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Datura Stramonium Poisoning


Presentation

  • The patients presented with visual hallucinations, disorientation, incomprehensible and nonsensical speech, and dilated sluggish pupils.[ncbi.nlm.nih.gov]
  • Mass spectral data on urine extracts of a 20-year-old male showed the molecular ions and principal fragment ions of scopolamine and atropine, present in Datura stramonium.[astm.org]
  • We present the case of two children admitted at the Children Emergency Room of a teaching hospital following ingestion of extract of Datura stramonium.[njcponline.com]
Fever
  • We describe the case of a boy who had slurred speech, fever, hallucinations, tachycardia, dilated pupi… Poisoned after Dinner: Dolma with Datura Stramonium.[unboundmedicine.com]
  • Haug Browse recently published Learning/CME Learning/CME View all learning/CME CME Case 3-2019: A 70-Year-Old Woman with Fever, Headache, and Progressive Encephalopathy Caplacizumab Treatment for Acquired Thrombotic Thrombocytopenic Purpura Randomized[nejm.org]
  • Fever : Jimson weed might make fever worse. Stomach ulcer : Jimson weed might delay stomach emptying and make ulcers worse. Stomach and intestinal infections : Jimson weed might slow down the emptying of the stomach and intestines.[webmd.com]
  • Symptoms of poisoning in humans and livestock include restlessness, irritability, depression, dilated pupils, delirium, impaired vision, constipation, fever, extreme thirst, and convulsions.[kswildflower.org]
  • Jimsonweed poisoning causes dry mucous membranes and skin, thirst, flushing, fever, blurred vision, altered mental status, mydriasis, urinary retention, tachycardia, coma, and, in rare cases, death ( 1 ,4 ).[cdc.gov]
Gastric Lavage
  • Intoxication was not thought in the hospital where the patient was first admitted and gastric lavage and active coal were not administered because 12 hours passed before she was admitted to our hospital.[dusunenadamdergisi.org]
Pathologist
  • Author Information: Bowerman, DL Pathologist, pathologist, and toxicologist, Toxicology Laboratory, St. Francis Hospital, Colorado Springs, CO Levisky, JA Pathologist, pathologist, and toxicologist, Toxicology Laboratory, St.[astm.org]
Decreased Bowel Sounds
  • Typical symptoms of DS intoxication are those of atropine intoxication, which are dry skin and mucosa, flushing, mydriasis, sinus tachycardia, hyperpyrexia, decreased bowel sounds, urinary retention, and neurological disorders with ataxia, impaired short-term[intjem.springeropen.com]
  • bowel sounds, urinary retention, and neurological disorders with ataxia, impaired short-term memory, disorientation, confusion, hallucinations (visual and auditory), psychosis, agitated delirium, seizures, and coma.[cjhr.org]
Nausea
  • It is poisonous and can cause many toxic effects including dry mouth and extreme thirst, vision problems, nausea and vomiting, fast heart rate, hallucinations, high temperature, seizures, confusion, loss of consciousness, breathing problems, and death[webmd.com]
  • […] however, restricted within the following countries: Australia: Datura is a Schedule I poison in Australia [ citation needed ], but scopolamine is Schedule 4 (Prescription only) and it is in over the counter drugs (Buscopan) to treat symptoms such as nausea[psychonautwiki.org]
Geophagia
  • She had a medical history of geophagia complicated by iron deficiency anemia, which had been treated 6 months ago.[intjem.springeropen.com]
  • Our case is original because of the young age of the victim and the underlying geophagia facilitating the occurrence of poisoning. Literatur 1. Kurzbaum A, Simsolo C, Kvasha L, Blum A: Toxic delirium due to Datura stramonium.[springermedizin.de]
Abdominal Pain
  • Abdominal pain Abdominal pain may have many underlying causes. Some of these causes include gall bladder stone and kidney stone. In these conditions, datura and medicines containing datura are used to alleviate the pain.[ayurtimes.com]
Abdominal Distension
  • Abdominal distension and urinary retention were noted. She was transferred to the pediatric intensive care unit. Gastric decontamination with nasogastric lavage and activated charcoal via a gastric tube was rapidly performed after admission.[intjem.springeropen.com]
Tachycardia
  • The patient presented with a typical anticholinergic syndrome (dryness of mouth, mydriasis, flushing, tachycardia, agitation, hallucinations) and was treated with symptomatic and supportive measures.[ncbi.nlm.nih.gov]
