Presents comprehensive coverage of valvular heart disease to provide you with a complete reference and one-stop shop for this specialty in cardiac medicine. [books.google.com]

The presence of a diastolic murmur at initial presentation was associated with a poor prognosis (p = 0.03).(ABSTRACT TRUNCATED AT 250 WORDS). [ncbi.nlm.nih.gov]

Most of these patients present with aortic regurgitation and on investigation aneurysm is detected. Owing to its rarity and disguised presentation it is important to be aware of this entity. [heartindia.net]

Risk of rupture esp when >5cm Triad of presentation: Hypotension Pulsatile abdo mass - blood flying out! Flank pain - blood is irritant also back pain [alancam.com]

Familial predisposition to thoracic aortic aneurysms and type A dissections (concerning the ascending aorta and/or the aortic arch) has been demonstrated in around 19% of patients presenting with thoracic aortic dissections and several loci have been [orpha.net]

• Swelling

  Any swelling or tumefaction. 2. SYN: neoplasm. 3. One of the four signs of inflammation (t., calor, dolor, rubor) enunciated by Celsus. [L. t., a swelling] acinar cell t. a … Medical dictionary [medicine.academic.ru]

  […] extremity occlusive dz 3. substernal back or neck pain, dyspnea, stridor, and cough; dysphagia; hoarseness; or symptoms of superior vena cava syndrome stridor = wheezing or crowing during breathing dysphagia = difficulty swallowing SVCS = lung cancer/ swelling [brainscape.com]

  Review Topic QID: 100577 1 Focal granulomatous inflammation with mural lymphocytes, macrophages, giant cells 3 Predominant neutrophilic infiltration with fibrinoid necrosis 4 Fibrinoid necrosis of blood vessel walls, endothelial swelling, and neutrophilic [medbullets.com]

  However, depending on the size, growth rate, and location of these abnormalities, they can cause pain in the jaw, neck, chest, or back; swelling in the arms, neck, or head; difficult or painful swallowing; hoarseness; shortness of breath; wheezing; a [icdlist.com]

• Pallor

  Aortic dissections usually cause severe, sudden chest or back pain, and may also result in unusually pale skin (pallor), a very faint pulse, numbness or tingling (paresthesias) in one or more limbs, or paralysis.Familial TAAD may not be associated with [icdlist.com]

• Short Stature

  The primary manifestations of TS are short stature, webbed-neck and infertility. [uscapknowledgehub.org]

• Dyspnea

  […] most are asymptomatic 1. but if symptomatic = pulsating abdominal mass, sometimes accompanied by abdominal or back pain 2. renal or lower extremity occlusive dz 3. substernal back or neck pain, dyspnea, stridor, and cough; dysphagia; hoarseness; or symptoms [brainscape.com]

• Chest Pain

  The proband (II-1) was thought to be in good health until she developed chest pain at age 56 and died of a dissecting aneurysm of the ascending aorta that ruptured into the pericardial space. [nature.com]

  Flank pain - blood is irritant also back pain [alancam.com]

  Case report A previously healthy 42-year-old man presented to our hospital with the complaints of severe chest pain. [heartindia.net]

  pain o Murmur or bruit of aortic regurgitation o Previously hypertensive, now possible shock o Asymmetric peripheral pulses o Pulmonary edema · Imaging Findings o Chest films § Mediastinal widening § Left paraspinal stripe § Displacement of intimal calcifications [learningradiology.com]

  The American College of Cardiology recently recognized Leesburg Regional Medical Center and The Villages ® Regional Hospital for their demonstrated expertise and commitment in treating patients with chest pain by awarding the Chest Pain Center Accreditation [centralfloridahealth.org]

• Vascular Disease

  See also Vascular disease. Aortic dissection. References [librepathology.org]

  […] of the Aorta 1473 Noninvasive Assessment of Peripheral Vascular Disease 1496 Cerebrovascular Disease 1511 Disease of Peripheral Vessels 1531 Renal Artery Disease 1549 Venous Thromboembolism 1569 Index 1585 Genetic Factors in Atherosclerosis 1589 Gene [books.google.com]

  The vascular disease in these patients is particularly aggressive, with a mean age of death of 26 years. [nap.edu]

  Ehlers-Danlos syndrome type IV (vascular type) is caused by defects in type III procollagen (COL3A1). This condition causes vascular fragility with aneurysm formation, rupture, and dissections. [emedicine.medscape.com]

Workup demonstrated marked dilatation of the ascending and descending aorta. This low-magnification view of the ascending aorta stained with Movat pentachrome stain shows necrotizing aortitis involving mainly the media. [emedicine.medscape.com]

• Mural Thrombus

  The walls may be thin or thickened by the presence of a mural thrombus (circumferential or more frequently eccentric). Calcified atherosclerotic disease is often identified not only in the wall of an aneurysm but adjacent arteries. [radiopaedia.org]

• Dyslipidemia

  Patients with TA aneurysms should have a long-term medical treatment regimen designed to achieve stringent control of cardiovascular risk factors such as hypertension, dyslipidemia, and tobacco exposure. [nap.edu]

