This is the emergency presentation of NIDDMs. [zen104556.zen.co.uk]

The moderate level of IRI (14 microU/ml) on admission and a good response to glucagon 2 months after admission also indicate that the present case is a typical hyperosmolar non-ketotic coma. [ncbi.nlm.nih.gov]

So we conclude that there are 3 possibilities: No acid-base disorder is present There are compensating disorders present (ie acidosis and alkalosis together) This is a rare case of a fully compensated disorder (This is considered very unusual but may [anaesthesiamcq.com]

New presentation diabetes, mildly ill Assessment < 3% dehydration, no acidosis and not vomiting Investigations for all children newly diagnosed with diabetes Check blood ketones (bedside test) on all patients presenting with BGL ≥11.1mmol/l. [rch.org.au]

Despite a total-body potassium deficit, the serum potassium at presentation may be normal or mildly high as a result of acidosis. Similarly, phosphate may be normal at presentation despite total body phosphate depletion. [accessmedicine.mhmedical.com]

• Fever

  The exam may show that you have: Extreme dehydration Fever higher than 100.4°F (38°C) Increased heart rate Low systolic blood pressure Test that may be done include: Blood osmolarity (concentration) BUN and creatinine levels Blood sodium level (needs [mountsinai.org]

  The features include hyperglycemic hyperosmolar coma complicated by a malignant hyperthermia-like picture with fever, rhabdomyolysis, and severe cardiovascular instability. Design. Case series. Setting. [pediatrics.aappublications.org]

  Fever and abdominal tenderness may also be present. Laboratory evaluation reveals hyperglycemia, ketosis (β-hydroxybutyrate > acetoacetate), and metabolic acidosis (arterial pH 6.8–7.3) with an increased anion gap ( Table 24-1 ). [accessmedicine.mhmedical.com]

• Fatigue

  […] and Charaachiness Stage 3 Ketones in the Urine (ketonuria) Thirst, urination, plus more significant fatigue, headache/body aches, and possible nausea Stage 4 Diabetic Ketoacidosis (DKA) Same as above, plus vomiting, discomfort, confusion, dizziness, [insulinnation.com]

  Symptoms frequently none, fatigue, recurrent infections. Ketosis resistant except during infection or stress. [quizlet.com]

  Fatigue: Because the body can't use glucose for energy properly, kids with hyperglycemia may be unusually tired. [kidshealth.org]

  "Symptoms also include fruity breath, nausea, vomiting, fatigue, flu-like symptoms, difficulty breathing and eventually coma," said Sylvia White, R.D., C.D.E., diabetes educator and owner of ParentingDiabetes.com. [eatingwell.com]

  The affected person may also experience symptoms such as rapid breathing, shortness of breath, a fruity scent to the breath, nausea, vomiting, fatigue, confusion, and eventually coma. [labtestsonline.org]

• Hypothermia

  (from hyperglycemia and acidosis) causes tachycardia, abdominal pain (ileus), gastric stasis, and leg cramps ketosis causes nausea and vomiting acidosis causes tachycardia, rapid deep breathing (Kussmaul), hypotension(vasodil.), impaired mentation, hypothermia [d3jonline.tripod.com]

  L–US: > 600 mg/dL, ↑ ketone bodies, relative ↑ in protein, albumin, Ca2+, BR, alk phos, AST, CK, anion gap, acidosis, dehydration, ↓ K+, Na+, phosphate Management Insulin, fluid and electrolyte replacement, treat initiating factors–eg, leukocytosis or hypothermia [medical-dictionary.thefreedictionary.com]

  […] illness Infection (32 – 60%) Pneumonia Urinary tract infection Sepsis Cerebrovascular accident Myocardial infarction Acute pancreatitis Acute pulmonary embolus Intestinal obstruction Dialysis, peritoneal Mesenteric thrombosis Renal failure Heat stroke Hypothermia [diabetesincontrol.com]

  Other clinical or laboratory parameters classically thought to be associated with infection showed no such association in our study: a history of DKA; alcohol abuse; the hemoglobin A 1C value; median temperature; hypothermia or fever at admission; and [academic.oup.com]

