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Dermatopathic Lymphadenopathy

Lymphadenitis Dermatopathic


Presentation

  • We present a case of a 43-year-old male presented with 3 months history of fatigue, fever, and lymphadenopathy. Initial work-up satisfactorily met the criteria for diagnosis of AOSD.[ncbi.nlm.nih.gov]
  • Dermatopathic lymphadenopathy presents a specific pathologic pattern found within the lymph nodes and is usually associated with cutaneous rashes.[ncbi.nlm.nih.gov]
  • In the present study, immunohistochemical and immuno-electron microscopic techniques were used to differentiate Langerhans cells (LC) from interdigitating cells (IDC) in the lymph nodes (LN) of dermatopathic lymphadenopathy.[ncbi.nlm.nih.gov]
  • The intensity of staining with anti-Ia-like serum on the interdigitating cells was comparable to the very strong staining of the fewer reticular cells present in the T dependent areas of normal nodes and normal spleen, and to the staining of Langerhans[ncbi.nlm.nih.gov]
  • Some eosinophils are usually present.[jcytol.org]
Generalized Lymphadenopathy
  • […] lymphadenopathy [ lim-fad″ĕ-nop ah-the ] angioimmunoblastic lymphadenopathy ( angioimmunoblastic lymphadenopathy with dysproteinemia (AILD)) a systemic disorder resembling lymphoma characterized by fever, night sweats, weight loss, generalized lymphadenopathy[medical-dictionary.thefreedictionary.com]
  • General Lymphadenopathy associated with a skin lesion. May not always be true. [1] Benign in itself. [2] May be associated with a malignancy - esp.[librepathology.org]
  • On examination, she had generalized lymphadenopathy with enlarged cervical, axillary, and inguinal group of lymph nodes [Figure 1] a]. There was no organomegaly.[jcytol.org]
  • Endocrinopathies Generalized lymphadenopathy rarely may accompany thyrotoxicosis and adrenal insufficiency.[tcd.ie]
  • Generalized lymphadenopathy, splenomegaly, autoimmune phenomena, usually presents in childhood. FAS mutation present. Both may show paracortical expansion by atypical T cell population, generalized lymphadenopathy.[surgpathcriteria.stanford.edu]
Lymphadenopathy
  • At least some of the patients with dermatopathic lymphadenopathy should be clinicopathologically differentiated from these lymphoproliferative disorders.[ncbi.nlm.nih.gov]
  • Dermatopathic lymphadenopathy should be considered in the differential diagnosis also in patients with minimal cutaneous findings.[ncbi.nlm.nih.gov]
  • In pathology , dermatopathic lymphadenopathy , also dermatopathic lymphadenitis , is lymph node pathology due to skin disease.[en.wikipedia.org]
  • Documenting focal mycosis fungoides in lymph node biopsies that exhibit dermatopathic lymphadenopathy is morphologically difficult.[ncbi.nlm.nih.gov]
  • A combination of S-100 immunocytochemistry and morphologic ultrastructural assessment can be of help in evaluation of lymphadenopathy in patients with mycosis fungoides.[ncbi.nlm.nih.gov]
Intravenous Drugs
  • This type of skin disease and lymph node pathology has not been found in other intravenous drug users who have been infected with HIV-1 alone or in patients in other risk groups for HIV-1 infection.[ncbi.nlm.nih.gov]
Parotid Mass
  • Hochman M, Anonsen CK: Dermatopathic lymphadenopathy presenting as a parotid mass. Otolaryngol Head Neck Surg 1990;102:281–284.[karger.com]

Workup

  • Rao 1 doctor agreed: Observation & workup: If it is proven by biopsy , close observation for development of lymphomas. ...Read more Dr.[healthtap.com]
  • Workup The laboratory evaluation of lymphadenopathy must be directed by the history and physical examination and is based on the size and other characteristics of the nodes and the overall clinical assessment of the patient.[emedicine.medscape.com]
  • That is, to avoid over-reacting or leaping into a lymphoma workup at the first sighting of a swollen lymph node; but at the same time, to not let a persistently swollen lymph node remain indefinitely without an appropriate investigation, which may include[verywell.com]
  • […] nodal stage; M0-1: visceral organs; B1-2: peripheral blood Prognosis The prognosis of MF/SS is primarily based on stage, particularly the extent/type of lesions and presence of extracutaneous disease, 1,2 emphasising the importance of thorough patient workup[skintherapyletter.com]

