Time from DMEK to presentation ranged from 5 to 15 weeks. Presenting features included corneal edema, pigmented keratic precipitates, mild anterior chamber inflammation, and raised intraocular pressure. [ncbi.nlm.nih.gov]

Special techniques help to confirm the presence of multiple organisms, especially if more than one virus is present. [histopathology-india.net]

• Splenomegaly

  Children born with congenital CMV infection may present with hepatomegaly, splenomegaly, jaundice, pneumonitis, fetal growth retardation, petechiae, purpura, and thrombocytopenia. [orpha.net]

  Hemophagocytic lymphohistiocytosis was diagnosed because our patient had elevated levels of serum ferritin, bicytopenia, splenomegaly, fever (> 38.5 °C), and hemophagocytosis shown in a bone marrow sample. [ncbi.nlm.nih.gov]

  In 95% of cases this occurs without symptoms, but some neonates may present jaundice, hepato-splenomegaly and retarded psycho-motorial development. [diesse.it]

  CMV may also produce a mononucleosis syndrome similar to Epstein-Barr virus (causing a febrile illness with splenomegaly, impaired liver function and abnormal lymphocytes in the blood) but without characteristic pharyngitis and lymphadenopathy. [patient.info]

• Generalized Lymphadenopathy

  When clinical manifestations are present, they include: malaise, fever, generalized lymphadenopathy, and hepatosplenomegaly. [perinatology.com]

  Fatigue and malaise may persist for 4 weeks or longer. 12 Physical examination shows cervical or generalized lymphadenopathy. Rarely, hepatomegaly, splenomegaly, or rash may develop. Jaundice is uncommon. [glowm.com]

• Cervical Lymphadenopathy

  Cervical lymphadenopathy is less commonly seen in heterophile-negative mononucleosis.The results of liver function tests are abnormal. [atsu.edu]

  EBV Mononucleosis syndrome associated with CMV infection differs from that caused by EBV. 13% – 17% patients with CMV-mononucleosis present with cervical lymphadenopathy, vs. 80% with EBV-associated mononucleosis. [pedclerk.bsd.uchicago.edu]

• Fever

  Hematochezia was more common in IBD patients (84.0% vs. 35.1%; p = .001), but fever and positive CMV antigenemia were more common in non-IBD patients (50.9% vs. 12.0%; p = .001; 54.4% vs. 28.0; p = .027). [ncbi.nlm.nih.gov]

  Both CMV and EBV mononucleosis cause fever and fatigue. But EBV also causes a severe sore throat. CMV does not. [msdmanuals.com]

  Symptoms may include: Fever Headache Fatigue Muscle aches Enlarged glands Sore throat Enlarged spleen. [southerncross.co.nz]

• Infectious Mononucleosis

  These cells are seen in viral infections, most commonly caused by the Epstein-Barr virus (infectious mononucleosis), cytomegalovirus diseases, and occasionally infectious hepatitis. This is an example of a type I Downy cell. [mountsinai.org]

  This study aimed to evaluate the cause of EBV and CMV IgM dual positivity to determine whether it represents a false-positive finding or a true coinfection.A total of 494 children diagnosed with primary EBV infection, manifesting as infectious mononucleosis [ncbi.nlm.nih.gov]

  Those who develop symptoms may experience an illness resembling infectious mononucleosis and have fever, swollen glands and feel tired. [www1.nyc.gov]

  Infection with CMV, like that with Epstein-Barr virus (EBV, a type 4 herpesvirus), can cause a type of infectious mononucleosis in adolescents and young adults. Both CMV and EBV mononucleosis cause fever and fatigue. [msdmanuals.com]

• Malaise

  These may include: Enlarged lymph nodes, especially in the neck Fever Fatigue Loss of appetite Malaise Muscle aches Rash Sore throat CMV can cause infections in different parts of the body. Symptoms vary depending on the area that is affected. [nlm.nih.gov]

  The major symptoms of the disease in organ transplant recipients include fever, myalgia, malaise, arthralgia, leucopenia, thrombocytopenia, and hepatitis. [canada.ca]

  Primary CMV infection in immunocompetent individuals may also manifest as a mononucleosis-type syndrome, similar to primary Epstein-Barr virus infection, with fever, malaise and lymphadenopathy. [mayomedicallaboratories.com]

