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Cytomegalovirus Infection


Presentation

  • CASE PRESENTATION: Case 1: A 33-year-old Gravida II Para I was referred for primary CMV infection at 15 weeks gestation presenting with a history of fever. HIG therapy was performed resulting in good neonatal outcome.[ncbi.nlm.nih.gov]
  • We present the case of an immunocompetent adult patient with unexpected severe evolution. CASE PRESENTATION: An otherwise healthy, 72-year-old Caucasian woman presented with complaints of progressive shoulder pain and dyspnoea on exertion.[ncbi.nlm.nih.gov]
  • Abstract We present the case of a 6-year-old boy who received a cochlear implant for profound sensorineural hearing loss after being born with cytomegalovirus (CMV) infection.[ncbi.nlm.nih.gov]
  • CASE PRESENTATION: We report the case of an 81-year-old Caucasian male presenting with idiopathic membranous nephropathy who developed fever, cough, dyspnea, pulmonary infiltrates, and abdominal pain shortly after the initiation of treatment with chlorambucil[ncbi.nlm.nih.gov]
  • We report a case of SOD concurrent with acquired cytomegalovirus (CMV) infection, who presented with prolonged jaundice as the first clinical sign.[ncbi.nlm.nih.gov]
Splenomegaly
  • Ultrasound confirmed massive splenomegaly with a span of 21 cm in the long axis. Serological tests confirmed the presence of both primary Epstein-Barr virus and cytomegalovirus infections.[ncbi.nlm.nih.gov]
  • It may be accompanied by low-grade fever, hepato-splenomegaly and lymphadenopathy.[ncbi.nlm.nih.gov]
  • Possible signs and symptoms include: jaundice / hepatomegaly / splenomegaly microcephaly sensorineural deafness chorioretinitis petechiae mental retardation seizures The degree of neurological impairment is variable, from mild learning and behavioral[radiopaedia.org]
  • CMV may also produce a mononucleosis syndrome similar to Epstein-Barr virus (causing a febrile illness with splenomegaly, impaired liver function and abnormal lymphocytes in the blood) but without characteristic pharyngitis and lymphadenopathy.[patient.info]
  • It is generally indistinguishable from Epstein-Barr virus (EBV) mononucleosis, although it is more common for splenomegaly to be associated with CMV mononucleosis.[cancertherapyadvisor.com]
Fever
  • CONCLUSION: CMV co-infection should be considered in patients with acute Q fever when they do not respond to standard antimicrobial agents.[ncbi.nlm.nih.gov]
  • INTERVENTIONS: Given the patient's immunocompetent state and resolution of fevers, antiviral therapy for CMV infection was not initiated.[ncbi.nlm.nih.gov]
  • Therefore, HCMV infection should always be included in the differential diagnosis of patients with unspecific signs of disease like depletion, subfebrile fever, and arthralgia. 2017 S. Karger AG, Basel.[ncbi.nlm.nih.gov]
  • The median duration of fever was 21.5 days (range 15-27). Tonsillitis and hepatitis are most of the time missing. A probable malignant diagnosis was raised in 3 cases.[ncbi.nlm.nih.gov]
  • In a multivariable model, only recent steroid treatment and fever were independently associated with colonic CMV infection.[ncbi.nlm.nih.gov]
Fatigue
  • RATIONALE: Herein, we present a case of seemingly unprovoked portal vein thrombosis (PVT) occurring in the context of an acute cytomegalovirus (CMV) infection and prolonged debilitating fatigue.[ncbi.nlm.nih.gov]
  • We present 11 symptomatic cases of HCMV infection in nonimmunocompromised patients with non-life-threatening symptoms like long-lasting depletion, fatigue, and subfebrile fever with or without muscular pain and arthralgia.[ncbi.nlm.nih.gov]
  • Abstract A 32-year-old man who was receiving adalimumab for seronegative rheumatoid arthritis presented with a 4-week history of fever, night sweats, fatigue, myalgias and diarrhoea.[ncbi.nlm.nih.gov]
  • Fatigue may linger for 2 to 3 months. Possible Complications Throat infection is the most common complication.[nicklauschildrens.org]
