The patients presented with visual hallucinations, disorientation, incomprehensible and nonsensical speech, and dilated sluggish pupils. [ncbi.nlm.nih.gov]

Mass spectral data on urine extracts of a 20-year-old male showed the molecular ions and principal fragment ions of scopolamine and atropine, present in Datura stramonium. [astm.org]

We report the intoxication of 5- and 4-year-old brothers with Datura stramonium, which presented in two different manners. The first child presented agitation, hallucination and mydriasis that improved rapidly with benzodiazepine medication. [pubmed.ncbi.nlm.nih.gov]

• Fever

  Fever : Jimson weed might make fever worse. Stomach ulcer : Jimson weed might delay stomach emptying and make ulcers worse. Stomach and intestinal infections : Jimson weed might slow down the emptying of the stomach and intestines. [webmd.com]

  Symptoms of poisoning in humans and livestock include restlessness, irritability, depression, dilated pupils, delirium, impaired vision, constipation, fever, extreme thirst, and convulsions. [kswildflower.org]

  We describe the case of a boy who had slurred speech, fever, hallucinations, tachycardia, dilated pupi… Poisoned after Dinner: Dolma with Datura Stramonium. [unboundmedicine.com]

  Haug Browse recently published Learning/CME Learning/CME View all learning/CME CME Case 3-2019: A 70-Year-Old Woman with Fever, Headache, and Progressive Encephalopathy Caplacizumab Treatment for Acquired Thrombotic Thrombocytopenic Purpura Randomized [nejm.org]

  Malaria fever Fresh Datura leaves are beneficial in malaria fever. A small amount of leaf paste is given with jaggery to lower the temperature in malaria. Abdominal pain Abdominal pain may have many underlying causes. [ayurtimes.com]

• Gastric Lavage

  Gastric lavage and activated charcoal administration were performed. The child was intubated and mechanically ventilated until consciousness improvement. [pubmed.ncbi.nlm.nih.gov]

  In addition, gastric lavage was done. About 19 hours after admission, he became fully conscious, cooperative, and communicating intelligently. He was also able to recognize familiar people. [njcponline.com]

  Salen P, Shih R, Sierzenski P, Reed J (2003) Effect of physostigmine and gastric lavage in a Datura stramonium-induced anticholinergic poisoning epidemic. Am J Emerg Med 21:316–317 PubMed Article Google Scholar 6. [link.springer.com]

  Intoxication was not thought in the hospital where the patient was first admitted and gastric lavage and active coal were not administered because 12 hours passed before she was admitted to our hospital. [dusunenadamdergisi.org]

• Anemia

  Keywords Iron Deficiency Anemia Physostigmine Tropane Alkaloid Accidental Ingestion Microcytic Anemia Introduction Datura stramonium L (DS) is a hallucinogenic plant widely found in urban and rural areas. [intjem.springeropen.com]

  White blood cell (WBC) and platelet levels were normal, but he had hypochromic microcytic anemia with a hemoglobin level of 7.8 g/dl. [cjhr.org]

  Investigations revealed mild anemia (hematocrit=28%), serum aspartate aminotransferase of 39 IU/l, and hyperglycemia (random blood sugar=14.2 mmol/l). [njcponline.com]

• Disability

  Please enable JS and disable any ad blocker [lequotidiendumedecin.fr]

• Vomiting

  Side-effects of Datura use include severe anxiety, heart palpitations, vomiting and the inability to urinate. These side-effects last anywhere from 24 to 48 hours, although some users claim their hallucinations lasted nearly two weeks. [dailymail.co.uk]

  It is poisonous and can cause many toxic effects including dry mouth and extreme thirst, vision problems, nausea and vomiting, fast heart rate, hallucinations, high temperature, seizures, confusion, loss of consciousness, breathing problems, and death [webmd.com]

