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Datura Stramonium Poisoning


Presentation

  • The patients presented with visual hallucinations, disorientation, incomprehensible and nonsensical speech, and dilated sluggish pupils.[ncbi.nlm.nih.gov]
  • We present the case of two children admitted at the Children Emergency Room of a teaching hospital following ingestion of extract of Datura stramonium.[ncbi.nlm.nih.gov]
  • The patient presented with a typical anticholinergic syndrome (dryness of mouth, mydriasis, flushing, tachycardia, agitation, hallucinations) and was treated with symptomatic and supportive measures.[ncbi.nlm.nih.gov]
  • Mass spectral data on urine extracts of a 20-year-old male showed the molecular ions and principal fragment ions of scopolamine and atropine, present in Datura stramonium.[astm.org]
  • We present the case of two children admitted at the Children Emergency Room of a teaching hospital following ingestion of extract of Datura stramonium .[njcponline.com]
Fever
  • We describe the case of a boy who had slurred speech, fever, hallucinations, tachycardia, dilated pupi... FREE Publisher Full Text Poisoned after Dinner: Dolma with Datura Stramonium.[unboundmedicine.com]
  • Symptoms of poisoning in humans and livestock include restlessness, irritability, depression, dilated pupils, delirium, impaired vision, constipation, fever, extreme thirst, and convulsions.[kswildflower.org]
  • Fever : Jimson weed might make fever worse. Stomach ulcer : Jimson weed might delay stomach emptying and make ulcers worse. Stomach and intestinal infections : Jimson weed might slow down the emptying of the stomach and intestines .[webmd.com]
  • Malaria fever Fresh Datura leaves are beneficial in malaria fever. A small amount of leaf paste is given with jaggery to lower the temperature in malaria. Abdominal pain Abdominal pain may have many underlying causes.[ayurtimes.com]
  • Elif Sağ, Gülay Kaya, Elif Bahat-Özdoğan, Süleyman Caner Karahan, Mustafa İmamoğlu, Haluk Sarıhan, Murat Çakır DOI : 10.24953/turkjped.2018.02.006 Evaluation of Restless Legs syndrome and growing pains in children with familial Mediterranean fever.[turkishjournalpediatrics.org]
Gastric Lavage
  • Intoxication was not thought in the hospital where the patient was first admitted and gastric lavage and active coal were not administered because 12 hours passed before she was admitted to our hospital.[dusunenadamdergisi.org]
Decreased Bowel Sounds
  • Typical symptoms of DS intoxication are those of atropine intoxication, which are dry skin and mucosa, flushing, mydriasis, sinus tachycardia, hyperpyrexia, decreased bowel sounds, urinary retention, and neurological disorders with ataxia, impaired short-term[intjem.springeropen.com]
  • bowel sounds, urinary retention, and neurological disorders with ataxia, impaired short-term memory, disorientation, confusion, hallucinations (visual and auditory), psychosis, agitated delirium, seizures, and coma.[cjhr.org]
Tachycardia
  • The patient presented with a typical anticholinergic syndrome (dryness of mouth, mydriasis, flushing, tachycardia, agitation, hallucinations) and was treated with symptomatic and supportive measures.[ncbi.nlm.nih.gov]
  • Blockade of visceral muscarinic receptors produces the following effects 1 Heart -diminished vagal tone at the SA node causes relative tachycardia 2 Blood vessels- vasoconstriction via muscarinic receptor blockade in endothelial cells results in decreased[usmle1-topscorer.blogspot.com]
  • Repeated neurological examination revealed a gradual improvement of her state of consciousness with disappearance of tachycardia, mydriasis, delirium, and agitation.[intjem.springeropen.com]
  • We describe the case of a boy who had slurred speech, fever, hallucinations, tachycardia, dilated pupi... FREE Publisher Full Text Poisoned after Dinner: Dolma with Datura Stramonium.[unboundmedicine.com]
  • During the next 6 hours in the emergency department, the six patients continued to experience tachycardia, mydriasis, and altered mental status. One remained unconscious.[cdc.gov]
Hypertension
  • Hilal Şahin, Yeliz Pekçevik DOI : 10.24953/turkjped.2018.02.013 A rare cause of neonatal hypertension: Congenital mesoblastic nephroma.[turkishjournalpediatrics.org]
