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Danazol


Presentation

  • We herein report clinical and thin-section computed tomography (CT) findings of two cases, in which one woman presented with catamenial haemoptysis (CH) alone and another woman presented with bilateral catamenial pneumothoraces (CP) coinciding with CH[ncbi.nlm.nih.gov]
  • This patient presents a chronological association between the treatment with danazol and the development of peliosis, which suggests a clear cause-effect relationship.[ncbi.nlm.nih.gov]
  • Two days after initial presentation, the patient was readmitted to the hospital due to nausea, dark urine, and oliguria.[ncbi.nlm.nih.gov]
  • This study presents the successful identification of sulfate metabolites of the doping agents oxandrolone and danazol in excretion urines by high performance liquid chromatography coupled to tandem mass spectrometry (HPLC-MS/MS).[ncbi.nlm.nih.gov]
  • The present report describes the first case of acute pancreatitis associated with danazol treatment of endometriosis.[ncbi.nlm.nih.gov]
Palpable Spleen
  • Three (17%) had excellent (E) response, defined by normalization of blood counts and non-palpable spleen, while eight (44%) had good (G) response, defined by rise of Hct by 7% and 50% reduction of spleen.[ncbi.nlm.nih.gov]
Virilization
  • Of the 94 completed pregnancies, 37 resulted in the birth of normal males, 34 in non-virilized females and 23 in virilized females.[ncbi.nlm.nih.gov]
  • At the time of discharge the female neonate had no signs of virilization or congenital anomalies. Low dose danazol was ineffective in treating this woman's HAE in pregnancy. The use of C1EI in pregnancy is associated with good outcomes.[ncbi.nlm.nih.gov]
  • Adverse effects (weight gain, virilization, menstrual irregularities, headache, depression, and/or liver adenomas) occurred in 93 of the 118 patients and led to discontinuation of danazol therapy in 30 patients.[ncbi.nlm.nih.gov]
  • Danazol worked well for this purpose, but unfortunately, due to its androgenic nature it did cause such virilization issues as deepening voice, facial and body hair, and enlarged clitoris.[evolutionary.org]
  • Virilization of the female fetus with maternal danazol exposure. Am J Obstet Gynecol 1984; 149: 99-100. Money J, Mathews O. Prenatal exposure to virilizing progestins: an adult follow-up study of twelve women. Arch sex behav 1982; 11: 73-83.[revista.fecolsog.org]
Acute Intermittent Porphyria
  • Administration of Danazol has been reported to cause exacerbation of the manifestations of acute intermittent porphyria. Special Precautions Epilepsy, migraine; cardiac, hepatic, renal disorders.[drugsupdate.com]
  • ., epilepsy, migraine, cardiac or renal dysfunction). b f Porphyria May induce 5-aminolevulinate synthetase activity and porphyrin; possible exacerbation of manifestations of acute intermittent porphyria. b f Contraindicated in patients with porphyria[drugs.com]
  • For this reason, danazol should not be used in patients with acute intermittent porphyria because it can precipitate an attack.[empower.pharmacy]
Camping
  • Danazol did not affect the viable cell numbers of unstimulated ESCs or 8Br-cAMP-stimulated decidualized ESCs, but significantly enhanced the viable cell numbers of 8-Br-cAMP-stimulated ESCs during decidualization in a dose-dependent manner.[ncbi.nlm.nih.gov]