  […] as a hare, blind as a bat, dry as a bone, red as a beet and mad has a hatter”. [3], [4], [6] Management Management of Anticholinergic Alkaloid Poisoning Management would include intravenous rehydration with electrolyte correction and anti-emetics if vomiting [globinmed.com]

  There was no history of vomiting, loose motions, or similar episodes in the past. At the time of admission, child had no injury marks, bite mark, rashes, or bleeding from any site. [cjhr.org]

  One of the family members vomited. The unaffected relative called emergency medical services, and all six were transported to the hospital by ambulance. On admission to the emergency department, two of the six patients were unconscious. [cdc.gov]

• Nausea

  It is poisonous and can cause many toxic effects including dry mouth and extreme thirst, vision problems, nausea and vomiting, fast heart rate, hallucinations, high temperature, seizures, confusion, loss of consciousness, breathing problems, and death [webmd.com]

  […] however, restricted within the following countries: Australia: Datura is a Schedule I poison in Australia [ citation needed ], but scopolamine is Schedule 4 (Prescription only) and it is in over the counter drugs (Buscopan) to treat symptoms such as nausea [psychonautwiki.org]

• Decreased Bowel Sounds

  Typical symptoms of DS intoxication are those of atropine intoxication, which are dry skin and mucosa, flushing, mydriasis, sinus tachycardia, hyperpyrexia, decreased bowel sounds, urinary retention, and neurological disorders with ataxia, impaired short-term [intjem.springeropen.com]

  bowel sounds, urinary retention, and neurological disorders with ataxia, impaired short-term memory, disorientation, confusion, hallucinations (visual and auditory), psychosis, agitated delirium, seizures, and coma. [cjhr.org]

• Abdominal Pain

  Abdominal pain Abdominal pain may have many underlying causes. Some of these causes include gall bladder stone and kidney stone. In these conditions, datura and medicines containing datura are used to alleviate the pain. [ayurtimes.com]

• Tachycardia

  The patient presented with a typical anticholinergic syndrome (dryness of mouth, mydriasis, flushing, tachycardia, agitation, hallucinations) and was treated with symptomatic and supportive measures. [ncbi.nlm.nih.gov]

  During the next 6 hours in the emergency department, the six patients continued to experience tachycardia, mydriasis, and altered mental status. One remained unconscious. [cdc.gov]

  Blockade of visceral muscarinic receptors produces the following effects 1 Heart -diminished vagal tone at the SA node causes relative tachycardia 2 Blood vessels- vasoconstriction via muscarinic receptor blockade in endothelial cells results in decreased [usmle1-topscorer.blogspot.com]

  Repeated neurological examination revealed a gradual improvement of her state of consciousness with disappearance of tachycardia, mydriasis, delirium, and agitation. [intjem.springeropen.com]

  Tachycardia usually responds to crystalloids. [11] In severe cases, physostigmine, a cholinesterase inhibitor, should be used to reverse anticholinergic toxicity. [cjhr.org]

• Hypertension

  [Hypertensive crisis and anticholinergic toxidrome secondary to accidental consumption of datura stramonium in two children]. Batouche DD, Benatta NF, Tabeliouna K, Boudjahfa S, Touhami Y, Hakkoum S. Batouche DD, et al. [pubmed.ncbi.nlm.nih.gov]

  He had tachycardia with pulse rate of 132 beats per minute and systolic hypertension with blood pressure of 150/55 mmHg. There were no focal neurological signs and other systemic examination findings were normal. [njcponline.com]

  […] cardiovascular disease, gangrene, asthma, glaucoma, and GI/GU obstruction.(2,7,10) Thus its use as a cholinergic agent in Jimson Weed poisoning is controversial and is generally reserved for life-threatening, intractable, anticholinergic effects including hypertension [erowid.org]

• Weak Pulse

  pulse, convulsions, and coma Toxic Principle: Tropane alkaloids Severity: Toxic only if large quantities are eaten. [plants.ces.ncsu.edu]