  • […] cardiovascular disease, gangrene, asthma, glaucoma, and GI/GU obstruction.(2,7,10) Thus its use as a cholinergic agent in Jimson Weed poisoning is controversial and is generally reserved for life-threatening, intractable, anticholinergic effects including hypertension[erowid.org]
Weak Pulse
  • pulse, convulsions, and coma Toxic Principle: Tropane alkaloids Severity: Toxic only if large quantities are eaten.[plants.ces.ncsu.edu]
Flushing
  • The patient presented with a typical anticholinergic syndrome (dryness of mouth, mydriasis, flushing, tachycardia, agitation, hallucinations) and was treated with symptomatic and supportive measures.[ncbi.nlm.nih.gov]
  • […] tone at the SA node causes relative tachycardia 2 Blood vessels- vasoconstriction via muscarinic receptor blockade in endothelial cells results in decreased nitric oxide synthesis In spite of this effect, atropine poisoning is associated with cutaneous flushing[usmle1-topscorer.blogspot.com]
  • Facial and truncal skin was normal, and flushing was not detected. She had a Glasgow Coma Scale score of 11/15.[intjem.springeropen.com]
  • After 6 hours of admission, child developed irrelevant speech, excitation, delirium, hallucinations, and flushing of face. He was agitated and aggressive with purposeless movements. Child had not passed urine for last 8 hours.[cjhr.org]
  • […] lavender purple Hardiness: frost sensitive Exposure: full sun Family: Solanaceae Origin: North America Distribution: Naturalized and weedy, cultivated Poison Part: All parts, mainly seeds and leaves Poison Delivery Mode: Ingestion Symptoms: Hot, dry, and flushed[plants.ces.ncsu.edu]
Blurred Vision
  • Written testimonials for Datura on the Erowid Web site , under titles like “Truly the Devil’s Weed,” “Nightmares in Flux” and “This is Madness,” include delusions of phantom cigarettes, conversations with imaginary friends, amnesia, blurred vision, a[cityroom.blogs.nytimes.com]
  • This results in blurred vision. There are also dry mouth with dysphagia and dysphonia, tachycardia and urinary retention. The skin may be flushed and dry accompanied by hyperthermia.[globinmed.com]
  • Blurred vision, palpitation, urinary retention, dry mouth, ileus, flushing, dysrhytmia, auditory and visual hallucinations and convulsions can be seen after its use (5).[dusunenadamdergisi.org]
  • Jimson weed may also cause liver damage, kidney damage, difficulty urinating or urinary retention, and blurred vision.[healthtools.aarp.org]
  • These would include incoherent speech, impaired coordination, rapid heart beat, dilated pupils, blurred vision and dry, flushed or hot skin. In extreme cases users can experience seizures, intense visual or auditory hallucination, or cardiac arrest.[aacc.org]
Photophobia
  • […] an anticholinergic delirium: a complete inability to differentiate reality from fantasy (frank delirium, as contrasted to hallucination); hyperthermia; tachycardia; bizarre, and possibly violent behavior; and severe mydriasis with resultant painful photophobia[link.springer.com]
  • […] complete inability to differentiate reality from fantasy (delirium, as contrasted to hallucination); hyperthermia; tachycardia (increased heart-rate); bizarre, and possibly violent behavior; and severe mydriasis (pupil dilation) with resultant painful photophobia[sabotagetimes.com]
Diplopia
  • This is followed by giddiness, ataxia, incoordination of muscles, a peculiar flushed appearance of the face, dry hot skin, rise in temperature, diplopia, dilated pupils with loss of accommodation, reddening of the conjunctiva and drowsiness.[dsprud.com]
Dry Eyes
  • […] unknown 3 GI- delayed gastric emptying, decreased intestinal motility, and secretion 4 Respiratory bronchodilatation 5 GU- urinary retention vi a detrusor relaxation and contraction of the external urethral sphincter 6 Secretions decreased lacrimation (dry[usmle1-topscorer.blogspot.com]
Agitation
  • The patient presented with a typical anticholinergic syndrome (dryness of mouth, mydriasis, flushing, tachycardia, agitation, hallucinations) and was treated with symptomatic and supportive measures.[ncbi.nlm.nih.gov]
  • They developed neurotoxicity (confusion, agitation, mydriasis, and hallucination) and were managed symptomatically with good outcome.[ncbi.nlm.nih.gov]
  • Jimson weed intoxication should be considered in cases of patients presenting with unexplained peripheral and central anticholinergic symptoms including delirium, agitation and seizures, especially among younger patients and partygoers.[ncbi.nlm.nih.gov]