  • Associate Professor, Division of Infectious Diseases, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School Cytomegalovirus infection is a common herpesvirus infection with a wide range of symptoms: from no symptoms to fever and fatigue[merckmanuals.com]
Malaise
  • After 28 months she developed bloody diarrhoea, abdominal pain, fever, nausea and general malaise suggesting severe pouchitis. Antibiotic treatment reduced humoral inflammation, but failed to resolve her fever.[ncbi.nlm.nih.gov]
  • The most frequent symptoms were malaise (67%), fever (46%), and sweats (46%), and the most frequent finding was abnormal liver function test results (69%).[academic.oup.com]
  • This syndrome is similar to infectious mononucleosis (caused by Epstein-Barr virus ) and is characterized by fever, malaise, and muscle and joint pain but without sore throat.[healthcentral.com]
  • These may include: Enlarged lymph nodes, especially in the neck Fever Fatigue Loss of appetite Malaise Muscle aches Rash Sore throat CMV can cause infections in different parts of the body. Symptoms vary depending on the area that is affected.[medlineplus.gov]
  • Symptoms Enlarged lymph nodes, especially in the neck Fever Fatigue Loss of appetite Malaise Muscle aches Rash Sore throat Less common symptoms include: Chest pain Cough Headache Hives Irregular heartbeat Jaundice Neck stiffness Rapid heart rate Sensitivity[nicklauschildrens.org]
Anorexia
  • The symptoms observed in patients with CMV involvement of the GIT included fever, diffuse abdominal pain, or pain located in the lower abdominal quadrants, anorexia, nausea, vomiting, weight loss, watery or bloody diarrhoea, haematochezia, and melaena[virologyj.biomedcentral.com]
  • Clinical features are low grade fever, weight loss, anorexia, malaise, and abdominal pain, or diarrhea [ 5 ]. It may be responsible for severe complications, such as GI bleeding or perforation [ 24 ].[omicsonline.org]
Pneumonia
  • More rarely, the infection may lead to severe organ complications with pneumonia, myocarditis, pericarditis, colitis and hemolytic anemia.[ncbi.nlm.nih.gov]
  • Pneumonia Immunocompetent: Pneumonia may occasionally occur with CMV mononucleosis. Usually, pneumonia is found on the CXR but is of no clinical significance and rapidly resolves with the disappearance of the primary infection.[patient.info]
  • Common symptomatic characteristics of the virus include microcephaly, jaundice, liver-spleen infections, pneumonia, cardiac anomalies, chorioretinitis, vision loss, sensory-neural hearing loss, mental retardation, and mononucleosis (Demmler, 1991; Kashden[ncbi.nlm.nih.gov]
  • CMV can cause tissue-invasive disease including pneumonia, hepatitis, colitis, retinitis, and encephalitis. Mortality in HCT recipients with CMV disease can be as high as 60%.[ncbi.nlm.nih.gov]
  • Only bacterial pneumonia tended to be associated with CLAD in the multivariate model (HR 2.579, P .062).[ncbi.nlm.nih.gov]
Sore Throat
  • Symptoms may include: Fever Headache Fatigue Muscle aches Enlarged glands Sore throat Enlarged spleen.[southerncross.co.nz]
  • This syndrome is similar to infectious mononucleosis (caused by Epstein-Barr virus ) and is characterized by fever, malaise, and muscle and joint pain but without sore throat.[healthcentral.com]
  • In some cases, infection in healthy people can cause mild illness that may include: Fever Sore throat Fatigue Swollen glands Occasionally, CMV can cause mononucleosis or hepatitis (liver problem).[cdc.gov]
  • CMV doesn't always cause symptoms Some people get flu-like symptoms the first time they catch CMV, including: a high temperature of 38C or more aching muscles tiredness feeling sick sore throat swollen glands If you do have symptoms, they normally get[nhs.uk]
  • These may include: Enlarged lymph nodes, especially in the neck Fever Fatigue Loss of appetite Malaise Muscle aches Rash Sore throat CMV can cause infections in different parts of the body. Symptoms vary depending on the area that is affected.[medlineplus.gov]
