The myxoid component which was present in the well differentiated liposarcomatous component gave the tumor atypical radiological features.[ncbi.nlm.nih.gov]
The follow-up surgical resection specimen showed a dedifferentiated liposarcoma with strong and diffuse immunoreactivity to vimentin, desmin and CD68 in the large, pleomorphic cells; focal and weak immunoreactivity to smooth muscle actin and S-100 in[ncbi.nlm.nih.gov]
The patient underwent splenectomy, and the adipose tissue surrounding the splenic hilum was also resected. Microscopically, the tumor mainly consisted of high-grade spindle cells similar to those seen in undifferentiated pleomorphic liposarcoma.[ncbi.nlm.nih.gov]
Initially, non-specific orbital inflammation was suspected while investigations were ongoing. A trial of steroids failed to resolve the proptosis to a significant extent.[ncbi.nlm.nih.gov]
We report such a case and our approach to an 83-year-old male with dedifferentiated liposarcoma of the spermatic cord with a history of inguinalhernia.[ncbi.nlm.nih.gov]
In this case, we inferred that the hard nodule located beneath the previous incision was local recurrence; the suprapubic and inguinalmasses were metastatic tumors either from the left intrascrotal tumor 2 years ago or from the right paratesticular DDL[ajandrology.com]
A woman who complained of dyspnea showed on imaging features a bulky posterior mediastinal mass which was completely excised and initially misdiagnosed as an angiomyolipoma.[ncbi.nlm.nih.gov]
The NDDLS-1 cell line was established from a pleuraleffusion associated with a lung metastasis. Pleomorphic tumor cells arranged in a haphazard growth pattern were seen in xenograft tumors.[ncbi.nlm.nih.gov]
Abdominal angiography showed small feeding vessels of the tumor from the ileocolic artery and the middle colic artery.[ncbi.nlm.nih.gov]
The ileocolic vein and artery, as well as an accessory right colic vein, were identified, ligated, and cut, and the main lymph nodes on the anterior surface of the inferior mesenteric vein from gastrocolic trunk to ileocolic vein were dissected.[surgicalcasereports.springeropen.com]
The patient was a 74-year-old man, complaining a loss of appetite. Abdominal computed tomography revealed a retroperitoneal mass, 10 cm in diameter, between the liver and the right adrenal gland.[ncbi.nlm.nih.gov]
We presented a 61-year old woman with giant primary synchronously bilateral mesenteric dedifferentiated liposarcoma with hyperparathyroidism, hyperthyroidism, Type-2 diabetes mellitus (T2DM) and hypertension.[ncbi.nlm.nih.gov]
Furthermore, she had a surgical history of myomectomy and her past medical history included hypertension and insomnia. A physical examination revealed a palpable mass in the right lower quadrant of the abdomen.[wjgnet.com]
A 71-year-old woman was referred to the Surgical Oncology Division of Napoleão Laureano Hospital (João Pessoa, PB, Brazil) due to a solid mass at the right side of the abdomen and fever, with no signs of jaundice.[ncbi.nlm.nih.gov]
The use of MDM2 immunostaining in differentiating benign lipomatous tumours from well-differentiated liposarcomas is mentioned, which is of value especially in lipomatous tumours of the gut where ulcerated benign tumours can show varying degrees of atypia[ncbi.nlm.nih.gov]
Gross examination revealed a submucosal polyp without a mucosal ulcer.[wjgnet.com]
The adjacent proximal femur showed irregular cortical new bone, eventually followed by intramedullary osteoblastic involvement and pathologic fracture.[ncbi.nlm.nih.gov]
Abstract We report the case of a 56-year-old female who presented to the ophthalmic casualty department with proptosis and diplopia. Initially, non-specific orbital inflammation was suspected while investigations were ongoing.[ncbi.nlm.nih.gov]
The patient presented with a painless right scrotalmass. Magnetic resonance imaging showed a large mass along the right spermatic cord.[ncbi.nlm.nih.gov]