  (21 percent). 6 View/Print Table TABLE 2 Precipitating Factors in Hyperosmolar Hyperglycemic State Coexisting diseases Acute myocardial infarction Adrenocorticotropic hormone-producing tumors Cerebrovascular accident Cushing’s syndrome Hyperthermia Hypothermia [aafp.org]

• Malaise

  […] ketosisケトーシス、ケトン症 Kussmaul's breathingク［ー］スマウル［大］呼吸〈糖尿病性大呼吸〉 l ligation 結紮 lipolysis脂肪分解 lipoproteinリポ蛋白［質］、リポプロテイン low-density lipoprotein (LDL)低比重リポ蛋白 luteinizing hormone-releasinghormone (LH-RH)LH放出ホルモン m macular edema (ME)黄斑浮腫 malabsorption吸収不良 malaise [tokyo-med.ac.jp]

  The following are other signs and symptoms of DKA: Malaise, generalized weakness, and fatigability Nausea and vomiting; may be associated with diffuse abdominal pain, decreased appetite, and anorexia Rapid weight loss in patients newly diagnosed with [emedicine.medscape.com]

• Kussmaul Respiration

  […] gap acidosis State of hyperosmolality with low or no ketone bodies Cause Excessive synthesis of ketone bodies from free fatty acids Severe hyperglycemia due to insufficient insulin resulting in plasma hyperosmolality and excessive water loss Symptoms Kussmaul [howmed.net]

  Classic signs of DKA include Kussmaul respirations and an acetone odor on the pt's breath. Volume depletion can lead to dry mucous membranes, tachycardia, and hypotension. Fever and abdominal tenderness may also be present. [accessmedicine.mhmedical.com]

  Respiratory compensation of acidosis can lead to tachypnoea or Kussmaul respiration (very deep, slowly rhythmic breathing). Examine the chest for signs of pneumonic consolidation. [patient.info]

  […] glucagon, growth hormone, catecholamine) results in hyperglycemia and ketonemia Most common in type I diabetes Precipitated by infections MI drugs (steroids, thiazide diuretics) noncompliance pancreatitis Presentation Symptoms vomiting abdominal pain Kussmaul [medbullets.com]

  respirations, 7) acetone noted on breath (fruity); 1) glucose > 250, 2) arterial blood pH < 7.3, 3) serum HCO3 < 16, 4) moderate to large ketones in urine/blood. 5) high anion gap (normal = 8-12 mEq/L) Anion Gap: Relationship to Metabolic Acidosis Formula [quizlet.com]

• Tachypnea

  Diagnosis On examination, general findings of DKA may include the following: Ill appearance Dry skin Labored respiration Dry mucous membranes Decreased skin turgor Decreased reflexes Characteristic acetone (ketotic) breath odor Tachycardia Hypotension Tachypnea [emedicine.medscape.com]

• Hyperpnea

  Inpatient care after an episode of ketoacidosis is the same as for diabetes mellitus. diabetic ketoacidosis A hyperglycemia-induced clinical crisis most common in type 1 DM Clinical N&V, thirst, diaphoresis, hyperpnea, drowsiness, fever, prostration, [medical-dictionary.thefreedictionary.com]

• Vomiting

  […] or abdominal pain (Vomiting can be caused by many illnesses, not just ketoacidosis. [diabetes.org]

  […] or no ketone bodies Cause Excessive synthesis of ketone bodies from free fatty acids Severe hyperglycemia due to insufficient insulin resulting in plasma hyperosmolality and excessive water loss Symptoms Kussmaul respiration, acetone breath, nausea, vomiting [howmed.net]

  Nausea, vomiting and severe abdominal cramps. Blurred vision Fruity or pungent smelling breath due to the presence of acetone and ketones in the breath. [news-medical.net]

  […] osmotic diuresis (from hyperglycemia) causes polyuria/polydipsia, systemic dehydration, and hypotension hyperkalemia (from hyperglycemia and acidosis) causes tachycardia, abdominal pain (ileus), gastric stasis, and leg cramps ketosis causes nausea and vomiting [d3jonline.tripod.com]

