The present report discusses the clinical indications that can support the administration of deferoxamine for iron intoxication in pregnancy and discusses the benefits and risks of its usage. [ncbi.nlm.nih.gov]

• Gangrene

  A 49-year-old woman undergoing long-term hemodialysis and treated with deferoxamine (DFO) 1.5 g twice weekly for aluminum bone disease developed fever and bilateral calf pain caused by myonecrosis with gas gangrene. She had a rapidly fatal outcome. [ncbi.nlm.nih.gov]

• Gagging

  The release of hypoxia related reparative factors by the cells on the collagen-GAG substrate was evaluated to detect if DFO produces results comparable to environmentally induced hypoxia to facilitate optimal clinical settings. [ncbi.nlm.nih.gov]

• Intestinal Perforation

  Despite the frequency of gastrointestinal disease caused by Yersinia enterocolitica, intestinal perforation is a rare complication of this infection and to date only eight cases have been reported in the English literature. [ncbi.nlm.nih.gov]

• Periodontitis

  The purpose of the present study was to investigate the influence of DFO on the proliferation, migration and osteogenic differentiation of human periodontal ligament cells (hPDLCs). [ncbi.nlm.nih.gov]

• Macula

  Infrared imaging showed areas of increased stippled infrared intensity through the macula. Fundus autofluorescence revealed diffuse areas of stippled hyperautofluorescence and hypoautofluorescence. [ncbi.nlm.nih.gov]

• Calf Pain

  A 49-year-old woman undergoing long-term hemodialysis and treated with deferoxamine (DFO) 1.5 g twice weekly for aluminum bone disease developed fever and bilateral calf pain caused by myonecrosis with gas gangrene. She had a rapidly fatal outcome. [ncbi.nlm.nih.gov]

• Skeletal Dysplasia

  RESULTS: Twenty-two (37.3%) children had variable degrees of skeletal dysplasia-like changes similar to those described with deferoxamine intake, mostly around the knees. [ncbi.nlm.nih.gov]

• Fear

  The use of the iron chelator, Deferoxamine (DFO), in pregnant thalassemia women with iron overload has been generally avoided due to fear of its potential teratogenicity. [ncbi.nlm.nih.gov]

• Myoclonus

  We describe a patient undergoing chronic hemodialysis who developed a neurologic syndrome consisting of seizures, progressive myoclonus, and mild dementia and who responded to chelation therapy with deferoxamine mesylate. [ncbi.nlm.nih.gov]

• Meningism

  The model comprises a co-culture system of cerebral astrocytes and meningeal fibroblasts, which form scar-like clusters when stimulated with transforming growth factor-β (TGF-β). [ncbi.nlm.nih.gov]

• Oliguria

  If oliguria or anuria develop, dialysis may be required. References… Bailey, B., Blais, R., Gaudreault, P., Gosselin, S., & Laliberte, M. (2009). Antidotes en toxicologie d'urgence (3rd ed.). Quebec, Canada: Centre antipoison du Quebec. [iwkpoisoncentre.ca]

  If oliguria or anuria develop, peritoneal dialysis or hemodialysis may become necessary to remove the ferrioxamine. [rxmed.com]

• Staphylococcus Aureus

  Moreover, immobilized deferoxamine can distinguish Y. enterocolitica, which binds ferrioxamine (deferoxamine-Fe), from Staphylococcus aureus, Mycobacterium smegmatis and Pseudomonas aeruginosa, which don't. [ncbi.nlm.nih.gov]

Recommended first line treatment is deferoxamine (DFO) from the age of 2 and second line treatment after the age of 6 is deferiprone (L1). [ncbi.nlm.nih.gov]

The frequent lack of early diagnosis, itself subsequent to a break away from the standard diagnostic tools (apart from biopsy and culture) makes the survival prognosis particularly critical. [ncbi.nlm.nih.gov]

Secondary injuries after ICH, such as PHE and neuronal death, are the main reasons leading to poor prognosis. [doi.org]

Bos R, van der Groep P, Greijer AE, Shvarts A, Meijer S, Pinedo HM, Semenza GL, van Diest PJ, van der Wall E: Levels of hypoxia-inducible factor-1alpha independently predict prognosis in patients with lymph node negative breast carcinoma. [karger.com]

Pharmacosurveillance and quality of care of thalassaemic patients: a large scale epidemiological survey. Eur J Clin Pharmacol. 2001 ; 56 : 915 -922. [bloodjournal.org]

Modell B, Darlison M (2008) Global epidemiology of haemoglobin disorders and derived service indicators. Bull World Health Organ 86: 480-487. PubMed: 18568278. View Article Google Scholar 3. [journals.plos.org]

We hypothesize that this elevation in CSF aluminum may account for the observed neurologic deterioration after deferoxamine and postulate various pathophysiologic mechanisms that might be involved. [ncbi.nlm.nih.gov]

Modell, “The Pathophysiology of Beta-Thalassaemia Major,” Journal of Clinical Pathology. Supplement (Royal College of Pathologists), Vol. 8, 1974, pp. 12-18. [ 31 ] A. [scirp.org]

Edwards, Genetic Testing for Disorders of Iron Homeostasis, Iron Physiology and Pathophysiology in Humans, 10.1007/978-1-60327-485-2_26, (529-565), (2011). [doi.org]

Neutrophils: molecules, functions and pathophysiological aspects. Lab. Invest. 80 : 617. Weinberg, E. D.. 1989. Iron, asbestos, and carcinogenicity. Lancet 1 : 1399. Nemeth, Z. H., E. A. Deitch, C. Szabo, Z. Fekete, C. J. Hauser, G. Hasko. 2002. [jimmunol.org]

Both L1 and DF could also prevent iron absorption. The new oral chelator deferasirox (DFX) increases iron excretion and decreases liver iron in TM and TI. [ncbi.nlm.nih.gov]

Researchers plan to continue studying patients receiving deferoxamine as treatment for the prevention of heart complications associated with repeated blood transfusions. [clinicaltrials.gov]

Both L 1 and DF could also prevent iron absorption. The new oral chelator deferasirox (DFX) increases iron excretion and decreases liver iron in TM and TI. [dovepress.com]