CONCLUSIONS: CMV colitis in immunocompetent patients presented in older patients and in those with other comorbidities. Gastrointestinal bleeding was the most common initial presentation. [ncbi.nlm.nih.gov]

• Recurrent Bacterial Infection

  Although there was amelioration of the colitis and clinical status after treatment with ganciclovir, the patient later deteriorated and died due to recurrent bacterial infections. [ncbi.nlm.nih.gov]

• Diarrhea

  An 84-year-old male presented with chronic diarrhea and CMV colitis; he had been experiencing protracted diarrhea since 2006. In October 2009 he failed a 21-day course of valgancyclovir 900 mg orally twice daily. [ncbi.nlm.nih.gov]

• Chronic Diarrhea

  Other pathogens should be considered in patients with chronic diarrhea who are refractory to initial treatments. [ncbi.nlm.nih.gov]

  The infectious disease team was consulted and it was determined that in the context of the patient's HIV infection, AIDS and resultant immunosuppression, CMV infection was contributing to chronic diarrhea, abdominal pain, and formation of a colovesical [cureus.com]

  Diagnostic Accuracy of Fecal Calprotectin Assay in Distinguishing Organic Causes of Chronic Diarrhea from Irritable Bowel Syndrome: A Prospective Study in Adults and Children. Clinical Chemistry 49:6 861–867. Available online at . Accessed Sep 2012. [labtestsonline.it]

  Investigation of chronic diarrhea in acquired immunodeficiency syndrome: a prospective study of 155 patients. Gut. 1996;39:824-32. [ Links ] 9. Chalasani N, Wilcox CM. Etiology and outcome of lower gastrointestinal bleeding in patients with AIDS. [scielo.br]

• Chronic Watery Diarrhea

  Chronic watery diarrhea was present in all the patients with colitis but was also present in 65% of the patients without colitis. [link.springer.com]

• Hyperactive Bowel Sounds

  Physical exam revealed a cachectic male with hyperactive bowel sounds without any abdominal tenderness or organomegaly. [acgcasereports.gi.org]

• Rectal Mass

  We report a case in which a previously healthy man presented with hematochezia and an obstructing rectal mass thought to be rectal adenocarcinoma. [acgcasereports.gi.org]

• Hyperactivity

  Physical exam revealed a cachectic male with hyperactive bowel sounds without any abdominal tenderness or organomegaly. [acgcasereports.gi.org]

Workup for Clostridium difficile and all enteric pathogens were negative. The patient remained febrile with abdominal pain. [ncbi.nlm.nih.gov]

Coverage begins with the patient's first visit and proceeds through the diagnostic workup: endoscopy, radiologic testing, and instruments for rating and classifying inflammatory bowel disease. [books.google.de]

Workup revealed intussusception with associated pneumatosis. A right hemicolectomy was performed. Pathologic examination revealed cytomegalovirus (CMV) colitis. [austinpublishinggroup.com]

"Cytomegalovirus (CMV) Workup." Medscape.com. Dec. 1, 2017.. Azevedo, L.S., et al. "Cytomegalovirus infection in transplant recipients." Clinics (Sao Paulo) 70.7 July 2015: 515-23. doi: 10.6061/clinics/2015(07)09. Epub 2015 Jul 1. Review. [medicinenet.com]

• Pneumoperitoneum

  […] attempt at air contrast reduction in an immunosuppressed patient with such extensive pneumatosis was contraindicated and operative intervention was planned immediately A computed tomography (CT) scan of the abdomen and pelvis was performed to evaluate for pneumoperitoneum [austinpublishinggroup.com]

  Abdominal CT showed a pneumoperitoneum, indicating perforation of the colon ( figure 1 A ), and the patient underwent emergency subtotal colectomy. [academic.oup.com]

• Microcytic Anemia

  Blood investigations showed normal white cell count (5400/μL) with normal differential, microcytic anemia with hemoglobin 10 g/dL, and hypoalbuminemia with otherwise normal liver enzymes. [acgcasereports.gi.org]

• Staphylococcus Aureus

  CASE PRESENTATION: We are presenting a 72-year-old African-American male transferred to our intensive care unit (ICU) with methicillin-resistant Staphylococcus aureus bacteremia, respiratory failure, and dialysis-dependent acute kidney injury. [ncbi.nlm.nih.gov]