• Nausea

  […] with low or no ketone bodies Cause Excessive synthesis of ketone bodies from free fatty acids Severe hyperglycemia due to insufficient insulin resulting in plasma hyperosmolality and excessive water loss Symptoms Kussmaul respiration, acetone breath, nausea [howmed.net]

  Since severe ketosis will likely make a person extremely nauseas in addition to their illness-induced nausea, it can be nearly impossible to consume enough fluids at home to re-hydrate the body. [diabetesdaily.com]

  Symptoms of HONK Before loss of consciousness and coma takes place, patients will display signs of very high blood sugar levels which may include: Extreme thirst Frequent need to urinate Disorientation Nausea The condition of very high blood glucose without [diabetes.co.uk]

  This is because the symptoms of gastritis – nausea, vomiting and reduced eating – make you think less insulin is needed. And insufficient amounts of insulin can quickly lead to diabetic acidosis. [netdoctor.co.uk]

  Nausea, vomiting and severe abdominal cramps. Blurred vision Fruity or pungent smelling breath due to the presence of acetone and ketones in the breath. [news-medical.net]

• Abdominal Pain

  pain Mental confusion, DehydrationComa Lab Investigations Plasma glucose Serum Urea Serum creatinine Serum ketones Serum electrolytes Plasma Osmolality Urine analysis (ketones) ABG analysis Complete blood count with differentiatials HbA1c Plasma glucose [howmed.net]

  Abdominal pain, sometimes mimicking an acute abdomen, is reported in 40-75% of DKA cases. [endocrinologyadvisor.com]

  Snap Shot A 12 year old boy, previously healthy, is admitted to the hospiral after 2 days of polyuria, polyphagia, nausea, vomting and abdominal pain. Temp is 37, BP 103/63, HR 112, RR 30. Physical exam shows a lethargic boy. [medbullets.com]

• Polydipsia

  […] not been previously diagnosed poor prognostic factors : age (65 or older), extreme acidosis (pH Signs and Symptoms – many gastric symptoms, probably protective against further ingestion of glucose osmotic diuresis (from hyperglycemia) causes polyuria/polydipsia [d3jonline.tripod.com]

  Hyperglycemia: Manifestations manifests as 1) polyuria: osmotic diuresis (glucose in renal tubules cannot be reabsorbed; consequent hyperosmolarity and osmotic pressure results in more water in tubules) 2) polyphagia followed by lack of appetite, 3) polydipsia [quizlet.com]

  Hyperglycaemia will lead to polyuria, dehydration, weight loss, polydipsia and thirst. [diapedia.org]

  […] which a person has high blood sugar, either because the pancreas does not produce enough insulin, or because cells do not respond to the insulin that is produced.This high blood sugar produces the classical symptoms of polyuria (frequent urination), polydipsia [intensivecarehotline.com]

  DKA typically presents with polyuria and polydipsia, vomiting, dehydration and, if severe, an altered mental state, including coma. [patient.info]

• Acute Abdomen

  Acidosis may rarely cause abdominal pain and simulate a surgical acute abdomen. The typical smell of acetone can be detected in the patient's breath, although some people are unable to detect this smell. [diapedia.org]

  Acute pancreatitis. Sepsis without ketoacidosis. Acute abdomen. Ketoacidosis due to starvation. Investigations Capillary blood glucose (remember to send a plasma glucose also). [patient.info]

  Abdominal pain, sometimes mimicking an acute abdomen, is reported in 40-75% of DKA cases. [endocrinologyadvisor.com]

• Hypotension

  […] hyperkalemia (from hyperglycemia and acidosis) causes tachycardia, abdominal pain (ileus), gastric stasis, and leg cramps ketosis causes nausea and vomiting acidosis causes tachycardia, rapid deep breathing (Kussmaul), hypotension(vasodil.), impaired [d3jonline.tripod.com]

  Hypotension also results in impaired tissue perfusion. Coma is the end stage of this hyperglycemic process, when severe electrolyte disturbances occur in association with hypotension. [emedicine.medscape.com]

  Volume depletion can lead to dry mucous membranes, tachycardia, and hypotension. Fever and abdominal tenderness may also be present. [accessmedicine.mhmedical.com]