• Flushing

  The patient presented with a typical anticholinergic syndrome (dryness of mouth, mydriasis, flushing, tachycardia, agitation, hallucinations) and was treated with symptomatic and supportive measures. [ncbi.nlm.nih.gov]

  […] tone at the SA node causes relative tachycardia 2 Blood vessels- vasoconstriction via muscarinic receptor blockade in endothelial cells results in decreased nitric oxide synthesis In spite of this effect, atropine poisoning is associated with cutaneous flushing [usmle1-topscorer.blogspot.com]

  After 6 hours of admission, child developed irrelevant speech, excitation, delirium, hallucinations, and flushing of face. He was agitated and aggressive with purposeless movements. Child had not passed urine for last 8 hours. [cjhr.org]

  […] lavender purple Hardiness: frost sensitive Exposure: full sun Family: Solanaceae Origin: North America Distribution: Naturalized and weedy, cultivated Poison Part: All parts, mainly seeds and leaves Poison Delivery Mode: Ingestion Symptoms: Hot, dry, and flushed [plants.ces.ncsu.edu]

  Facial and truncal skin was normal, and flushing was not detected. She had a Glasgow Coma Scale score of 11/15. [intjem.springeropen.com]

• Blurred Vision

  Written testimonials for Datura on the Erowid Web site, under titles like “Truly the Devil’s Weed,” “Nightmares in Flux” and “This is Madness,” include delusions of phantom cigarettes, conversations with imaginary friends, amnesia, blurred vision, a desire [cityroom.blogs.nytimes.com]

  This results in blurred vision. There are also dry mouth with dysphagia and dysphonia, tachycardia and urinary retention. The skin may be flushed and dry accompanied by hyperthermia. [globinmed.com]

  Blurred vision, palpitation, urinary retention, dry mouth, ileus, flushing, dysrhytmia, auditory and visual hallucinations and convulsions can be seen after its use (5). [dusunenadamdergisi.org]

  These would include incoherent speech, impaired coordination, rapid heart beat, dilated pupils, blurred vision and dry, flushed or hot skin. In extreme cases users can experience seizures, intense visual or auditory hallucination, or cardiac arrest. [aacc.org]

  An 82 year old male mistakenly ate the root of an Angel's Trumpet, Datura innoxia for a horseradish in his garden.(8) "Gardener's Mydriasis" was reported in a 54 year old male who complained of blurred vision after cutting Angel's Trumpet, Datura suaveolens [erowid.org]

• Photophobia

  […] an anticholinergic delirium: a complete inability to differentiate reality from fantasy (frank delirium, as contrasted to hallucination); hyperthermia; tachycardia; bizarre, and possibly violent behavior; and severe mydriasis with resultant painful photophobia [link.springer.com]

  […] complete inability to differentiate reality from fantasy (delirium, as contrasted to hallucination); hyperthermia; tachycardia (increased heart-rate); bizarre, and possibly violent behavior; and severe mydriasis (pupil dilation) with resultant painful photophobia [sabotagetimes.com]

• Dry Eyes

  eyes), salivation (dry mouth) and sweating (dry and hot skin) Atropine decreases one's ability to sweat, contributing to hyperthermia 7 Eye- mydriasis (dilated pupils) and cycloplegia (inability to focus on the near objects, blurry vision) 8 CNS -hallucinations [usmle1-topscorer.blogspot.com]

• Visual Hallucination

  The patients presented with visual hallucinations, disorientation, incomprehensible and nonsensical speech, and dilated sluggish pupils. [ncbi.nlm.nih.gov]

  Blurred vision, palpitation, urinary retention, dry mouth, ileus, flushing, dysrhytmia, auditory and visual hallucinations and convulsions can be seen after its use (5). [dusunenadamdergisi.org]

  Case 1 AU, a 14-year-old boy presented with history of restlessness, excessive and incoherent talks, visual hallucination, inability to recognize familiar people, and irrational behavior (fighting other students and staff). [njcponline.com]

