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Dextromethorphan

D Methorphan


Presentation

  • We present a case of a young woman who presented to our emergency department (ED) initially diagnosed with recurrent seizures. Paramedics brought a 19-year-old woman to the ED. Witnesses noted "shaking," which the patient did not recall.[ncbi.nlm.nih.gov]
  • CASE REPORT: We report here two cases of dextromethorphan overdose that presented to the Pediatric Toxicology Service at Siriraj Hospital, Bangkok, Thailand.[ncbi.nlm.nih.gov]
  • For patients who present with acute intoxication, management is mainly supportive.[doi.org]
  • In summary, the present data suggest that glutamatergic neurotransmission across the NMDAR is only one among many determinants of intact visual perception.[ncbi.nlm.nih.gov]
  • The authors describe an unusual case of a known asthmatic presenting with somnolence, who appeared to be in end-stage respiratory failure. Her partial response to routine naloxone, 1 mg, was surprising.[ncbi.nlm.nih.gov]
Bilateral Flank Pain
  • OBJECTIVE: We describe the case of a 22-year-old male who developed severe bilateral flank pain, hematuria, and oliguria after an isolated recreational ingestion of guaifenesin and dextromethorphan.[ncbi.nlm.nih.gov]
Uremia
  • DISCUSSION: As the patient's dialysis schedule was adequate, these symptoms were likely not due to uremia.[ncbi.nlm.nih.gov]
Extrapyramidal Symptoms
  • DISCUSSION: A moderate ingestion of dextromethorphan in a toddler resulted in extrapyramidal symptoms with opisthotonus that responded to diphenhydramine.[ncbi.nlm.nih.gov]

Workup

  • She was scheduled for a cardiac syncope workup, but never followed through. Two months later, she presented to the hospital again for a similar complaint. Coworkers reported witnessing sudden tonic-clonic movements and confusion.[ncbi.nlm.nih.gov]
Nephrolithiasis
  • BACKGROUND: Guaifenesin is a common nonprescription medication that has been implicated in drug-induced nephrolithiasis.[ncbi.nlm.nih.gov]

Treatment

  • No changes were made to the pre-existing drug regimen during the course of treatment with DMQ. The primary outcome measure was the Clinical Global Impression-Improvement (CGI-I) score after 90 days of treatment.[ncbi.nlm.nih.gov]
  • Outcome was measured on the basis of patient self-report, treatment team evaluation, and physical examination by psychiatrists and primary care physicians.[ncbi.nlm.nih.gov]
  • Long-term Risp treatment attenuated inflammation and potentiated the neurotrophic function but also produced a certain degree of toxicity. Risp DM was more beneficial and less toxic than Risp-only treatment.[ncbi.nlm.nih.gov]
  • Four clinical trials have evaluated the use of DM/Q for the treatment of PBA. Although the therapeutic outcomes with DM/Q have been positive, interpretation of the published evidence is limited by small sample size and short treatment duration.[ncbi.nlm.nih.gov]
  • The patients at BP goal after each treatment period were defined as the responders and kept on the same combination till the end of the study. The responder rate of each treatment period was recorded.[ncbi.nlm.nih.gov]

Prognosis

  • Abstract Nonketotic hyperglycinemia (NKH) is an inborn error of glycine degradation causing muscular hypotonia, seizures, apnea, and lethargy; it has a poor prognosis.[ncbi.nlm.nih.gov]
  • The prognosis for recovery is good (Ellenhorn & Barceloux, 1988).[web.archive.org]

Etiology

  • Increasing evidence suggests that inflammation contributes to the etiology and progression of schizophrenia.[ncbi.nlm.nih.gov]
  • Possible medical and psychiatric etiologies related to this brief psychotic episode in a geriatric patient are also discussed.[ncbi.nlm.nih.gov]
  • The etiology and the precise underlying mechanism of the progressive neurodegeneration remain poorly understood.[doi.org]
  • Unfortunately in our present state of knowledge there is only a relatively few areas where we can specifically intervene in the etiology of cough.[issc.info]

Epidemiology

  • This was supplemented by references gleaned from recent epidemiological surveys and credible online sources to ensure most up to date information is gathered.[ncbi.nlm.nih.gov]
  • This review presents current perspectives on epidemiology, detection, and clinical challenges of inhalant abuse and offers advice regarding the medical and mental health providers' roles in the prevention and management of this substance abuse problem[ncbi.nlm.nih.gov]
  • Epidemiology of acute cough A number of interesting features of acute cough may be gleaned from the Morbidity Statistics in General Practice Survey.[web.archive.org]
  • Griffiths , Classic Psychedelics: An integrative review of epidemiology, mystical experience, brain network function, and therapeutics , Pharmacology & Therapeutics , 10.1016/j.pharmthera.2018.11.010 , (2018) . Torsten Passie and Simon D.[doi.org]
Sex distribution
Age distribution

Pathophysiology

  • If DXM reduces FM pain, it will provide important information about the nature of FM pathophysiology. Fibromyalgia (FM) is a chronic, widespread pain syndrome.[clinicaltrials.gov]
  • Jeffery , Pathophysiology and treatment of neuropathic pain associated with syringomyelia , The Veterinary Journal , 175 , 2 , (164) , (2008) . Karol A.[doi.org]
  • In another pathophysiologic study, pregabalin with naproxen or gabapentin with naproxen had additive or synergic effects on reversing hyperalgesia in cases of peripheral inflammation ( 32 ).[ncbi.nlm.nih.gov]

Prevention

  • Because dextromethorphan is misused primarily by younger adolescents, the early identification and treatment of dextromethorphan abuse may be important in preventing broader substance abuse in these children.[ncbi.nlm.nih.gov]
  • The combination regimen of dextromethorphan and cyclosporine A could be effective for the treatment and prevention of acute encephalopathy with biphasic seizures and late reduced diffusion. Copyright 2013 Elsevier Inc. All rights reserved.[ncbi.nlm.nih.gov]
  • These results suggest that DM prevents TMT-induced neurotoxicity, at least in part, via sigma(1) receptor stimulation.[ncbi.nlm.nih.gov]
  • Today, StopMedicineAbuse.org is a hub of prevention-related information and a host of free resources.[chpa.org]
  • Use proper storage and disposal, to help prevent abuse. Take action by having frequent conversations with the teens and young adults in your life about the dangers of medicine abuse. Learn how.[medicineabuseproject.org]

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