Pharyngitis
  • On examination, he had obvious splenomegaly but no lymphadenopathy or pharyngitis. Full blood count revealed mild neutropenia and significant lymphocytosis, with a blood film showing atypical lymphocytes.[ncbi.nlm.nih.gov]
  • A syndrome that is similar to infectious mononucleosis but lacks severe pharyngitis is common.[msdmanuals.com]
  • ., fever, cervical lymphadenopathy, pharyngitis) do not have a heterophile antibody response. Patients who are positive for heterophile antibodies have mononucleosis due to EBV and not due to CMV.[atsu.edu]
  • CMV may also produce a mononucleosis syndrome similar to Epstein-Barr virus (causing a febrile illness with splenomegaly, impaired liver function and abnormal lymphocytes in the blood) but without characteristic pharyngitis and lymphadenopathy.[patient.info]
Abdominal Pain
  • CASE PRESENTATION: We report the case of an 81-year-old Caucasian male presenting with idiopathic membranous nephropathy who developed fever, cough, dyspnea, pulmonary infiltrates, and abdominal pain shortly after the initiation of treatment with chlorambucil[ncbi.nlm.nih.gov]
  • We report a 50-year-old Caucasian man with AIDS, presented 3 weeks after developing abdominal pain and distension. He was treated for CMV retinitis in the past. His adherence to antiretroviral therapy was poor.[ncbi.nlm.nih.gov]
  • After 28 months she developed bloody diarrhoea, abdominal pain, fever, nausea and general malaise suggesting severe pouchitis. Antibiotic treatment reduced humoral inflammation, but failed to resolve her fever.[ncbi.nlm.nih.gov]
  • PATIENT CONCERNS: A 46-year-old male airline pilot presented with a 2 week history of abdominal pain, nausea, vomiting, watery diarrhea, and daily recurrent fevers.[ncbi.nlm.nih.gov]
  • Ulcerative disease of the colon (with abdominal pain and GI bleeding) or of the esophagus (with odynophagia) may occur.[msdmanuals.com]
Diarrhea
  • ., 6-weeks-old, born small for gestational age, was admitted in our Hospital for gastrointestinal signs: diarrhea, abdominal distension, observed three days earlier.[ncbi.nlm.nih.gov]
  • PATIENT CONCERNS: A 46-year-old male airline pilot presented with a 2 week history of abdominal pain, nausea, vomiting, watery diarrhea, and daily recurrent fevers.[ncbi.nlm.nih.gov]
  • Patients with CMV enterocolitis most often present with diarrhea, fever and weight loss, abdominal pain and hematochezia 2 . It is important to note that in up to a third of patients, diarrhea is not a prominent feature 4 .[radiopaedia.org]
  • You could have: Blind spots or moving black spots, called "floaters," in your eyesight Blurred vision Blindness Diarrhea Belly pain Painful or difficult swallowing Pain, weakness, or numbness at the base of your spine that makes walking a struggle In[webmd.com]
Loss of Appetite
  • […] individual experiencing constitutional symptoms (fever, chills, fatigue, loss of appetite, etc) should seek medical attention immediately.[physio-pedia.com]
  • These may include: Enlarged lymph nodes, especially in the neck Fever Fatigue Loss of appetite Malaise Muscle aches Rash Sore throat CMV can cause infections in different parts of the body. Symptoms vary depending on the area that is affected.[medlineplus.gov]
  • Symptoms Enlarged lymph nodes, especially in the neck Fever Fatigue Loss of appetite Malaise Muscle aches Rash Sore throat Less common symptoms include: Chest pain Cough Headache Hives Irregular heartbeat Jaundice Neck stiffness Rapid heart rate Sensitivity[nicklauschildrens.org]
  • If you do experience symptoms, they will be similar to flu symptoms or symptoms of glandular fever and can include: a high temperature of 38oC (100.4oF) or above extreme tiredness sore throat swollen glands muscle and joint pain loss of appetite These[your.md]
Hematochezia
