male puberty inadequate gonadal steroid secretion due to defection LH FSH from anterior pituitary due to defective production of GnRH from hypo pituitary secondary male hypogonadism, low T, and or sperm with low or inappropriately LH and LSH indicates [brainscape.com]

Ambler GR ; Androgen therapy for delayed male puberty. Curr Opin Endocrinol Diabetes Obes. 2009 Jun16(3):232-9. Soliman AT, De Sanctis V ; An approach to constitutional delay of growth and puberty. [patient.info]

[…] are not limited to, the following: Turner syndrome (females) - Short stature and gonadal failure; abnormality of X chromosome Noonan syndrome - Turner phenotype but normal karyotype; often with abnormalities of pubertal development Kallmann syndrome - Hyposmia [emedicine.medscape.com]

1 Findings suggestive of chronic disease Overt chronic illness signs or symptoms Short Stature Slow growth rate Bone Age less than Chronological age Differential Diagnosis Anorexia Nervosa Malnutrition Kallmann's Syndrome Hypopituitarism Anosmia or Hyposmia [fpnotebook.com]

A history of anosmia or hyposmia points to Kallmann syndrome, which is the result of a rare genetic mutation and can affect boys and girls. [endocrinenews.endocrine.org]

It may also be associated with inability (anosmia) or reduced ability (hyposmia) to smell. Many hypothalamic (GnRH) and pituitary (LH and FSH) synthesis and secretory defects result in hypogonadotropic hypogonadism. [kallmannsyndrome.wordpress.com]

Indeed, delayed puberty has a significant genetic basis often demonstrating an autosomal dominant mode of inheritance, with or without incomplete penetrance. [ 3 ] The presence of an absent or abnormal sense of smell (anosmia or hyposmia) strongly suggests [pubs.sciepub.com]

Acne face, facialhair and slight alteration voice (hoarseness) are seen. Next, pubarche begins in conjunction with penile enlargement. The last stage is a dramatic increase in growth velocity. [lecturio.com]

Testicular functional damage Viral orchitis Cytotoxic drugs/irradiation Tumour See Testicular mass Vanishing testis syndrome Severe chronic illness Severe nutritional deficiency, including Anorexia nervosa Gross zinc deficiency Zinc. [rcpa.edu.au]

Turner Syndrome) Radiation exposure Head Trauma Brain Tumor Constitutional delay of growth and Puberty (60% of boys, 30% of girls) Most common cause of Delayed Puberty (diagnosis of exclusion) Consistent findings Delayed Bone Age Family History of Delayed [fpnotebook.com]

Bone age: a delayed bone age may occur in CDGP, growth hormone deficiency and hypothyroidism. Bone age is established by a wrist X-ray. MRI or CT scan of the pituitary and surrounding structures may be indicated. [patient.info]

Delayed bone age is also seen in children with gonadal failure, hypogonadotropic hypogonadism and children with chronic illness. If a tumor is suspected, prolactin and hCG levels may aid in diagnosis. [lecturio.com]

Note: calcium supplementation during adolescence results in increase bone density -- small breast mound -- sparse pubic hair -- breasts grow some -- more pubic hair -- areola sticks out from breast -- adult pubic hair on mons only -- areola recesses - [quizlet.com]