  • Further, danazol increases intracellular cyclic adenosine monophosphate (cAMP) levels through the rapid activation of membrane-associated androgen, steroid binding globulin, and calcium channel receptors.[ampiopharma.com]
Upper Abdominal Pain
  • Her anemia gradually became aggravated, and the patient complained of intermittent left upper-abdominal pain.[ncbi.nlm.nih.gov]
Hirsutism
  • […] urinary usually vellus hair virilizing adrenal hyperplasia woman women with hirsutism Bibliografische Informationen Titel Hirsutism Autoren Alan N.[books.google.com]
  • Endometriosis Hereditary angioedema Fibrocystic breast disease Contraindications Pregnancy or breast feeding Genital bleeding Thrombosis or thromboembolic disease Marked hepatic, renal, or cardiac dysfunction Androgen-dependent tumor Toxicity Weight gain Acne Hirsutism[step1.medbullets.com]
  • These include acne, hirsutism (excess hair in females, with an adult male pattern of distribution), weight gain, irritability, musculoskeletal pain, hot flushes, and breast atrophy , which many women may not tolerate.[cochrane.org]
Acne Vulgaris
  • These effects include weight gain, acne vulgaris, seborrhea, hirsutism, edema, alopecia, deepening of the voice, pharyngitis, or hoarseness. Rarely, clitoral hypertrophy or testicular atrophy can occur.[empower.pharmacy]
Dysarthria
  • […] year-old Asian woman (height, 155 cm; weight, 54 kg; and body mass index, 22.5 kg/m2) presented to the outpatient neurology clinic with acute progressive quadriparesis and generalized myalgia (without focal sensory loss, numbness, dizziness, diplopia, dysarthria[ncbi.nlm.nih.gov]
Neurologic Manifestation
  • We report a case of catastrophic antiphospholipid-antibody syndrome, with renal and neurological manifestations, which presented shortly after the institution of danazol for the treatment of refractory thrombocytopenia.[ncbi.nlm.nih.gov]
Motor Symptoms
  • Statin-induced rhabdomyolysis must be considered whenever muscle or motor symptoms occur, especially when concomitant treatment with known inhibitors of statin metabolism is administered.[ncbi.nlm.nih.gov]
Amenorrhea
  • At 800 mg/day for 21-240 days, Danazol inhibited follicle-stimulating hormone (FSH) and luteinizing hormone (LH) peaks and temperature curves and caused amenorrhea in 31 normal women. All began menstruating 4-6 weeks after stopping.[popline.org]
  • In endometriosis, danazol induces amenorrhea and a hypoestrogenic state, resulting in endometrial atrophy.[ncbi.nlm.nih.gov]
  • Other possible endocrine effects are menstrual disturbances including spotting, alteration of the timing of the cycle and amenorrhea.[rxlist.com]
  • Note: Drug-induced amenorrhea is reversible. Ovulation and cyclic bleeding usually return within 60–90 d after therapeutic regimen is discontinued as well as the potential for conception.[robholland.com]
  • Dosage ADULT Endometriosis : PO initially 400 mg bid to achieve rapid response and amenorrhea; decrease to dose sufficient to maintain amenorrhea (100-200 mg bid) for 3-9 mo. Fibrocystic breast disease : PO 100-400 mg/day in 2 divided doses.[nmihi.com]
Incontinence
  • […] weight, 54 kg; and body mass index, 22.5 kg/m2) presented to the outpatient neurology clinic with acute progressive quadriparesis and generalized myalgia (without focal sensory loss, numbness, dizziness, diplopia, dysarthria, dysphagia, or sphincter incontinence[ncbi.nlm.nih.gov]