  • Blockade of visceral muscarinic receptors produces the following effects 1 Heart -diminished vagal tone at the SA node causes relative tachycardia 2 Blood vessels- vasoconstriction via muscarinic receptor blockade in endothelial cells results in decreased[usmle1-topscorer.blogspot.com]
  • Repeated neurological examination revealed a gradual improvement of her state of consciousness with disappearance of tachycardia, mydriasis, delirium, and agitation.[intjem.springeropen.com]
  • We describe the case of a boy who had slurred speech, fever, hallucinations, tachycardia, dilated pupi… Poisoned after Dinner: Dolma with Datura Stramonium.[unboundmedicine.com]
  • During the next 6 hours in the emergency department, the six patients continued to experience tachycardia, mydriasis, and altered mental status. One remained unconscious.[cdc.gov]
Weak Pulse
  • pulse, convulsions, and coma Toxic Principle: Tropane alkaloids Severity: Toxic only if large quantities are eaten.[plants.ces.ncsu.edu]
Hypertension
  • […] cardiovascular disease, gangrene, asthma, glaucoma, and GI/GU obstruction.(2,7,10) Thus its use as a cholinergic agent in Jimson Weed poisoning is controversial and is generally reserved for life-threatening, intractable, anticholinergic effects including hypertension[erowid.org]
Flushing
  • The patient presented with a typical anticholinergic syndrome (dryness of mouth, mydriasis, flushing, tachycardia, agitation, hallucinations) and was treated with symptomatic and supportive measures.[ncbi.nlm.nih.gov]
  • […] tone at the SA node causes relative tachycardia 2 Blood vessels- vasoconstriction via muscarinic receptor blockade in endothelial cells results in decreased nitric oxide synthesis In spite of this effect, atropine poisoning is associated with cutaneous flushing[usmle1-topscorer.blogspot.com]
  • Facial and truncal skin was normal, and flushing was not detected. She had a Glasgow Coma Scale score of 11/15.[intjem.springeropen.com]
  • After 6 hours of admission, child developed irrelevant speech, excitation, delirium, hallucinations, and flushing of face. He was agitated and aggressive with purposeless movements. Child had not passed urine for last 8 hours.[cjhr.org]
  • […] lavender purple Hardiness: frost sensitive Exposure: full sun Family: Solanaceae Origin: North America Distribution: Naturalized and weedy, cultivated Poison Part: All parts, mainly seeds and leaves Poison Delivery Mode: Ingestion Symptoms: Hot, dry, and flushed[plants.ces.ncsu.edu]
Blurred Vision
  • Written testimonials for Datura on the Erowid Web site, under titles like “Truly the Devil’s Weed,” “Nightmares in Flux” and “This is Madness,” include delusions of phantom cigarettes, conversations with imaginary friends, amnesia, blurred vision, a desire[cityroom.blogs.nytimes.com]
  • This results in blurred vision. There are also dry mouth with dysphagia and dysphonia, tachycardia and urinary retention. The skin may be flushed and dry accompanied by hyperthermia.[globinmed.com]
  • Blurred vision, palpitation, urinary retention, dry mouth, ileus, flushing, dysrhytmia, auditory and visual hallucinations and convulsions can be seen after its use (5).[dusunenadamdergisi.org]
  • These would include incoherent speech, impaired coordination, rapid heart beat, dilated pupils, blurred vision and dry, flushed or hot skin. In extreme cases users can experience seizures, intense visual or auditory hallucination, or cardiac arrest.[aacc.org]
  • Jimsonweed poisoning causes dry mucous membranes and skin, thirst, flushing, fever, blurred vision, altered mental status, mydriasis, urinary retention, tachycardia, coma, and, in rare cases, death ( 1 ,4 ).[cdc.gov]
Photophobia
  • […] an anticholinergic delirium: a complete inability to differentiate reality from fantasy (frank delirium, as contrasted to hallucination); hyperthermia; tachycardia; bizarre, and possibly violent behavior; and severe mydriasis with resultant painful photophobia[link.springer.com]
  • […] complete inability to differentiate reality from fantasy (delirium, as contrasted to hallucination); hyperthermia; tachycardia (increased heart-rate); bizarre, and possibly violent behavior; and severe mydriasis (pupil dilation) with resultant painful photophobia[sabotagetimes.com]
Dry Eyes
  • […] unknown 3 GI- delayed gastric emptying, decreased intestinal motility, and secretion 4 Respiratory bronchodilatation 5 GU- urinary retention vi a detrusor relaxation and contraction of the external urethral sphincter 6 Secretions decreased lacrimation (dry[usmle1-topscorer.blogspot.com]
Agitation