• Agitation

  The patient presented with a typical anticholinergic syndrome (dryness of mouth, mydriasis, flushing, tachycardia, agitation, hallucinations) and was treated with symptomatic and supportive measures. [ncbi.nlm.nih.gov]

  Repeated neurological examination revealed a gradual improvement of her state of consciousness with disappearance of tachycardia, mydriasis, delirium, and agitation. [intjem.springeropen.com]

  If patient is severely agitated then benzodiazepines can be used for sedation (6). [dusunenadamdergisi.org]

• Seizure

  Jimson weed intoxication should be considered in cases of patients presenting with unexplained peripheral and central anticholinergic symptoms including delirium, agitation and seizures, especially among younger patients and partygoers. [ncbi.nlm.nih.gov]

  Seizures : Jimson weed can cause seizures. Do not use jimson weed if you suffer from frequent seizures. [webmd.com]

  Among the serious neurologic and medical complications are coma, trauma, infection, seizures, stroke, altered mentation, peripheral neuropathies, myelopathies, Parkinsonism, visual disturbances, dyskinesias, cerebellar ataxia, impotence, and fetal effects [books.google.com]

  Phenothiazines for agitated delirium should be avoided due to their anticholinergic properties, and barbiturates can be administered in the case of seizures refractory to benzodiazepines [ 1, 10 ]. [intjem.springeropen.com]

  However physostigmine's use may precipitate seizures, cholinergic crisis, bradyarrhythmias and asystole. [erowid.org]

• Confusion

  They developed neurotoxicity (confusion, agitation, mydriasis, and hallucination) and were managed symptomatically with good outcome. [ncbi.nlm.nih.gov]

  They developed neurotoxicity (confusion, agitation, mydriasis, and hallucination) and were managed symptomatically with… CONTINUE READING Highly Cited This paper has 23 citations. REVIEW CITATIONS From This Paper Topics from this paper. [semanticscholar.org]

  The others demonstrated confusion, aggression, agitation, disorganized speech, incoherence, and hallucinations. All six were admitted to the hospital, five to the intensive-care unit. [cdc.gov]

  As many psychiatric symptoms and signs such as bizarre behaviors, hallucinations and agitation can be observed in the patient, delirium can often be confused with other psychiatric disorders (2,3). [dusunenadamdergisi.org]

• Headache

  The less alarming sequelae are myriad (fatigue, loss of appetite, headaches, dizziness, etc.). Dr. Brust has written the most comprehensive source available to the point of being encyclpedic, including references. [books.google.com]

  full sun Family: Solanaceae Origin: North America Distribution: Naturalized and weedy, cultivated Poison Part: All parts, mainly seeds and leaves Poison Delivery Mode: Ingestion Symptoms: Hot, dry, and flushed skin, hallucinations, pupil dilation, headache [plants.ces.ncsu.edu]

  Haug Browse recently published Learning/CME Learning/CME View all learning/CME CME Case 3-2019: A 70-Year-Old Woman with Fever, Headache, and Progressive Encephalopathy Caplacizumab Treatment for Acquired Thrombotic Thrombocytopenic Purpura Randomized [nejm.org]

  Symptoms associated with D. metel poisoning include flushed skin, headaches, hallucinations, and possibly convulsions or even a coma. [keys.lucidcentral.org]

• Excitement

  Also called thorn apple. datura, Datura a genus of toxic plants in the family Solanaceae; contain tropane alkaloids including hyoscine (scopolamine), hyoscyamine, atropine which cause excitement, restlessness, pupillary dilation, dryness of the oral mucosa [medical-dictionary.thefreedictionary.com]

  Case report A 3.5-year-old girl was brought to the emergency department by her parents for excitation, delirium, and hallucinations occurring within the hour following accidental ingestion of DS. [intjem.springeropen.com]