  • Patients with CMV enterocolitis most often present with diarrhea, fever and weight loss, abdominal pain and hematochezia 2 . It is important to note that in up to a third of patients, diarrhea is not a prominent feature 4 .[radiopaedia.org]
  • Infection of the gastrointestinal tract can result in CMV colitis with symptoms of diarrhea, hematochezia, and abdominal pain that may progress to perforation of bowel. CMV esophagitis presents with odynophagia.[renalandurologynews.com]
Abdominal Distension
  • ., 6-weeks-old, born small for gestational age, was admitted in our Hospital for gastrointestinal signs: diarrhea, abdominal distension, observed three days earlier.[ncbi.nlm.nih.gov]
Jaundice
  • RATIONALE: Septo-optic dysplasia (SOD) is a rare congenital disorder that may cause jaundice in infants.[ncbi.nlm.nih.gov]
  • Common symptomatic characteristics of the virus include microcephaly, jaundice, liver-spleen infections, pneumonia, cardiac anomalies, chorioretinitis, vision loss, sensory-neural hearing loss, mental retardation, and mononucleosis (Demmler, 1991; Kashden[ncbi.nlm.nih.gov]
  • Anamnesis offered reliable diagnostic criteria for intrauterine infection (flu during first trimester of pregnancy, intrauterine growth restriction, prolonged jaundice).[ncbi.nlm.nih.gov]
  • A newborn symptomatic is defined by the existence of clinical and / or biological signs and / or neonatal imaging, the most frequent clinical signs are: hepatosplenomegaly (60%), microcephaly (53%), jaundice (67%), petechiae (76%), at least one neurological[ncbi.nlm.nih.gov]
  • Possible signs and symptoms include: jaundice / hepatomegaly / splenomegaly microcephaly sensorineural deafness chorioretinitis petechiae mental retardation seizures The degree of neurological impairment is variable, from mild learning and behavioral[radiopaedia.org]
Hepatosplenomegaly
  • Typical ultrasound signs that should arouse suspicion of intrauterine CMV infection can be distinguished into CNS signs such as ventriculomegaly or microcephaly and extracerebral infection signs such as hepatosplenomegaly or hyperechogenic bowel.[ncbi.nlm.nih.gov]
  • We report a case of a term neonate with ventriculomegaly on prenatal ultrasound who presented with low birth weight, small head circumference, hepatosplenomegaly, and purpuric rash on physical exam.[ncbi.nlm.nih.gov]
  • After a prolonged recovery, the infant developed a sepsis-like condition with hyperpyrexia, hepatosplenomegaly, and pancytopenia.[ncbi.nlm.nih.gov]
  • A newborn symptomatic is defined by the existence of clinical and / or biological signs and / or neonatal imaging, the most frequent clinical signs are: hepatosplenomegaly (60%), microcephaly (53%), jaundice (67%), petechiae (76%), at least one neurological[ncbi.nlm.nih.gov]
  • Cytomegalic inclusion disease of the neonatal (newborn) period is characterized by variable severity ranging from an asymptomatic infection to a disease with fever, hepatosplenomegaly (enlarged liver and spleen), mental or motor retardation, and sometimes[healthcentral.com]
Hepatomegaly
  • Radiologic examinations were carried out, and the computed tomography scan revealed a hepatomegaly and a chest X-ray showed evidence of a unilateral pleural effusion.[ncbi.nlm.nih.gov]
  • Possible signs and symptoms include: jaundice / hepatomegaly / splenomegaly microcephaly sensorineural deafness chorioretinitis petechiae mental retardation seizures The degree of neurological impairment is variable, from mild learning and behavioral[radiopaedia.org]
Eruptions
  • A 22 old women without a history of systemic disease developed a cutaneous eruption with fever and myalgia persistant for 2 weeks.[ncbi.nlm.nih.gov]
  • We report a case of a 3-year-old girl presenting generalized, pruritic, papulovesicular eruption on the face and extremities for one month.[ncbi.nlm.nih.gov]
  • Similar to EBV infection, 80-100% of patients develop a maculopapular, morbilliform eruption when given ampicillin (or other penicillins) during the illness.[renalandurologynews.com]
