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Datura Stramonium Poisoning


Presentation

  • The patients presented with visual hallucinations, disorientation, incomprehensible and nonsensical speech, and dilated sluggish pupils.[ncbi.nlm.nih.gov]
  • We present the case of two children admitted at the Children Emergency Room of a teaching hospital following ingestion of extract of Datura stramonium.[ncbi.nlm.nih.gov]
  • The patient presented with a typical anticholinergic syndrome (dryness of mouth, mydriasis, flushing, tachycardia, agitation, hallucinations) and was treated with symptomatic and supportive measures.[ncbi.nlm.nih.gov]
  • Mass spectral data on urine extracts of a 20-year-old male showed the molecular ions and principal fragment ions of scopolamine and atropine, present in Datura stramonium.[astm.org]
Fever
  • We describe the case of a boy who had slurred speech, fever, hallucinations, tachycardia, dilated pupi… Poisoned after Dinner: Dolma with Datura Stramonium.[unboundmedicine.com]
  • Haug Browse recently published Learning/CME Learning/CME View all learning/CME CME Case 3-2019: A 70-Year-Old Woman with Fever, Headache, and Progressive Encephalopathy Caplacizumab Treatment for Acquired Thrombotic Thrombocytopenic Purpura Randomized[nejm.org]
  • Fever : Jimson weed might make fever worse. Stomach ulcer : Jimson weed might delay stomach emptying and make ulcers worse. Stomach and intestinal infections : Jimson weed might slow down the emptying of the stomach and intestines .[webmd.com]
  • Symptoms of poisoning in humans and livestock include restlessness, irritability, depression, dilated pupils, delirium, impaired vision, constipation, fever, extreme thirst, and convulsions.[kswildflower.org]
  • Jimsonweed poisoning causes dry mucous membranes and skin, thirst, flushing, fever, blurred vision, altered mental status, mydriasis, urinary retention, tachycardia, coma, and, in rare cases, death ( 1 ,4 ).[cdc.gov]
Gastric Lavage
  • Intoxication was not thought in the hospital where the patient was first admitted and gastric lavage and active coal were not administered because 12 hours passed before she was admitted to our hospital.[dusunenadamdergisi.org]
Fatigue
  • The less alarming sequelae are myriad (fatigue, loss of appetite, headaches, dizziness, etc.). Dr. Brust has written the most comprehensive source available to the point of being encyclpedic, including references.[books.google.com]
Decreased Bowel Sounds
  • bowel sounds, urinary retention, and neurological disorders with ataxia, impaired short-term memory, disorientation, confusion, hallucinations (visual and auditory), psychosis, agitated delirium, seizures, and coma.[cjhr.org]
Tachycardia
  • The patient presented with a typical anticholinergic syndrome (dryness of mouth, mydriasis, flushing, tachycardia, agitation, hallucinations) and was treated with symptomatic and supportive measures.[ncbi.nlm.nih.gov]
  • Blockade of visceral muscarinic receptors produces the following effects 1 Heart -diminished vagal tone at the SA node causes relative tachycardia 2 Blood vessels- vasoconstriction via muscarinic receptor blockade in endothelial cells results in decreased[usmle1-topscorer.blogspot.com]
  • We describe the case of a boy who had slurred speech, fever, hallucinations, tachycardia, dilated pupi… Poisoned after Dinner: Dolma with Datura Stramonium.[unboundmedicine.com]
  • During the next 6 hours in the emergency department, the six patients continued to experience tachycardia, mydriasis, and altered mental status. One remained unconscious.[cdc.gov]
  • There were anticholinergic signs such as fever, pupillary dilatation, delirium and tachycardia in our case.[dusunenadamdergisi.org]
Weak Pulse
  • pulse, convulsions, and coma Toxic Principle: Tropane alkaloids Severity: Toxic only if large quantities are eaten.[plants.ces.ncsu.edu]
Flushing
  • The patient presented with a typical anticholinergic syndrome (dryness of mouth, mydriasis, flushing, tachycardia, agitation, hallucinations) and was treated with symptomatic and supportive measures.[ncbi.nlm.nih.gov]
  • […] tone at the SA node causes relative tachycardia 2 Blood vessels- vasoconstriction via muscarinic receptor blockade in endothelial cells results in decreased nitric oxide synthesis In spite of this effect, atropine poisoning is associated with cutaneous flushing[usmle1-topscorer.blogspot.com]
  • After 6 hours of admission, child developed irrelevant speech, excitation, delirium, hallucinations, and flushing of face. He was agitated and aggressive with purposeless movements. Child had not passed urine for last 8 hours.[cjhr.org]
  • […] lavender purple Hardiness: frost sensitive Exposure: full sun Family: Solanaceae Origin: North America Distribution: Naturalized and weedy, cultivated Poison Part: All parts, mainly seeds and leaves Poison Delivery Mode: Ingestion Symptoms: Hot, dry, and flushed[plants.ces.ncsu.edu]
  • This is followed by giddiness, ataxia, incoordination of muscles, a peculiar flushed appearance of the face, dry hot skin, rise in temperature, diplopia, dilated pupils with loss of accommodation, reddening of the conjunctiva and drowsiness.[dsprud.com]
Blurred Vision
  • This results in blurred vision. There are also dry mouth with dysphagia and dysphonia, tachycardia and urinary retention. The skin may be flushed and dry accompanied by hyperthermia.[globinmed.com]
  • Blurred vision, palpitation, urinary retention, dry mouth, ileus, flushing, dysrhytmia, auditory and visual hallucinations and convulsions can be seen after its use (5).[dusunenadamdergisi.org]
  • These would include incoherent speech, impaired coordination, rapid heart beat, dilated pupils, blurred vision and dry, flushed or hot skin. In extreme cases users can experience seizures, intense visual or auditory hallucination, or cardiac arrest.[aacc.org]
  • Jimsonweed poisoning causes dry mucous membranes and skin, thirst, flushing, fever, blurred vision, altered mental status, mydriasis, urinary retention, tachycardia, coma, and, in rare cases, death ( 1 ,4 ).[cdc.gov]
Photophobia
