A case of true cyclopia with normal karyotype is presented. There was a history of the use of an intrauterine device for contraception and of drug ingestion during early pregnancy. [ncbi.nlm.nih.gov]

The baby presented the malformation of the head consisting of single orbital cavity in the midline containing one eyeball with two fused corneas and one pupil, no nose nor oral cavity, but synotia. [jpatholtm.org]

The upper and lower lip were present but small. The upper jaw was short due to the absence of the os incisivum and the deformity of the maxilla. A well marked malformed was present. [scopemed.org]

• Developmental Disorder

  Cyclopia and milder forms of the same developmental disorder result from holoprosencephaly which is a failure of the embryonic forebrain to subdivide properly. [medicinenet.com]

• Cough

  The Khoisan of the South African Cape were also using the tea for treatment of coughs and other upper respiratory symptoms associated with infections. [itmonline.org]

• Vomiting

  Mostly in pregnancy when women start vomiting they take hellebore plant but in some cases they mix it up with a plant Veratrum californicum that have deoxyjervine which causes cyclopia Another reason of Cyclopia is associated to alcoholism and diabetes [howshealth.com]

  Hellebore is an herb used to treat vomiting and cramps, two common symptoms of pregnancy. Another cause of Cyclopia is directly related to alcoholism and diabetes. In alcoholic and diabetic mothers, the toxins can build up in the body quickly. [babymed.com]

  The mistake of humans ingesting Veratrum californicum while pregnant is often due to hellebore, an unrelated plant with the same name, being recommended as a "natural" treatment for vomiting, cramps, and poor circulation, three conditions which may be [en.wikipedia.org]

  The mistake of ingesting Veratrum californicum while pregnant is often due to the fact that hellebore, a plant with which it is easily confused, is recommended as a natural treatment for vomiting, cramps, and poor circulation, three conditions that are [ispub.com]

• Failure to Thrive

  Lissencephaly is further characterized by microcephaly (reduced head size) and by symptoms such as muscle spasms, seizures, abnormal facial expressions, failure to thrive, and deformation of the hands, fingers, or toes. [britannica.com]

  […] to thrive, feeding issues, and gastroesophageal reflux. [emedicine.medscape.com]

• Osteoporosis

  Active Constituents of Honey Bush Tea: ISOFLAVONES AND COUMESTANS These show estrogenic activity and are advantageous for: Regulation of the menstrual cycle Prevention of breast, prostrate and uterus cancer Reducing risk of osteoporosis These also show [web.archive.org]

  Anabolic effect of estrogen replacement on bone in postmenopausal women with osteoporosis: histomorphometric evidence in a longitudinal study. J. Clin. Endocrinol. Metab. 86, 289-295. [ Links ] 31. Mendelsohn M.E. and Karas R.H. (1999). [scielo.org.za]

• Dry Eyes

  They had a single large round eye in the center of the forehead. The word "cyclops" itself comes from the Greek "kyklos" (circle) + "ops" (eye). Cyclopia is also called synophthalmia. QUESTION What causes dry eyes? See Answer [medicinenet.com]

They may have neurodevelopmental issues. [11, 12, 13, 14, 15] Workup Prenatal diagnosis options include karyotype analysis, microarray testing, ultrasonography, and magnetic resonance imaging (MRI). [emedicine.medscape.com]

Virology: Research and Treatment about the journal submit your research Indexing: DOAJ, EBSCO, PubMed Central (PMC) and more. [insights.sagepub.com]

Traditional medicinal uses of Athrixia phylicoides DC., or bush tea, another indigenous South African plant with very limited localised use as herbal tea, include treatment of boils, acne, infected wounds and infected throats. [ncbi.nlm.nih.gov]

Treatments for Cycolpia is to avoid prohibited medicines during pregnancy. Quit the intake of alochol or any other toxic thing. Just avoid prohibited medicines!! There are a lot of visible deformities associated with Cyclopia. [briannafetters.weebly.com]

Three dormancy-breaking treatments (wet heat, dry heat and microwave energy) were identified as potential alternatives to conventional sulphuric acid scarification. [pubag.nal.usda.gov]

The prognosis with colpocephaly is directly correlated with the degree of abnormality. Holoprosencephaly Holoprosencephaly results from the failed development of the prosencephalon (forebrain) in the embryo. [britannica.com]

[…] cases, when the prosencephalon fails to cleave sagittally into cerebral hemispheres or transversely into telencephalon and diencephalon or horizontally into the optic and olfactory bulbs, the neural tube vesicles remain holistic as alobar HPE with grave prognosis [neurologyindia.com]

The prognosis of holoprosencephaly depends on the severity of the malformation. [emedicine.medscape.com]

The polluting landfill remains as a possible etiological factor. 2008 Wiley-Liss, Inc. [ncbi.nlm.nih.gov]

Conjoined twins (CT) are a very rare developmental accident of uncertain etiology. Prevalence has been previously estimated to be 1 in 50,000 to 1 in 100,000 births. [stacks.cdc.gov]

Epidemiologic data on phocomelia are scarce. This study presents an epidemiologic analysis of the largest series of phocomelia cases known to date. [stacks.cdc.gov]

Epidemiology Unit. IFC-CNR. Pisa, Italy. Texas Department of State Health Services. Birth Defects Epidemiology and Surveillance Branch. Texas, USA. University of Padua. Clinical Genetics Unit. Department of Pediatrics. Padua, Italy. [arca.fiocruz.br]

In a large epidemiologic study, Croen et al found the prevalence of holoprosencephaly to be 1.2 per 10,000 live births and fetal deaths. [appliedradiology.com]

The anomalies are organized by anatomical system and presented in a consistent manner, including details of the clinical presentation, epidemiology, embryology, treatment and prevention for each anomaly. [books.google.com]

Pathophysiology A combination of genetic and environmental factors is thought to be responsible for the pathogenesis of holoprosencephaly. [emedicine.medscape.com]

The indirect removal of UVB damaged keratinocytes by herbal tea extracts via apoptosis may find application in the prevention of photo-induced inflammation. [mdpi.com]

The anomalies are organized by anatomical system and presented in a consistent manner, including details of the clinical presentation, epidemiology, embryology, treatment and prevention for each anomaly. [books.google.com]

Cyclopia results when these toxins prevent the brain from developing properly. La ciclopia compare quando queste tossine impediscono al cervello di svilupparsi adeguatamente. [it.glosbe.com]