  • Repeated neurological examination revealed a gradual improvement of her state of consciousness with disappearance of tachycardia, mydriasis, delirium, and agitation.[intjem.springeropen.com]
  • They developed neurotoxicity (confusion, agitation, mydriasis, and hallucination) and were managed symptomatically with… CONTINUE READING[semanticscholar.org]
Seizure
  • Jimson weed intoxication should be considered in cases of patients presenting with unexplained peripheral and central anticholinergic symptoms including delirium, agitation and seizures, especially among younger patients and partygoers.[ncbi.nlm.nih.gov]
  • Among the serious neurologic and medical complications are coma, trauma, infection, seizures, stroke, altered mentation, peripheral neuropathies, myelopathies, Parkinsonism, visual disturbances, dyskinesias, cerebellar ataxia, impotence, and fetal effects[books.google.com]
  • Physostigmine is recommended when the patient has severe agitation or psychosis not controlled with bezodiazepines or has intractable seizures or tachydysrhythmias with hemodynamic compromise [ 1 ].[intjem.springeropen.com]
  • Seizures : Jimson weed can cause seizures. Do not use jimson weed if you suffer from frequent seizures.[webmd.com]
  • However physostigmine's use may precipitate seizures, cholinergic crisis, bradyarrhythmias and asystole.[erowid.org]
Confusion
  • They developed neurotoxicity (confusion, agitation, mydriasis, and hallucination) and were managed symptomatically with good outcome.[ncbi.nlm.nih.gov]
  • They developed neurotoxicity (confusion, agitation, mydriasis, and hallucination) and were managed symptomatically with… CONTINUE READING[semanticscholar.org]
  • […] intoxication are those of atropine intoxication, which are dry skin and mucosa, flushing, mydriasis, sinus tachycardia, hyperpyrexia, decreased bowel sounds, urinary retention, and neurological disorders with ataxia, impaired short-term memory, disorientation, confusion[intjem.springeropen.com]
  • The others demonstrated confusion, aggression, agitation, disorganized speech, incoherence, and hallucinations. All six were admitted to the hospital, five to the intensive-care unit.[cdc.gov]
Ataxia
  • Among the serious neurologic and medical complications are coma, trauma, infection, seizures, stroke, altered mentation, peripheral neuropathies, myelopathies, Parkinsonism, visual disturbances, dyskinesias, cerebellar ataxia, impotence, and fetal effects[books.google.com]
  • Typical symptoms of DS intoxication are those of atropine intoxication, which are dry skin and mucosa, flushing, mydriasis, sinus tachycardia, hyperpyrexia, decreased bowel sounds, urinary retention, and neurological disorders with ataxia, impaired short-term[intjem.springeropen.com]
  • This is followed by giddiness, ataxia, incoordination of muscles, a peculiar flushed appearance of the face, dry hot skin, rise in temperature, diplopia, dilated pupils with loss of accommodation, reddening of the conjunctiva and drowsiness.[dsprud.com]
  • […] crawling insects. [11] Typical symptoms of DS intoxication are those of atropine intoxication, which are dry skin and mucosa, flushing, mydriasis, sinus tachycardia, hyperpyrexia, decreased bowel sounds, urinary retention, and neurological disorders with ataxia[cjhr.org]
Headache
  • The less alarming sequelae are myriad (fatigue, loss of appetite, headaches, dizziness, etc.). Dr. Brust has written the most comprehensive source available to the point of being encyclpedic, including references.[books.google.com]
  • : full sun Family: Solanaceae Origin: North America Distribution: Naturalized and weedy, cultivated Poison Part: All parts, mainly seeds and leaves Poison Delivery Mode: Ingestion Symptoms: Hot, dry, and flushed skin, hallucinations, pupil dilation, headache[plants.ces.ncsu.edu]
  • Symptoms associated with D. metel poisoning include flushed skin, headaches, hallucinations, and possibly convulsions or even a coma .[keys.lucidcentral.org]
  • Use cautiously with headache, hyperthyroidism (overactive thyroid), or if fair-skinned. Avoid if pregnant or breastfeeding. Black tea : Black tea is made from the dried leaves of Camellia sinensis , a perennial evergreen shrub.[naturallivingcenter.net]

