Presentation
present the importance regarding the impacts of diabetic neuropathic deficits on patients' functional capacity. [ncbi.nlm.nih.gov]
Associated autonomic symptoms may be present. Examination shows distal loss of pinprick, temperature, touch and vibration sense. with reduced or absent Ankle jerks and weakness of toe flexors and extensors may be present. [jpma.org.pk]
Peripheral sensory neuropathy Sensory neuropathy most commonly presents as symptomless symmetrical sensory loss in distal extremities i.e. feet and less commonly hands. [nhshighland.scot.nhs.uk]
Respiratoric
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Yawning
By Richard Klasco, M.D Photo Credit Ask Well Photo Credit Why Do We Yawn? Reading about yawning makes people yawn. You are probably yawning right now. By Roni Caryn Rabin Latest Search Latest Articles Search Articles 13845 results for sorted by [nytimes.com]
Musculoskeletal
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Foot Pain
On the 10th day, we found a decrease of 33% in foot pain and by the end of the second month, it fell by 65.5% (p 0.0001). [ncbi.nlm.nih.gov]
Symptoms can include: Vision trouble Shin or foot pain Severe lower back or pelvis pain Pain in the chest, side or belly [mainehealth.org]
Symptoms are specific to the affected nerve, and may include: Paralysis on one side of the face (Bell’s Palsy) Difficulty focusing, double vision or pain behind one eye Pain in the shin or foot Pain in the lower back or pelvis Pain in the front of the [informationaboutdiabetes.com]
So, any of the following could be an indication of this disease: Paralysis on one side of the face (Bell’s palsy) Pain in the shin or foot Pain in the front of the thigh Abdominal or chest pain Problems focusing the eyes or double vision (mononeuropathy [availclinical.com]
Leg, shin, or foot pain. Lower back, pelvic, or abdominal pain. To manage symptoms, seek medical treatment if you experience symptoms of mononeuropathy, and tell your physician about all the symptoms you’re experiencing. [wwmedgroup.com]
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Myopathy
Tendon reflexes: Reduced at ankles (50%) Treatment: Improvement in 1 patient with reduction of triglycerides Other disorders Tangier disease Triglyceride storage disease with impaired long-chain fatty acid oxidation Neutral lipid storage disease with myopathy [neuromuscular.wustl.edu]
Eyes
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Ptosis
On the 10th day, we found significant improvement in the clinical signs of diabetic mononeuropathy - double vision, motility and position of the eyeball, ptosis of the upper eyelid and mydriasis. [ncbi.nlm.nih.gov]
Distribution: Common areas effected Wrist Drop ( Radial Nerve ) Loss of finger flexion and grip ( Median Nerve ) Foot drop (deep peroneal nerve, L4-L5) Recurrent laryngeal nerve Cranial Nerve palsy ( CN 3, CN 4, CN 6 ) Ophthalmoplegia, Ptosis, Diplopia [fpnotebook.com]
In addition to the double vision, damage to the third nerve may result in ptosis (dropping eyelid) and a dilated pupil. [diabetesmonitor.com]
No specific treatment is required other than prismatic help with diplopia as the ptosis recovers. Complete resolution normally occurs over 3–6 months. [jnnp.bmj.com]
Diabetic third nerve palsy presents with abrupt onset retro-orbital pain, followed by double vision, unilateral ptosis, restriction of medial and upgaze and sparing of the pupil. [jpma.org.pk]
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Blepharoptosis
Diplopia, blepharoptosis and decreased range of ocular movement, which were observed on admission, immediately began to improve at 1-4 days after the beginning of the treatment. [ncbi.nlm.nih.gov]
Neurologic
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Foot Drop
