Presentation
We present a case of a 43-year-old male presented with 3 months history of fatigue, fever, and lymphadenopathy. Initial work-up satisfactorily met the criteria for diagnosis of AOSD. [ncbi.nlm.nih.gov]
Some eosinophils are usually present. [jcytol.org]
Some phagocytic histiocytes also can be present, and these cells may contain cytoplasmic lipid and appear foamy; others have cytoplasmic pigment that can be abundant ( Fig. 41.4 ). [basicmedicalkey.com]
The Demos Surgical Pathology Guides series presents in summary and visual form the basic knowledge base that every practicing pathologist needs every working day. [books.google.de]
Immune System
- Generalized Lymphadenopathy
Aggressive clinical course with generalized lymphadenopathy or mass lesions. Localized lymphadenopathy, viral syndrome, viral serologies. [surgpathcriteria.stanford.edu]
Endocrinopathies Generalized lymphadenopathy rarely may accompany thyrotoxicosis and adrenal insufficiency. [tcd.ie]
lymphadenopathy [ lim-fad″ĕ-nop´ah-the ] angioimmunoblastic lymphadenopathy ( angioimmunoblastic lymphadenopathy with dysproteinemia (AILD)) a systemic disorder resembling lymphoma characterized by fever, night sweats, weight loss, generalized lymphadenopathy [medical-dictionary.thefreedictionary.com]
Dermatopathic lymphadenopathy, abbreviated DL, is a rare pathology of the lymph nodes. General Lymphadenopathy associated with a skin lesion. May not always be true. [1] Benign in itself. [2] May be associated with a malignancy - esp. [librepathology.org]
On examination, she had generalized lymphadenopathy with enlarged cervical, axillary, and inguinal group of lymph nodes [Figure 1] a]. There was no organomegaly. [jcytol.org]
Entire Body System
- Lymphadenopathy
At least some of the patients with dermatopathic lymphadenopathy should be clinicopathologically differentiated from these lymphoproliferative disorders. [ncbi.nlm.nih.gov]
Respiratoric
- Sputum
This has been found in other studies too. [8], [9] In this study, the AFB was also graded according to their morphology and number in accordance with the original grading of the AFB of the sputum smears. [mjdrdypu.org]
Skin
- Skin Disease
Skin disease List of cutaneous conditions Dermatopathic lymphadenitis - pathconsultddx.com. [en.wikipedia.org]
These changes are usually associated with skin disease. Synonym Dermatopathic lymphadenitis; lipomelanotic reticulosis. [basicmedicalkey.com]
In 35 of 40 cases the patients had active skin disease at the time of the biopsy; one of the remaining five patients had Hodgkin's disease, one had multiple myeloma and one had secondary syphilis. In the other two, no organic cause was found. [ncbi.nlm.nih.gov]
- Skin Ulcer
[…] melanic reticulosis in pigmented animals, especially black dogs chronic inflammatory skin conditions lead to melanin deposition in hyperplastic nodules also occurs in nodes draining skin melanomas where the pigment may be the result of skin ulceration [en.wikivet.net]
Workup
Workup The laboratory evaluation of lymphadenopathy must be directed by the history and physical examination and is based on the size and other characteristics of the nodes and the overall clinical assessment of the patient. [emedicine.medscape.com]
Rao 1 doctor agreed: Observation & workup: If it is proven by biopsy, close observation for development of lymphomas. ...Read more Dr. [healthtap.com]
[…] nodal stage; M0-1: visceral organs; B1-2: peripheral blood Prognosis The prognosis of MF/SS is primarily based on stage, particularly the extent/type of lesions and presence of extracutaneous disease, 1,2 emphasising the importance of thorough patient workup [skintherapyletter.com]
Serum
- Thrombocytosis
Thedocumented presence of atypical blast cells shouldorient the doctor toward either lymphoid or non-lymphoid leukemia, while considerable granulocyto-sis with thrombocytosis must cast suspicion onchronic myeloid leukosis. [dokumen.tips]
The documented presence of atypical blast cells should orient the doctor toward either lymphoid or nonlymphoid leukemia, while considerable granulocytosis with thrombocytosis must cast suspicion on chronic myeloid leukosis. [kipdf.com]
Treatment
Friedlander 12 12 Causes & treatment of reactive follicular hyperplasia of lymph node? Dr. Ed Friedlander Dr. [healthtap.com]
It has a characteristic pattern of histomorphology and immunohistochemical staining: Paracortical histiocytosis Melanin-laden macrophages Eosinophils Plasma cells (medulla of lymph node) Cutaneous T cell lymphoma Hodgkin's lymphoma Melanoma The treatment [en.wikipedia.org]
Treatment of the underlying skin irritation or mycosis fungoides (if present) Clinical images Images hosted on other servers: Cervical lymphadenopathy Elastic firm nodules Gross description Enlarged lymph nodes with firm tan to yellow cut surface There [pathologyoutlines.com]