  […] impairs protein synthesis and causes protein degradation, resulting in nitrogen losses (amino acids contain NH2) 1) EARLY: may present as lethargy, weakness 2) dehydration resulting in poor skin turgor, dry mucous membranes, 3) tachycardia, 4) orthostatic hypotension [quizlet.com]

  Hypotension. Check temperature, pulse and blood pressure. Smell the breath for the characteristic fruity/musty odour of ketones - the smell is akin to pear drops or nail-polish remover. [patient.info]

• Tachycardia

  abdominal pain (ileus), gastric stasis, and leg cramps ketosis causes nausea and vomiting acidosis causes tachycardia, rapid deep breathing (Kussmaul), hypotension(vasodil.), impaired mentation, hypothermia Etiology – DKA is due to loss of insulin, [d3jonline.tripod.com]

  Volume depletion can lead to dry mucous membranes, tachycardia, and hypotension. Fever and abdominal tenderness may also be present. [accessmedicine.mhmedical.com]

  […] alcohol intake without food, 2) too little food or skipping meals 3) too much diabetic medication 4) too much exercise, 5) mismatch of medications and food, 6) weight loss without medication adjustment, Hypoglycemia: Manifestations MILD: sweating, tremor, tachycardia [quizlet.com]

  Electrolyte disturbances result from loss of water usually in excess of salt loss; hypovolaemia and severe intravascular dehydration will be accompanied by tachycardia and may give rise to thromboembolic complications (such as stroke or myocardial infarction [diapedia.org]

  Physical examination reveals signs of dehydration, including loss of skin turgor, dry mucous membranes, tachycardia and hypotension. [endocrinologyadvisor.com]

• Ketotic Breath

  Moreover, acetone produces the fruity breath odor that is characteristic of ketotic patients. Glucosuria leads to osmotic diuresis, dehydration and hyperosmolarity. [emedicine.medscape.com]

• Polyuria

  […] diabetes had not been previously diagnosed poor prognostic factors : age (65 or older), extreme acidosis (pH Signs and Symptoms – many gastric symptoms, probably protective against further ingestion of glucose osmotic diuresis (from hyperglycemia) causes polyuria [d3jonline.tripod.com]

  Hyperglycaemia will lead to polyuria, dehydration, weight loss, polydipsia and thirst. [diapedia.org]

  The initial symptoms of DKA include anorexia, nausea, vomiting, polyuria, and thirst. Abdominal pain, altered mental function, or frank coma may ensue. Classic signs of DKA include Kussmaul respirations and an acetone odor on the pt's breath. [accessmedicine.mhmedical.com]

  Polyuria — Excessive secretion of urine. Type I diabetes — Also called juvenile diabetes. Type I diabetes typically begins early in life. Affected individuals have a primary insulin deficiency and must take insulin injections. [medical-dictionary.thefreedictionary.com]

  […] too little diabetic medications, 3) inactivity, 4) emotional/physical stress, 5) poor absorption of insulin 6) illness 7) corticosteroids **counterregulatory hormones released when stress, illness persist Hyperglycemia: Manifestations manifests as 1) polyuria [quizlet.com]

• Anuria

  […] hyperglycemia (greater b/c no ketogenesis) which results in profound fluid loss (osmotic diuresis) 2) profound dehydration 3) decreased Na, K and phosphorus As fluid loss continues, eventually hypovolemia occurs: 1) decreased renal perfusion leads to anuria [quizlet.com]

• Confusion

  Excessive synthesis of ketone bodies from free fatty acids Severe hyperglycemia due to insufficient insulin resulting in plasma hyperosmolality and excessive water loss Symptoms Kussmaul respiration, acetone breath, nausea, vomiting, abdominal pain Mental confusion [howmed.net]

  Hyperosmolar diabetic non-ketotic coma is a metabolic emergency usually seen in elderly non-insulin dependent diabetics, characterized by severe hyperglycaemia, volume depletion, altered consciousness, confusion and less frequently neurological deficit [ncbi.nlm.nih.gov]

  […] lost because there are very few negative ketones whose charge needs balancing by excretion of sodium; any acidosis is being compensated for with sodium retention and hydrogen ion loss hypernatraemia + dehydration -> intense thirst weight loss mental confusion [zen104556.zen.co.uk]

