Presentation
Results of the prospective study were presented at the 2017 International Congress of Parkinson's Disease and Movement Disorders. [quanterix.com]
This condition tends to present in one of two ways. Firstly, it may present as disordered behavior (usually either with disinhibited behavior or with apathy). [dartmouth.edu]
A few children have normal intelligence, in which case the main symptom is severe motor function impairment presenting in childhood. [wilhelmfoundation.org]
Presented at: 2017 International Congress of Parkinson’s Disease and Movement Disorders. June 4-8, 2017; Vancouver, BC, Canada. Magdalinou N, Lees AJ, Zetterberg H. [neurologyadvisor.com]
When dementia and depression are present together, intellectual deterioration may be exaggerated. Depression, whether present alone or in combination with dementia, can be reversed with proper treatment. [alzcare.org]
Entire Body System
- Progressive Dementia
The brain degeneration is associated with common symptoms of CTE including memory loss, confusion, impaired judgment, impulse control problems, aggression, depression, suicidality, parkinsonism, and eventually progressive dementia. [bu.edu]
French composer Maurice Ravel suffered from a mysterious progressive dementia from about 1927 when he was 52 years old. He gradually lost the ability to speak, write and play the piano. [nature.com]
Causes include: Alzheimer's disease Vascular dementia, the second most common cause of dementia, accounting for up to 20% of all dementias Huntington disease, a progressive degenerative disease that causes dance-like movements and mental deterioration [diagnose-me.com]
Gradually, as the disease ravages their brain, their symptoms grow worse, including blindness and deafness, seizures, loss of muscle control, and progressive dementia. [stopald.org]
As the disease progresses, some patients may experience problems with thinking and memory, including memory loss, confusion, impaired judgment, and eventually progressive dementia. [concussionfoundation.org]
- Cerebral Palsy
Palsy 764,000 MyChild at CerebralPalsy.org: Prevalence of Cerebral Palsy Chronic Fatigue Syndrome 2,500,000 Institute of Medicine of the National Academies: Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Redefining an Illness Hearing Impaired [ohsu.edu]
It may result from spinal cord injury, multiple sclerosis, cerebral palsy, stroke, brain damage caused by a lack of oxygen, severe head injury and metabolic diseases such as Lou Gehrig's disease (ALS). [aans.org]
- Unconsciousness
Initial mild symptoms can progress rapidly to unconsciousness and death, if untreated. This is also referred to as an extradural hematoma. [webmd.com]
(RamachandranTTB, 303) Consists of brief spells of unconsciousness lasting for a few seconds, during which posture and balance are maintained. The eyes stare blankly and there may be fluttering movements of the lids. [richardsonthebrain.com]
- Poor Feeding
[…] disorders and poor weight gain are common 30. [slideshare.net]
Cardiovascular
- Heart Disease
Heart disease that is left untreated can progress to heart failure, a heart attack, a stroke, aneurysm (widening of the blood vessel), blockage of the vessels in the legs (peripheral artery disease) and cardiac arrest (heart stops beating). [livestrong.com]
For 30 years, the Surgeon General told us red meat was linked to heart disease. Then we learn that the healthy heart diet might not be all it was cracked up to be. I’ll not bore readers with similar examples ad nauseum. [intellectualtakeout.org]
These days we frequently hear about breakthroughs in our understanding of diseases like cancer, heart disease, diabetes, and arthritis, but when the discussion turns to the brain, there seems to be very little news. [thedailybeast.com]
These diseases have also become more prominent as the life expectancy increases because of advances in the treatment of cancers, infectious diseases and heart disease, the other largest number of ill people. [jonlieffmd.com]
Psychiatrical
- Aggressive Behavior
SSPE The initial clinical manifestations include personality changes, aggressive behavior, and impaired cognitive function. Myoclonic seizures soon dominate the clinical picture. [slideshare.net]
Neurologic
- Aphasia