• Fever of Unknown Origin

  […] of unknown origin who was referred to a tertiary hospital.19 Her liver enzyme levels were elevated, and an abdominal CT scan was consistent with acute hepatitis. [mja.com.au]

  Symptomatic CMV disease can affect almost every organ of the body, resulting in fever of unknown origin, pneumonia, hepatitis, encephalitis, myelitis, colitis, uveitis, retinitis, and neuropathy. [emedicine.medscape.com]

• Nausea

  We describe a 88-year-old male presenting with a week-long history of intractable abdominal discomfort, bloating, nausea and diarrhea. Flexible sigmoidoscopy revealed significant ulceration with yellowish slough. [ncbi.nlm.nih.gov]

  Gastrointestinal symptoms include nausea and epigastric pain when the infection is in the stomach or duodenum, and severe diarrhea and cramps when it is located in the lower gastrointestinal tract. [hematologyandoncology.net]

  Symptoms include sore throat, swollen glands, swollen tonsils, tiredness, and nausea. It can cause liver inflammation, or hepatitis, and spleen enlargement. CMV mononucleosis is similar to classic mononucleosis, caused by the Epstein-Barr Virus. [medicalnewstoday.com]

• Vomiting

  A 56-year-old man was admitted to the hospital reporting 5 months of progressive ascending lower extremity weakness and numbness, inability to walk, bowel incontinence,urinary retention and several episodes of nausea and vomiting. [ncbi.nlm.nih.gov]

  Symptoms can include painful and difficult swallowing, nausea, vomiting, abdominal pain, yellow skin and watery or bloody diarrhea. [drugs.com]

  She had suffered from vomiting and diarrhea for the last two weeks. [scielo.isciii.es]

• Periodontitis

  KEYWORDS: HCMV; cytomegalovirus; herpes; keratinocyte; lytic; oral; pentamer; periodontal [ncbi.nlm.nih.gov]

• Hepatomegaly

  On examination, the neonate was found to have respiratory distress, an extensive rash (Panel A), and hepatomegaly. [doi.org]

  Babies who are infected with CMV before birth are at higher risk of several defects such as microcephaly (small head size), hepatomegaly (enlarged liver), jaundice (yellow color of skin and eyes), anemia (low blood count), pneumonia, seizures, vision [birthdefects.org]

  Children born with congenital CMV infection may present with hepatomegaly, splenomegaly, jaundice, pneumonitis, fetal growth retardation, petechiae, purpura, and thrombocytopenia. [orpha.net]

  Olgunun fizik muayenesinde dismorfik yüz görünümü ve 3 cm hepatomegali tespit edildi. [sislietfaltip.org]

• Cutaneous Manifestation

  Introduction Cutaneous T-cell lymphomas (CTCLs) are clonal T-cell malignancies with primary cutaneous manifestations. [doi.org]

• Guillain-Barré Syndrome

  Rare complications include: Colitis Guillain-Barré syndrome Nervous system (neurologic) complications Pericarditis or myocarditis Pneumonia Rupture of the spleen Inflammation of liver (hepatitis) When to Contact a Medical Professional Call for an appointment [ufhealth.org]

  Cytomegalovirus Infection in a Normal Person Common Less common Rare Asymptomatic* Exudative pharyngitis Icteric hepatitis Mononucleosis syndrome Splenomegaly Guillain-Barré syndrome Fever Cervical adenopathy Encephalitis Malaise Nonspecific rash Myocarditis [aafp.org]

  Complications of infection are uncommon in immunocompetent hosts but include: Guillain-Barré syndrome. Meningoencephalitis. Pericarditis. Myocarditis. Thrombocytopenia. Haemolytic anaemia. [patient.info]

  Rarer manifestations of CMV infections in immunocompetent individuals include Guillain-Barré syndrome, meningoencephalitis, pericarditis, myocarditis, thrombocytopenia, and hemolytic anemia. [emedicine.medscape.com]

A negative pulmonary workup led to an endomyocardial biopsy and the diagnosis of cytomegalovirus (CMV) myocarditis. The patient was treated with ganciclovir and intravenous immunoglobulin. [ncbi.nlm.nih.gov]

"Cytomegalovirus (CMV) Workup." Medscape.com. May 5, 2018. <http://emedicine.medscape.com/article/215702-workup>. Azevedo, L.S., et al. "Cytomegalovirus infection in transplant recipients." [medicinenet.com]