  • The patient presented with a typical anticholinergic syndrome (dryness of mouth, mydriasis, flushing, tachycardia, agitation, hallucinations) and was treated with symptomatic and supportive measures.[ncbi.nlm.nih.gov]
  • Repeated neurological examination revealed a gradual improvement of her state of consciousness with disappearance of tachycardia, mydriasis, delirium, and agitation.[intjem.springeropen.com]
  • They developed neurotoxicity (confusion, agitation, mydriasis, and hallucination) and were managed symptomatically with… CONTINUE READING Highly Cited This paper has 23 citations. REVIEW CITATIONS From This Paper Topics from this paper.[semanticscholar.org]
Seizure
  • Jimson weed intoxication should be considered in cases of patients presenting with unexplained peripheral and central anticholinergic symptoms including delirium, agitation and seizures, especially among younger patients and partygoers.[ncbi.nlm.nih.gov]
  • Among the serious neurologic and medical complications are coma, trauma, infection, seizures, stroke, altered mentation, peripheral neuropathies, myelopathies, Parkinsonism, visual disturbances, dyskinesias, cerebellar ataxia, impotence, and fetal effects[books.google.com]
  • Phenothiazines for agitated delirium should be avoided due to their anticholinergic properties, and barbiturates can be administered in the case of seizures refractory to benzodiazepines [ 1, 10 ].[intjem.springeropen.com]
  • Seizures : Jimson weed can cause seizures. Do not use jimson weed if you suffer from frequent seizures.[webmd.com]
  • There was no preceding history of trauma, seizures, or drug intake. There was no history of vomiting, loose motions, or similar episodes in the past. At the time of admission, child had no injury marks, bite mark, rashes, or bleeding from any site.[cjhr.org]
Confusion
  • They developed neurotoxicity (confusion, agitation, mydriasis, and hallucination) and were managed symptomatically with good outcome.[ncbi.nlm.nih.gov]
  • They developed neurotoxicity (confusion, agitation, mydriasis, and hallucination) and were managed symptomatically with… CONTINUE READING Highly Cited This paper has 23 citations. REVIEW CITATIONS From This Paper Topics from this paper.[semanticscholar.org]
  • The others demonstrated confusion, aggression, agitation, disorganized speech, incoherence, and hallucinations. All six were admitted to the hospital, five to the intensive-care unit.[cdc.gov]
  • […] intoxication are those of atropine intoxication, which are dry skin and mucosa, flushing, mydriasis, sinus tachycardia, hyperpyrexia, decreased bowel sounds, urinary retention, and neurological disorders with ataxia, impaired short-term memory, disorientation, confusion[intjem.springeropen.com]
Headache
  • The less alarming sequelae are myriad (fatigue, loss of appetite, headaches, dizziness, etc.). Dr. Brust has written the most comprehensive source available to the point of being encyclpedic, including references.[books.google.com]
  • Haug Browse recently published Learning/CME Learning/CME View all learning/CME CME Case 3-2019: A 70-Year-Old Woman with Fever, Headache, and Progressive Encephalopathy Caplacizumab Treatment for Acquired Thrombotic Thrombocytopenic Purpura Randomized[nejm.org]
  • : full sun Family: Solanaceae Origin: North America Distribution: Naturalized and weedy, cultivated Poison Part: All parts, mainly seeds and leaves Poison Delivery Mode: Ingestion Symptoms: Hot, dry, and flushed skin, hallucinations, pupil dilation, headache[plants.ces.ncsu.edu]
  • Symptoms associated with D. metel poisoning include flushed skin, headaches, hallucinations, and possibly convulsions or even a coma.[keys.lucidcentral.org]
Ataxia
  • Among the serious neurologic and medical complications are coma, trauma, infection, seizures, stroke, altered mentation, peripheral neuropathies, myelopathies, Parkinsonism, visual disturbances, dyskinesias, cerebellar ataxia, impotence, and fetal effects[books.google.com]
  • Typical symptoms of DS intoxication are those of atropine intoxication, which are dry skin and mucosa, flushing, mydriasis, sinus tachycardia, hyperpyrexia, decreased bowel sounds, urinary retention, and neurological disorders with ataxia, impaired short-term[intjem.springeropen.com]
  • […] crawling insects. [11] Typical symptoms of DS intoxication are those of atropine intoxication, which are dry skin and mucosa, flushing, mydriasis, sinus tachycardia, hyperpyrexia, decreased bowel sounds, urinary retention, and neurological disorders with ataxia[cjhr.org]