  When to go to the hospital A person with diabetes should be taken to a hospital's emergency department if they appear significantly ill, dehydrated, confused, or very weak. [emedicinehealth.com]

• Lethargy

  Nonketotic hyperosmolar coma [ edit ] Nonketotic hyperosmolar coma usually develops more insidiously than diabetic ketoacidosis because the principal symptom is lethargy progressing to obtundation, rather than vomiting and an obvious illness. [en.wikipedia.org]

  Symptoms of ketoacidosis Symptoms of ketoacidosis are: extreme thirst lethargy frequent urination (due to high blood glucose levels) nausea vomiting abdominal pain progressive drowsiness deep, rapid breathing a fruity or acetone smell on the breath. [betterhealth.vic.gov.au]

  Possibilities include headache, lethargy, irritability, leg cramps, constipation and heart palpitations. These side effects are usually relatively minor and transient, and most of them can be avoided by getting enough fluid and salt. [dietdoctor.com]

  Some common DKA symptoms include: high blood sugar levels frequent urination (polyuria) and thirst fatigue and lethargy nausea vomiting abdominal pain fruity odor to breath rapid, deep breathing muscle stiffness or aching coma Diagnosis Diagnosis requires [medical-dictionary.thefreedictionary.com]

  […] hydrogen ions. 4) As hypoxia worsens lactic acid builds up contributing to the acidosis. 5) insulin deficiency impairs protein synthesis and causes protein degradation, resulting in nitrogen losses (amino acids contain NH2) 1) EARLY: may present as lethargy [quizlet.com]

• Stupor

  Typically, the patient, a middle-aged or old person with diabetes mellitus of recent onset or without previous history of the disease, lapses into stupor and unconsciousness after manifesting prodromal neurological symptoms, such as convulsions, aphasia [jamanetwork.com]

  Because phosphate replacement can cause severe hypocalcemia in this setting, serum calcium levels should be monitored closely. 25 Hypomagnesemia may manifest as arrhythmias, muscle weakness, convulsions, stupor, and agitation. [aafp.org]

  Vinik A, Seftel H, Joffe BI (1970) Metabolic findings in hyperosmolar, non-ketotic diabetic stupor. SLancet 2: 797-799. [omicsonline.org]

  Gastrointestinal symptoms such as nausea, vomiting, and/or abdominal pain were present in 98 episodes (79.6%); asthenia was a presenting symptom in 60 (48.7%); neurological symptoms such as altered consciousness, disorientation, or stupor occurred in [academic.oup.com]

• Altered Mental Status

  Both disorders are associated with absolute or relative insulin deficiency, volume depletion, and altered mental status. The metabolic similarities and differences in DKA and HHS are summarized in Table 24-1. [accessmedicine.mhmedical.com]

  Blood glucose level Serum osmolarity Generally, hyperosmolar hyperglycemic state is initially suspected when a markedly elevated glucose level is found in a fingerstick specimen obtained in the course of a workup of altered mental status. [merckmanuals.com]

  On the other end of the spectrum are the patients brought in for altered mental status and even coma in severe cases. Typical symptoms are those of hyperglycemia, including polyuria and polydipsia, seen in about 75% of patients with DKA. [ahcmedia.com]

  Mental status changes can be seen with mild-to-moderate DKA; more severe deterioration in mental status is typical with moderate-to-severe DKA. [emedicine.medscape.com]

• Asthenia

  Gastrointestinal symptoms such as nausea, vomiting, and/or abdominal pain were present in 98 episodes (79.6%); asthenia was a presenting symptom in 60 (48.7%); neurological symptoms such as altered consciousness, disorientation, or stupor occurred in [academic.oup.com]

Blood glucose level Serum osmolarity Generally, hyperosmolar hyperglycemic state is initially suspected when a markedly elevated glucose level is found in a fingerstick specimen obtained in the course of a workup of altered mental status. [merckmanuals.com]

Workup The workup for DKA consists of three parts: establishing the diagnosis, gathering data to direct a treatment plan, and searching for a precipitant. [ahcmedia.com]