The infectious disease team was consulted, and a thorough workup was completed. JD tested negative for syphilis, influenza, Epstein-Barr virus, herpes simplex virus, and Lyme disease. [journals.lww.com]

• Anergy

  PD-1 expression and IL-2 loss of cytomegalovirus- specific T cells correlates with viremia and reversible functional anergy. Am J Transplant, 8 (2008), pp. 1486-1497 [6.] A.A. Rahman, M. Teschner, K.K. Sethi, H. Brandis. [elsevier.es]

  PD-1 expression and IL-2 loss of cytomegalovirus- specific T cells correlates with viremia and reversible functional anergy. Am. J. [frontiersin.org]

• Colitis

  CONCLUSIONS: In active CMV colitis, the specificity and negative predictive value of blood PCR are high, while the sensitivity grows with the intensity of colon infection. [ncbi.nlm.nih.gov]

  PubMed Search: CMV colitis[TI] OR cytomegalovirus colitis[TI] colon Advertisement Page views in 2018: 8,804 Page views in 2019 to date: 1,926 Cite this page: Bansal N. Cytomegalovirus (CMV) colitis. [pathologyoutlines.com]

  The patient was treated with mesalamine for suspected ulcerative colitis, with minimal effect. A positive faecal occult blood test result raised the suspicion of ischaemic colitis. [mja.com.au]

  Clinical Characteristics of CMV Colitis in the Immunocompetent Host Klauber et al. [39] reported 15 immunocompetent adults with CMV colitis. [karger.com]

• Viral Inclusion Body

  Histological examination of the gallbladder wall was positive for multiple viral inclusion bodies. [ncbi.nlm.nih.gov]

  The pathologic hallmark of CMV infection is an enlarged cell with viral inclusion bodies. Cells that exhibit cytomegaly are also seen in infections caused by other Betaherpesvirinae. [emedicine.medscape.com]

Despite a subsequent isolated episode of right heart thrombosis that resolved with heparin treatment, the patient showed a favourable response to eculizumab (300 mg/15 days), with improved renal function, normal haematological values, and no treatment [ncbi.nlm.nih.gov]

The syndrome mainly affects children and young adults; the prognosis is favorable with complete or nearly complete neurological and radiological resolution within days or weeks. [ncbi.nlm.nih.gov]

HCMV and tumor-infiltrating T cells Using immunohistochemical staining, quantitative PCR, and large-scale flowcytometry, recent studies have demonstrated the critical role of localized adaptive immune reaction in the prognosis of cancer behavior and prognosis [doi.org]

Etiology and causality of HCMV infection with IBC now needs to be rigorously examined. [ncbi.nlm.nih.gov]

Further investigation of CMV as an etiologic agent for ALL is warranted. Submitted July 5, 2016. Accepted September 17, 2016. Copyright © 2016 American Society of Hematology [bloodjournal.org]

Abstract Purpose: Recent epidemiological data indicate that a history of increased exposure to sexually transmitted diseases is associated with an increased risk of prostate cancer. [doi.org]

1 Department of Pediatrics, University of Alberta, Edmonton, AB, Canada. 2 DynaLife Medical Labs, Edmonton, AB, Canada. 3 Department of Medicine, University of Alberta, Edmonton, AB, Canada. 4 Canadian Blood Services, Ottawa, ON, Canada. 5 School of Epidemiology [ncbi.nlm.nih.gov]

The exact pathophysiology is unknown; however, infectious-related MERS (in particular virus associated MERS) remains the most common cause of reversible splenial lesions in childhood. [ncbi.nlm.nih.gov]

Useful For Suggests clinical disorders or settings where the test may be helpful Aiding in the diagnosis of acute or past infection with cytomegalovirus (CMV) Determination of prior exposure to CMV Clinical Information Discusses physiology, pathophysiology [mayomedicallaboratories.com]

[…] can be acquired during birth, breast feeding, close contact, sexual contact, transfusion or with organ transplant ( Scand J Gastroenterol 2010;45:1295 ) Sites Most common sites of CMV related gastrointestinal involvement are the esophagus and colon Pathophysiology [pathologyoutlines.com]

Although available anti-CMV therapies may be effective for the prevention of CMV, they are plagued by unacceptable toxicities that prohibit their use in the post-transplant period. [ncbi.nlm.nih.gov]

Scientists are working on CMV vaccines and are looking for other ways to prevent congenital CMV infection. [sites.google.com]