Abstract Diabetic polyneuropathy (DPN) has several forms of clinical presentation. It may be asymptomatic, or present with prominent sensory symptoms, including neuropathic pain. [ncbi.nlm.nih.gov]

• Burning Feet

  The first signs and symptom are hypoalgesia, burning feet particularly during the night increasing with touch, and paraesthesia of the feet. Paroxysmal shooting pains also occur. [pijn.com]

  For sensory neuropathy: Numbness or tingling in the feet Pain or discomfort in the feet or legs, including prickly, sharp pain or burning feet For motor neuropathy: Muscle weakness and loss of muscle tone in the feet and lower legs Loss of balance Changes [foothealthfacts.org]

  Besides that, patients with burning feet due to small fiber neuropathy are not expected to have abnormalities in nerve conduction studies. [scielo.br]

  One individual, who reported burning feet at night, slept with her feet uncovered and a fan blowing cool air on them. [nfb.org]

• Progressive Polyneuropathy

  Ms Q is a 52-year-old woman who has had progressive polyneuropathy in the setting of diabetes for the past 8 years. [ncbi.nlm.nih.gov]

• Numbness of the Feet

  There may be loss of muscle in the feet, legs, hands, and hips along with difficulties with walking, balance, and coordination. With numbness of the feet, pressure points from shoes may not be felt, leading to ulcers and infections. [jamanetwork.com]

  The primary outcome measure was the change from baseline of the Total Symptom Score (TSS), including stabbing pain, burning pain, paresthesia, and asleep numbness of the feet. [drperlmutter.com]

  Symptoms can range from pain and numbness in your feet to problems with the functions of your internal organs, such as your heart and bladder. What Is Diabetic Neuropathy? Diabetic neuropathy is nerve damage that is caused by diabetes. [niddk.nih.gov]

  Peripheral neuropathy most commonly causes : pain, burning, tingling, and numbness of the feet and lower legs. [medicinenet.com]

• Myofascial Trigger Point

  Joint dysfunction was detected in the mortise and intertarsal joints and myofascial trigger points were found in the quadratus plantae muscles. [ncbi.nlm.nih.gov]

• Paresthesia

  Its symptoms are paresthesia, dysesthesia and pain. The signs of damage to the peripheral neurons are hypoesthesia, hypoalgesia, hyperesthesia and hyperalgesia, decreased tendon reflexes, and, possibly, weakness and muscle atrophy. [ncbi.nlm.nih.gov]

  Numbness and paresthesia may accompany or precede loss of motor function, which varies from mild to severe. Laboratory findings include elevated protein levels in the cerebrospinal fluid. [medical-dictionary.thefreedictionary.com]

  Treatment Treatment of diabetic neuropathies depends on optimum diabetic control, exercise and weight loss to reduce insulin resistance, and symptomatic control when paresthesias are painful. [hopkinsmedicine.org]

• Dysesthesia

  Abstract Patients with diabetes occasionally develop diabetic polyneuropathy (DPN), which is characterized by both positive symptoms such as pain and negative symptoms such as numbness/dysesthesia. [ncbi.nlm.nih.gov]

  […] standing up a faster heart rate than normal excessive sweating, even in cool temperatures or while at rest bladder problems, for example, difficulty emptying the bladder completely when urinating, leading to incontinence sexual dysfunction in men and women dysesthesia [medicalnewstoday.com]

• Decreased Ankle Reflex

  Clinically, contrasting loss of sharp touch and temperature with subjective increased pain is common. 1,2, 7,9,12 Decreased vibration and position sense occur frequently, but are less sensitive. 2, 7,9,12 Decreased ankle reflexes are also common, as well [dynamicchiropractic.com]

The workup is completed by the performance of an electromyogram with nerve conduction studies to quantitate the extent of involvement of the peripheral nervous system. Diabetic neuropathy, unfortunately, has no effective treatment at this point. [bcm.edu]

(See Workup.) Management of diabetic neuropathy should begin at the initial diagnosis of diabetes. [emedicine.medscape.com]

• Neurophysiologic Abnormalities

  Normal deviate (from percentiles) composite scores of NC included: representative of neurophysiological abnormalities; sensitive and specific for diagnosis and useful for epidemiological surveys; randomized trials; and medical practice. [ncbi.nlm.nih.gov]

Preoperative clinical sensory testing did not differentiate between treatment responders from non-responders. CONCLUSIONS: SCS seems to be an efficacious and feasible treatment for intractable PDP. [ncbi.nlm.nih.gov]

Non-somatic Treatment Psychological Treatment Depression Treatment Cognitive-Behavioural Treatment Rehabilitation Treatment Somatic Treatment Pharmacological treatment: Tricyclic antidepressants Anticonvulsives: carbamazepine, oxcarbazepine, gabapentine [pijn.com]

AIMS/HYPOTHESIS: Early diagnosis of diabetic polyneuropathy (DPN) is critical for a good prognosis. [ncbi.nlm.nih.gov]

The prognosis for diabetic neuropathy is based on the type of neuropathy. As discussed in an earlier question, there are several type of diabetic neuropathy and listed below is the prognosis of each. [sharecare.com]

Prognosis for Diabetics with Neuropathy The prognosis for diabetic neuropathy depends largely on how well the underlying condition of diabetes is handled. [agingcare.com]

When the velocity of the fastest conducting fibers is maintained, the prognosis is favorable. Neurological impairment is less likely in this instance. [dynamicchiropractic.com]

Prognosis of Diabetic Neuropathy The prognosis for diabetic neuropathy depends largely on how well the underlying condition of diabetes is handled. Treating diabetes may halt progression and improve symptoms of the neuropathy, but recovery is slow. [sydneynorthneurology.com.au]

Treatment should be directed to improve etiologic factors besides reducing symptoms; several approaches have been evaluated to reduce neuropathic impairments and improve nerve conduction, such as oral antidiabetics, statins, and antioxidants (alpha-lipoic [ncbi.nlm.nih.gov]

Antioxidants are considered to be the only etiologic management for diabetic polyneuropathy, and statins such as rosuvastatin increase nitric oxide bioavailability and reduce lipid peroxidation. [dovepress.com]

Additionally, patients can be referred if the diagnosis is unclear or if a different etiology is suspected. [pharmacytimes.com]

Proposed vascular etiologies include nerve dysfunction secondary to disease of vasa nervorum, the microvasculature to the nerves. [practicalpainmanagement.com]

You can also refer if the diagnosis is unclear or different etiology is suspected. [labblog.uofmhealth.org]

Abstract This chapter outlines: (1) the reasons why epidemiologic surveys and randomized controlled clinical trials (RCTs) of diabetic polyneuropathy (DPN) are difficult and expensive, and often poorly done, (2) primary and secondary neuropathy end points [ncbi.nlm.nih.gov]

Epidemiological correlates of diabetic neuropathy. Report from Pittsburgh Epidemiology of Diabetes Complications Study. Diabetes 1989;38:1456–1461. PubMed CrossRef Google Scholar 5. Ziegler D. [link.springer.com]

The epidemiology of diabetic neuro-pathy depends on the case definitions used. [practicalpainmanagement.com]

Its pathophysiological mechanism is not completely clarified and major occurrences boil down to the change in neural phenotype and vasa nervorum. [ncbi.nlm.nih.gov]

We concentrate on the prevention of the long-term deficits of neuropathy. [ncbi.nlm.nih.gov]

Recommendations for overall diabetic neuropathy prevention are as follows: For patients with type 1 diabetes, try to control glucose as soon as possible to prevent or delay the development of DSPN and CAN. [pharmacytimes.com]