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Diabetic Embryopathy

Maternal Riboflavin Deficiency


Presentation

  • His co-twin was normal at birth, but at 3 months of life, presented with intractable seizures later associated with developmental delay.[ncbi.nlm.nih.gov]
  • Results of this research were presented at the 51th annual meeting of the teratology society (Pavlinkova, G., Bohuslavova R., Kuthanova L., Sedmera, D., Bloudickova, S.[cordis.europa.eu]
  • A review of this research during 1997 and 1998 is presented for the pediatrician in order to enhance the awareness of DE and its possible role in “idiopathic” malformations for children. 1999 Lippincott Williams & Wilkins, Inc.[journals.lww.com]
Hydrops Fetalis
  • CMV also include hypertrophic cardiomyopathy, which is generally benign and transient, although it may be lethal if associated with hydrops fetalis, especially in case of severe macrosomia.[orpha.net]
  • fetalis Immune hydrops (erythroblastosis fetalis, hemolytic disease of the newborn) Nonimmune hydrops Hygroma colli cysticum Pierre-Robin sequence Caudal regression syndrome (sacral agenesis) VACTERL association Pathology of twinning Complications of[atlases.muni.cz]
Cryptorchidism
  • 457742 ) VACTERL association ( 118181216 ) femoral hypoplasia i( 18051935, 8960613, 8330451 ) femoral hypoplasia-unusual facies syndrome (FHUFS) ( 17668891, 8960613, 6854450 ) bifid tongue ( 17663469 ) holoprosencephaly ( 17274816, 8330451 ) congenital cryptorchidism[humpath.com]
  • […] malformations of female genitalia Congenital malformations of the internal genitalia Congenital malformations associated with congenital malformations of urinary system Congenital malformations of the vulva Congenital malformations of the male genital organs Cryptorchidism[atlases.muni.cz]
Mental Deterioration
  • Since age 19 years, the maternal aunt has had recurrent strokes, seizures, mental deterioration and deafness, later diagnosed as MELAS syndrome due to the tRNA(Leu(UUR)) A-- G mutation.[ncbi.nlm.nih.gov]

Treatment

  • Make the best clinical decisions with an enhanced emphasis on evidence-based practice and expert opinions on treatment strategies. Zero in on the most relevant and useful references with the aid of a more focused, concise bibliography.[books.google.de]
  • The book provides much-needed information on the best drug treatment options and on dietary management, patient education, genetics, perinatal counseling, diabetes prevention, and long-term care of complications.[books.google.es]
  • The embryos and decidua from diabetic rats showed reduced expression of PPARs and increased concentration of lipoperoxidation, MMPs and TIMPs, whereas the maternal treatments enriched in olive oil increased PPARδ in embryos and PPARγ and PPARγ-coactivator[ri.conicet.gov.ar]

Prognosis

  • Prognosis The perinatal outcome in diabetes mellitus is strongly associated with tight glycemic control before and during pregnancy.[folk.uio.no]
  • Large for gestational age infant 48 Long Term Prognosis Growth / Development Childhood obesity (50%, 5 fold higher at adolescence) Risk of Developing Insulin Dependent DM. Diabetic mother 2%.[slideplayer.com]
  • Prognosis Duodenal atresia Small left colon syndrome : self-limiting inability to pass meconium Vertebral anomalies Cleft palate Flexion contracture of the limbs Renal agenesis Diabetic fetopathy Onset : second and third trimester Pathophysiology : chronic[amboss.com]
  • Hypertrophic cardiomyopathy of IDM have good prognosis and this cardiomyopathy is reversible in nature but these neonates requires close monitoring and regular follow-up.[mjdrdypu.org]
  • Hydramnios (increased liquor amnii ) was also well described at the time, as well as the prevalence of PET that contributed to both maternal and foetal death(3).With time the prognosis improved for the mother and foetus by the introduction of optimal[householdmedicalmanual.wordpress.com]

Etiology

  • Because the development of the embryo critically depends on the maternal and the embryonic signaling pathways, a defective signaling mechanism between the maternal and the embryonic tissues appears to be involved in the etiology of diabetic embryopathy[ncbi.nlm.nih.gov]

Epidemiology

  • Summary Epidemiology Several reports show that the birth prevalence of congenital malformations can be cut by a third by using strict preconception glycemia control, but the challenge of implementing this approach remains.[orpha.net]
  • .: Clinical-epidemiologic assessment of patterns of birth defects associated with human teratogens: application to diabetic embryopathy. Pediatrics 84:658–665, 1989. PubMed Google Scholar 25. Kicklighter SD: Infant of diabetic mother.[link.springer.com]
  • Epidemiology of cardiovascular malformations: prevalence and risk factors. Am J Med Genet 2000;97(4):319-25. 7. Moore LL, Singer MR, Bradlee ML, Rothman KJ, Milunsky A.[aap.org]
  • […] fetal polyuria ) Hypothyroidism Leads to congenital hypothyroidism (secondary to iodine deficiency ) References: [6] [7] [8] [9] [10] [11] [12] [13] [14] [15] [16] [17] Substance abuse Alcohol: Fetal alcohol syndrome ( embryo-fetal alcohol syndrome) Epidemiology[amboss.com]
Sex distribution
Age distribution

Pathophysiology

  • Pathophysiology - insulin effects Insulin stimulates glycogen deposition and decreases hepatic glucose production.[quizlet.com]
  • The functional and morphological changes demonstrated in this study may increase our understanding of the pathophysiology of diabetic embryopathy.[ncbi.nlm.nih.gov]
  • The pathophysiologic mechanisms and life-long sequelae of fetal growth abnormalities such as growth retardation and overgrowth require further study.[diamap.eu]
  • Prognosis Duodenal atresia Small left colon syndrome : self-limiting inability to pass meconium Vertebral anomalies Cleft palate Flexion contracture of the limbs Renal agenesis Diabetic fetopathy Onset : second and third trimester Pathophysiology : chronic[amboss.com]
  • […] malformation related to diabetes times more often in IDMs Sacral agenesis with hypoplastic pelvis and spinopelvic instability Usually with other malformations like: femoral hypoplasia, extrophy of the bladder, and club foot 22 Diabetic Embryopathy -Pathophysiology[slideplayer.com]

Prevention

  • Similar preventive effects are also observed when apoptosis signal-regulating kinase 1, JNK1/2, or ER stress is inhibited. Cell membrane stabilizers and antioxidant supplements are also effective in prevention of diabetes-induced birth defects.[ncbi.nlm.nih.gov]
  • However, it is not known how Pax3 destabilizes p53, nor whether degradation of p53 in response to Pax3 prevents the loss of stem cell characteristics as embryo cells start to differentiate.[grantome.com]
  • Seite 193 - Evidence-based nutrition principles and recommendations for the treatment and prevention of diabetes and related complications. ‎[books.google.de]

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