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Deep Dermatophytosis
Disseminated Granulomatous Dermatophytosis

Presentation

OBJECTIVE: To present the 15-year experience of a tertiary dermato-mycology clinic with the diagnosis and treatment of deep dermatophytosis. METHODS: Patients were identified by database search. [ncbi.nlm.nih.gov]

The experience of a tertiary dermato-mycology clinic in Israel is presented. [life-worldwide.org]

Tinea incognito This is tinea corporis with an altered, nonclassic presentation due to corticosteroid treatment. [5] See Clinical Presentation for more detail. [emedicine.medscape.com]

This article will review the clinical presentations, pathologic characteristics, underlying disease and treatment outcome of patients with deep dermatophytosis reported in published studies. [afwgonline.com]

Skin

  • Subcutaneous Nodule

    A patient treated with immunosuppressant drug therapy for a non-Hodgkin's lymphoma and who presented with a tinea corporis developed a sudden outbreak of numerous subcutaneous nodules. [ncbi.nlm.nih.gov]

    Groin induration with erythema AMB Resolved 64 F MDS/AML, mitoxantrone Leg erythema and induration AMB FLC Resolved Nir-Paz, 2003[ 34 ] 56 M Mixed CTD, prednisone, cyclosporine, azathioprine Multiple subcutaneous nodules on bilateral lower extremities [academic.oup.com]

    Subcutaneous nodules attributed to nocardiosis in a renal transplant recipient on tacrolimus therapy. Am J Nephrol2000;20:138-41. [docslide.net]

Workup

See Workup for more detail. Management Topical therapy is recommended for a localized infection because dermatophytes rarely invade living tissues. [emedicine.medscape.com]

Treatment

Systemic antifungal treatment leads to complete resolution. The urgent need for the treatment of superficial fungal infections in immunocompromised patients is emphasized. [ncbi.nlm.nih.gov]

Treatment Currently, there are no treatment guidelines available for deep dermatophytosis. But considering the depth of invasion, systemic antifungal agents should always be used. [afwgonline.com]

Despite improvements in supportive care and patient selection, death after ASCT remains a concern due to progressive disease, infection, and other treatment- and non-treatment-related causes. [medworm.com]

Orally administered griseofulvin remains the standard treatment for tinea capitis. Topical treatment of onychomycosis with ciclopirox nail lacquer has a low cure rate. [aafp.org]

Transient response was observed after each treatment. In the last 2 years, the lesions progressed with poor response to combined antifungal treatment, consisting of voriconazole and L-AMB. [aspergillus.org.uk]

Prognosis

The host immune status plays a major role in disease pathogenesis, extent and prognosis. Systemic antifungal treatment is always necessary. [afwgonline.com]

Etiology

T. rubrum - the predominant etiological agent in human dermatophytoses in Chennai, India. Afr J Microbiol Res 2007;52:09-12. 12. Chander J. Dermatophytoses, textbook of medical mycology.1995;1:91-112. 13. Wagner DK, Sohnle PG. [e-ijd.org]

Infectious etiologies include the hematogenous dissemination of bacteria such as that found in septic emboli from endocarditis, ecthyma gangrenosum, or meningococcemia. [academic.oup.com]

Epidemiology

It provides a comprehensive review of the epidemiology, diagnosis, and management of opportunistic infections and presents strategies for infection prevention and control. [books.google.de]

AP-HP), and University Paris Descartes, Dermatology Unit (H.B.) and Skin Research Institute (L.M.), INSERM Unité 697, Saint Louis Hospital, INSERM Unité 781, Necker-Enfants Malades Hospital (H.B.), Human Histopathology and Animal Models, Infection and Epidemiology [ncbi.nlm.nih.gov]

These variations have not been recorded in a formal study and provide more reason why an all-encompassing epidemiologic study is urgently needed. [ijdvl.com]

Epidemiology and ecology of onychomycosis. Dermatology. 1997;194 (Suppl 1):32–36. 4. Akiba H, Motoki Y, Satoh M, Iwatsuki K, Kaneko F. [dovepress.com]

Pathophysiology

However, the immune response that is raised, and especially the degree of inflammation, varies according to the dermatophyte species, the host species and the pathophysiological status of the host. [4], [5], [14] In general, the zoophilic species cause [e-ijd.org]

Prevention

It provides a comprehensive review of the epidemiology, diagnosis, and management of opportunistic infections and presents strategies for infection prevention and control. [books.google.de]

There is no vaccine for EBV, but infection can be prevented by not sharing personal items or saliva with an infected person. [fi.nativelib.net]

[…] summarizes the clinicalcourse of 3 fatal cases of RMSF in children and relatedillness in family members during the summer of 2003.These cases underscore the importance of prompt diag-nosis and appropriate antimicrobial therapy in patientswith RMSF to prevent [dokumen.tips]

“As we discover more of these single-gene, inborn immune system defects, we can give susceptible individuals with a family history of the disease a chance to prevent it, through molecular diagnosis and genetic counseling, as well as targeted treatments [biosciencetechnology.com]

"As we discover more of these single-gene, inborn immune system defects, we can give susceptible individuals with a family history of the disease a chance to prevent it, through molecular diagnosis and genetic counseling, as well as targeted treatments [sciencedaily.com]

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