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Desquamative Interstitial Pneumonia


Presentation

  • There was no honeycombing on CT or HRCT scans at presentation.[ncbi.nlm.nih.gov]
  • A unique association between desquamative interstitial pneumonia and granulomatous lymphadenopathy in a six-year-old black girl is presented.[ncbi.nlm.nih.gov]
  • An infant presented with failure to thrive, tachypnoea, and hypoxia reversed by oxygen. Lung function showed decreased pulmonary compliance; lung biopsy showed desquamative interstitial pneumonitis.[ncbi.nlm.nih.gov]
  • In this report, we describe a never-smoker female presenting with Raynaud phenomenon and ILD that demonstrated desquamative interstitial pneumonia (DIP) on surgical lung biopsy.[ncbi.nlm.nih.gov]
  • A 25-year-old African-American woman presented in the emergency room of a community hospital complaining of shortness of breath. The patient was admitted with a diagnosis of atypical pneumonia.[ncbi.nlm.nih.gov]
Turkish
  • History Meanings of "desquamative interstitial pneumonia" in Turkish English Dictionary : 1 result(s) Category English Turkish Medical 1 Medical desquamative interstitial pneumonia deskuamatif interstisyel pnömoni Pronunciation of desquamative interstitial[tureng.com]
Cough
  • He noticed a dry cough and shortness of breath on exertion when the pigment of other colors was added at the age of 27. He visited our hospital two years later because of severe dyspnea.[ncbi.nlm.nih.gov]
  • Cough, difficulty in breathing, cyanosis, and failure to gain weight appeared during the first month of life; progressive hypoxia followed, and the three infants died in respiratory failure before the age of 4 months despite intensive drug and supportive[ncbi.nlm.nih.gov]
  • Our patient was a 56-year-old male, heavy smoker, with bilateral lung infiltrations of unknown etiology and several months of discomfort in the form of dry cough and shortness of breath.[ncbi.nlm.nih.gov]
  • Over-the-counter medications can help relieve some symptoms, such as the dry coughing. There is no current cure for desquamative interstitial pneumonia.[wisegeek.com]
  • Breathlessness during exercise is one of the initial symptoms of these diseases, while a dry cough may also be present. People with different types of ILD may have the same kind of symptoms but their symptoms may vary in severity.[books.google.de]
Dyspnea
  • He visited our hospital two years later because of severe dyspnea. He was diagnosed with desquamative interstitial pneumonia by surgical lung biopsy.[ncbi.nlm.nih.gov]
  • A chest X-ray revealed reticulo-nodular shadows in the bilateral lung fields, and the patient had mild dyspnea on exertion. Without treatment, these shadows decreased gradually and disappeared after several months.[ncbi.nlm.nih.gov]
  • A 45-year-old male smoker heavily used a waterproofing spray gas, and presented with chills and fever that was followed by progressive dyspnea. Because steroid pulse therapy did not improve his symptoms, he was referred to our hospital.[ncbi.nlm.nih.gov]
  • Two patients with diffuse interstitial lung disease after long-term nitrofurantoin therapy were characterized clinically by exertional dyspnea and basilar rales, roentgenographically by diffuse interstitial infiltrate and physiologically by a restrictive[ncbi.nlm.nih.gov]
  • Definition Diffuse expansion and filling of alveoli by macrophages Diagnostic Criteria Clinical Nearly all affected patients are smokers Adults, average age 30-60 Generally subacute dyspnea, cough Good response to steroids and smoking cessation 70% 10[surgpathcriteria.stanford.edu]
Pulmonary Disorder
  • If confirmed, this observation would add DIP to the list of pulmonary disorders that are amenable to the beneficial antiinflammatory effects of macrolides.[ncbi.nlm.nih.gov]
  • The presence of DIP-like reactions around a variety of spaces that occupy pulmonary lesions and of some diffuse pulmonary disorders further limit the diagnostic application of small-tissue biopsies: this mandates close radiographic correlation with findings[err.ersjournals.com]
Persistent Cough
  • The most frequent presenting features of DIP are the onset of breathlessness during exercise and a persistent cough that is not always productive of sputum [ 1, 3, 5, 6 ].[err.ersjournals.com]
  • The most frequent presenting features of DIP are the onset of breathlessness during exercise and a persistent cough that is not always productive of sputum [ 1 , 3 , 5 , 6 ].[err.ersjournals.com]
  • Case 1 (above): 68 year old man, ex-smoker (60 pack-years), presented with persistent cough - Biopsy from S5 Images hosted on other servers: Trichrome staining H&E and IHC of CD68 Virtual slides Images hosted on other servers: Dr.[pathologyoutlines.com]
Rales
  • Two patients with diffuse interstitial lung disease after long-term nitrofurantoin therapy were characterized clinically by exertional dyspnea and basilar rales, roentgenographically by diffuse interstitial infiltrate and physiologically by a restrictive[ncbi.nlm.nih.gov]
  • […] loss of volume is characteristic of either UIP or scleroderma Clinically Symptoms include SOB, non-productive cough and fatigue Clubbing of the fingers is very common (85%) Cyanosis and pulmonary hypertension usually occur late in the disease “Velcro” rales[learningradiology.com]
Failure to Thrive
  • An infant presented with failure to thrive, tachypnoea, and hypoxia reversed by oxygen. Lung function showed decreased pulmonary compliance; lung biopsy showed desquamative interstitial pneumonitis.[ncbi.nlm.nih.gov]

