The myxoid component which was present in the well differentiated liposarcomatous component gave the tumor atypical radiological features. [ncbi.nlm.nih.gov]

• Fishing

  To the best of our knowledge, this is the first report of MDM2 FISH amplification in a liposarcoma performed on an aspirate smear. [ncbi.nlm.nih.gov]

• Splenectomy

  The patient underwent splenectomy, and the adipose tissue surrounding the splenic hilum was also resected. Microscopically, the tumor mainly consisted of high-grade spindle cells similar to those seen in undifferentiated pleomorphic liposarcoma. [ncbi.nlm.nih.gov]

• Inguinal Mass

  In this case, we inferred that the hard nodule located beneath the previous incision was local recurrence; the suprapubic and inguinal masses were metastatic tumors either from the left intrascrotal tumor 2 years ago or from the right paratesticular DDL [ajandrology.com]

• Aspiration

  We present a case of a dedifferentiated liposarcoma arising in the soft tissue of the posterior neck of an 86-year-old man and diagnosed by fine-needle aspiration. Aspirate smears showed a dual population of atypical lipomatous and spindled cells. [ncbi.nlm.nih.gov]

  Fine needle aspiration biopsy diagnosis of dedifferentiated liposarcoma: Cytomorphology and MDM2 amplification by FISH. [cytojournal.com]

• Pleural Effusion

  The NDDLS-1 cell line was established from a pleural effusion associated with a lung metastasis. Pleomorphic tumor cells arranged in a haphazard growth pattern were seen in xenograft tumors. [ncbi.nlm.nih.gov]

• Dysphagia

  The patient denied dysphagia or bucking (choking cough). The other physical examination findings were fairly unremarkable. [ajnr.org]

• Ulcer

  The use of MDM2 immunostaining in differentiating benign lipomatous tumours from well-differentiated liposarcomas is mentioned, which is of value especially in lipomatous tumours of the gut where ulcerated benign tumours can show varying degrees of atypia [ncbi.nlm.nih.gov]

  Gross examination revealed a submucosal polyp without a mucosal ulcer. [wjgnet.com]

• Neck Mass

  A contrast-enhanced CT scan of the head and neck revealed a large neck mass that had 3 components of differing attenuation, including a lipomatous region with thick septa, a low-attenuation high-water-content component, and a sporadic heterogeneous high-attenuation [ajnr.org]

• Scrotal Mass

  The patient presented with a painless right scrotal mass. Magnetic resonance imaging showed a large mass along the right spermatic cord. [ncbi.nlm.nih.gov]

Diagnostic Workup The diagnosis and treatment of STS mandates a multidisciplinary approach ideally carried out in reference centers treating a high number of patients annually ( 11 ). [frontiersin.org]

• Mediastinal Mass

  A woman who complained of dyspnea showed on imaging features a bulky posterior mediastinal mass which was completely excised and initially misdiagnosed as an angiomyolipoma. [ncbi.nlm.nih.gov]

• Anterior Mediastinal Mass

  We found an undiagnosed anterior mediastinal mass in a 56- year-old man for whom we performed a complete tumor resection through median sternotomy. [ncbi.nlm.nih.gov]

• Posterior Mediastinal Mass

  A woman who complained of dyspnea showed on imaging features a bulky posterior mediastinal mass which was completely excised and initially misdiagnosed as an angiomyolipoma. [ncbi.nlm.nih.gov]

• Pleural Mass

  The differential diagnosis of the pleural mass included malignant solitary fibrous tumor. Cytogenetic analysis showed supernumerary ring chromosomes in the pleural tumor, as well as strong amplification of MDM2 and CDK4 genes in both tumors. [ncbi.nlm.nih.gov]

• Lymphocytic Infiltrate

  The results favor a reactive lymphocytic infiltration versus a neoplastic one, which might be caused for example by chemoattractive agents. [ncbi.nlm.nih.gov]

• Pleural Effusion

  The NDDLS-1 cell line was established from a pleural effusion associated with a lung metastasis. Pleomorphic tumor cells arranged in a haphazard growth pattern were seen in xenograft tumors. [ncbi.nlm.nih.gov]

The treatment strategy for abdominal dedifferentiated liposarcoma is surgical resection with a wide surgical margin. [ncbi.nlm.nih.gov]

Loss of 19q13, but not 11q23-24, was associated with poor prognosis. [ncbi.nlm.nih.gov]

The etiology and the exact mechanism of dedifferentiation remains unknown. It is, however, thought to occur spontaneously due to certain chromosomal abnormalities. [enzolifesciences.com]

(Etiology) The exact cause and mechanism of formation of Dedifferentiated Liposarcoma is unknown It is thought to occur spontaneously due to certain genetic mutations (chromosomal abnormalities) Contrary to some beliefs, trauma does not contribute to [dovemed.com]

The Surveillance, Epidemiology and End Results (SEER) database was also queried to identify adult patients diagnosed with WD/DD liposarcoma between 1973-2012. [ncbi.nlm.nih.gov]

Categories Cancer Topics Breast Cancer Cancer Genetics Prevention & Epidemiology Central Nervous System Clinical Trials Developmental Therapeutics Gastrointestinal Cancers Genitourinary Cancers Geriatric Oncology Gynecologic Cancers Head & Neck Cancers [shop.asco.org]

Epidemiology Dedifferentiation is much more common in retroperitoneal well differentiated liposarcoma than in those occurring in the limbs. 90% of cases are primary, 10% of instances of dedifferentiation occur in recurrences. [e-immunohistochemistry.info]

TERMINOLOGY Abbreviations Dedifferentiated liposarcoma (DDLS) Definitions Malignant lipogenic neoplasm with abrupt or gradual transition from atypical lipomatous tumor to nonlipogenic sarcoma of variable histology CLINICAL ISSUES Epidemiology Incidence [basicmedicalkey.com]

Well-differentiated liposarcomas treated with surgery, intraoperative distilled water lavage [7] and radiation have a low recurrence rate (about 10%) and rarely metastasize. [8] Five-year survival rates vary from 56 to 100% based on histological subtype. [8] Epidemiology [en.wikipedia.org]

Awareness of this finding can prevent one from misdiagnosing dedifferentiated liposarcoma as inflammatory myofibroblastic tumor, a much less aggressive neoplasm. [ncbi.nlm.nih.gov]

Therefore, it is important to try and prevent R2 resection and detect recurrences as early as possible. [jstage.jst.go.jp]

Song CH, Chai FY, Saukani MF, Singh H, Jiffre D: Management and prevention of recurrent paratesticular liposarcoma. Malays J Med Sci 2013; 20:95–97. [karger.com]

Categories Cancer Topics Breast Cancer Cancer Genetics Prevention & Epidemiology Central Nervous System Clinical Trials Developmental Therapeutics Gastrointestinal Cancers Genitourinary Cancers Geriatric Oncology Gynecologic Cancers Head & Neck Cancers [shop.asco.org]