We present the fourth case of a 26-year-old woman who presented with abdominal fullness for months. Ultrasound exam showed a right adnexal mass with cystic feature and foci solid components. [ncbi.nlm.nih.gov]

At present, there are relatively fewwell-characterized MB cell lines available to the researchcommunity for the study of MB molecular and cellularbiology. [research-repository.uwa.edu.au]

• Fishing

  Molecular analysis of recurrent tumor using fluorescent in situ hybridization (FISH) revealed PTEN and/ or PTCH1 loss in 2 patients. [ncbi.nlm.nih.gov]

  ATRT-FISH ATRT. Chromosome 22 FISH. A normal cell (left) has two 9 chromosome signals (red) and two 22 signal (green). The ATRT cell (right) has only one chromosome 22. [neuropathology-web.org]

  PMID 9307291 Detection of i(17q) chromosome by fluorescent in situ hybridization (FISH) with interphase nuclei in medulloblastoma. [atlasgeneticsoncology.org]

• Intermittent Fever

  Case Report A previously well 10-month-old boy presented with a 6-week history of intermittent fever, irritability, and loss of developmental milestones. [pediatrics.aappublications.org]

• Abdominal Fullness

  We present the fourth case of a 26-year-old woman who presented with abdominal fullness for months. Ultrasound exam showed a right adnexal mass with cystic feature and foci solid components. [ncbi.nlm.nih.gov]

• Severe Abdominal Pain

  During adjuvant chemotherapy, two patients reported severe abdominal pain and obstipation that was diagnosed as subileus with spontaneous remission in both cases (10%). [bmccancer.biomedcentral.com]

• Alopecia

  Most patients experienced temporary tiredness, and reported tolerable nausea and transient alopecia. Treatment-refractory nausea with vomiting (n 2; 10%) and severe fatigue syndrome (n 4; 20%) were rarely diagnosed. [bmccancer.biomedcentral.com]

• Ulcer

  Acute skin-related toxicity was observed in two patients who suffered from retroauricular ulcerations (10%). [bmccancer.biomedcentral.com]

• Excitement

  This exciting new, full-color reference provides you with the most comprehensive, authoritative, up-to-date information for diagnosing and treating children with cancer. [books.google.de]

• Hyperreflexia

  Clinical examination was significant for generalized hypertonia, hyperreflexia, and right upper limb dysmetria. [pediatrics.aappublications.org]

• Peripheral Neuropathy

  Chronic toxicity comprised peripheral neuropathy in six patients, all of whom had been treated with concomitant or adjuvant vincristine (30%). [bmccancer.biomedcentral.com]

• Adnexal Mass

  Ultrasound exam showed a right adnexal mass with cystic feature and foci solid components. A partial oophorectomy was performed, and the mass was a desmoplastic medulloblastoma arising from an ovarian teratoma. [ncbi.nlm.nih.gov]

METHODS: The medical records of 76 consecutive children who received surgical treatment for MB between 1970 and 2000 were studied. [ncbi.nlm.nih.gov]

The purpose of a Phase II trial is to learn if a new treatment works in treating a specific type of cancer and how it affects the body. That means it is done to learn more about how well treatments work and the side effects of the treatments. [childrensoncologygroup.org]

Treatment repeats every 42 days for 2 courses in the absence of disease progression or unacceptable toxicity. After completion of study treatment, patients are followed up at 3, 6, 9, 12, 16, 20, 24, 36, 48, 60, and 72 months. [clinicaltrials.gov]

Although patients with NBCCS are predisposed to develop multiple basal cell carcinomas and intracranial tumors in the field of irradiation, the prognosis for syndromic MBs was much better compared with the prognosis for sporadic MBs. [ncbi.nlm.nih.gov]

Desmoplastic medulloblastoma is more common in children younger than 3 years of age and has a better prognosis. 14 As in neuroblastoma, maturation of medulloblastoma cells may be associated with a better prognosis. 11 This case suggests that some types [pediatrics.aappublications.org]

[…] mo·plas·tic me·dul·lo·blas·to·ma subtype of medulloblastoma with a biphasic pattern of compact sheets of undifferentiated cells alternating with islands of more loosely cohesive cells, generally occurs in adolescence and young adults and has a better prognosis [medical-dictionary.thefreedictionary.com]

Etiology Although the etiology and pathogenesis of medulloblastoma is not entirely understood at present, some recent molecular genetic studies have provided important insights into possible disease mechanisms. [4] (See Molecular/Genetics.) [emedicine.medscape.com]

(Etiology) The cause of Adult Medulloblastoma is currently unknown Like all other types of cancer, Medulloblastoma is caused by genetic changes that turn healthy cells into cancer cells. [dovemed.com]

The etiology of cerebellar mutism syndrome remains unclear, although cerebellar vermian damage and/or disruption of cerebellar-cortical tracts has been postulated as the possible cause for the mutism.[ 4, 5 ]; [ 6 ][ Level of evidence: 3iC ] In two Children [cancer.gov]

[…] genetically or histologically defined There are are 4 histologically defined medulloblastomas; desmoplastic / nodular medulloblastoma, medulloblastoma with extensive nodularity (MBEN), classic medulloblastoma and large cell / anaplastic medulloblastoma Epidemiology [pathologyoutlines.com]

Histology of Medulloblastoma fast and infiltrative growth (WHO grade IV) desmoplastic/nodular medulloblastoma anaplastic medulloblastoma medulloblastoma with extensive nodularity large cell medulloblastoma Epidemiology of Medulloblastoma represent 20% [hirntumorhilfe.org]

Giordana MT, Schiffer P, Lanotte M, Girardi P, Chio A (1999) Epidemiology of adult medulloblastoma. Int J Cancer.80(5):689-92. [path.upmc.edu]

Epidemiology It represents 10 at 20 % of brain tumours and 30 % of tumours localized in posterior fossa; annual incidence is 0,5 per 100 000 children; peak of occurrence at 7 years. [atlasgeneticsoncology.org]

It brings together the pathophysiology of disease with detailed clinical guidance on diagnosis and management for the full range of childhood cancers, including aspects important in optimal supportive care. [books.google.de]

Pathophysiology The true cell of origin of medulloblastoma remains a point of some controversy and mystery. [radiologykey.com]

Mutism and pseudobulbar symptoms after resection of posterior fossa tumors in children: incidence and pathophysiology. Neurosurgery 37 (5): 885-93, 1995. [cancer.gov]

Infants with DMB and GS should be treated aggressively with chemotherapy at diagnosis to prevent relapse but radiotherapy should be avoided. [ncbi.nlm.nih.gov]

Patients are checked for side effects of the treatment and to learn whether the treatment prevents the majority of children from tumor recurrence. It is important to understand that participating in a clinical trial is entirely voluntary. [childrensoncologygroup.org]

Application of these in vitro models to intra-axial metastatic medulloblastoma may provide further insight into the pathogenic mechanism of leptomeningeal spread and, in turn, may hold promise for the development of future strategies to prevent late recurrences [path.upmc.edu]