  • Morbiliform eruptions, purpura, vesiculobullous lesions, nodules, papular eruptions, verrucous lesions and ulcers were also reported [2, 6].[symbiosisonlinepublishing.com]
  • In addition, categories of CMV infections characterized as severe included any CMV infection causing vascular thrombosis; weight loss of over 10 kg; a vasculitic rash; perineal ulcers; or an eruption consisting of numerous vesicular or pustular lesions[virologyj.biomedcentral.com]
Small Head
  • We report a case of a term neonate with ventriculomegaly on prenatal ultrasound who presented with low birth weight, small head circumference, hepatosplenomegaly, and purpuric rash on physical exam.[ncbi.nlm.nih.gov]
  • These can include deafness, poor eyesight, intellectual disability, an enlarged liver or spleen, and a small head.[betterhealth.vic.gov.au]
  • Those who do may have : premature delivery small size or low birth weight jaundice an enlarged liver and spleen microcephaly (small head) feeding difficulties These babies are also at risk for hearing, vision, neurological, and developmental problems.[kidshealth.org]
  • This can result in lasting problems such as hearing loss, vision loss, small head size, cerebral palsy, developmental delay or intellectual disability. In rare cases infection in babies may be fatal.[conditions.health.qld.gov.au]
  • These can include hearing loss, vision loss, small head size, cerebral palsy, developmental delay or intellectual disability, and in rare cases, death.[health.nsw.gov.au]
Myalgia
  • A 22 old women without a history of systemic disease developed a cutaneous eruption with fever and myalgia persistant for 2 weeks.[ncbi.nlm.nih.gov]
  • A 64-year-old woman (Case 1) and a 65-year-old man (Case 2), who had each received a kidney from a living unrelated donor, were admitted with complaints of weakness in both legs and myalgia.[ncbi.nlm.nih.gov]
  • Abstract A 32-year-old man who was receiving adalimumab for seronegative rheumatoid arthritis presented with a 4-week history of fever, night sweats, fatigue, myalgias and diarrhoea.[ncbi.nlm.nih.gov]
  • Some of these patients had non-specific symptoms, such as fever, myalgia, asthenia, chills, or cough. The virus affected the eyes in 16 immunocompetent patients, who developed uveitis, retinitis, corneal endothelitis, or papillitis.[virologyj.biomedcentral.com]
  • Fifty-one percent of patients had headache, 46% had myalgia, and 36% had splenomegaly. Respiratory and neurological symptoms were noted in 8% and 1% of patients, respectively.[academic.oup.com]
Arthralgia
  • Therefore, HCMV infection should always be included in the differential diagnosis of patients with unspecific signs of disease like depletion, subfebrile fever, and arthralgia. 2017 S. Karger AG, Basel.[ncbi.nlm.nih.gov]
Seizure
  • While receiving antiviral and corticosteroid therapy, the patient developed seizures related to a cerebral vasculitis. The outcome was favorable when intravenous immunoglobulins were associated.[ncbi.nlm.nih.gov]
  • Seizures, pancytopenia, diabetes, diarrhoea, and (probably) drug-induced liver damage and cholangitis were observed in the course of treatment. At 3 months of hospitalization, the patient was discharged home with viral load of 8000 copies.[ncbi.nlm.nih.gov]
  • Possible signs and symptoms include: jaundice / hepatomegaly / splenomegaly microcephaly sensorineural deafness chorioretinitis petechiae mental retardation seizures The degree of neurological impairment is variable, from mild learning and behavioral[radiopaedia.org]
  • Most newborns (about 90%) who are infected appear healthy at birth but may develop hearing or vision problems, pneumonia , seizures, and/or delayed mental development a few months later.[labtestsonline.org]
  • Symptomatic infants have a 40%-90% risk of subsequent neurologic sequelae, including mental retardation, microcephaly, developmental delay, seizure disorders, and cerebral palsy.[cancertherapyadvisor.com]

