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Dermatopathic Lymphadenopathy

Lymphadenitis Dermatopathic


Presentation

  • We present a case of a 43-year-old male presented with 3 months history of fatigue, fever, and lymphadenopathy. Initial work-up satisfactorily met the criteria for diagnosis of AOSD.[ncbi.nlm.nih.gov]
  • Dermatopathic lymphadenopathy presents a specific pathologic pattern found within the lymph nodes and is usually associated with cutaneous rashes.[ncbi.nlm.nih.gov]
  • Abstract In the present study, immunohistochemical and immuno-electron microscopic techniques were used to differentiate Langerhans cells (LC) from interdigitating cells (IDC) in the lymph nodes (LN) of dermatopathic lymphadenopathy.[ncbi.nlm.nih.gov]
  • The intensity of staining with anti-Ia-like serum on the interdigitating cells was comparable to the very strong staining of the fewer reticular cells present in the T dependent areas of normal nodes and normal spleen, and to the staining of Langerhans[ncbi.nlm.nih.gov]
  • Some eosinophils are usually present.[jcytol.org]
Lymphadenopathy
  • At least some of the patients with dermatopathic lymphadenopathy should be clinicopathologically differentiated from these lymphoproliferative disorders.[ncbi.nlm.nih.gov]
  • Dermatopathic lymphadenopathy should be considered in the differential diagnosis also in patients with minimal cutaneous findings.[ncbi.nlm.nih.gov]
  • Abstract Documenting focal mycosis fungoides in lymph node biopsies that exhibit dermatopathic lymphadenopathy is morphologically difficult.[ncbi.nlm.nih.gov]
  • A combination of S-100 immunocytochemistry and morphologic ultrastructural assessment can be of help in evaluation of lymphadenopathy in patients with mycosis fungoides.[ncbi.nlm.nih.gov]
  • In nine cases (22.5 per cent), the histological pattern typical of dermatopathic lymphadenopathy was associated with malignant lymphoma.[ncbi.nlm.nih.gov]
Falling
  • According to the shape of the nucleus, arrangement of the tubulovesicular complexes (TVC) and amount of melanin granules, these cells fall into two types: type I has a marked indented nucleus, innumerable TVC and some desmosomal junctions and fewer melanin[ncbi.nlm.nih.gov]
  • Erythrocyte sedimentation rate (ESR) was 7 mm fall/1st hour. Renal parameter and lipid profile were within normal limits. She did not have any obvious skin lesions.[jcytol.org]
Intravenous Drugs
  • This type of skin disease and lymph node pathology has not been found in other intravenous drug users who have been infected with HIV-1 alone or in patients in other risk groups for HIV-1 infection.[ncbi.nlm.nih.gov]
Generalized Lymphadenopathy
  • […] lymphadenopathy [ lim-fad″ĕ-nop ah-the ] angioimmunoblastic lymphadenopathy ( angioimmunoblastic lymphadenopathy with dysproteinemia (AILD)) a systemic disorder resembling lymphoma characterized by fever, night sweats, weight loss, generalized lymphadenopathy[medical-dictionary.thefreedictionary.com]
  • General Lymphadenopathy associated with a skin lesion. May not always be true. [1] Benign in itself. [2] May be associated with a malignancy - esp.[librepathology.org]
  • On examination, she had generalized lymphadenopathy with enlarged cervical, axillary, and inguinal group of lymph nodes [Figure 1] a]. There was no organomegaly.[jcytol.org]
  • Endocrinopathies Generalized lymphadenopathy rarely may accompany thyrotoxicosis and adrenal insufficiency.[tcd.ie]
  • FOLLICULAR rheumatoid arthritis giant lymph node hyperplasia (Castleman's disease) AIDS (persistent generalized lymphadenopathy)* idiopathic (most common) SINUS sinus histiocytosis with massive lymphadenopathy lymphangiogram effect * increasingly frequent[med-ed.virginia.edu]
Parotid Mass
  • Hochman M, Anonsen CK: Dermatopathic lymphadenopathy presenting as a parotid mass. Otolaryngol Head Neck Surg 1990;102:281–284.[karger.com]
Irritability
  • Definition / general Type of paracortical hyperplasia, commonly occurring in lymph nodes draining areas with chronic skin irritation Essential features Paracortical expansion with nodular proliferation of interdigitating dendritic cells, Langerhans cells[pathologyoutlines.com]
  • In addition, DL does not always correlate with contemporary skin irritation, and sometimes may reflect a history of dermatitis that has healed ( 4 ).[basicmedicalkey.com]
  • Cualing 2 doctors agreed: Yes: Irritative, contact, active dermatitis like metal-allergic reactions or erosive abrasions on skin adjacent to lymph nodes elicit dermatopathic lymphadenitis; a benign condition characterized by pathology showing abnormal[healthtap.com]
  • […] atopic dermatitis Psoriasis, especially after withdrawal of systemic steroids or other treatment Pityriasis rubra pilaris Other skin diseases that less frequently cause erythroderma include: Other forms of dermatitis : contact dermatitis ( allergic or irritant[dermnetnz.org]
  • These findings are associated with LNs that drain the sites of skin irritation, inflammation, or infection.[journals.lww.com]