Treatment

  • The treatment of choice for anticholinergic poisoning is mainly supportive care and gastrointestinal decontamination with activated charcoal.[ncbi.nlm.nih.gov]
  • Although physostigmine is the antidote for anticholinergic toxicity, its use is controversial despite recent reports of it being a safe treatment.[intjem.springeropen.com]
  • Please find relevant information on First Aid for Datura Stramonium Poisoning regarding cause, signs & symptoms, administration of first aid treatment, prognosis, preventive measures, and additional resources HERE.[dovemed.com]
  • […] by increasing the concentration of acetylcholine in the synaptic cleft increased acetylcholine concentrations are produced by cholinesterase inhibitors that suppress acetylcholine degradation Physostigmine, a cholinesterase inhibitor, can be used for treatment[usmle1-topscorer.blogspot.com]
  • Rodgers GC Jr, Von Kanel RL: Conservative treatment of jimsonweed ingestion. Vet Hum Toxicol 1993, 35: 32–3.[springermedizin.de]

Prognosis

  • Please find relevant information on First Aid for Datura Stramonium Poisoning regarding cause, signs & symptoms, administration of first aid treatment, prognosis, preventive measures, and additional resources HERE.[dovemed.com]
  • The prognosis of DS intoxication is usually favorable, as in our case, but it may be fatal, especially during massive intoxications meant to be autolytic or the result of toxicomania [ 6 ].[intjem.springeropen.com]
  • Prognosis is usually favorable. Key words: Datura Poisoning Anticholinergic syndrome Hallucinations El Texto completo solo está disponible en PDF Bibliografía [1.] B.T. Vanderhoff, K.H.[analesdepediatria.org]
  • […] seriously ill from intentionally ingesting datura. [6] [7] There are also several reports in the medical literature of deaths from D. stramonium and D. ferox intoxication. [8] [9] [10] Children are especially vulnerable to atropine poisoning and their prognosis[psychonautwiki.org]

Etiology

  • Delirium is a complicated condition due to variable symptoms, signs and clinical courses and presence of several risk and etiological factors and advanced age is considered as an important predisposing factor.[dusunenadamdergisi.org]

Epidemiology

  • Epidemiology Frequency United States Incidence is sporadic, with clusters of poisoning cases, mostly among adolescents using plants for their hallucinogenic effects.[emedicine.medscape.com]
  • Epidemiology and Social History - The plant has been described throughout history as a toxin famous for its mind altering properties. There are references to it in Homer's Odyssey and Shakespeare plays.[aacc.org]
  • EPIDEMIOLOGY The plant has been described throughout history as a toxin famous for its mind-altering properties.[erowid.org]
Sex distribution
Age distribution

Pathophysiology

  • Pathophysiology Toxicity from plants containing tropane alkaloids manifests as classic anticholinergic poisoning.[emedicine.medscape.com]

Prevention

  • Please find relevant information on First Aid for Datura Stramonium Poisoning regarding cause, signs & symptoms, administration of first aid treatment, prognosis, preventive measures, and additional resources HERE.[dovemed.com]
  • The best form of invasive species management is prevention. If prevention is no longer possible, it is best to treat the weed infestations when they are small to prevent them from establishing (early detection and rapid response).[keys.lucidcentral.org]
  • From the Centers for Disease Control and Prevention. Jimson weed poisoning-Texas, New York, and California, 1994. MMWR 1995; 44: 41-44 [8.] D.L. Savitt, J.R. Roberts, E.G. Siegel Anisocoria from Jimson weed Jama, 255 (1986), pp. 1439-1440 [9.] M.[analesdepediatria.org]
  • PREVENTION Defoliation programs are one way to decrease access to Jimson Weed. It is important to educate health care providers about the hazards and symptoms involved with contact with Datura stramonium.[erowid.org]
  • From the Centers for Disease Control and Prevention. Scopolamine poisoning among heroin users--New York City, Newark, Philadelphia, and Baltimore, 1995 and 1996. JAMA. 1996 Jul 10. 276(2):92-3. [Medline]. CDC.[emedicine.medscape.com]

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