Workup

  • Further workup exposed elevated transaminases consistent with mild hepatitis without synthetic dysfunction and colonoscopy revealed colitis. A comprehensive evaluation for liver disease was notable for a markedly elevated ferritin level.[ncbi.nlm.nih.gov]
Pneumoperitoneum
  • The plain X-ray of the abdomen revealed a double wall sign (Rigler's sign), indicating pneumoperitoneum due to the bowel perforation. The upper endoscopy was normal. His CD4 count was 30 cells/mm(3) He was treated with cidofovir infusion.[ncbi.nlm.nih.gov]
Enlargement of the Spleen
  • Older kids and teens who are infected may have mono-like symptoms, including tiredness, muscle aches, headache , fever , and an enlarged liver and spleen. These symptoms tend to be mild and usually last only 2 to 3 weeks.[kidshealth.org]
  • Cytomegalic inclusion disease of the neonatal (newborn) period is characterized by variable severity ranging from an asymptomatic infection to a disease with fever, hepatosplenomegaly (enlarged liver and spleen), mental or motor retardation, and sometimes[healthcentral.com]
  • These can include deafness, poor eyesight, intellectual disability, an enlarged liver or spleen, and a small head.[betterhealth.vic.gov.au]
  • Symptoms may include: Fever Headache Fatigue Muscle aches Enlarged glands Sore throat Enlarged spleen.[southerncross.co.nz]
  • […] liver or spleen.[nationalcmv.org]
Enlargement of the Liver
  • The other 10 to 15 percent of newborns infected with CMV in the womb have serious complications that are present at birth, such as central nervous system abnormalities, growth restriction, an unusually small head, an enlarged spleen and liver, jaundice[babycenter.com]
  • For infants who are infected by their mothers before birth, two potential problems exist: Generalised infection may occur, with symptoms ranging from moderate enlargement of the liver and spleen with jaundice, to stillbirth or neonatal/infant death.[ideas.health.vic.gov.au]
  • , poorly-functioning liver, with jaundice Low blood platelet count Abnormal white blood cell levels (high or low) Enlarged spleen Anemia Children affected by Cytomegalic Inclusion Disease are at high risk of developing complications such as hearing loss[ada.com]
  • A few babies may be stillborn, while others may have symptoms at birth such as jaundice , anemia , an enlarged spleen or liver, and a small head. In those with weakened immune systems, CMV could cause serious illness and death.[labtestsonline.org]
Coxiella Burnetii
  • Abstract BACKGROUND: Coxiella burnetii is an obligate bacterial pathogen that causes Q fever. Cytomegalovirus (CMV) commonly exists as a latent infection in healthy people. Co-infection with both pathogens is rare.[ncbi.nlm.nih.gov]

Treatment

  • Treatment with double-dose ganciclovir and anti-CMV immunoglobulins did not decrease CMV viremia, so we diagnosed ganciclovir-resistant CMV infection. We decided to discontinue mycophenolic acid treatment and start leflunomide 20 mg BID.[ncbi.nlm.nih.gov]
  • The viral load at the start of re-treatment was 6 million copies. In view of ganciclovir treatment failure, Sando immunoglobulins were administered.[ncbi.nlm.nih.gov]
  • GR-CMV is difficult to manage, and treatment options are limited. We report a descriptive case series of 15 patients who had documented GR-CMV at our center and review the literature on treatment of GR-CMV.[ncbi.nlm.nih.gov]
  • The variables related to transplantation were collected from transplantation process data and included CMV infection or disease, CMV treatment, and immunosuppressive treatment.[ncbi.nlm.nih.gov]
  • When a high dose was assessed with a need for treatment, the chance of needing treatment increased more than eight times (P .024; odds ratio 8.25; 95% CI 1.33 to 51.26), which was different from results found with high-dose tacrolimus (P 1.0).[ncbi.nlm.nih.gov]

Prognosis

  • The prognosis of individuals with CMV is highly variable, and the prognosis of individuals with congenital CMV can usually be determined based on the extent of infection at birth.[ncbi.nlm.nih.gov]
  • KEYWORDS: Cytomegalovirus; Diagnosis; Pregnancy; Prognosis; Serology; Virology[ncbi.nlm.nih.gov]
  • Many imaging features of congenital cytomegalovirus are distinctive, and can spur a diagnostic work-up as well as help provide a prognosis. The Author(s) 2016. KEYWORDS: TORCH infection; congenital CNS infection; cytomegalovirus[ncbi.nlm.nih.gov]
  • Infantile nephrotic syndrome often has a genetic origin; the treatment is then symptomatic, with a poor prognosis, and a rapid evolution to chronic kidney disease. However, non-genetic infantile nephrotic syndrome has been identified.[ncbi.nlm.nih.gov]
  • However, screening for congenital CMV infection is not currently recommended in the UK. [ 13 ] Prognosis The prognosis of patients with CMV hepatitis is generally good. Most patients recover completely.[patient.info]

