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Deficiency of Interleukin-36-Receptor Antagonist



  • Intense irritability was present during flares without fever. Moreover, since 1 month of age the infant presented with diarrhea, dysphagia, and reduced feeding rate, with failure to thrive.[ncbi.nlm.nih.gov]
  • Case 1 A 4-year-old boy, born from unrelated parents, presented at the age of 3 years with inverse psoriasis in the genital area.[ard.bmj.com]
  • Tenosynovitis may also be present. Conjunctivitis is common. However, more severe ocular manifestations including uveitis and iritis may also be present.[rheumatologyadvisor.com]
High Fever
  • DITRA is a recently described autoinflammatory disease characterized by repeated flares of generalized pustular psoriasis, high fever, asthenia, and systemic inflammation.[ncbi.nlm.nih.gov]
  • Some with acral pustules and nail damage, or chronic plaques. [58] [61] Neurologic: Sudden-onset high fever 40 C with chills.[autoinflammatory-search.org]
  • The disease presents with high fever episodes, skin rash, neurological abnormalities such as hearing loss, cerebral atrophy, chronic meningitis, and severe deformities of the joints.[rheumatologyadvisor.com]
  • Let's catch us some fish (which might also be phrased Let's catch some fish for ourselves [ citation needed ] ) This construction could also be an extension of a reflexive construction.[en.wikipedia.org]
  • We marked off the location of the vanity using blue painter’s tape. Each heating cable will have a cold splice. This splice has to be set in the DITRA-HEAT membrane.[homerepairtutor.com]
Severe Clinical Course
  • We present two paediatric cases of DITRA with a severe clinical course, resistant to multiple therapies in whom the use of high doses of ustekinumab (a monoclonal antibody against the p40 subunit of both IL-12 and IL-23) lead to a persistent control of[ard.bmj.com]
  • So having the cold splice flush with the DITRA-HEAT membrane is good. Step 10: Heating Cable Installation in the Membrane Heating cable should be no more or less than 3 studs apart.[homerepairtutor.com]
  • The height of the grate is adjusted via the height adjustment collar and aligned flush with the top of the tile covering.[flooringsupplyshop.com]
  • That would be close to a ½” added height. ) This is wasted height when an anti-fracture membrane isn't needed. *DITRA means Quick and Simple Installation No. Both modified and unmodified thinset are required, more time mixing, and more waste.[warmlyyours.com]
  • Our community of experts & coaches is exploring opportunities and realising change every day: Driving transformation but also taking care of day to day issues that otherwise distract from the path to glory.[ditragroup.com]
  • 03-03-2015, 03:54 PM # 2 Grunt Trade: Residential Remodeler Join Date: Feb 2015 Location: Long Island, NY Posts: 172 Rewards Points: 320 Re: Ditra Heat Questions Mike, I've installed Ditra heat in a few bathroom renovations.[contractortalk.com]
  • Also, don’t forget to snap the plastic guard onto the thermostat. It covers the terminal screws. Bill used a 22.0 cubic inch electrical box for this project. Primarily because there are a lot of wires that need to fit in the box.[homerepairtutor.com]


  • The hypothesis was reinforced by parental consanguinity, and absence of skin lesion improvement under standard topical treatment.[ncbi.nlm.nih.gov]
  • Different treatments (acitretin, high-dose ciclosporin, … View Full Text Request Permissions If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service.[ard.bmj.com]


  • However, its differential diagnosis includes idiopathic PG, as well as PG secondary to other etiologies including inflammatory bowel disease or malignancy.[rheumatologyadvisor.com]


  • Macy, EM, Hayes, TE, Tracy, RP: Variability in the measurement of C-reactive protein in healthy subjects: implications for reference intervals and epidemiological applications. Clin Chem 1997, 43: 52-58. [Pubmed] 67.[nefrologiaaldia.org]
Sex distribution
Age distribution


  • The innate immune system plays the primary pathophysiologic role in autoinflammatory diseases and in fact, these diseases are synonymous with dysregulation of the cells and molecular cascades intrinsic to innate immunity.[rheumatologyadvisor.com]


  • Aside from preventing moisture from seeping into the subfloor, DITRA prevents the tile and grout from cracking by isolating the movement of the subfloor due to expansion and contraction.[homeguides.sfgate.com]
  • It prevents tile and grout from cracking, blocks moisture migration into your subfloor, prevents mold and mildew and provides heavy load support. In short, your tile will last a lifetime.[greenbuildingsupply.com]

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