Workup

  • Rao 1 doctor agreed: Observation & workup: If it is proven by biopsy , close observation for development of lymphomas. ...Read more Dr.[healthtap.com]
  • Workup The laboratory evaluation of lymphadenopathy must be directed by the history and physical examination and is based on the size and other characteristics of the nodes and the overall clinical assessment of the patient.[emedicine.medscape.com]

Treatment

  • It has a characteristic pattern of histomorphology and immunohistochemical staining: Paracortical histiocytosis Melanin-laden macrophages Eosinophils Plasma cells (medulla of lymph node) Cutaneous T cell lymphoma Hodgkin's lymphoma Melanoma The treatment[en.wikipedia.org]
  • Friedlander 12 12 Causes & treatment of reactive follicular hyperplasia of lymph node? Dr. Ed Friedlander Dr.[healthtap.com]
  • Stay at the forefront of your field with updated treatment methods throughout, as well as an increased focus on patients with skin of color.[books.google.de]
  • Intravenous fluid supplementation with subsequent decline of creatinine, UVB treatment, clemastine, and topical use of emollients led to a relief of the uremic pruritus and the lymph nodes' size normalized within 8 weeks.[ncbi.nlm.nih.gov]
  • Treatment of the underlying skin irritation or mycosis fungoides (if present) Clinical images Images hosted on other servers: Cervical lymphadenopathy Elastic firm nodules Gross description Enlarged lymph nodes with firm tan to yellow cut surface There[pathologyoutlines.com]

Prognosis

  • Abstract Lymph node involvement in mycosis fungoides (MF) is associated with a poor prognosis, Histologically, in most cases of clinical lymphadenopathy the excised lymph node shows dermatopathic lymphadenopathy (DL).[ncbi.nlm.nih.gov]
  • The presence of lymphadenopathy in MF/SS patients correlates with a poorer prognosis, regardless of histologic findings (i.e., DL versus MF/SS) ( 6 ).[basicmedicalkey.com]
  • […] can be ruled out by testing for T cell clonality with PCR Laboratory Peripheral blood eosinophilia Radiology images Images hosted on other servers: CT showing enlarged lymph nodes Prognostic factors Association with mycosis fungoides confers a poorer prognosis[pathologyoutlines.com]
  • Prognosis of erythroderma depends on the underlying disease process. If the cause can be removed or corrected, prognosis is generally good.[dermnetnz.org]
  • […] inflammatory skin conditions lead to melanin deposition in hyperplastic nodules also occurs in nodes draining skin melanomas where the pigment may be the result of skin ulceration or secondary tumour deposit these two should not be confused since the prognosis[en.wikivet.net]

Etiology

  • Some patients with mild dermatopathic lymphadenopathy do not have skin disease or other discernible etiologies to explain the lymph node findings.[link.springer.com]
  • In 16.6% of cases, etiology could not be ascertained. Clinico-histopathological correlation could be established in 73.3% of cases. Conclusion: Clinical features were identical irrespective of etiology.[idoj.in]
  • Management Treatment is determined by the specific underlying etiology of lymphadenopathy. Most clinicians treat children with cervical lymphadenopathy conservatively. Antibiotics should be given only if a bacterial infection is suspected.[emedicine.medscape.com]
  • Each of these morphologically recognizable patterns is associated with certain antigenic stimuli, thus the morphologic type of lymphadenopathy may offer clues as to the etiology of the lymphadenopathy.[med-ed.virginia.edu]
  • One hundred and twelve of 186 (63%) patients with benign lymphadenopathy had a non-specific or reactive etiology (no causative agent found) and the remainder had a specific cause demonstrated 5.[ispub.com]

Epidemiology

  • Paracortical expansion with nodular proliferation of interdigitating dendritic cells, Langerhans cells and histiocytes Most often pigment in the histiocytic cytoplasm, including melanin and rarely iron ICD coding I88.9 Nonspecific lymphadenitis, unspecified Epidemiology[pathologyoutlines.com]
  • We studied 30 consecutive cases of erythroderma with respect to the epidemiological, clinical and histological data. Clinico-histological correlation was analyzed for etiology of erythroderma.[idoj.in]
Sex distribution
Age distribution

Pathophysiology

  • […] chronic exfoliative or eczematoid skin disease Dermatopathic lymphadenitis can occur as a reaction to mycosis fungoides / Sézary syndrome Men are affected twice as frequently as women Sites Axillary and inguinal lymph nodes are most commonly affected Pathophysiology[pathologyoutlines.com]

Prevention

  • How can erythroderma be prevented? In most cases, erythroderma cannot be prevented. People with known drug allergy should be made aware that they should avoid the drug forever, and if their reaction was severe, wear a drug alert bracelet.[dermnetnz.org]
  • Neck cancer information including symptoms, diagnosis, misdiagnosis, treatment, causes, patient stories, videos, forums, prevention, and prognosis.[rufdi.mooiebenen.amsterdam]

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