Distribution: Common areas effected Wrist Drop ( Radial Nerve ) Loss of finger flexion and grip ( Median Nerve ) Foot drop (deep peroneal nerve, L4-L5) Recurrent laryngeal nerve Cranial Nerve palsy ( CN 3, CN 4, CN 6 ) Ophthalmoplegia, Ptosis, Diplopia [fpnotebook.com]
drop) Symptoms/Signs numbness edema pain prickling Mononeuropathies CN III, IV, and VI (and other CN's affected) causing diplopia and abnormality of visual fields *unilateral pain near the affected eye paralysis of the eye muscle double vision Foot care [quizlet.com]
Some of the most common are: axillary nerve dysfunction carpal tunnel syndrome common peroneal nerve dysfunction cranial mononeuropathy femoral neuropathy radial nerve dysfunction ulnar nerve dysfunction unilateral foot drop sciatic nerve dysfunction [healthline.com]
Sahani B, Spalding JMK: Diabetes mellitus presenting with bilateral foot drop. Lancet 1969;2:930–931. CrossRef Google Scholar (33). [link.springer.com]
Lower limb Foot drop, caused by a common peroneal nerve mononeuropathy, is uncommon. [diabetesincontrol.com]
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Sciatica
The technical medical term for that is radiculopathy, although most people refer to it as sciatica. If there’s also shooting nerve pain involved, this form of neuropathy can also be called polyradiculopathy-diabetic amyotrophy. [endocrineweb.com]
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Mydriasis
On the 10th day, we found significant improvement in the clinical signs of diabetic mononeuropathy - double vision, motility and position of the eyeball, ptosis of the upper eyelid and mydriasis. [ncbi.nlm.nih.gov]
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Encephalopathy
Painful Diabetic Neuropathy 351 Focal and Multifocal Diabetic Neuropathy 367 Hypoglycemia and the Autonomic Nervous System 379 Cardiovascular Autonomic Neuropathy 389 Postural Hypotension and Anhidrosis 413 Structure and Function in Diabetes 165 Diabetic Encephalopathy [books.google.com]
Workup
(See Workup.) Management of diabetic neuropathy should begin at the initial diagnosis of diabetes. [emedicine.medscape.com]
Increased temperature changes with edema can be quite concerning and complete workup is required to “arrest” the development of breakdown of the arch with subsequent deformity, such as a rocker bottom type of foot. [ahcmedia.com]
Treatment
On the 10th day, we established a decrease in total symptom score by an average of 2.7 /- 1.4 points and by the end of the treatment period it was improved by 5.9 /- 1.9 points (p 0.04). [ncbi.nlm.nih.gov]
المحتويات Aldose Reductase Inhibitors for the Treatment 309 Other Therapeutic Agents for the Treatment 321 Pathophysiology of Neuropathic Pain 339 Treatment of Painful Diabetic Neuropathy 351 Focal and Multifocal Diabetic Neuropathy 367 Hypoglycemia and [books.google.com]
Prognosis
Prognosis for Diabetics with Neuropathy The prognosis for diabetic neuropathy depends largely on how well the underlying condition of diabetes is handled. [agingcare.com]
What Is the Prognosis for Neuropathy? The outlook for nerve damage depends upon its cause. [emedicinehealth.com]
Prognosis [ 7, 9 ] Autonomic neuropathy is associated with a high mortality rate, mainly due to its association with chronic kidney disease, cardiopathy and hypotension. [patient.info]
IVIg: Hastens recovery; dose 2g/kg q month x3 Prognosis Slow recovery over 6 to 24 months after diabetic control Partial or complete Variant syndrome: Diabetic amyotrophy Nosology: Proximal diabetic neuropathy Frequency: Rare Onset: Sub-acute Associations [neuromuscular.wustl.edu]
The prognosis is generally good, and patients typically recover their baseline weight with resolution of the painful sensory symptoms within 1 year. 2. [health.am]
Etiology
Abstract Fifty-one diabetic patients with mononeuropathy were studied to examine possible etiological factors, to determine the relationship with other diabetic complications, and to correlate with the presence and severity of background peripheral and [diabetes.diabetesjournals.org]