If erythroderma is the result of a generalised spread of a primary skin disorder such as psoriasis or dermatitis, it usually clears with appropriate treatment of the skin disease but may recur at any time. [dermnetnz.org]
Intravenous fluid supplementation with subsequent decline of creatinine, UVB treatment, clemastine, and topical use of emollients led to a relief of the uremic pruritus and the lymph nodes' size normalized within 8 weeks. [ncbi.nlm.nih.gov]
Prognosis
Abstract Lymph node involvement in mycosis fungoides (MF) is associated with a poor prognosis, Histologically, in most cases of clinical lymphadenopathy the excised lymph node shows dermatopathic lymphadenopathy (DL). [ncbi.nlm.nih.gov]
Staging of MF/SS (ISCL/EORTC revision) 2,3 T1-4: tumor stage; N0-3: nodal stage; M0-1: visceral organs; B1-2: peripheral blood Prognosis The prognosis of MF/SS is primarily based on stage, particularly the extent/type of lesions and presence of extracutaneous [skintherapyletter.com]
Prognosis of erythroderma depends on the underlying disease process. If the cause can be removed or corrected, prognosis is generally good. [dermnetnz.org]
[…] inflammatory skin conditions lead to melanin deposition in hyperplastic nodules also occurs in nodes draining skin melanomas where the pigment may be the result of skin ulceration or secondary tumour deposit these two should not be confused since the prognosis [en.wikivet.net]
The presence of lymphadenopathy in MF/SS patients correlates with a poorer prognosis, regardless of histologic findings (i.e., DL versus MF/SS) ( 6 ). [basicmedicalkey.com]
Etiology
In 16.6% of cases, etiology could not be ascertained. Clinico-histopathological correlation could be established in 73.3% of cases. Conclusion: Clinical features were identical irrespective of etiology. [idoj.in]
Management Treatment is determined by the specific underlying etiology of lymphadenopathy. Most clinicians treat children with cervical lymphadenopathy conservatively. Antibiotics should be given only if a bacterial infection is suspected. [emedicine.medscape.com]
Each of these morphologically recognizable patterns is associated with certain antigenic stimuli, thus the morphologic type of lymphadenopathy may offer clues as to the etiology of the lymphadenopathy. [med-ed.virginia.edu]
Some patients with mild dermatopathic lymphadenopathy do not have skin disease or other discernible etiologies to explain the lymph node findings. [link.springer.com]
This is chronic disease and unknown etiology. Age: This is mainly seen in children and young adults. Signs and symptoms There is massive increase in the size of lymph nodes. There may be fever. [labpedia.net]
Epidemiology
Paracortical expansion with nodular proliferation of interdigitating dendritic cells, Langerhans cells and histiocytes Most often pigment in the histiocytic cytoplasm, including melanin and rarely iron ICD coding I88.9 Nonspecific lymphadenitis, unspecified Epidemiology [pathologyoutlines.com]
It was intended that such material would have constituted the basis of a hypothetic decision-making tree, but this was impossible because of the lack of epidemiological investigation and registry data. [kipdf.com]
It was intended that suchmaterial would have constituted the basis of a hypo-thetic decision-making tree, but this was impossiblebecause of the lack of epidemiological investigationand registry data. [dokumen.tips]
Epidemiology of tuberculosis current status in India. Indian J Med Res. 2004; 120(4): 248-276. [panafrican-med-journal.com]
Pathophysiology
[…] chronic exfoliative or eczematoid skin disease Dermatopathic lymphadenitis can occur as a reaction to mycosis fungoides / Sézary syndrome Men are affected twice as frequently as women Sites Axillary and inguinal lymph nodes are most commonly affected Pathophysiology [pathologyoutlines.com]
Prevention
How can erythroderma be prevented? In most cases, erythroderma cannot be prevented. People with known drug allergy should be made aware that they should avoid the drug forever, and if their reaction was severe, wear a drug alert bracelet. [dermnetnz.org]
Neck cancer information including symptoms, diagnosis, misdiagnosis, treatment, causes, patient stories, videos, forums, prevention, and prognosis. [rufdi.mooiebenen.amsterdam]
Risk and prevention in pregnant mothers If mother is HBs positive then infectivity for newborn is 40 %. If mother is HBs positive and HBe positive then infectivity for new born is 85 to 95 %. [labpedia.net]
Hence, the diagnosis of this by least intervention method helps in preventing and treating the disease. The cytomorphological pattern in tuberculosis is varied and can be divided into three patterns [Table 1]. [mjdrdypu.org]
It is advocated that the only way to effectively prevent, detect and treat the rising number of cancers in the developing world is to develop broad and effective partnership of research institutions, international organisations, NGOs, national governments [panafrican-med-journal.com]