We present the case of a 73 years old patient known with multiple cardiovascular comorbidities, stroke sequelae and a large abdominal mass evolving for 3 years. He was referred to our clinic for abdominal pain and bowel disorders.[ncbi.nlm.nih.gov]
Diagnostic Workup The diagnosis and treatment of STS mandates a multidisciplinary approach ideally carried out in reference centers treating a high number of patients annually ( 11 ).[frontiersin.org]
A woman who complained of dyspnea showed on imaging features a bulky posterior mediastinalmass which was completely excised and initially misdiagnosed as an angiomyolipoma.[ncbi.nlm.nih.gov]
We found an undiagnosed anteriormediastinalmass in a 56- year-old man for whom we performed a complete tumor resection through median sternotomy.[ncbi.nlm.nih.gov]
A woman who complained of dyspnea showed on imaging features a bulky posteriormediastinalmass which was completely excised and initially misdiagnosed as an angiomyolipoma.[ncbi.nlm.nih.gov]
The differential diagnosis of the pleuralmass included malignant solitary fibrous tumor. Cytogenetic analysis showed supernumerary ring chromosomes in the pleural tumor, as well as strong amplification of MDM2 and CDK4 genes in both tumors.[ncbi.nlm.nih.gov]
The NDDLS-1 cell line was established from a pleuraleffusion associated with a lung metastasis. Pleomorphic tumor cells arranged in a haphazard growth pattern were seen in xenograft tumors.[ncbi.nlm.nih.gov]
The etiology and the exact mechanism of dedifferentiation remains unknown. It is, however, thought to occur spontaneously due to certain chromosomal abnormalities.[enzolifesciences.com]
(Etiology) The exact cause and mechanism of formation of Dedifferentiated Liposarcoma is unknown It is thought to occur spontaneously due to certain genetic mutations (chromosomal abnormalities) Contrary to some beliefs, trauma does not contribute to[dovemed.com]
The Surveillance, Epidemiology and End Results (SEER) database was also queried to identify adult patients diagnosed with WD/DD liposarcoma between 1973-2012.[ncbi.nlm.nih.gov]
Categories Cancer Topics Breast Cancer Cancer Genetics Prevention & Epidemiology Central Nervous System Clinical Trials Developmental Therapeutics Gastrointestinal Cancers Genitourinary Cancers Geriatric Oncology Gynecologic Cancers Head & Neck Cancers[shop.asco.org]
Epidemiology Dedifferentiation is much more common in retroperitoneal well differentiated liposarcoma than in those occurring in the limbs. 90% of cases are primary, 10% of instances of dedifferentiation occur in recurrences.[e-immunohistochemistry.info]
TERMINOLOGY Abbreviations Dedifferentiated liposarcoma (DDLS) Definitions Malignant lipogenic neoplasm with abrupt or gradual transition from atypical lipomatous tumor to nonlipogenic sarcoma of variable histology CLINICAL ISSUES Epidemiology Incidence[basicmedicalkey.com]
Well-differentiated liposarcomas treated with surgery, intraoperative distilled water lavage [7] and radiation have a low recurrence rate (about 10%) and rarely metastasize. [8] Five-year survival rates vary from 56 to 100% based on histological subtype. [8] Epidemiology[en.wikipedia.org]
Awareness of this finding can prevent one from misdiagnosing dedifferentiated liposarcoma as inflammatory myofibroblastic tumor, a much less aggressive neoplasm.[ncbi.nlm.nih.gov]
Therefore, it is important to try and prevent R2 resection and detect recurrences as early as possible.[jstage.jst.go.jp]
Song CH, Chai FY, Saukani MF, Singh H, Jiffre D: Management and prevention of recurrent paratesticular liposarcoma. Malays J Med Sci 2013; 20:95–97.[karger.com]
Categories Cancer Topics Breast Cancer Cancer Genetics Prevention & Epidemiology Central Nervous System Clinical Trials Developmental Therapeutics Gastrointestinal Cancers Genitourinary Cancers Geriatric Oncology Gynecologic Cancers Head & Neck Cancers[shop.asco.org]