See Workup for more detail. [emedicine.medscape.com]

• Ketonuria

  Because of a preferential increase in 3-OHBA, ketonuria seemed to be absent in the regular nitroprusside test. [ncbi.nlm.nih.gov]

  Similarly, ketonuria clearance also reflects the speed with which insulin needs are met; in our study, ketonuria clearance was slower in the patients with infection, who were more likely not to have complete clearance of ketonuria within 12 h of ICU admission [academic.oup.com]

  Initially high anion gap but as ketones excreted becomes normal anion gap acidosis - hyperkalaemia usual, but hypokalaemia possible - features of dehydration - glycosuria and ketonuria while urine flow adequate - ECG - CXR - cultures - FBC Treatment General [aic.cuhk.edu.hk]

  However, when there is excessive ketone accumulation, it is excreted in the urine, leading to ketonuria. If not treated promptly, this results in metabolic acidosis or ketoacidosis. [healthhype.com]

  DKA is characterised by hyperglycaemia, acidosis and ketonaemia: [ 1 ] Ketonaemia (3 mmol/L and over), or significant ketonuria (more than 2+ on standard urine sticks). [patient.info]

• Hyperglycemia

  Diabetic Ketoacidosis and Non-Ketotic Hyperosmolar Coma Diabetic Ketoacidosis (DKA) – associated with type 1 diabetes Clinical Presentation – hyperglycemia (>250 mg/dl), acidosis (pH < 7.35), and high serum ketone bodies these three criteria are diagnostic [d3jonline.tripod.com]

  Non-Ketotic Hyperglycaemic Coma and Diabetic Ketoacidosis Random Stuff 3,293 Views The differences between diabetic ketoacidosis and hyperglycemic non-ketotic hyperosmolar coma are: Diabetic ketoacidosis Non-ketotic hyperosmolar coma Definition Triad of: hyperglycemia [howmed.net]

  While DKA is characterized by severe hyperglycemia, the presence of ketoacidosis without hyperglycemia in an alcoholic patient is virtually diagnostic of alcoholic ketoacidosis. [endocrinologyadvisor.com]

  Non-ketotic hyperglycemic hemichorea (NHH), also known as diabetic striatopathy or chorea, hyperglycemia, basal ganglia (C-H-BG) syndrome, is a rare cause of T1 bright basal ganglia and one of the neurological complications of non-ketotic hyperglycemia [radiopaedia.org]

• Hyponatremia

  Two patients presented hyponatremia simultaneously. No patients had benefit with phenytoin or diazepam, and one patient got worse after them. Seizure control occurred after insulin and electrolytic treatment. [ncbi.nlm.nih.gov]

  Hyperglycemia may cause dilutional hyponatremia, so measured serum sodium is corrected by adding 1.6 mEq/L (1.6 mmol/L) for each 100 mg/dL (5.6 mmol/L) elevation of serum glucose over 100 mg/dL (5.6 mmol/L). [merckmanuals.com]

  Review Topic QID: 109465 1 Hyponatremia is independently associated with a poor prognosis 2 Hyperkalemia is independent of the patient's total body potassium stores 3 Hyperglycemia to this magnitude supports hyperglycemic hyperosmolar nonketotic syndrome [medbullets.com]

  High serum osmolarity also drives water from intracellular to extracellular space, causing dilutional hyponatremia. Sodium also is lost in the urine during the osmotic diuresis. [emedicine.medscape.com]

  Hyponatremia: evaluating the correction factor for hyperglycemia. Am J Med. 2000;108:180–1. 26. Hillier TA, Abbott RD, Barrett EJ. Hyponatremia: evaluating the correction factor for hyperglycemia. Am J Med. 1999;106:399–403. 27. Magee MF, Bhatt BA. [aafp.org]

• Hypertriglyceridemia

  Leukocytosis, hypertriglyceridemia, and hyperlipoproteinemia are common. Hyperamylasemia is usually of salivary origin but may suggest a diagnosis of pancreatitis. [accessmedicine.mhmedical.com]

  If the patient has significant hypertriglyceridemia, it can falsely lower glucose and sodium measurements by dilution. Leukocytosis may be present in DKA without infection. [aafp.org]

