of fibromyalgia.[doi.org]
  • The patient experienced resolution of his symptoms after 3 days of treatment and remained symptom-free 6 months after completion of therapy.[ncbi.nlm.nih.gov]
  • Area under the plasma concentration-time curve for unchanged cyclobenzaprine, however, was less for the oral treatment than for the parenteral treatments.[ncbi.nlm.nih.gov]

Prognosis

  • They talked about side effects and how Jen should take cyclobenzaprine, and Jen left feeling better about her prognosis. Muscle injuries are common in athletes like Jen.[study.com]
  • Depending on your circumstances and prognosis, you may want to ask your doctor about possible issues with building a tolerance to Flexeril and its effectiveness over time.* But in my experience, I would say Flexeril is only good for breaking the initial[viewpoints.com]

Etiology

  • DISCUSSION: The patient's lacosamide, cyclobenzaprine and levetiracetam overdose was associated with QRS prolongation and terminal right axis deviation--suggesting sodium channel blockade as a likely etiology for her cardiac arrest.[ncbi.nlm.nih.gov]
  • Enrico Bellato, Eleonora Marini, Filippo Castoldi, Nicola Barbasetti, Lorenzo Mattei, Davide Edoardo Bonasia and Davide Blonna, Fibromyalgia Syndrome: Etiology, Pathogenesis, Diagnosis, and Treatment, Pain Research and Treatment, 10.1155/2012/426130,[doi.org]

Epidemiology

  • Human rabies epidemiology and diagnosis [Chapter 10]. In: Tkachev S, ed. Non-flavivirus encephalitis. Rijeka, Crotia: InTech Open Science, 2011.[imic.or.jp]
Sex distribution
Age distribution

Pathophysiology

  • Clauw, Fibromyalgia: from pathophysiology to therapy, Nature Reviews Rheumatology, 10.1038/nrrheum.2011.98, 7, 9, (518-527), (2011) ., (2011).[doi.org]

Prevention

  • Preventing Heat-Induced Death and Illness [ hide all summaries ] (June 2018) This article lists practical steps to take to avoid death, hospitalization or other medical problems caused by heat stress.[worstpills.org]
  • Cyclobenzaprine (also called Flexeril ) is a medicine that helps relax muscles and prevent muscle spasms. It is available as a 10-mg tablet.[stjude.org]
  • Report Abuse and Neglect Know the Americans with Disabilities Act Abuse and Neglect Registry Safety Alerts & Advisories Emergency and Safety Information Fire Prevention and Safety Training HIPAA Notice Commissioner Jordan A.[ct.gov]
  • It suppresses muscle spasms - and so may prevent pain caused by MP - without interfering with muscle function. The purpose of this review was to assess how effective cyclobenzaprine is at reducing pain and improving sleep in patients with MP.[cochrane.org]

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