Adults of any age can develop primary progressive aphasia (PPA), but it is more common in people under the age of 65. Individuals with PPA may have difficulties in word-finding, word usage, word order, word comprehension or word spelling. [brain.northwestern.edu]
Despite trouble finding the right words, repetition of even complex phrases is preserved (a transcortical aphasia). Alzheimer disease is the most common cause of dementia of age. [dartmouth.edu]
One, progressive primary aphasia, erodes the brain's language centres. The other, corticobasal degeneration, robs patients of movement control. [nature.com]
Primary progressive aphasia (PPA) is the second major form of frontotemporal degeneration that affects language skills, speaking, writing and comprehension. PPA normally comes on in midlife, before age 65, but can occur in late life also. [alz.org]
Initial cognitive symptoms include a nonfluent, progressive aphasia and impairments in executive function. [rarediseases.org]
- Slurred Speech
Symptoms can include: difficulty controlling your limb on one side of the body (a "useless" hand) muscle stiffness shaking ( tremors ), jerky movements and spasms ( dystonia ) problems with balance and co-ordination slow and slurred speech symptoms of [nhs.uk]
The 68-year-old is now wheelchair-bound with slurred speech, and has more than 70 direct descendants in the region who are all at risk of developing the disease. [abc.net.au]
Other symptoms of Huntington's disease include personality change, memory disturbance, slurred speech, impaired judgment and psychiatric problems. Huntington's disease currently affects more than 25,000 Americans. [alzcare.org]
Fatigue, problems with sleep, headaches, stupor, slurred speech, and anemia are also found in chronic lead poisoning. • A "lead hue" of the skin with pallor • ]Burton line • Children with chronic poisoning may refuse to play or may have hyperkinetic or [slideshare.net]
- Meningism
Encephalitis : An inflammation of the brain tissue, usually due to a viral infection ; meningitis and encephalitis often occur together, which is called meningoencephalitis. [webmd.com]
Other conditions which may cause or mimic dementia include depression, brain tumors, nutritional deficiencies, head injuries, hydrocephalus, infections (AIDS, meningitis, syphilis), drug reactions and thyroid problems. [alzcare.org]
Inflammation in the meninges also occurs seen as the disease progresses and after death. There is reason to believe that these regions of inflammation support destruction of myelin. [jonlieffmd.com]
Birth history: Term/preterm Postnatal complications Meningitis Head trauma kernicterus 38. Developmental history: Detailed development history- decide whether there is delayed development milestones or regression of milestones Family [slideshare.net]
- Cerebellar Ataxia
Homepage Rare diseases Search Search for a rare disease Autosomal recessive degenerative and progressive cerebellar ataxia ORPHA:98098 Synonym(s): - Prevalence: - Inheritance: - Age of onset: - ICD-10: - OMIM: - UMLS: - MeSH: - GARD: - MedDRA: - Summary [orpha.net]
ataxia in diseases classified elsewhere G32.89 Other specified degenerative disorders of nervous system in diseases classified elsewhere G35 Multiple sclerosis G36 Other acute disseminated demyelination G36.0 Neuromyelitis optica [Devic] G36.1 Acute [icd10data.com]
Friedreich ataxia has its onset in childhood or adolescence, with ataxia that is due to a combination of proprioceptive loss and cerebellar ataxia. There is atrophy of the small muscles of the feet, indicating a peripheral neuropathy. [dartmouth.edu]
- Apraxia
Such motor abnormalities include muscle rigidity and the inability to perform purposeful or voluntary movements (apraxia). [rarediseases.org]
(Goldberg, 25) Dressing apraxia may result from an inability to mentally formulate the act of placing clothes on the body. (MeSH) Gait Apraxia : difficulty in walking. [richardsonthebrain.com]
Therefore, mild anomia (trouble finding nouns) and constructional apraxia are also common early signs. [dartmouth.edu]
Treatment
These treatments may involve diet, special dietary supplements, pharmacological agents and transplants. [kennedykrieger.org]
Specifically, all patients remained free of major functional disabilities post-treatment with Lenti-D. [medpagetoday.com]