Etiology

  • Conclusions: Liver cirrhosis at this age is very rare; the most frequent etiology is viral. The late diagnosis of this case led to the impossibility of etiological treatment.[ncbi.nlm.nih.gov]
  • KEYWORDS: Cytomegalovirus infection; Etiology; Gianotti-Crosti syndrome (GCS)[ncbi.nlm.nih.gov]
  • CONCLUSIONS: We conclude that CMV is an important etiologic agent of congenital infections in symptomatic infants in Tehran, IRAN (prevalence: 58%) and CMV-DNA detection immediately after delivery is recommended for early treatment and reduction of post[ncbi.nlm.nih.gov]
  • Accurate diagnosis and cochlear implantation at the appropriate time are important for successful speech development, and each patient needs a personalized habilitation program based on their etiology and brain function. Copyright 2013 The Authors.[ncbi.nlm.nih.gov]
  • No statistically significant difference was observed in etiology of liver disease (P .38), Chid-Turcotte-Pugh (CTP) (P .41), and Model for End-stage Liver Disease (MELD) (P .12) scores between the groups.[ncbi.nlm.nih.gov]

Epidemiology

  • Although vaccine development to modify this congenital infection is ongoing, the unique epidemiology of maternal HCMV infections appears discordant with strategies for vaccine development.[ncbi.nlm.nih.gov]
  • In 1987, Adam et al. were the first to report an association between HCMV infection and atherosclerosis (AS), and later, many serum epidemiology and molecular biology studies showed that HCMV-infected endothelial cells play an important role in the development[ncbi.nlm.nih.gov]
  • 1 Department of Pediatrics, University of Alberta, Edmonton, AB, Canada. 2 DynaLife Medical Labs, Edmonton, AB, Canada. 3 Department of Medicine, University of Alberta, Edmonton, AB, Canada. 4 Canadian Blood Services, Ottawa, ON, Canada. 5 School of Epidemiology[ncbi.nlm.nih.gov]
  • We performed a detailed review of the literature in view of diagnosis, epidemiology and management of CMV infection in pregnancy.[ncbi.nlm.nih.gov]
  • BACKGROUND: Despite, Cytomegalovirus (CMV) infection being associated with a potential risk to the fetus, there is limited data from Tanzania and many other developing countries regarding the epidemiology and the impact of CMV infections.[ncbi.nlm.nih.gov]
Sex distribution
Age distribution

Pathophysiology

  • […] damage Sites May infect all levels of the nervous system but classically, CMV encephalitis causes damage to subependymal regions of the cerebrum, cerebellum and brainstem Spinal cord and nerve root infection is also common in immunocompromised hosts Pathophysiology[pathologyoutlines.com]
  • Useful For Suggests clinical disorders or settings where the test may be helpful Aiding in the diagnosis of acute or past infection with cytomegalovirus (CMV) Determination of prior exposure to CMV Clinical Information Discusses physiology, pathophysiology[mayomedicallaboratories.com]
  • Welcome to PT 635 Pathophysiology of Complex Patient Problems This is a wiki created by and for the students in the School of Physical Therapy at Bellarmine University in Louisville KY.[physio-pedia.com]
  • Pathophysiology Upon infection of cells, CMV causes cytomegaly and condensation of the nuclear mass, while infection of organs results in inflammation and resultant organ dysfunction.[renalandurologynews.com]
  • Pathophysiology Causal agent CMV or HHV-5 (type 5 of Human Herpes Virus) is a double-stranded DNA virus. It is the largest of the human herpes viruses with a 230 kb genome encoding 165 genes [ 11 ].[omicsonline.org]

Prevention

  • The following concepts were tested in one or more of the three phases of research: CMV is severe, CMV is common, CMV is preventable, CMV preventive strategies are similar to other behavior changes women make during pregnancy, CMV preventive strategies[ncbi.nlm.nih.gov]
  • Prevention strategies decrease post-transplant CMV infection and disease. Copyright 2017 Sociedad Española de Nefrología. Published by Elsevier España, S.L.U. All rights reserved.[ncbi.nlm.nih.gov]
  • Although available anti-CMV therapies may be effective for the prevention of CMV, they are plagued by unacceptable toxicities that prohibit their use in the post-transplant period.[ncbi.nlm.nih.gov]
  • This preliminary result suggests that intravenous immunoglobulin injections are not effective for the prevention of mother-to-fetus CMV transmission in the present protocol.[ncbi.nlm.nih.gov]
  • Although progress toward development of a vaccine has been limited by an incomplete understanding of the correlates of protective immunity for the fetus, knowledge about some of the key components of the maternal immune response necessary for preventing[ncbi.nlm.nih.gov]

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