Additionally, patients can be referred if the diagnosis is unclear or if a different etiology is suspected. [pharmacytimes.com]
Disease Etiology With over 100 known types of peripheral neuropathy, the pathophysiology of this disease is not quite clear. [endocrinologyadvisor.com]
You can also refer if the diagnosis is unclear or different etiology is suspected. DSPN pain management Pop-Busui mentions pain is often the reason many diabetic neuropathy patients seek help from their providers. [sciencedaily.com]
You can also refer if the diagnosis is unclear or different etiology is suspected. [labblog.uofmhealth.org]
Epidemiology
Epidemiological correlates of diabetic neuropathy. Report from Pittsburgh Epidemiology of Diabetes Complications Study. Diabetes 1989;38:1456–1461. PubMed CrossRef Google Scholar 7. Maser RE, Nielsen VK, Bass EB, et al. [link.springer.com]
Epidemiology and classification of diabetic neuropathy. Shefner JM, Dashe JF, eds. UptoDate. Wolters Kluwer Health. Accessed at: www.uptodate.com. 2013. 2. Rutkove SB. Overview of upper extremity peripheral nerve syndromes. [type2diabetes.com]
[…] types IV & V collagen: Especially in innermost lamellae Endoneurial microvessles Increased types IV, V and VI collagen around microvessels CNS: Spinal cord atrophy reported with diabetes DIABETIC NEUROPATHIES: SYMMETRIC Chronic Distal: Sensory Autonomic Epidemiology [neuromuscular.wustl.edu]
Report from Pittsburgh Epidemiology of Diabetes Complications Study. Diabetes. 1989, 38: 1456-1461. [bmcneurol.biomedcentral.com]
Determination of peripheral neuropathy prevalence and associated factors in Chinese subjects with diabetes and pre-diabetes - ShangHai Diabetic Neuropathy Epidemiology and Molecular Genetics Study (SH-DREAMS). [scielo.br]
Pathophysiology
المحتويات Aldose Reductase Inhibitors for the Treatment 309 Other Therapeutic Agents for the Treatment 321 Pathophysiology of Neuropathic Pain 339 Treatment of Painful Diabetic Neuropathy 351 Focal and Multifocal Diabetic Neuropathy 367 Hypoglycemia and [books.google.com]
THE PATHOPHYSIOLOGY To better understand the pathophysiology of the disease, the Mayo researchers performed ipsilateral nerve biopsies on the 33 patients in their prospective study. [journals.lww.com]
Disease Etiology With over 100 known types of peripheral neuropathy, the pathophysiology of this disease is not quite clear. [endocrinologyadvisor.com]
Classification, clinical features and pathophysiological basis. Neurologist. 2005;11(2):63-79. [ Links ] 31 Lu B, Hu J, Wen J, Zhang Z, Zhou L, Li T, Hu R. [scielo.br]
This should include symptoms and signs, quantitative sensory testing, and electrophysiology [4] Classification A classification system by Thomas [11] combines anatomy and pathophysiology. [physio-pedia.com]
Prevention
These findings might assist both patients and clinicians in better realizing the impacts of neuropathic hands, and planning suitable strategies of intervention or health education to prevent declines in hand functions. 2017 The Authors. [ncbi.nlm.nih.gov]
The statement contains recommendations for physicians on the overall prevention of diabetic neuropathy, highlighting prevention as a key component because of the lack of treatment to reverse this condition. [empr.com]
In type 2 diabetes, work to effectively control glucose to prevent or slow the progression of DSPN. With type 2 diabetes, consider a multifactorial approach with targeting glycemia and other risk factors to prevent CAN. [sciencedaily.com]
Recommendations for overall diabetic neuropathy prevention are as follows: For patients with type 1 diabetes, try to control glucose as soon as possible to prevent or delay the development of DSPN and CAN. [pharmacytimes.com]