Treatment

  • The treatment of choice for anticholinergic poisoning is mainly supportive care and gastrointestinal decontamination with activated charcoal.[ncbi.nlm.nih.gov]
  • Please find relevant information on First Aid for Datura Stramonium Poisoning regarding cause, signs & symptoms, administration of first aid treatment, prognosis, preventive measures, and additional resources HERE .[dovemed.com]
  • Although physostigmine is the antidote for anticholinergic toxicity, its use is controversial despite recent reports of it being a safe treatment.[intjem.springeropen.com]
  • […] by increasing the concentration of acetylcholine in the synaptic cleft increased acetylcholine concentrations are produced by cholinesterase inhibitors that suppress acetylcholine degradation Physostigmine, a cholinesterase inhibitor, can be used for treatment[usmle1-topscorer.blogspot.com]
  • Rodgers GC Jr, Von Kanel RL: Conservative treatment of jimsonweed ingestion. Vet Hum Toxicol 1993, 35: 32–3.[springermedizin.de]

Prognosis

  • Please find relevant information on First Aid for Datura Stramonium Poisoning regarding cause, signs & symptoms, administration of first aid treatment, prognosis, preventive measures, and additional resources HERE .[dovemed.com]
  • The prognosis of DS intoxication is usually favorable, as in our case, but it may be fatal, especially during massive intoxications meant to be autolytic or the result of toxicomania [ 6 ].[intjem.springeropen.com]
  • […] seriously ill from intentionally ingesting datura. [6] [7] There are also several reports in the medical literature of deaths from D. stramonium and D. ferox intoxication. [8] [9] [10] Children are especially vulnerable to atropine poisoning and their prognosis[psychonautwiki.org]

Etiology

  • Delirium is a complicated condition due to variable symptoms, signs and clinical courses and presence of several risk and etiological factors and advanced age is considered as an important predisposing factor.[dusunenadamdergisi.org]

Epidemiology

  • Epidemiology Frequency United States Incidence is sporadic, with clusters of poisoning cases, mostly among adolescents using plants for their hallucinogenic effects.[emedicine.medscape.com]
  • Epidemiology and Social History - The plant has been described throughout history as a toxin famous for its mind altering properties. There are references to it in Homer's Odyssey and Shakespeare plays.[aacc.org]
  • EPIDEMIOLOGY The plant has been described throughout history as a toxin famous for its mind-altering properties.[erowid.org]
Sex distribution
Age distribution

Pathophysiology

  • Pathophysiology Toxicity from plants containing tropane alkaloids manifests as classic anticholinergic poisoning.[emedicine.medscape.com]

Prevention

  • Please find relevant information on First Aid for Datura Stramonium Poisoning regarding cause, signs & symptoms, administration of first aid treatment, prognosis, preventive measures, and additional resources HERE .[dovemed.com]
  • The best form of invasive species management is prevention. If prevention is no longer possible, it is best to treat the weed infestations when they are small to prevent them from establishing (early detection and rapid response).[keys.lucidcentral.org]
  • Tea tree oil : Tea tree oil is purported to have antiseptic properties, and has been used traditionally to prevent and treat infections.[naturallivingcenter.net]
  • PREVENTION Defoliation programs are one way to decrease access to Jimson Weed. It is important to educate health care providers about the hazards and symptoms involved with contact with Datura stramonium.[erowid.org]
  • Indeed, they were not very cleanly; for they would have wallowed in their own excrements, if they had not been prevented.”[sabotagetimes.com]

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