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Dengue Virus
Presentation
- The compounds present in T. officinale, were luteolin and caffeoylquinic acids derivatives and quercertin diclycosides.[ncbi.nlm.nih.gov]
- We postulate that temporal factors may play a role in the different clinical manifestations, i.e. that acute parainfectious dengue infection presents with flaccid paralysis, whereas late-stage (postinfectious) dengue infection, presents with spastic weakness[ncbi.nlm.nih.gov]
- Dengue viral infections present a significant risk during pregnancy to both mother and fetus. A young woman at 13 weeks' gestation presented with fever and abdominal pain following a diarrheal illness after returning from Puerto Rico.[ncbi.nlm.nih.gov]
- At present, CYD-TDV or Dengvaxia is the only approved vaccine, but potent inhibitors are currently under development.[ncbi.nlm.nih.gov]
- The patient presented with ADAMTS13 inhibitor (IgG) during the acute phase of the disease, without anti-platelet antibodies detectable. Dengue infection had laboratorial confirmation.[ncbi.nlm.nih.gov]
Respiratoric
Sputum
- The patient presented with classic dengue symptoms, along with early minor bleeding (blood-stained sputum) during the first 5 days of illness. Continuous inpatient imatinib treatment for CML was given without blood transfusion.[ncbi.nlm.nih.gov]
Course
Severe Clinical Course
- The variants 124Met/166Ser (amino acid positions according to the report GenBank AJL35015.1), were associated with a severe clinical course of the disease.[ncbi.nlm.nih.gov]
Skin
Ulcer
- Gastric ulcer, erythematous gastritis, duodenal ulcer, erosive gastritis, and hemorrhagic gastritis were found in 52.3%, 33.3%, 28.6%, 28.6%, and 14.3% of 42 patients with GI bleeding who had undergone endoscopic examination, respectively.[ncbi.nlm.nih.gov]
Musculoskeletal
Neck Weakness
- The remaining 3 cases had quadriparesis with trunk and neck weaknesses, sparing of respiratory muscles, creatine phosphokinase levels up to 3000 U/L. However, a complete recovery was observed in these patients within 4 weeks.[ncbi.nlm.nih.gov]
Buttock Pain
- She had serologically confirmed dengue infection 10 days prior to the onset of buttock pain. A clinical examination revealed features of right sacroiliitis. An X-ray of her sacroiliac joint showed joint space widening and reactive bone changes.[ncbi.nlm.nih.gov]
Hip Pain
- A 14-year-old Sri Lankan female presented to our medical unit with right buttock and hip pain of 3 weeks' duration. She had serologically confirmed dengue infection 10 days prior to the onset of buttock pain.[ncbi.nlm.nih.gov]
Neurologic
Flaccid Paralysis
- We postulate that temporal factors may play a role in the different clinical manifestations, i.e. that acute parainfectious dengue infection presents with flaccid paralysis, whereas late-stage (postinfectious) dengue infection, presents with spastic weakness[ncbi.nlm.nih.gov]
Workup
- Results vary depending on whether the infection is primary or secondary (see Presentation and Workup). Dengue is a reportable disease in the United States; known or suspected cases should be reported to public health authorities.[emedicine.medscape.com]
Treatment
- Clinical monitoring of hematologic changes is needed in dengue patients undergoing anticancer treatment.[ncbi.nlm.nih.gov]
- Treatment of both cell lines with compounds 2 or 4 showed increased dengue viral titers at all three tested doses.[ncbi.nlm.nih.gov]
- The emergence of dengue hemorrhagic fever in most tropical countries has made its control a public health priority, but no vaccines or treatments exist.[ncbi.nlm.nih.gov]
- There is therefore an urgent need for the development of antiviral drugs for the treatment of dengue.[ncbi.nlm.nih.gov]
- Our results demonstrate that geraniin has the potential to be developed into an effective antiviral treatment, particularly for early phase dengue viral infection.[ncbi.nlm.nih.gov]
Prognosis
- Complications Add text here Prognosis Add text here Add text here[eyewiki.aao.org]
- For those who do develop symptoms, prognosis is still very good for full recovery within a few weeks.[labtestsonline.org]