  Extreme hypertriglyceridemia, which may be present during DKA due to impaired lipoprotein lipase activity, may cause lipemic serum with spurious lowering of serum glucose (pseudonormoglycemia) 23 and serum sodium (pseudohyponatremia) 24 in laboratories [spectrum.diabetesjournals.org]

• Glucagon Increased

  Increased concentration of glucagon lowers the hepatic levels of malonyl coenzyme A (CoA) by blocking the conversion of pyruvate to acetyl CoA through inhibition of acetyl CoA carboxylase, the first rate-limiting enzyme in the novo fatty acid synthesis [endocrinologyadvisor.com]

  Increased concentration of glucagon lowers the hepatic levels of malonyl coenzyme A (CoA) by blocking the conversion of pyruvate to acetyl CoA through inhibition of acetyl CoA carboxylase, the first rate-limiting enzyme in de novo fatty acid synthesis [spectrum.diabetesjournals.org]

• Anion Gap Increased

  These biochemical changes are frequently associated with increased anion gap, increased serum osmolarity and increased serum uric acid. (See Clinical Presentation.) [emedicine.medscape.com]

• Leukocytosis

  Leukocytosis, hypertriglyceridemia, and hyperlipoproteinemia are common. Hyperamylasemia is usually of salivary origin but may suggest a diagnosis of pancreatitis. [accessmedicine.mhmedical.com]

  […] often > 33.6 mmol/L–US: > 600 mg/dL, ↑ ketone bodies, relative ↑ in protein, albumin, Ca2+, BR, alk phos, AST, CK, anion gap, acidosis, dehydration, ↓ K+, Na+, phosphate Management Insulin, fluid and electrolyte replacement, treat initiating factors–eg, leukocytosis [medical-dictionary.thefreedictionary.com]

  Patients with DKA frequently present with leukocytosis in the absence of infection. However, a leukocyte count greater than 25,000 mm 3 or the presence of greater than 10% neutrophil bands is seldom seen in the absence of bacterial infection. [endocrinologyadvisor.com]

  Leukocytosis may be present in DKA without infection. Treatment A priority of treatment should be to protect and maintain the airway, particularly in the obtunded patient, and to treat shock if present. [aafp.org]

Make the best clinical decisions with an enhanced emphasis on evidence-based practice and expert opinions on treatment strategies. Zero in on the most relevant and useful references with the aid of a more focused, concise bibliography. [books.google.it]

What Are The Treatment Of Diabetes Mellitus Lisinopril Diabetes : What Are The Treatment Of Diabetes Mellitus : Fast Online Service Exposicin Diabetes Mellitus 2. [ipmgroup.eu]

– b -sympathomimetic agents bolster catecholamines, which can tip the balance Treatment of DKA (1) fluids (saline) – normal perfusion of lung and kidney is necessary to eliminate glucose, ketones, and acid lungs – hyperventilation alkalizes blood and [d3jonline.tripod.com]

Cerebral edema typically occurs 4-12 hours after treatment is activated, but it can be present before treatment has begun or may develop any time during treatment for DKA. [endocrinologyadvisor.com]

[…] acute phase shift treatment to diet or oral drugs eg sulphonylureas or biguanides 3) Prevent arterial thrombosis with s.c. heparin if at risk of GI bleeding or i.v. heparin if not at risk 4) Stop potential precipitating factors eg diuretics or phenytoin Prognosis [zen104556.zen.co.uk]

Treatment and prognosis Symptoms and imaging findings usually resolve upon normalization of glucose levels 7. [radiopaedia.org]

Coma on admission adversely affects the prognosis. The major causes of death are circulatory collapse, hypokalemia, infection, and cerebral edema. [medical-dictionary.thefreedictionary.com]

"Course and prognosis of 132 patients with diabetic non ketotic hyperosmolar state." Diabete & metabolisme 20.1 (1993): 43-48. Gouveia, Catherine F., and Tahseen A. Chowdhury. [derangedphysiology.com]