The studies covered a wide variety of licensed and unlicensed smoking cessation medications, comparing the treatments with placebo, and the three main treatments with each other. [jpost.com]
There’s no cure for neurodegenerative diseases, but treatment can still help. Treatment for these diseases tries to reduce symptoms and maintain quality of life. Treatment often involves the use of medications to control symptoms. [healthline.com]
This discovery may uncover new treatments for millions of people suffering from degenerative brain conditions more widely. [monash.edu]
Prognosis
As the population in the developed world continues to age, neuroimaging for diagnosis, prognosis, and therapy monitoring of neurodegenerative diseases becomes increasingly important and there has been a recent surge of clinical and pre-clinical applications [books.google.com]
This approach may provide increased accuracy for clinicians when discussing a patient’s prognosis; thereby assisting affected individuals in making important decisions for their future,” Dr Philpott said. [monash.edu]
Affected individuals should talk to their physician and medical team about their specific case, associated symptoms and overall prognosis. [rarediseases.org]
The prognosis depends on the severity of the spasticity and the underlying disorder(s). TD is a muscle disorder that results from prolonged exposure to some types of antipsychotic and neuroleptic medications. [aans.org]
Etiology
Abstract Background Neurodegenerative diseases (ND) consist of divers affections of the central nervous system related to etiology, localization, and of course of the disease. [ncbi.nlm.nih.gov]
However, we are still left with a large number of progressive diseases of unknown etiology, and their classification is based on pathologic and clinical findings. [dartmouth.edu]
Epidemiology
Methods Based on epidemiological data, the current neurological bibliography of ND has been considered. Additional ophthalmological data containing age-related retinal diseases were included in a comparative manner. [ncbi.nlm.nih.gov]
Migraines 28,000,000 American Headache Society: Epidemiology and Impact of Headache and Migraine (PDF) Multiple Sclerosis 350,000 National Institute of Neurological Disorders and Stroke: Multiple Sclerosis: Hope Through Research Neurofibromatosis 100,000 [ohsu.edu]
Epidemiologic and a few prospective studies suggest that there may be some element of inflammation in the condition and some have suggested excess oxidation as a contributing factor. [dartmouth.edu]
Pathophysiology
Differential diagnosis of degenerative brain diseases Project Year: 2006 Usefulness of the clock reading test in the clinical settings Project Year: 2007 Association between ADL and cognitive functions in patients with Alzheimer's disease Project Year: 2006 Pathophysiologic [researchmap.jp]
More information about the gene products and understanding of pathophysiological mechanisms will open the way to specific treatments. The most common degenerative disease is Alzheimer's disease and the second most frequent is Parkinson's disease. [neuropathology-web.org]
As time passes, it is quite likely that the specific biochemical and pathophysiological processes underpinning many of these diseases will be elucidated and their classifications will change. [dartmouth.edu]
Prevention
In this paper, authors contended that Alzheimer prevention starts with marijuana. That’s right, the conclusion drawn is that chemical compounds in cannabis can be used to prevent the onset of the brain disease. [intellectualtakeout.org]
This could open the door to new ways of treating these devastating conditions that intervene early enough to prevent some of the most devastating effects or that even change the course of the disease. [valleysleepcenter.com]
Shurkin 2.3 Preventing Alzheimer's Part 1: The Columbian Cluster by Gary Stix 2.4 Preventing Alzheimer's Part 2: The Trial by Gary Stix Section 3: Parkinson’s Disease 3.1 New Movement in Parkinson’s by Andres M. Lozano & Suneil K. [scientificamerican.com]
Preventing iatrogenic CJD Hospitals and other medical institutions follow explicit policies to prevent iatrogenic CJD. [mayoclinic.org]
There is up till now no effective way to prevent Alzheimer's disease. However, multi-infarct dementia is caused by damaged blood vessels, and can be prevented through healthy living habits. [diagnose-me.com]