Abstract Percutaneous transluminal angioplasty has been shown to be both feasible and efficacious for the treatment of aortic coarctation. [ncbi.nlm.nih.gov]

الصفحة 24 - Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). ‏ الصفحة 134 - Sacks FM, Pfeffer MA, Moye LA et al. [books.google.com]

TREATMENT The treatment for aortic aneurysms may involve surgical or endovascular repair of the weakened arterial wall. Endovascular aneurysm repair (EVAR) now accounts for 56 percent of repairs in patients with AAA. [nap.edu]

Treatment options include: open repair elephant graft repair endovascular repair In general, when possible, endovascular repair is the treatment of choice, with reduced morbidity and mortality 2. [radiopaedia.org]

It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice . [uniprot.org]

The presence of a diastolic murmur at initial presentation was associated with a poor prognosis (p = 0.03).(ABSTRACT TRUNCATED AT 250 WORDS). [ncbi.nlm.nih.gov]

The presence of a diastolic murmur at initial presentation was associated with a poor prognosis (p = 0.03). [onlinejacc.org]

Type A Dissecting aneurysm Involves the descending aorta - more distal thus less dangerous and has a better prognosis. [quizlet.com]

The average growth of a thoracic aneurysm appears to be lower than that of abdominal aneurysms, typically in the order of 1-2 mm/year and correlates with a better prognosis for thoracic aneurysms when controlled for size 3. [radiopaedia.org]

By providing an atlas style review of ischemic and non-ischemic etiologies of sudden cardiac death, this book opens a window to see the underlying pathology first hand. [books.google.com]

However, a few reasons suggested are that there is difference in composition between the ascending and descending aorta, which is responsible for difference in the etiology of aneurysms that develop in these areas. [heartindia.net]

The aim of the present article is to provide a comprehensive overview of the CMN lesion in terms of pathologic features, clinical implications and etiologies based on molecular research results. [ncbi.nlm.nih.gov]

Common etiologies for dissection are HTN, cystic medial necrosis as with Marfan's syndrome, jet lesions from valve defects, medial necrosis from thrombosis of the vasa vasorum, and other connective tissue disorders affecting the media of the aorta. [med.illinois.edu]

The relationship between the extent of cystic medial necrosis and the etiology of TAA has been extensive studied. [emedicine.medscape.com]

Genetics Genetic variants include ACTA2 as well as: Associated Conditions There is an association between cystic medial necrosis and the following disorders: Marfan syndrome Ehlers-Danlos syndrome Annuloaortic ectasia Acromegaly [4] Epidemiology and Demographics [wikidoc.org]

[…] aorta Type IIIa: involves descending thoracic aorta from left subclavian artery to celiac artery Type IIIb: involves descending thoracic aorta from left subclavian and tracts distal to celiac artery Synonym(s): dissecting aneurysm; dissecting hematoma Epidemiology [unboundmedicine.com]

Epidemiologic studies have pointed to an autosomal dominant inheritance, but no specific genetic aberration has been identified to date. [27] Marfan syndrome has been extensive studied clinically and genetically. [emedicine.medscape.com]

EPIDEMIOLOGY, NATURAL HISTORY, AND TYPES OF AORTIC ANEURYSMS Abdominal aortic aneurysms (AAAs), involving the infradiaphragmatic abdominal area, are the most common type of aneurysms. [nap.edu]

1243 Percutaneous Coronary Intervention 1258 Percutaneous Cardiac Procedures 1273 Coronary Artery Bypass Surgery 1290 Approaches to the Patient with Prior Bypass Surgery 1306 Percutaneous Valve Dilatations 1316 Global Pandemic of Heart Failure 1330 Pathophysiology [books.google.com]

[…] unknown due to undiagnosed/misdiagnosed cases resulting in sudden death without subsequent autopsy Prevalence United States: 6,000 to 10,000 cases annually Present in 3 out of every 1,000 patients presenting to ED with chest and/or back pain Etiology and Pathophysiology [unboundmedicine.com]

Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. ‏ [books.google.com]

Marfan’s Ehlers-Danlos Usually surgically* DeBakey Type III (most common) Stanford Type B Descending aorta only Hypertension Atherosclerosis Usually medically *Goal is to prevent backward involvement of the aortic valve or rupture into pericardium · Clinical [learningradiology.com]

[…] arteritis, giant cell arteritis, Behçet arteritis Other: polycystic kidney disease, pregnancy Recreational drug use: tobacco use, cocaine, methamphetamine Trauma (catheters, motor vehicle accidents, vascular surgery, intra-aortic balloon pump) General Prevention [unboundmedicine.com]

It is currently accepted that the aneurysms are not due to flow-related disturbances secondary to valvar insufficiency or stenosis; for this reason, wrapping of the aorta to prevent progressive dilatation after valve repair is often advocated. [14] Patients [emedicine.medscape.com]

Failure to prevent progressive dilation of ascending aorta by aortic valve replacement in patients with bicuspid aortic valve: comparison with tricuspid aortic valve. Circulation 2003;108:II291-4. Russo CF, Mazzetti S, Garatti A, et al. [annalscts.com]