Presentation
The water consumed by the patient presented high contamination levels (MLN/100 mL >16). [scielo.br]
Case presentation We present a case of delayed diagnosis of Cystoisospora belli (C. belli) in an immunocompetent 28-year-old refugee from Myanmar. [bmcinfectdis.biomedcentral.com]
The present report adds chronic alcoholism as another risk factor for development of clinical isosporiasis. Our patient presented with chronic enteritis with recurrent diarrhea and severe weight loss. [parasitol.kr]
Infection in immunocompetent may go unnoticed or be present with cervical lymphadenopathy. In immunocompromised patients, the location varies depending on the activation, and it can cause encephalitis, pneumonitis and mainly chorioretinitis. [medicineonline.es]
Abstract A review article discussing the taxonomy, parasite life cycle and laboratory diagnosis of Isospora belli is presented. [pubmed.ncbi.nlm.nih.gov]
Gastrointestinal
- Abdominal Pain
Other symptoms can include abdominal pain, cramps, loss of appetite, nausea, vomiting, and fever. If untreated, people with weak immune systems, such as people with AIDS, may be at higher risk for severe or prolonged illness. [cdc.gov]
Two days later, complete blood count showed a high eosinophilia (3,910 eosinophils per mm3, 39.9% of the total WBC), without fever or exacerbation of abdominal pain. [parasitol.kr]
Affected people also can have crampy abdominal pain, flatulence, nausea, vomiting, anorexia, and low-grade fever. [clinicalinfo.hiv.gov]
Abdominal pain and diarrhea continued despite TMP-SMZ; nausea and vomiting did not improve significantly. [hindawi.com]
Neurologic
- Headache
In immunocompetent patients, I. belli infection is frequently asymptomatic, but can cause acute or chronic enteritis with variable clinical symptoms, including diarrhea, steatorrhea, headache, fever, malaise, abdominal pain, vomiting, dehydration, and [parasitol.kr]
CLINICAL MANIFESTATIONS Symptoms of I. belli infection include diarrhea, steatorrhea, headache, fever, malaise, abdominal pain, vomiting, dehydration, and weight loss (6, 22,37). Blood is not usually present in the feces. [antimicrobe.org]
Workup
(See Workup.) Cystoisosporiasis is an AIDS-defining illness, so an appropriate workup for HIV infection should be performed, if necessary. Also see Common Intestinal Parasites, a Critical Images slideshow, to help make an accurate diagnosis. [emedicine.medscape.com]
Tests for HTLV-1 and 2 antibody must be part of the routine workup, especially in individuals living in developed countries as it can cause immunocompromise similar to HIV. [hindawi.com]
Treatment
Treatment Recommendations Treating Disease TMP-SMX is the recommended treatment for isosporiasis. [clinicalinfo.hiv.gov]
Although unresponsive to many treatments, the diarrhea and infection resolved promptly with treatment with co-trimoxazole. [acpjournals.org]
Anti-I. belli treatment is usually effective in controlling symptoms, but recurrences are common after treatment is stopped. [antimicrobe.org]
The choice treatment of these parasites is electrolyte replacement and drugs (cotrimoxazole for isosporiasis and cyclosporiasis, nitazoxamida in cryptosporidiosis). Microsporidio treatment depends of the species. [medicineonline.es]
Prognosis
Prognosis Prognosis is excellent with therapy (and prophylaxis, if appropriate). In immunocompetent patients, cystoisosporiasis is usually a transient, self-limited illness but can sometimes result in a protracted diarrheal illness. [emedicine.medscape.com]
Isosporiasis Microchapters Home Patient Information Overview Historical Perspective Pathophysiology Causes Differentiating Isosporiasis from other Diseases Epidemiology and Demographics Risk Factors Natural History, Complications and Prognosis Diagnosis [wikidoc.org]
Etiology
Etiology The causative pathogen of cystoisosporiasis is C belli, a protozoan that belongs to the subclass Coccidia in the phylum Apicomplexa. [emedicine.medscape.com]
It was first linked with human disease in 1915 and is believed to infect only humans.1 Isosporiasis, also known as cystoisosporiasis, occurs worldwide but is more prevalent in tropical and subtropical regions; it has been reported as an etiologic agent [clinicalinfo.hiv.gov]
Epidemiology
Epidemiology United States statistics The exact incidence of cystoisosporiasis in humans is unknown. [emedicine.medscape.com]
The pathology, epidemiology, clinical findings and therapy of human intestinal infection with Isospora belli are also addressed. Similar articles [Isosporiasis (Isospora belli)]. Kamiya H. Kamiya H. [pubmed.ncbi.nlm.nih.gov]
Molecular testing for clinical diagnosis and epidemiological investigations of intestinal parasitic infections. Clin Microbiol Rev. 2014;27(2):371–418. Article PubMed PubMed Central Google Scholar Ryan UM, Bath C, Robertson I, et al. [bmcinfectdis.biomedcentral.com]
Epidemiology of isosporiasis among persons with acquired immunodeficiency syndrome in Los Angeles County. Am J Trop Med Hyg 1995;53:656-659. [PubMed] 37. Trier JS, Moxey PC, Schimmel EM, Robles E. [antimicrobe.org]
Isosporiasis Microchapters Home Patient Information Overview Historical Perspective Pathophysiology Causes Differentiating Isosporiasis from other Diseases Epidemiology and Demographics Risk Factors Natural History, Complications and Prognosis Diagnosis [wikidoc.org]
Pathophysiology
The pathophysiology of I. belli-induced diarrhea is unknown. Laboratory diagnosis is readily performed with the examination of unstained and stained stool specimens particularly by the modified Ziehl-Nielsen method. [pubmed.ncbi.nlm.nih.gov]
Pathophysiology C belli is ingested in contaminated food or water, and its life cycle requires a stage outside the host. [emedicine.medscape.com]
Isosporiasis Microchapters Home Patient Information Overview Historical Perspective Pathophysiology Causes Differentiating Isosporiasis from other Diseases Epidemiology and Demographics Risk Factors Natural History, Complications and Prognosis Diagnosis [wikidoc.org]
Prevention
Polymerase chain reaction is a promising diagnostic tool but is not yet commercially available in the United States.13 Prevention Recommendations Preventing Exposure Avoiding food or water that might be contaminated with stool may help prevent infection [clinicalinfo.hiv.gov]
How can Cystoisospora infection be prevented? Avoiding food or water that might be contaminated with stool may help prevent infection. As always, good handwashing and personal-hygiene practices should be followed. [cdc.gov]
Guidelines for the prevention and treatment of opportunistic infections in HIV-exposed and HIV-infected children: recommendations from the National Institutes of Health, Centers for Disease Control and Prevention, the HIV Medicine Association of the Infectious [pubmed.ncbi.nlm.nih.gov]
Transmission and Prevention This parasite is transmitted by ingesting food or water that has been contaminated with feces from someone who is infected. [wikidoc.org]