  • […] an anticholinergic delirium: a complete inability to differentiate reality from fantasy (frank delirium, as contrasted to hallucination); hyperthermia; tachycardia; bizarre, and possibly violent behavior; and severe mydriasis with resultant painful photophobia[link.springer.com]
  • […] complete inability to differentiate reality from fantasy (delirium, as contrasted to hallucination); hyperthermia; tachycardia (increased heart-rate); bizarre, and possibly violent behavior; and severe mydriasis (pupil dilation) with resultant painful photophobia[sabotagetimes.com]
Diplopia
  • This is followed by giddiness, ataxia, incoordination of muscles, a peculiar flushed appearance of the face, dry hot skin, rise in temperature, diplopia, dilated pupils with loss of accommodation, reddening of the conjunctiva and drowsiness.[dsprud.com]
Dry Eyes
  • […] unknown 3 GI- delayed gastric emptying, decreased intestinal motility, and secretion 4 Respiratory bronchodilatation 5 GU- urinary retention vi a detrusor relaxation and contraction of the external urethral sphincter 6 Secretions decreased lacrimation (dry[usmle1-topscorer.blogspot.com]
Agitation
  • The patient presented with a typical anticholinergic syndrome (dryness of mouth, mydriasis, flushing, tachycardia, agitation, hallucinations) and was treated with symptomatic and supportive measures.[ncbi.nlm.nih.gov]
  • They developed neurotoxicity (confusion, agitation, mydriasis, and hallucination) and were managed symptomatically with good outcome.[ncbi.nlm.nih.gov]
  • Jimson weed intoxication should be considered in cases of patients presenting with unexplained peripheral and central anticholinergic symptoms including delirium, agitation and seizures, especially among younger patients and partygoers.[ncbi.nlm.nih.gov]
  • They developed neurotoxicity (confusion, agitation, mydriasis, and hallucination) and were managed symptomatically with… CONTINUE READING Highly Cited This paper has 23 citations. REVIEW CITATIONS From This Paper Topics from this paper.[semanticscholar.org]
  • […] salivation (dry mouth) and sweating (dry and hot skin) Atropine decreases one's ability to sweat, contributing to hyperthermia 7 Eye- mydriasis (dilated pupils) and cycloplegia (inability to focus on the near objects, blurry vision) 8 CNS -hallucinations, agitation[usmle1-topscorer.blogspot.com]
Seizure
  • Jimson weed intoxication should be considered in cases of patients presenting with unexplained peripheral and central anticholinergic symptoms including delirium, agitation and seizures, especially among younger patients and partygoers.[ncbi.nlm.nih.gov]
  • Among the serious neurologic and medical complications are coma, trauma, infection, seizures, stroke, altered mentation, peripheral neuropathies, myelopathies, Parkinsonism, visual disturbances, dyskinesias, cerebellar ataxia, impotence, and fetal effects[books.google.com]
  • Seizures : Jimson weed can cause seizures. Do not use jimson weed if you suffer from frequent seizures.[webmd.com]
  • There was no preceding history of trauma, seizures, or drug intake. There was no history of vomiting, loose motions, or similar episodes in the past. At the time of admission, child had no injury marks, bite mark, rashes, or bleeding from any site.[cjhr.org]
  • Signs and symptoms such as mydriasis, tachycardia, arrhythmias, agitation, seizures and coma can appear.Diagnosis is clinical and early treatment should be given, including gastrointestinal decontamination, supportive care and physostigmine in life-threatening[analesdepediatria.org]
Confusion
  • They developed neurotoxicity (confusion, agitation, mydriasis, and hallucination) and were managed symptomatically with good outcome.[ncbi.nlm.nih.gov]
  • They developed neurotoxicity (confusion, agitation, mydriasis, and hallucination) and were managed symptomatically with… CONTINUE READING Highly Cited This paper has 23 citations. REVIEW CITATIONS From This Paper Topics from this paper.[semanticscholar.org]
  • The others demonstrated confusion, aggression, agitation, disorganized speech, incoherence, and hallucinations. All six were admitted to the hospital, five to the intensive-care unit.[cdc.gov]
  • As many psychiatric symptoms and signs such as bizarre behaviors, hallucinations and agitation can be observed in the patient, delirium can often be confused with other psychiatric disorders (2,3).[dusunenadamdergisi.org]
  • It is poisonous and can cause many toxic effects including dry mouth and extreme thirst, vision problems, nausea and vomiting , fast heart rate , hallucinations, high temperature, seizures , confusion, loss of consciousness, breathing problems , and death[webmd.com]
Ataxia
  • Among the serious neurologic and medical complications are coma, trauma, infection, seizures, stroke, altered mentation, peripheral neuropathies, myelopathies, Parkinsonism, visual disturbances, dyskinesias, cerebellar ataxia, impotence, and fetal effects[books.google.com]
  • This is followed by giddiness, ataxia, incoordination of muscles, a peculiar flushed appearance of the face, dry hot skin, rise in temperature, diplopia, dilated pupils with loss of accommodation, reddening of the conjunctiva and drowsiness.[dsprud.com]
  • […] crawling insects. [11] Typical symptoms of DS intoxication are those of atropine intoxication, which are dry skin and mucosa, flushing, mydriasis, sinus tachycardia, hyperpyrexia, decreased bowel sounds, urinary retention, and neurological disorders with ataxia[cjhr.org]
Headache
  • The less alarming sequelae are myriad (fatigue, loss of appetite, headaches, dizziness, etc.). Dr. Brust has written the most comprehensive source available to the point of being encyclpedic, including references.[books.google.com]
  • Haug Browse recently published Learning/CME Learning/CME View all learning/CME CME Case 3-2019: A 70-Year-Old Woman with Fever, Headache, and Progressive Encephalopathy Caplacizumab Treatment for Acquired Thrombotic Thrombocytopenic Purpura Randomized[nejm.org]
  • : full sun Family: Solanaceae Origin: North America Distribution: Naturalized and weedy, cultivated Poison Part: All parts, mainly seeds and leaves Poison Delivery Mode: Ingestion Symptoms: Hot, dry, and flushed skin, hallucinations, pupil dilation, headache[plants.ces.ncsu.edu]