Etiology
- Although dengue viruses (DENV) infecting humans can cause major epidemics and severe disease, relatively little is known about the epidemiology and etiology of sylvatic dengue viruses.[ncbi.nlm.nih.gov]
- […] the ability to culture and characterize the etiologic agent.[books.google.it]
- At present, no etiological treatment or effective globally distributed vaccine against the four DENV serotypes exists.[scielo.conicyt.cl]
- Tian , Aruna D de Silva , Gregory Seumois , Pandurangan Vijayanand , Sunil Premawansa , Gayani Premawansa , Ananda Wijewickrama , Bjoern Peters and Alessandro Sette J Immunol May 1, 2017, 198 (1 Supplement) 78.17; Abstract Dengue virus (DENV) is the etiologic[jimmunol.org]
- Etiology Risk Factors Travel to endemic areas and exposure to infected female Aedes aegypti mosquitoes.[eyewiki.aao.org]
Epidemiology
- Although the real incidence of dengue-related TMA is unknown, this case provides the basis for future epidemiologic studies on acquired ADAMTS13 deficiency in DV infection.[ncbi.nlm.nih.gov]
- Roux, F‐75015 Paris, France Search for more papers by this author Laurent Belkadi Institut Pasteur, Unit of Molecular Prevention and Therapy of Human Diseases, Department of Infection and Epidemiology, rue du Dr.[doi.org]
- The purpose of this study was to elucidate the epidemiology of one local community outbreak caused by DENV-4 in Guangzhou city, China, in 2010; and to determine the molecular characteristics of the genotype II virus involved.[ncbi.nlm.nih.gov]
- Although dengue viruses (DENV) infecting humans can cause major epidemics and severe disease, relatively little is known about the epidemiology and etiology of sylvatic dengue viruses.[ncbi.nlm.nih.gov]
- Numerous foundational and clinical investigations on viral epidemiology, structure and function analysis, infection source and route, therapeutic targets, vaccines, and therapeutic drugs have been conducted by both academic and industrial researchers.[ncbi.nlm.nih.gov]
Sex distribution
Age distribution
Pathophysiology
- We review the pathophysiological basis of TTP in dengue infection, and suggest that jaundice with disproportionate elevation of serum aspartate aminotransferase level in a patient with dengue should arouse the suspicion of TTP.[ncbi.nlm.nih.gov]
- The pathophysiology of SD is not entirely clear.[ncbi.nlm.nih.gov]
- Abstract Plasma leakage is the main pathophysiological feature in severe dengue, resulting from altered vascular barrier function associated with an inappropriate immune response triggered upon infection.[ncbi.nlm.nih.gov]
- Global Dengue Burden 2014 General Pathology Add text here Pathophysiology Dengue virus employs many mechanisms to utilize host cell machinery in order to facilitate viral replication.[eyewiki.aao.org]
- Vaccinia virus, 16 cytomegalovirus, 17 HIV, 18 influenza virus, 19 and hepatitis C virus 20 along with DENV are examples of a broad range of virus types that interact with platelets, suggesting a general pathophysiological platelet-virus relationship.[bloodjournal.org]
Prevention
- Roux, F‐75015 Paris, France Search for more papers by this author Laurent Belkadi Institut Pasteur, Unit of Molecular Prevention and Therapy of Human Diseases, Department of Infection and Epidemiology, rue du Dr.[doi.org]
- ., Malaysia. edayu_hanna@yahoo.com. 2 Southeast Asia Disaster Prevention Research Initiative (SEADPRI-UKM), Institute for Environment and Development (LESTARI), Universiti Kebangsaan Malaysia, Bangi 43600, Selangor D.E., Malaysia. babybabeoo@gmail.com[ncbi.nlm.nih.gov]
- This study, thus, provides new information and tools for effective vaccine design to prevent dengue disease.[ncbi.nlm.nih.gov]
- Despite the use of a mosquito-repellent spray as reported by two patients, the infection could not be prevented.[ncbi.nlm.nih.gov]
- Currently, the most effective prevention measures lie in mosquito control. References: Kautner, Ingrid PhD; Robinson, Max MD; Kuhnle, Ursula MD. "Dengue virus infection: Epidemiology, pathogenesis, clinical presentation, diagnosis, and prevention."[web.stanford.edu]