[…] hyperglycemia and acidosis) causes tachycardia, abdominal pain (ileus), gastric stasis, and leg cramps ketosis causes nausea and vomiting acidosis causes tachycardia, rapid deep breathing (Kussmaul), hypotension(vasodil.), impaired mentation, hypothermia Etiology [d3jonline.tripod.com]

The underlying etiology of this syndrome remains unclear. [pediatrics.aappublications.org]

Etiology The most common scenarios for diabetic ketoacidosis (DKA) are underlying or concomitant infection (40%), missed or disrupted insulin treatments (25%), and newly diagnosed, previously unknown diabetes (15%). [emedicine.medscape.com]

If the serum osmolality is less than 320 mOsm per kg (320 mmol per kg), etiologies other than DKA should be considered. 3 Osmolality can be calculated using the formula for effective osmolality (mOsm per kg): View/Print Table TABLE 3 Standard Laboratory [aafp.org]

The evolution of diabetic ketoacidosis: An update of its etiology, pathogenesis and management. Metabolism 2016;65:507-521. Ely SF, Neitzel AR, Gill JR. Fatal diabetic ketoacidosis and antipsychotic medication. J Forensic Sci 2013;58:398-403. [ahcmedia.com]

Epidemiology of acute manifestations and complications. [diabetesincontrol.com]

Diabetic Ketoacidosis (DKA) – associated with type 1 diabetes Clinical Presentation – hyperglycemia (>250 mg/dl), acidosis (pH < 7.35), and high serum ketone bodies these three criteria are diagnostic – i.e., only ketoacidosis can cause all three symptoms Epidemiology [d3jonline.tripod.com]

Epidemiology - 10/100 000/yr - 6 times less common than DKA - 30% previously undiagnosed diabetics Clinical features - more common in elderly - onset insidious - infection, intercurrent cardiovascular disease, steroids, diuretics and intake of glucose [aic.cuhk.edu.hk]

Epidemiology of the Hyperglycaemic Hyperosmolar State HHS principally affects those with type 2 diabetes, either as the first presentation of the disease or in those with poor compliance to medication. [diapedia.org]

However, hyperglycaemia may not always be present and low blood ketone levels ( [ 2 ] Epidemiology DKA is normally seen in people with type 1 diabetes. [patient.info]

Each disease-oriented section begins with an up-to-date review of pathophysiology and then focuses on specific diseases. [books.google.it]

Beside this pessimistic development of the pathophysiology of coma in DKA there are also more optimistic aspects. [omicsonline.org]

Clinical features, pathophysiology, renal function, acid-base balance, plasma cerebrospinal fluid equilibria and the effects of therapy in 37 cases. Medicine (Baltimore) 51, 73–94. CrossRef Google Scholar Coghlan, J. D. 1981. [link.springer.com]

Pathophysiology Although DKA can occur in patients with type 2 diabetes, it mainly develops in people with type 1 diabetes who need to take insulin for their condition. If individuals do not receive insulin, they will develop DKA. [news-medical.net]

The exact underlying pathophysiology of changes seen on imaging of patients with non-ketotic hyperglycemic hemichorea is not fully understood 1,2. [radiopaedia.org]

Stroke / DVT / PE / mesenteric artery thrombosis NB These patients are NOT ketotic or acidotic - this is because the insulin level, while not high enough to prevent hyperglycaemia or liver gluconeogenesis, is enough to prevent lipolysis; therefore ketones [zen104556.zen.co.uk]

You can treat it and prevent it, too. What Causes DKA? It usually happens because your body doesn't have enough insulin. Your cells can't use the sugar in your blood for energy, so they use fat for fuel instead. [webmd.com]

[…] bodies (2) insulin – turn off gluconeogenesis/glycogenolysis [K + ] must be carefully monitored, since insulin causes K + to enter cells – hyperkalemia Þ hypokalemia (3) do NOT use alkali – unless pH < 7.0 (4) find and treat the precipitating factor to prevent [d3jonline.tripod.com]

However, in order to prevent hypoglycaemic emergencies in a timely manner, it is important to be aware of your symptoms and treatment options. [mylife-diabetescare.com]

To prevent any hypoglycaemic coma, it is the practice to treat any blood glucose less than 4 mmol/L. [star2.com]