Treatment

  • The treatment of choice for anticholinergic poisoning is mainly supportive care and gastrointestinal decontamination with activated charcoal.[ncbi.nlm.nih.gov]
  • Please find relevant information on First Aid for Datura Stramonium Poisoning regarding cause, signs & symptoms, administration of first aid treatment, prognosis, preventive measures, and additional resources HERE .[dovemed.com]
  • […] by increasing the concentration of acetylcholine in the synaptic cleft increased acetylcholine concentrations are produced by cholinesterase inhibitors that suppress acetylcholine degradation Physostigmine, a cholinesterase inhibitor, can be used for treatment[usmle1-topscorer.blogspot.com]
  • Rodgers GC Jr, Von Kanel RL: Conservative treatment of jimsonweed ingestion. Vet Hum Toxicol 1993, 35: 32–3.[springermedizin.de]
  • Haug Browse recently published Learning/CME Learning/CME View all learning/CME CME Case 3-2019: A 70-Year-Old Woman with Fever, Headache, and Progressive Encephalopathy Caplacizumab Treatment for Acquired Thrombotic Thrombocytopenic Purpura Randomized[nejm.org]

Prognosis

  • Please find relevant information on First Aid for Datura Stramonium Poisoning regarding cause, signs & symptoms, administration of first aid treatment, prognosis, preventive measures, and additional resources HERE .[dovemed.com]
  • Prognosis is usually favorable. Key words: Datura Poisoning Anticholinergic syndrome Hallucinations El Texto completo solo está disponible en PDF Bibliografía [1.] B.T. Vanderhoff, K.H.[analesdepediatria.org]

Etiology

  • Delirium is a complicated condition due to variable symptoms, signs and clinical courses and presence of several risk and etiological factors and advanced age is considered as an important predisposing factor.[dusunenadamdergisi.org]

Epidemiology

  • Epidemiology and Social History - The plant has been described throughout history as a toxin famous for its mind altering properties. There are references to it in Homer's Odyssey and Shakespeare plays.[aacc.org]
Sex distribution
Age distribution

Prevention

  • Please find relevant information on First Aid for Datura Stramonium Poisoning regarding cause, signs & symptoms, administration of first aid treatment, prognosis, preventive measures, and additional resources HERE .[dovemed.com]
  • From the Centers for Disease Control and Prevention. Jimson weed poisoning-Texas, New York, and California, 1994. MMWR 1995; 44: 41-44 [8.] D.L. Savitt, J.R. Roberts, E.G. Siegel Anisocoria from Jimson weed Jama, 255 (1986), pp. 1439-1440 [9.] M.[analesdepediatria.org]
  • A group of drugs or substances which prevents acetylcholine from binding muscarinic receptors may cause anticholinergic syndrome (6).[dusunenadamdergisi.org]
  • Indeed, they were not very cleanly; for they would have wallowed in their own excrements, if they had not been prevented.”[sabotagetimes.com]

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