  After 6 hours of admission, child developed irrelevant speech, excitation, delirium, hallucinations, and flushing of face. He was agitated and aggressive with purposeless movements. Child had not passed urine for last 8 hours. [cjhr.org]

Monitoring and supportive treatment were administered. Treatment of anticholinergic intoxication is mainly supportive and its specific antidote is physostigmine. [dusunenadamdergisi.org]

The treatment of choice for anticholinergic poisoning is mainly supportive care and gastrointestinal decontamination with activated charcoal. [ncbi.nlm.nih.gov]

Although physostigmine is the antidote for anticholinergic toxicity, its use is controversial despite recent reports of it being a safe treatment. [intjem.springeropen.com]

Please find relevant information on First Aid for Datura Stramonium Poisoning regarding cause, signs & symptoms, administration of first aid treatment, prognosis, preventive measures, and additional resources HERE. [dovemed.com]

[…] by increasing the concentration of acetylcholine in the synaptic cleft increased acetylcholine concentrations are produced by cholinesterase inhibitors that suppress acetylcholine degradation Physostigmine, a cholinesterase inhibitor, can be used for treatment [usmle1-topscorer.blogspot.com]

Please find relevant information on First Aid for Datura Stramonium Poisoning regarding cause, signs & symptoms, administration of first aid treatment, prognosis, preventive measures, and additional resources HERE. [dovemed.com]

Prognosis is usually favorable. Key words: Datura Poisoning Anticholinergic syndrome Hallucinations El Texto completo está disponible en PDF Bibliografía [1.] B.T. Vanderhoff, K.H. Mosser. [analesdepediatria.org]

The prognosis of DS intoxication is usually favorable, as in our case, but it may be fatal, especially during massive intoxications meant to be autolytic or the result of toxicomania [ 6 ]. [intjem.springeropen.com]

[…] seriously ill from intentionally ingesting datura. [6] [7] There are also several reports in the medical literature of deaths from D. stramonium and D. ferox intoxication. [8] [9] [10] Children are especially vulnerable to atropine poisoning and their prognosis [psychonautwiki.org]

Delirium is a complicated condition due to variable symptoms, signs and clinical courses and presence of several risk and etiological factors and advanced age is considered as an important predisposing factor. [dusunenadamdergisi.org]

Epidemiology Frequency United States Incidence is sporadic, with clusters of poisoning cases, mostly among adolescents using plants for their hallucinogenic effects. [emedicine.medscape.com]

Epidemiology and Social History - The plant has been described throughout history as a toxin famous for its mind altering properties. There are references to it in Homer's Odyssey and Shakespeare plays. [aacc.org]

EPIDEMIOLOGY The plant has been described throughout history as a toxin famous for its mind-altering properties. [erowid.org]

Pathophysiology Toxicity from plants containing tropane alkaloids manifests as classic anticholinergic poisoning. [emedicine.medscape.com]

The best form of invasive species management is prevention. If prevention is no longer possible, it is best to treat the weed infestations when they are small to prevent them from establishing (early detection and rapid response). [keys.lucidcentral.org]

Please find relevant information on First Aid for Datura Stramonium Poisoning regarding cause, signs & symptoms, administration of first aid treatment, prognosis, preventive measures, and additional resources HERE. [dovemed.com]

Adolescents must have access to correct and detailed information on poisoning prevention since this remains one of the effective interventions in solving health and social challenges facing them. [njcponline.com]

From the Centers for Disease Control and Prevention. Jimson weed poisoning-Texas, New York, and California, 1994. MMWR 1995; 44: 41-44 [8.] D.L. Savitt, J.R. Roberts, E.G. Siegel. Anisocoria from Jimson weed. Jama, 255 (1986), pp. 1439-1440 [9.] M. [analesdepediatria.org]

PREVENTION Defoliation programs are one way to decrease access to Jimson Weed. It is important to educate health care providers about the hazards and symptoms involved with contact with Datura stramonium. [erowid.org]