Treatment

  • It has a characteristic pattern of histomorphology and immunohistochemical staining : Paracortical histiocytosis Melanin-laden macrophages Eosinophils Plasma cells (medulla of lymph node) Treatment [ edit ] The treatment is based on the underlying cause[en.wikipedia.org]
  • Friedlander 12 12 Causes & treatment of reactive follicular hyperplasia of lymph node? Dr. Ed Friedlander Dr.[healthtap.com]
  • Intravenous fluid supplementation with subsequent decline of creatinine, UVB treatment, clemastine, and topical use of emollients led to a relief of the uremic pruritus and the lymph nodes' size normalized within 8 weeks.[ncbi.nlm.nih.gov]
  • Treatment of the underlying skin irritation or mycosis fungoides (if present) Clinical images Images hosted on other servers: Cervical lymphadenopathy Elastic firm nodules Gross description Enlarged lymph nodes with firm tan to yellow cut surface There[pathologyoutlines.com]

Prognosis

  • Lymph node involvement in mycosis fungoides (MF) is associated with a poor prognosis, Histologically, in most cases of clinical lymphadenopathy the excised lymph node shows dermatopathic lymphadenopathy (DL).[ncbi.nlm.nih.gov]
  • The presence of lymphadenopathy in MF/SS patients correlates with a poorer prognosis, regardless of histologic findings (i.e., DL versus MF/SS) ( 6 ).[basicmedicalkey.com]
  • […] can be ruled out by testing for T cell clonality with PCR Laboratory Peripheral blood eosinophilia Radiology images Images hosted on other servers: CT showing enlarged lymph nodes Prognostic factors Association with mycosis fungoides confers a poorer prognosis[pathologyoutlines.com]
  • For patients with a disease or cancer prognosis background becomes the trigger of the disease.[medicaldb.blogspot.com]

Etiology

  • Some patients with mild dermatopathic lymphadenopathy do not have skin disease or other discernible etiologies to explain the lymph node findings.[link.springer.com]
  • In 16.6% of cases, etiology could not be ascertained. Clinico-histopathological correlation could be established in 73.3% of cases. Conclusion: Clinical features were identical irrespective of etiology.[idoj.in]
  • Management Treatment is determined by the specific underlying etiology of lymphadenopathy. Most clinicians treat children with cervical lymphadenopathy conservatively. Antibiotics should be given only if a bacterial infection is suspected.[emedicine.medscape.com]
  • Each of these morphologically recognizable patterns is associated with certain antigenic stimuli, thus the morphologic type of lymphadenopathy may offer clues as to the etiology of the lymphadenopathy.[med-ed.virginia.edu]

Epidemiology

  • Paracortical expansion with nodular proliferation of interdigitating dendritic cells, Langerhans cells and histiocytes Most often pigment in the histiocytic cytoplasm, including melanin and rarely iron ICD-10 coding I88.9 Nonspecific lymphadenitis, unspecified Epidemiology[pathologyoutlines.com]
  • It was intended that such material would have constituted the basis of a hypothetic decision-making tree, but this was impossible because of the lack of epidemiological investigation and registry data.[kipdf.com]
  • It was intended that suchmaterial would have constituted the basis of a hypo-thetic decision-making tree, but this was impossiblebecause of the lack of epidemiological investigationand registry data.[dokumen.tips]
  • Epidemiology of tuberculosis current status in India. Indian J Med Res. 2004; 120(4): 248-276.[panafrican-med-journal.com]
  • Hemophilic patient with multiple transfusions serum reacted with serum of Australian patient ,so this is called as Australia antigen Epidemiology Long incubation period Asymptomatic period is from 4 to 26 weeks. Average time is 1.5 to 2 months.[labpedia.net]
Sex distribution
Age distribution

Pathophysiology

  • […] chronic exfoliative or eczematoid skin disease Dermatopathic lymphadenitis can occur as a reaction to mycosis fungoides / Sézary syndrome Men are affected twice as frequently as women Sites Axillary and inguinal lymph nodes are most commonly affected Pathophysiology[pathologyoutlines.com]

Prevention

  • How can erythroderma be prevented? In most cases, erythroderma cannot be prevented. People with known drug allergy should be made aware that they should avoid the drug forever, and if their reaction was severe, wear a drug alert bracelet.[dermnetnz.org]
  • Neck cancer information including symptoms, diagnosis, misdiagnosis, treatment, causes, patient stories, videos, forums, prevention, and prognosis.[rufdi.mooiebenen.amsterdam]
  • Risk and prevention in pregnant mothers If mother is HBs positive then infectivity for newborn is 40 %. If mother is HBs positive and HBe positive then infectivity for new born is 85 to 95 %.[labpedia.net]
  • Hence, the diagnosis of this by least intervention method helps in preventing and treating the disease. The cytomorphological pattern in tuberculosis is varied and can be divided into three patterns [Table 1] .[mjdrdypu.org]
  • It is advocated that the only way to effectively prevent, detect and treat the rising number of cancers in the developing world is to develop broad and effective partnership of research institutions, international organisations, NGOs, national governments[panafrican-med-journal.com]

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