Workup

  • His entire workup failed to demonstrate cystic fibrosis, or any infectious or immune-related diseases. Chest imaging and clinical picture suggested parenchymal lung disease.[ncbi.nlm.nih.gov]
  • It is possible that bronchiolocentric interstitial pneumonia represents a form of chronic hypersensitivity pneumonitis for which the inhalational stimulus has not been identified despite our extensive workup for this condition.[nature.com]
Pulmonary Infiltrate
  • Since DIP is treatable, HCV patients with pulmonary infiltrates should be thoroughly investigated for this disorder.[ncbi.nlm.nih.gov]
Fusarium
  • The authors of this study suggested a potential role for mycotoxins inhaled from the work environment (aflatoxins from Fusarium spp. cultured from specimens taken from the work environment) [ 37 ].[err.ersjournals.com]
Lymphocytic Infiltrate
  • The widespread, patchy intraalveolar histiocytic desquamation was associated with lymphocytic infiltration of bronchiolar and aveolar walls, which together provided convincing evidence that an interstitial pneumonitis was the cause of death.[ncbi.nlm.nih.gov]

Treatment

  • The patient was completely asymptomatic during four years' treatment and six months after stopping treatment.[ncbi.nlm.nih.gov]
  • Eleven patients with UIP and 11 with DIP received treatment between the initial and follow-up CT scans.[ncbi.nlm.nih.gov]
  • Noninvasive methods for diagnosis, assessing prognosis, and following response to treatment in idiopathic pulmonary fibrosis (IPF) have yet to prove their usefulness.[ncbi.nlm.nih.gov]
  • Without treatment, 21.9 per cent with the desquamative but none with the usual type improved.[ncbi.nlm.nih.gov]
  • We report the first case of desquamative interstitial pneumonia (DIP) showing a favorable response to treatment with clarithromycin.[ncbi.nlm.nih.gov]

Prognosis

  • Hazy densities in a peripheral distribution on CT may indicate active IPF associated with a good prognosis.[ncbi.nlm.nih.gov]
  • Desquamative interstitial pneumonia (DIP), also known as alveolar macrophage pneumonia (AMP), represents a subset of idiopathic interstitial pneumonia that responds better to steroids and has a more favourable prognosis than usual interstitial pneumonia[ncbi.nlm.nih.gov]
  • Desquamative interstitial pneumonia (DIP) is an uncommon form of interstitial lung disease demonstrating good response to corticosteroid therapy and favorable prognosis.[ncbi.nlm.nih.gov]
  • We conclude that the histologic classification of chronic interstitial pneumonia used here permits forecasts of prognosis and response to treatment that cannot be deduced from other data.[ncbi.nlm.nih.gov]
  • It is important to recognize that desquamative interstitial pneumonia has distinctive clinical features, prognosis, and response to treatment.[histopathology-india.net]

Etiology

  • Our patient was a 56-year-old male, heavy smoker, with bilateral lung infiltrations of unknown etiology and several months of discomfort in the form of dry cough and shortness of breath.[ncbi.nlm.nih.gov]
  • A viral etiology seems most likely in view of the accompanying chronic inflammation of bronchial submucosal glands.[ncbi.nlm.nih.gov]
  • Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology.[icd10coded.com]
  • The pathogenesis and etiology of DIP are not clear.[histopathology-india.net]
  • […] interstitial lung disease Use of immunosuppressive or immunomodulatory therapy Innovative therapies for refractory disease Referral for lung transplant evaluation Idiopathic pulmonary fibrosis/Usual interstitial pneumonitis remains a disease of unknown etiology[bumc.bu.edu]

Epidemiology

  • The epidemiological and clinical features of DIP are summarised in table 1 . Table 1.[err.ersjournals.com]
  • The epidemiological and clinical features of DIP are summarised in table 1. Table 1.[err.ersjournals.com]
  • Based on the Bernalillo County, NM, USA registry data published in 1994, the overall estimated incidence is approximately 30 cases per 100,000 persons per year. [2] Rates of interstitial lung disease are somewhat higher in men than in women, and the epidemiology[emedicine.medscape.com]
  • Other causes of the usual interstitial pneumonia pattern include domestic and occupational environmental exposures, connective tissue disease, and drug toxicity. 28 An epidemiologic association between smoking and usual interstitial pneumonia is well[mdedge.com]
  • Pulmonary hypertension in advanced sarcoidosis: Epidemiology and clinical characteristics. Eur Respir J 2005;25:783–88. Corte TJ, Wort SJ, Gatzoulis MA, Macdonald P, Hansell DM, Wells AU.[racgp.org.au]
Sex distribution
Age distribution

Pathophysiology

  • Introduction Definition restricted lung expansion results in reduced lung volumes (TLC and FVC) Pathophysiology poor breathing mechanics with normal lung function muscle weakness polio and myasthenia gravis chest wall limitation kyphosis, scoliosis, and[medbullets.com]
  • […] macrophage pneumonia”, it is still officially called “desquamative interstitial pneumonia” ( Am J Respir Crit Care Med 2002;165:277 ) ICD coding Desquamative interstitial pneumonia: J84.117 Sites Bilateral (or sometimes unilateral) lobes of the lung Pathophysiology[pathologyoutlines.com]

Prevention

  • Getting a flu shot every year can help prevent both the flu and pneumonia. In addition, pneumococcal bacteria can cause minor problems such as ear infections.[cedars-sinai.edu]
  • Can interstitial lung disease be prevented? Interstitial lung disease can be prevented only to the extent that its individual causes may be prevented.[rxlist.com]
  • […] resting hypoxemia in patients with interstitial lung disease is V/Q mismatch, with DLCO defect contributing to hypoxemia with activity increased expiratory flow rates due to increased radial traction (result of increased elastic recoil) on airway walls prevents[medbullets.com]
  • […] pneumonia or Acute Respiratory Distress Syndrome (ARDS)) based on clinical or radiological evidence of consolidation and ar لا يمكن السماح لها بالدخول في رأسك en There is growing consensus on a core set of family care practices that address five common, preventable[ar.glosbe.com]

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