Presentation
RESULTS: Twenty-seven RCTs were identified and included in the present systematic review and meta-analysis, involving a total of 7343 patients. [ncbi.nlm.nih.gov]
At present, its role in carcinoid heart disease is unknown. Conference: 7th Annual ENETS Conference (2010) Category: Clinical Presenting Author: Dr. [enets.org]
Entire Body System
-
Anemia
In addition, more incidences of grade 3 or 4 anemia, thrombocytopenia, and neurotoxicity were observed in the doublet combination group. [ncbi.nlm.nih.gov]
If proper precautions are not observed thiotepa may cause leukopenia, thrombocytopenia and anemia. [rxmed.com]
Cytoxan can also cause bone marrow suppression, resulting in low red and/or white blood cell counts ( anemia, leukopenia) and low platelets (thrombocytopenia), which can raise the risk of bleeding and infection (especially shingles ). [verywell.com]
-
Arm Pain
Dose-limiting toxicity took the form of infusional arm pain, in some cases associated with facial discomfort, that was of rapid onset and subsided quickly on the cessation of infusion. [ncbi.nlm.nih.gov]
Jaw & Teeth
-
Sore Mouth
This may lead to a sore mouth, a dry mouth or other mouth problems. Routine good mouth care will help to prevent mouth problems from developing or from becoming more serious. [patient.info]
Skin
-
Cutaneous Manifestation
Low-dose methotrexate administered weekly is an effective corticosteroid-sparing agent for the treatment of the cutaneous manifestations of dermatomyositis. J Am Acad Dermatol. 1997; 36:67-71. Cronin ME, Miller FW, Hicks JE, Dalakas M, Plotz PH. [annals.org]
Eyes
-
Ptosis
Sporadic ptosis and conjunctivitis were observed at doses of 300 mg/m2. The plasma elimination of tirapazamine fitted a monoexponential open model, with rapid elimination from the plasma (t1/2 36 /- 0.65 min) occurring at the LD10 dose of 294 mg/m2. [ncbi.nlm.nih.gov]
Urogenital
-
Flank Pain
A 19 years old, male patient presented with symptoms of smoky urine for 2 weeks, puffiness of face and diminished urine output for 3 weeks associated with occasional lower abdominal and flank pain. [ncbi.nlm.nih.gov]
-
Smoky Urine
A 19 years old, male patient presented with symptoms of smoky urine for 2 weeks, puffiness of face and diminished urine output for 3 weeks associated with occasional lower abdominal and flank pain. [ncbi.nlm.nih.gov]
Workup
Biopsy
-
Hepatocellular Carcinoma
Abstract Transarterial chemoembolization (TACE) is the main treatment for intermediate stage hepatocellular carcinoma (HCC) with Barcelona Clinic Liver Cancer classification because of its exclusive arterial blood supply. [ncbi.nlm.nih.gov]
Cao Y, Karsten U, Otto G, Bannasch P (1999) Expression of MUC1, Thomsen-Friedenreich antigen, Tn, sialosyl-Tn, and α2,6-linked sialic acid in hepatocellular carcinomas and preneoplastic hepatocellular lesions. Virchows Archiv 434: 503–509. [journals.plos.org]
Treatment
Two patients from each group interrupted treatment because of side effects or inefficacy. CONCLUSION: Most nephrotic patients with membranous nephropathy responded to either treatment. [ncbi.nlm.nih.gov]
Prognosis
The overall prognosis for this group of patients is still poor, emphasizing the importance of more effective therapies. Betulinic acid (Bet A) has been described as a novel cytotoxic compound active against melanoma and neuroblastoma cells. [ncbi.nlm.nih.gov]
Pancreatic adenocarcinoma is a highly aggressive cancer with poor prognosis. The majority of patients are diagnosed with advanced-stage disease and have limited treatment options. [roswellpark.org]
Can plantar soft tissue mechanics enhance prognosis of diabetic foot ulcer?. Diabetes Res Clin Pract. 2017 Feb 10. 126:182-91. [Medline]. Marshall MC Jr. Diabetes in African Americans. Postgrad Med J. 2005 Dec. 81(962):734-40. [Medline]. [medscape.com]
[…] clear evidence for the benefit of pulsed intravenous cyclophosphamide over steroids alone in reducing clinical and serological activity of lupus, histological damage, and end stage renal failure. 34 35 Before the routine use of cyclophosphamide, the prognosis [adc.bmj.com]
Etiology
[…] is unknown whether this is a function of inadequate or incomplete suppression of immune pathways mediating the abnormality; the influences of pathogenic mechanisms that are unaffected by these drugs; or, perhaps most likely, the failure to eliminate etiologic [annals.org]
Epidemiology
Controlled epidemiological surveys suggest that cytotoxic drugs are associated with reproduction toxicology, embryo toxicity and teratogenicity, as well as an increased risk of malignant tumours. [hospitalpharmacyeurope.com]
Pathophysiology
They also address the consequences of drug interactions and the basic pathophysiology of central nervous system toxicity. [books.google.ro]
In addition, drug combinations have been advocated on the premise that synergisms might result from disruptions of separate pathophysiologic pathways involved in synovitis. [annals.org]
Fourth, the proportion of IL-4–positive T cells was greater in patients with progressive disease, compared with stable patients, suggesting that IL-4 played pathophysiologic roles in suppressing cell death. 15 Finally, CLL cells within lymph nodes and [bloodjournal.org]
Prevention
Knowledge of specific measures for preventing and managing associated side effects and dose modifications is integral to the provision of optimal care. [ncbi.nlm.nih.gov]
Useful in prevention of recurrence after condyloma ablation if started within 4 wk, especially in immunocompromised patients. [emedicine.medscape.com]
Footwear and offloading interventions to prevent and heal foot ulcers and reduce plantar pressure in patients with diabetes: a systematic review. Diabetes Metab Res Rev. 2015 Sep 5. [Medline]. [medscape.com]