Workup

  • Extensive workup for HCS was negative. IV heparin was withheld for colonoscopy for possible gastrointestinal neoplasm, at which time DVT recurred, necessitating another thrombolysis and heparin infusion.[ncbi.nlm.nih.gov]

Treatment

  • Treatment with androgens prevents attacks for those with this condition. OBJECTIVE: To examine the benefits and risks of long-term treatment with danazol.[ncbi.nlm.nih.gov]
  • The improvement was still present six months after treatment was stopped. There was some evidence that women who took danazol were satisfied with the treatment compared with women who had inactive treatment.[doi.org]
  • Autoimmune progesterone dermatitis is a rare condition appearing during the perimenstrual period or following progesterone treatment. Various treatment modalities have been suggested, but most have proved to be ineffective.[ncbi.nlm.nih.gov]
  • To determine the effectiveness of danazol compared to placebo or no treatment in the treatment of the symptoms and signs, other than infertility, of endometriosis in women of reproductive age.[ncbi.nlm.nih.gov]
  • The oral treatments were a Standard treatment, a Standard 800 ml water treatment and a Standard lipid-rich meal treatment.[ncbi.nlm.nih.gov]

Prognosis

  • Abstract Background: Severe thrombocytopenia is an uncommon event in lower risk MDS patients, but it may significantly influence the prognosis. In fact, when it occurs, major bleeding may be a life-threatening complication.[bloodjournal.org]
  • Prognosis With proper diagnosis and treatment, prognosis for patients with HAE is good. The prognosis of AAE depends on the underlying disorder. The documents contained in this web site are presented for information purposes only.[orpha.net]
  • Camitta BM, Storb R, Thomas ED (1982) Aplastic anemia (first of two parts): pathogenesis, diagnosis, treatment, and prognosis. N Engl J Med 306(11):645–652 PubMed CrossRef Google Scholar 17.[link.springer.com]

Etiology

  • However, the discovery of loss-of-function mutations in genes of the telomerase complex (TERC, TERT) established a genetic etiology for telomere attrition in some patients with marrow failure who did not have the stigmata associated to an inherited bone[clinicaltrials.gov]
  • Introduction Ovarian cancer is the leading cause of death from gynecologic cancer, yet its etiology is unknown. Sex hormones, including androgens, have been hypothesized to have potentially mutagenic effects on the ovarian epithelium (1) .[clincancerres.aacrjournals.org]
  • Etiology Angioedema can be caused by quantitative or functional defects of the plasma protease C1 inhibitor (C1-INH encoded by the SERPING1 gene; 11q12-q13-1) or by gain-of-function mutations of coagulation factor 12 (Hageman factor; F12; 5q33-qter).[orpha.net]
  • However, identifying the etiology is of great importance for specifying treatment strategies and improving the prognosis of patients.[journals.lww.com]

Epidemiology

  • […] has been reported Contraindications Pregnancy, breastfeeding Porphyria Undiagnosed abnormal genital bleeding Severe liver/renal/cardiac disease, Hypersensitivity Cautions Breast cancer Epilepsy Migraine Cardiac dysfunction Renal impairment Preliminary epidemiological[reference.medscape.com]
  • Data, from two case-control epidemiological studies, were pooled to examine the relationship between endometriosis, endometriosis treatments and ovarian cancer.[medicines.org.uk]
  • Young NS, Kaufman DW (2008) The epidemiology of acquired aplastic anemia. Haematologica 93(4):489–492 PubMed CrossRef Google Scholar 2.[link.springer.com]
Sex distribution
Age distribution

Pathophysiology

  • We chose to study the role of CD4 CD25 high CD127 low FoxP3 T regulatory cells (T-regs) in the pathophysiology of AA and their response to treatment with Danazol alone or in combination with immunosuppressive treatment (IST).[ncbi.nlm.nih.gov]
  • Results of controlled prospective clinical studies on the drug have increased our understanding of the pathophysiology of several poorly understood diseases. Danazol is well tolerated by most patients; the side effects are mild and reversible.[annals.org]
  • Young NS, Calado RT, Scheinberg P (2006) Current concepts in the pathophysiology and treatment of aplastic anemia. Blood 108(8):2509–2519. doi: 10.1182/blood-2006-03-010777 PubMed CrossRef Google Scholar 3. Young NS (2002) Acquired aplastic anemia.[link.springer.com]

Prevention

  • We used the anabolic androgen danazol as a preventive treatment for recurrent episodes of autoimmune progesterone dermatitis in two young women.[ncbi.nlm.nih.gov]
  • These studies demonstrate that: (1) danazol prevents the midcycle surge of luteinizing hormone (LH) and follicle-stimulating hormone (FSH); (2) danazol does not significantly suppress basal LH or FSH in gonadally intact human beings; (3) in castrated[ncbi.nlm.nih.gov]
  • We conclude that r-HuEPO-induced thrombosis is associated with impaired fibrinolysis due to acquired elevation of PAI which can be effectively prevented by small doses of danazol.[ncbi.nlm.nih.gov]
  • Danazol did not prevent recurrence of symptoms, its use was discontinued after six weeks. Thereafter, the patient was treated exclusively with C1EI at weekly intervals for exacerbations of her HAE.[ncbi.nlm.nih.gov]
  • Patients receiving warfarin who are prescribed danazol must be monitored closely to prevent excessive anticoagulation and subsequent bleeding. Studies are needed to determine the frequency of this interaction and its underlying mechanisms.[ncbi.nlm.nih.gov]

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