• Colitis

  Our experience suggests that biopsies may be necessary to detect CMV and the prompt management of CMV colitis should be instituted when intractable ischemic colitis is observed. [ncbi.nlm.nih.gov]

• Viral Inclusion Body

  Light microscopy of selected viral diseases (morphology of viral inclusion bodies). Pathol Annu 1976;11:53-75. [ PUBMED ] 34. Schwartz DA, Wilcox CM. [jdeonline.in]

Three weeks into treatment he continued with copious amounts of diarrhea, with no relief from loperamide, which was titrated from 2 mg/day to 2 mg every 6 hours. [ncbi.nlm.nih.gov]

Despite aggressive clinical manifestations, the prognosis of CMV colitis is good if diagnosed and treated early. [ncbi.nlm.nih.gov]

In patients without immunocompromised status, the prognosis appears to be age dependent, with patients older than 55 years having a higher mortality. Males and patients who need surgery also have a poorer prognosis. [emedicine.medscape.com]

[…] the case of a patient who presented with abdominal pain 4 years after heart transplantation; clinical and x-ray findings were suggestive of a neoplastic or ischemic stenosis, and histopathological examination likewise initially suggested an ischemic etiology [ncbi.nlm.nih.gov]

Physical exam is often not specific to the diagnosis of CMV colitis; fever in these patients can be indicative of an infectious etiology. [clinicaladvisor.com]

(Etiology) Cytomegalovirus Gastroenteritis/Colitis disease is an indication of a frail immune system (which is caused by other medical conditions or viral infections). [dovemed.com]

Etiology Pathogen : cytomegalovirus ( CMV, human herpes virus 5, HHV-5 ) Transmission Blood transfusions Sexual transmission Droplet transmission Transplant-transmitted infection (e.g., bone marrow, lungs, kidneys) References: [1] [2] [3] Pathophysiology [amboss.com]

Search for other works by this author on: Ulrich von Both 1Division of Infectious Diseases and Hospital Epidemiology, Zurich, Switzerland Search for other works by this author on: Reto Laffer 1Division of Infectious Diseases and Hospital Epidemiology, [academic.oup.com]

Jeffrey D Band, MD, FACP, FIDSA Professor of Medicine, Oakland University William Beaumont School of Medicine; Health System Chair, Healthcare Epidemiology and International Medicine, Beaumont Health System; Former Chief of Infectious Diseases, Beaumont [emedicine.medscape.com]

[…] antiviral drugs, such as ganciclovir or valganciclovir Terminology CMV infection: refers to presence of detectable CMV levels in the human body CMV disease: CMV disease relates to symptoms due to CMV ICD coding B25.8: other cytomegaloviral diseases Epidemiology [pathologyoutlines.com]

CMV Epidemiology CMV has been cultured from multiple sites, including the urine, blood, throat, cervix, semen, stool, tears, and breast milk [ 7, 8 ]. [karger.com]

Infection can be acquired during birth, breast feeding, close contact, sexual contact, transfusion or with organ transplant (Scand J Gastroenterol 2010;45:1295) Sites Most common sites of CMV related gastrointestinal involvement are the esophagus and colon Pathophysiology [pathologyoutlines.com]

Pathophysiology Cytomegalovirus (CMV) has 3 major patterns of infection. [emedicine.medscape.com]

bone marrow, lungs, kidneys) References: [1] [2] [3] Pathophysiology Clinical features CMV infection is usually asymptomatic. Severe manifestations occur in immunocompromised states (e.g., following organ transplantation, AIDS ). [amboss.com]

The pathophysiology of a disease may compromise the immune system. [journals.plos.org]

Guidelines for the prevention and treatment of opportunistic infections in adults and adolescents with HIV: recommendations from the Centers for Disease Control and Prevention, the National Institutes of Health, and the HIV Medicine Association of the [karger.com]

European evidence-based consensus on the prevention, diagnosis and management of opportunistic infections in inflammatory bowel disease. J Crohns Colitis. 2009;3(2):47-91. [consultant360.com]

Seite 170 - Rotavirus vaccine for the prevention of rotavirus gastroenteritis among children. Recommendations of the Advisory Committee on Immunization Practices (ACIP). ‎ Seite 18 - Griffin. 1990. [books.google.de]